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Volumn 16, Issue 1, 2011, Pages 1-8

The Role of Interleukin-17 in the Helicobacter pylori Induced Infection and Immunity

Author keywords

Cag A; Helicobacter pylori; Helicobacter pylori infection; Interleukin 17; Interleukin 23

Indexed keywords

CHEMOKINE; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; STAT3 PROTEIN;

EID: 78751559343     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2010.00812.x     Document Type: Review
Times cited : (75)

References (60)
  • 1
    • 0028844280 scopus 로고
    • The transmission of Helicobacter pylori. A critical review of the evidence
    • Goodman KJ, Correa P. The transmission of Helicobacter pylori. A critical review of the evidence. Int J Epidemiol 1995;24:875-87.
    • (1995) Int J Epidemiol , vol.24 , pp. 875-87
    • Goodman, K.J.1    Correa, P.2
  • 2
    • 0028361702 scopus 로고
    • NIH Consensus Development Panel on Helicobacter pylori in peptic ulcer disease
    • NIH Consensus Development Panel on Helicobacter pylori in peptic ulcer disease. J Am Med Assoc 1994; 272:65-9.
    • (1994) J Am Med Assoc , vol.272 , pp. 65-9
  • 3
    • 12344299467 scopus 로고    scopus 로고
    • The relation of Helicobacter pylori to gastric adenocarcinoma and lymphoma: pathophysiology, epidemiology, screening, clinical presentation, treatment, and prevention
    • Marshall BJ, Windsor HM. The relation of Helicobacter pylori to gastric adenocarcinoma and lymphoma: pathophysiology, epidemiology, screening, clinical presentation, treatment, and prevention. Med Clin North Am 2005;89:313-44.
    • (2005) Med Clin North Am , vol.89 , pp. 313-44
    • Marshall, B.J.1    Windsor, H.M.2
  • 4
    • 31144461664 scopus 로고    scopus 로고
    • Helicobacter infection and gastric neoplasia
    • Peek RM Jr, Crabtree JE. Helicobacter infection and gastric neoplasia. J Pathol 2006;208:233-48.
    • (2006) J Pathol , vol.208 , pp. 233-48
    • Peek Jr, R.M.1    Crabtree, J.E.2
  • 5
    • 65749100406 scopus 로고    scopus 로고
    • Effect of Helicobacter pylori eradication on incidence of gastric cancer in human and animal models: underlying biochemical and molecular events
    • Kabir S. Effect of Helicobacter pylori eradication on incidence of gastric cancer in human and animal models: underlying biochemical and molecular events. Helicobacter 2009;14:159-71.
    • (2009) Helicobacter , vol.14 , pp. 159-71
    • Kabir, S.1
  • 7
    • 33947314338 scopus 로고    scopus 로고
    • Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori
    • Necchi V, Candusso ME, Tava F, Luinetti O, Ventura U, Fiocca R, Ricci V, Solcia E. Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori. Gastroenterology 2007;132:1009-23.
    • (2007) Gastroenterology , vol.132 , pp. 1009-23
    • Necchi, V.1    Candusso, M.E.2    Tava, F.3    Luinetti, O.4    Ventura, U.5    Fiocca, R.6    Ricci, V.7    Solcia, E.8
  • 8
    • 33847040290 scopus 로고    scopus 로고
    • The current status of Helicobacter pylori vaccines: a review
    • Kabir S. The current status of Helicobacter pylori vaccines: a review. Helicobacter 2007;12:89-102.
    • (2007) Helicobacter , vol.12 , pp. 89-102
    • Kabir, S.1
  • 9
    • 34447092208 scopus 로고    scopus 로고
    • Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies
    • Wilson KT, Crabtree JE. Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies. Gastroenterology 2007;133:288-308.
    • (2007) Gastroenterology , vol.133 , pp. 288-308
    • Wilson, K.T.1    Crabtree, J.E.2
  • 10
    • 0034326645 scopus 로고    scopus 로고
    • Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa
    • Luzza F, Parrello T, Monteleone G, Sebkova L, Romano M, Zarrilli R, Imeneo M, Pallone F. Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosa. J Immunol 2000;165:5332-7.
    • (2000) J Immunol , vol.165 , pp. 5332-7
    • Luzza, F.1    Parrello, T.2    Monteleone, G.3    Sebkova, L.4    Romano, M.5    Zarrilli, R.6    Imeneo, M.7    Pallone, F.8
