The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator

Journal of Biological Chemistry

Volumn 286, Issue 3, 2011, Pages 2171-2182

  Wang, Guangyu ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP-BINDING CASSETTE TRANSPORTERS; CHANNEL ACTIVITY; CHANNEL GATING; CHANNEL OPENING; CHLORIDE CHANNELS; CONTROLLED NOT; CURCUMIN; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; CYTOPLASMIC LOOPS; DOUBLE MUTANTS; ELECTRON CRYOMICROSCOPY; HYDROGEN BOND DONORS; HYDROPHILIC RESIDUES; IN-VITRO; INHIBITION MECHANISMS; LINKING STRATEGY; NUCLEOTIDE-BINDING DOMAIN; PHOSPHORYLATION SITES; PROTEIN KINASE A; REGULATORY DOMAIN; SINGLE CHANNEL RECORDING; STRUCTURAL MODELS; SULFHYDRYL; UNDERLYING MECHANISM;

AMINO ACIDS; CHLORINE COMPOUNDS; FETAL MONITORING; HYDROGEN; HYDROGEN BONDS; MODEL STRUCTURES;

PHOSPHORYLATION;

HISTIDINE; SERINE; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; GENE MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; HEK293 CELLS; HUMANS; HYDROGEN BONDING; ION CHANNEL GATING; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SERINE;

EID: 78751472530     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.145540     Document Type: Article

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