The Raf/MEK inhibitor PD98059 enhances ERK1/2 phosphorylation mediated by peroxynitrite via enforced mitochondrial formation of reactive oxygen species

FEBS Letters

Volumn 547, Issue 1-3, 2003, Pages 92-96

  Cerioni, Liana ^a   Palomba, Letizia ^a   Cantoni, Orazio ^a  

^a UNIVERSITY OF URBINO   (Italy)

Author keywords

Extracellular signal regulated kinase phosphorylation; Mitochondrion; PC12 cell; PD98059; Peroxynitrite; Reactive oxygen species

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE 1; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CELL STRAIN; CONTROLLED STUDY; EXPOSURE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RESPIRATORY CHAIN;

EID: 0038304819     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(03)00675-6     Document Type: Article

References (13)

1. Jope R.S., Zhang L., Song L. Arch. Biochem. Biophys. 376:2000;365-370.
2. Zhang P., Wang Y.Z., Kagan E., Bonner J.C. J. Biol. Chem. 275:2000;22479-22486.
3. Bapat S., Verkleij A., Post J.A. FEBS Lett. 499:2001;21-26.
4. Zouki C., Zhang S.L., Chan J.S.D., Filep J.G. FASEB J. 15:2001;25-27.
5. Guidarelli A., Cantoni O. Biochem. J. 366:2002;307-314.
6. Radi R., Beckman S., Bush H.M., Freeman B.A. Arch. Biochem. Biophys. 288:1991;481-487.
7. Lee S.A., Park J.K., Kang E.K., Bae H.R., Bae K.W., Park H.T. Mol. Brain Res. 75:2000;16-24.
8. Guyton K.Z., Gorospe M., Kensler T.M., Holbrook N.J. Cancer Res. 56:1996;3480-3485.
9. Guyton K.Z., Liu Y., Gorospe M., Xu Q., Holbrook N.J. J. Biol. Chem. 271:1996;4138-4142.
10. Favata M.F., Horiuchi K.Y., Manos E.J., Daulerio A.J., Stradley D.A., Feeser W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F., Copeland R.A., Magolda R.L., Scherle P.A., Trzaskos J.M. J. Biol. Chem. 273:1998;18623-18632.
11. Beckman J.S., Crow J.P. Soc. Trans. 21:1993;330-334.
12. Stanciu M., Wang Y., Kentor R., Burke N., Watkins S., Kress G., Reynolds I., Klann E., Angiolieri M.R., Johnson J.W., DeFranco D.B. J. Biol. Chem. 275:2000;12200-12206.
13. Guidarelli A., Tommasini I., Fiorani M., Cantoni O. IUBMB Life. 50:2000;195-201.