  • 12
    • 0027215897 scopus 로고
    • CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
    • Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J Immunol 1993;150:5445-56.
    • (1993) J Immunol , vol.150 , pp. 5445-56
    • Rouvier, E.1    Luciani, M.F.2    Mattéi, M.G.3    Denizot, F.4    Golstein, P.5
  • 15
    • 0036144194 scopus 로고    scopus 로고
    • IL-17: prototype member of an emerging cytokine family
    • Aggarwal S, Gurney AL. IL-17: prototype member of an emerging cytokine family. J Leukoc Biol 2002;71:1-8.
    • (2002) J Leukoc Biol , vol.71 , pp. 1-8
    • Aggarwal, S.1    Gurney, A.L.2
  • 16
    • 17944368518 scopus 로고    scopus 로고
    • IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding
    • Hymowitz SG, Filvaroff EH, Yin JP, et al. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding. EMBO J 2001;20:5332-41.
    • (2001) EMBO J , vol.20 , pp. 5332-41
    • Hymowitz, S.G.1    Filvaroff, E.H.2    Yin, J.P.3
  • 17
    • 38849097777 scopus 로고    scopus 로고
    • An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment
    • Liang SC, Long AJ, Bennett F, et al. An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol 2007;179:7791-9.
    • (2007) J Immunol , vol.179 , pp. 7791-9
    • Liang, S.C.1    Long, A.J.2    Bennett, F.3
  • 18
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003;278:1910-4.
    • (2003) J Biol Chem , vol.278 , pp. 1910-4
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 19
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, Turner H, Murphy TL, Murphy KM, Weaver CT. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005;6:1123-32.
    • (2005) Nat Immunol , vol.6 , pp. 1123-32
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6    Weaver, C.T.7
  • 21
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation in-17 family members and inflammation
    • Kolls JK, Lindén A. Interleukin-17 family members and inflammation in-17 family members and inflammation. Immunity 2004;21:467-76.
    • (2004) Immunity , vol.21 , pp. 467-76
    • Kolls, J.K.1    Lindén, A.2
  • 22
    • 68849084891 scopus 로고    scopus 로고
    • Structure and signalling in the IL-17 receptor family
    • Gaffen SL. Structure and signalling in the IL-17 receptor family. Nat Rev Immunol 2009;9:556-67.
    • (2009) Nat Rev Immunol , vol.9 , pp. 556-67
    • Gaffen, S.L.1
  • 23
    • 55149113836 scopus 로고    scopus 로고
    • The roles of IL-17A in inflammatory immune responses and host defense against pathogens
    • Iwakura Y, Nakae S, Saijo S, Ishigame H. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev 2008;226:57-79.
    • (2008) Immunol Rev , vol.226 , pp. 57-79
    • Iwakura, Y.1    Nakae, S.2    Saijo, S.3    Ishigame, H.4
  • 24
    • 33646417072 scopus 로고    scopus 로고
    • The Il-23/Il-17 axis in inflammation
    • Iwakura Y, Ishigame H. The Il-23/Il-17 axis in inflammation. J Clin Invest 2006;116:1218-22.
    • (2006) J Clin Invest , vol.116 , pp. 1218-22
    • Iwakura, Y.1    Ishigame, H.2
  • 25
    • 29544444414 scopus 로고    scopus 로고
    • Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization
    • Mizuno T, Ando T, Nobata K, et al. Interleukin-17 levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization. World J Gastroenterol 2005;11:6305-11.
    • (2005) World J Gastroenterol , vol.11 , pp. 6305-11
    • Mizuno, T.1    Ando, T.2    Nobata, K.3
  • 26
    • 4544388059 scopus 로고    scopus 로고
    • Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells
    • Sebkova L, Pellicanò A, Monteleone G, Grazioli B, Guarnieri G, Imeneo M, Pallone F, Luzza F. Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells. Infect Immun 2004;72:5019-26.
    • (2004) Infect Immun , vol.72 , pp. 5019-26
    • Sebkova, L.1    Pellicanò, A.2    Monteleone, G.3    Grazioli, B.4    Guarnieri, G.5    Imeneo, M.6    Pallone, F.7    Luzza, F.8
  • 27
    • 42249087970 scopus 로고    scopus 로고
    • IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa
    • Caruso R, Fina D, Paoluzi OA, et al. IL-23-mediated regulation of IL-17 production in Helicobacter pylori-infected gastric mucosa. Eur J Immunol 2008;38:470-8.
    • (2008) Eur J Immunol , vol.38 , pp. 470-8
    • Caruso, R.1    Fina, D.2    Paoluzi, O.A.3
  • 31
    • 55949111960 scopus 로고    scopus 로고
    • IL-17 is involved in Helicobacter pylori-induced gastric inflammatory responses in a mouse model
    • Shiomi S, Toriie A, Imamura S, et al. IL-17 is involved in Helicobacter pylori-induced gastric inflammatory responses in a mouse model. Helicobacter 2008;13:518-24.
    • (2008) Helicobacter , vol.13 , pp. 518-24
    • Shiomi, S.1    Toriie, A.2    Imamura, S.3
  • 32
    • 77954513720 scopus 로고    scopus 로고
    • Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice
    • Shi Y, Liu XF, Zhuang Y, et al. Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. J Immunol 2010;184:5121-9.
    • (2010) J Immunol , vol.184 , pp. 5121-9
    • Shi, Y.1    Liu, X.F.2    Zhuang, Y.3
  • 34
    • 0030475737 scopus 로고    scopus 로고
    • Establishment of gastric Helicobacter pylori infection in Mongolian gerbils
    • Hirayama F, Takagi S, Yokoyama Y, Iwao E, Ikeda Y. Establishment of gastric Helicobacter pylori infection in Mongolian gerbils. J Gastroenterol 1996;31(Suppl 9):24-8.
    • (1996) J Gastroenterol , vol.31 , Issue.SUPPL. 9 , pp. 24-8
    • Hirayama, F.1    Takagi, S.2    Yokoyama, Y.3    Iwao, E.4    Ikeda, Y.5
  • 35
    • 71049186020 scopus 로고    scopus 로고
    • Gastric mucosal interleukin-17 and -18 mRNA expression in Helicobacter pylori-induced Mongolian gerbils
    • Sugimoto M, Ohno T, Graham DY, Yamaoka Y. Gastric mucosal interleukin-17 and -18 mRNA expression in Helicobacter pylori-induced Mongolian gerbils. Cancer Sci 2009;100:2152-9.
    • (2009) Cancer Sci , vol.100 , pp. 2152-9
    • Sugimoto, M.1    Ohno, T.2    Graham, D.Y.3    Yamaoka, Y.4
  • 36
    • 33746525675 scopus 로고    scopus 로고
    • CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo
    • Rad R, Brenner L, Bauer S, et al. CD25+/Foxp3+ T cells regulate gastric inflammation and Helicobacter pylori colonization in vivo. Gastroenterology 2006;131:525-37.
    • (2006) Gastroenterology , vol.131 , pp. 525-37
    • Rad, R.1    Brenner, L.2    Bauer, S.3
  • 38
    • 38649132571 scopus 로고    scopus 로고
    • Helicobacter pylori gastritis in children is associated with a regulatory T-cell response
    • Harris PR, Wright SW, Serrano C, et al. Helicobacter pylori gastritis in children is associated with a regulatory T-cell response. Gastroenterology 2008;134:491-9.
    • (2008) Gastroenterology , vol.134 , pp. 491-9
    • Harris, P.R.1    Wright, S.W.2    Serrano, C.3
  • 39
    • 77249095912 scopus 로고    scopus 로고
    • Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice
    • Kao JY, Zhang M, Miller MJ, et al. Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology 2010;138: 1046-54.
    • (2010) Gastroenterology , vol.138 , pp. 1046-54
    • Kao, J.Y.1    Zhang, M.2    Miller, M.J.3
  • 40
    • 59849109226 scopus 로고    scopus 로고
    • Vaccination of mice against H pylori induces a strong Th-17 response and immunity that is neutrophil dependent
    • DeLyria ES, Redline RW, Blanchard TG. Vaccination of mice against H pylori induces a strong Th-17 response and immunity that is neutrophil dependent. Gastroenterology 2009;136:247-56.
    • (2009) Gastroenterology , vol.136 , pp. 247-56
    • DeLyria, E.S.1    Redline, R.W.2    Blanchard, T.G.3
  • 43
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • Saraiva M, O'Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol 2010;10:170-81.
    • (2010) Nat Rev Immunol , vol.10 , pp. 170-81
    • Saraiva, M.1    O'Garra, A.2
  • 44
    • 0037378907 scopus 로고    scopus 로고
    • (-/-) mice delays clearance of gastric Helicobacter infection and decreases the Th1 immune response to Helicobacter
