Peptides and aptamers targeting HSP70: A novel approach for anticancer chemotherapy

Cancer Research

Volumn 71, Issue 2, 2011, Pages 484-495

  Rérole, Anne Laure ^a   Gobbo, Jessica ^a   De Thonel, Aurelie ^a   Schmitt, Elise ^a   Pais De Barros, Jean Paul ^a   Hammann, Arlette ^a   Lanneau, David ^a   Fourmaux, Eric ^a   Deminov, Oleg ^a   Micheau, Olivier ^a   Lagrost, Laurent ^a   Colas, Pierre ^b   Kroemer, Guido ^c,d,e   Garrido, Carmen ^a,f,g  

^a Chu   (France)

^b Protein Phosphorylation and Human Disease Group   (France)

^c Institut Gustave Roussy   (France)

^d INSTITUT GUSTAVE ROUSSY   (France)

^e UNIVERSITÉ PARIS SACLAY   (France)

^f UNIVERSITÉ DE BOURGOGNE   (France)

^g DIJON UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 70; PEPTIDE APTAMER;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER THERAPY; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG BINDING; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APTAMERS, PEPTIDE; HELA CELLS; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RATS; TRANSFECTION;

EID: 78751478982     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1443     Document Type: Article

References (40)

1. Shi Y, Thomas JO. The transport of proteins into the nucleus requires the 70-kilodalton heat shock protein or its cytosolic cognate. Mol Cell Biol 1992;12:2186-92.
2. Murakami H, Pain D, Blobel G. 70-kD heat shock-related protein is one of at least two distinct cytosolic factors stimulating protein import into mitochondria. J Cell Biol 1988;107:2051-57.
3. Beckmann RP, Mizzen LE, Welch WJ. Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly. Science 1990;248:850-4.
4. Seo JS, Park YM, Kim JI, Shim EH, Kim CW, Jang JJ, et al. T cell lymphoma in transgenic mice expressing the human Hsp70 gene. Biochem Biophys Res Commun 1996;218:582-7.
5. Volloch VZ, Sherman MY. Oncogenic potential of Hsp72. Oncogene 1999;18:3648-51.
6. Jaattela M. Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells. Int J Cancer 1995;60:689-93.
7. Vargas-Roig LM, Gago FE, Tello O, Aznar JC, Ciocca DR. Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy. Int J Cancer 1998;79:468-75.
8. Nylandsted J, Rohde M, Brand K, Bastholm L, Elling F, Jaattela M. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc Natl Acad Sci U S A 2000;97:7871-6.
9. Gurbuxani S, Bruey JM, Fromentin A, Larmonier N, Parcellier A, Jaattela M, et al. Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells. Oncogene 2001;20:7478-85.
10. Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, et al. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol 2000;2:469-75.
11. Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, et al. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol 2001;3:839-43.
12. Chiosis G. Discovery and development of purine-scaffold Hsp90 inhibitors. Curr Top Med Chem 2006;6:1183-91.
13. Chiosis G, Timaul MN, Lucas B, Munster PN, Zheng FF, Sepp- Lorenzino L, et al. A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. Chem Biol 2001; 8:289-99.
14. Neckers L, Neckers K. Heat-shock protein 90 inhibitors as novel cancer chemotherapeutic agents. Expert Opin Emerg Drugs 2002; 7:277-88.
15. Usmani SZ, Bona R, Li Z. 17 AAG for HSP90 inhibition in cancer-from bench to bedside. Curr Mol Med 2009;9:654-64.
16. Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, et al. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Oncogene 2003;22:6669-78.
17. Schmitt E, Parcellier A, Gurbuxani S, Cande C, Hammann A, Morales MC, et al. Chemosensitization by a non-apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res 2003;63:8233-40.
18. Steele AJ, Prentice AG, Hoffbrand AV, Yogashangary BC, Hart SM, Lowdell MW, et al. 2-Phenylacetylenesulfonamide (PAS) induces p53- independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood 2009;114:1217-25.
