State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3

Journal of Biological Chemistry

Volumn 285, Issue 52, 2010, Pages 40438-40447

  Wang, Guangyu ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP BINDING; ATP-BINDING CASSETTE TRANSPORTERS; CHANNEL FUNCTIONS; CHANNEL GATING; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; CYTOPLASMIC LOOPS; HIGH AFFINITY; INDEPENDENT CHANNELS; MULTIPLE EFFECT; PATHOPHYSIOLOGICAL; PHENANTHROLINES; REGULATORY DOMAIN; STATE-DEPENDENT; UNDERLYING MECHANISM;

PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATE; ADENYLYLIMIDODIPHOSPHATE; ASPARTIC ACID; CELL PROTEIN; CYSTEINE; CYTOPLASMIC LOOP 3; EDETIC ACID; FERRIC ION; HISTIDINE; NUCLEOTIDE BINDING PROTEIN; PHENANTHROLINE; PROTEIN NBD1; PROTEIN NBD2; SERINE; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELLULAR DISTRIBUTION; CHANNEL GATING; CONTROLLED STUDY; DIMERIZATION; GENE CONTROL; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE MUTATION; HOMEOSTASIS; HUMAN; HUMAN CELL; IRON BINDING CAPACITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SENSITIVITY ANALYSIS;

ADENOSINE TRIPHOSPHATE; ADENYLYL IMIDODIPHOSPHATE; AMINO ACID SUBSTITUTION; CHELATING AGENTS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EDETIC ACID; HEK293 CELLS; HUMANS; INFERTILITY; ION CHANNEL GATING; IRON; MUTATION, MISSENSE; PHENANTHROLINES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 78650344900     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.161497     Document Type: Article

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