    • (-/-) mice delays clearance of gastric Helicobacter infection and decreases the Th1 immune response to Helicobacter. J Immunol 2003;170:3782-9.
    • (2003) J Immunol , vol.170 , pp. 3782-9
    • Ismail, H.F.1    Fick, P.2    Zhang, J.3    Lynch, R.G.4    Berg, D.J.5
  • 46
    • 64049095835 scopus 로고    scopus 로고
    • IL-17 and anti-bacterial immunity: protection versus tissue damage
    • Cooper AM. IL-17 and anti-bacterial immunity: protection versus tissue damage. Eur J Immunol 2009;39:649-52.
    • (2009) Eur J Immunol , vol.39 , pp. 649-52
    • Cooper, A.M.1
  • 47
    • 58149296036 scopus 로고    scopus 로고
    • Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens
    • Curtis MM, Way SS. Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens. Immunology 2009;126:177-85.
    • (2009) Immunology , vol.126 , pp. 177-85
    • Curtis, M.M.1    Way, S.S.2
  • 49
    • 53049107872 scopus 로고    scopus 로고
    • Interleukin-17A mediates acquired immunity to pneumococcal colonization
    • Lu Y-J, Gross J, Bogaert D, et al. Interleukin-17A mediates acquired immunity to pneumococcal colonization. PLoS Pathog 2008;4:e1000159.
    • (2008) PLoS Pathog , vol.4
    • Lu, Y.1    Gross, J.2    Bogaert, D.3
  • 51
    • 21244455537 scopus 로고    scopus 로고
    • Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis
    • McAllister F, Henry A, Kreindler JL, et al. Role of IL-17A, IL-17F, and the IL-17 receptor in regulating growth-related oncogene-alpha and granulocyte colony-stimulating factor in bronchial epithelium: implications for airway inflammation in cystic fibrosis. J Immunol 2005;175:404-12.
    • (2005) J Immunol , vol.175 , pp. 404-12
    • McAllister, F.1    Henry, A.2    Kreindler, J.L.3
  • 54
    • 67449149677 scopus 로고    scopus 로고
    • Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis
    • Shibata T, Tahara T, Hirata I, Arisawa T. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. Hum Immunol 2009;70:547-51.
    • (2009) Hum Immunol , vol.70 , pp. 547-51
    • Shibata, T.1    Tahara, T.2    Hirata, I.3    Arisawa, T.4
  • 55
    • 77953457048 scopus 로고    scopus 로고
    • Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer
    • Wu X, Zeng Z, Chen B, Yu J, Xue L, Hao Y, Chen M, Sung JJ, Hu P. Association between polymorphisms in interleukin-17A and interleukin-17F genes and risks of gastric cancer. Int J Cancer 2010;127:86-92.
    • (2010) Int J Cancer , vol.127 , pp. 86-92
    • Wu, X.1    Zeng, Z.2    Chen, B.3    Yu, J.4    Xue, L.5    Hao, Y.6    Chen, M.7    Sung, J.J.8    Hu, P.9
  • 56
    • 59549083038 scopus 로고    scopus 로고
    • Interleukin-17 as a drug target in human disease
    • Ivanov S, Lindén A. Interleukin-17 as a drug target in human disease. Trends Pharmacol Sci 2009;30:95-103.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 95-103
    • Ivanov, S.1    Lindén, A.2
  • 57
    • 78751517113 scopus 로고    scopus 로고
    • A Dose-Ranging and Efficacy Study of LY2439821 (an Anti-IL-17 Antibody) in Patients with Moderate-to-Severe Psoriasis. ClinicalTrials.gov Identifier: NCT01107457. URL:
    • A Dose-Ranging and Efficacy Study of LY2439821 (an Anti-IL-17 Antibody) in Patients with Moderate-to-Severe Psoriasis. ClinicalTrials.gov Identifier: NCT01107457. URL:
  • 58
    • 78751563195 scopus 로고    scopus 로고
    • An Open Label Safety and Tolerability Study of AIN457 in Patients with Moderate to Severe Crohn's Disease. ClinicalTrials.gov Identifier: NCT01009281. URL:
    • An Open Label Safety and Tolerability Study of AIN457 in Patients with Moderate to Severe Crohn's Disease. ClinicalTrials.gov Identifier: NCT01009281. URL:
  • 59
    • 70349968220 scopus 로고    scopus 로고
    • IL-17 as a future therapeutic target for rheumatoid arthritis
    • van den Berg WB, Miossec P. IL-17 as a future therapeutic target for rheumatoid arthritis. Nat Rev Rheumatol 2009;10:549-53.
    • (2009) Nat Rev Rheumatol , vol.10 , pp. 549-53
    • van den Berg, W.B.1    Miossec, P.2


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