19. Leu JI, Pimkina J, Frank A, Murphy ME, George DL. A small molecule inhibitor of inducible heat shock protein 70. Mol Cell 2009; 36:15-27.
20. Brunet Simioni M, De Thonel A, Hammann A, Joly AL, Bossis G, Fourmaux E, et al. Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity. Oncogene 2009;28:3332-44.
21. Schmitt E, Maingret L, Puig PE, Rerole AL, Ghiringhelli F, Hammann A, et al. Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma. Cancer Res 2006;66:4191-7.
22. Ghiringhelli F, Puig PE, Roux S, Parcellier A, Schmitt E, Solary E, et al. Tumor cells convert immature myeloid dendritic cells into TGF-betasecreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med 2005;202:919-29.
23. de Thonel A, Vandekerckhove J, Lanneau D, Selvakumar S, Courtois G, Hazoume A, et al. HSP27 controls GATA-1 protein level during erythroid cell differentiation. Blood 2010;116:85-96.
24. Bickle MB, Dusserre E, Moncorge O, Bottin H, Colas P. Selection and characterization of large collections of peptide aptamers through optimized yeast two-hybrid procedures. Nat Protoc 2006;1:1066-91.
25. Abed N, Bickle M, Mari B, Schapira M, Sanjuan-Espana R, Robbe Sermesant K, et al. A comparative analysis of perturbations caused by a gene knock-out, a dominant negative allele, and a set of peptide aptamers. Mol Cell Proteomics 2007;6:2110-21.
26. Nylandsted J, Wick W, Hirt UA, Brand K, Rohde M, Leist M, et al. Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion. Cancer Res 2002;62:7139-42.
27. Kim YS, Alarcon SV, Lee S, Lee MJ, Giaccone G, Neckers L, et al. Update on Hsp90 inhibitors in clinical trial. Curr Top Med Chem 2009;9:1479-92.
28. McMillan DR, Xiao X, Shao L, Graves K, Benjamin IJ. Targeted disruption of heat shock transcription factor 1 abolishes thermotolerance and protection against heat-inducible apoptosis. J Biol Chem 1998;273:7523-8.
29. Xiao X, Zuo X, Davis AA, McMillan DR, Curry BB, Richardson JA, et al. HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice. Embo J 1999;18:5943-52.
30. Pirkkala L, Nykanen P, Sistonen L. Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 2001;15:1118-31.
31. Chalmin F, Ladoire S, Mignot G, Vincent J, Bruchard M, Remy-Martin JP, et al. Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J Clin Invest 2010; 120:457-71.
32. Lins L, Piron S, Conrath K, Vanloo B, Brasseur R, Rosseneu M, et al. Enzymatic hydrolysis of reconstituted dimyristoylphosphatidylcholine- apo A-I complexes. Biochim Biophys Acta 1993;1151:137-42.
33. Hanson CL, Ilag LL, Malo J, Hatters DM, Howlett GJ, Robinson CV. Phospholipid complexation and association with apolipoprotein C-II: insights from mass spectrometry. Biophys J 2003;85:3802-12.
34. Bach SP, Williamson SE, O'Dwyer ST, Potten CS, Watson AJ. Regional localisation of p53-independent apoptosis determines toxicity to 5-fluorouracil and pyrrolidinedithiocarbamate in the murine gut. Br J Cancer 2006;95:35-41.
35. Welty FK, Lichtenstein AH, Barrett PH, Dolnikowski GG, Schaefer EJ. Interrelationships between human apolipoprotein A-I and apolipoproteins B-48 and B-100 kinetics using stable isotopes. Arterioscler Thromb Vasc Biol 2004;24:1703-07.
36. Parcellier A, Gurbuxani S, Schmitt E, Solary E, Garrido C. Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun 2003;304:505-12.
37. Hantschel M, Pfister K, Jordan A, Scholz R, Andreesen R, Schmitz G, et al. Hsp70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients. Cell Stress Chap 2000;5:438-42.
38. Schmitt E, Gehrmann M, Brunet M, Multhoff G, Garrido C. Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy. J Leukoc Biol 2007;81:15-27.
39. Multhoff G.Heat shock proteins in immunity. Handb Exp Pharmacol 2006:279-304.
40. Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 2007;13:54-61.