The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer

Digestive Diseases and Sciences

Volumn 53, Issue 2, 2008, Pages 467-473

  Takami, Yoji ^a   Higashi, Morihiro ^a   Kumagai, Shinpei ^a   Kuo, Paul C ^b   Kawana, Hidetada ^a   Koda, Keiji ^c   Miyazaki, Masaru ^a   Harigaya, Kenichi ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c TEIKYO UNIVERSITY CHIBA MEDICAL CENTER   (Japan)

Author keywords

Colorectal neoplasms; Metastasis; Rac1; RhoA

Indexed keywords

RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE COURSE; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

ADULT; AGED; AGED, 80 AND OVER; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; ENZYME ACTIVATION; FEMALE; HUMANS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; RAC1 GTP-BINDING PROTEIN; RHOA GTP-BINDING PROTEIN;

EID: 38649118554     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-007-9887-0     Document Type: Article

References (15)

1. Quigley JP, Armstrong PB (1998) Tumor cell intravasation alu-cidated: the chick embryo opens the window. Cell 94:281-284
2. Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509-514
3. Bouzahzah B et al (2001) Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways. Mol Med 7:816-830
4. Fritz G, Just I, Kaina B (1999) Rho GTPases are over-expressed in human tumors. Int J Cancer 81:682-687
5. Suwa H et al (1998) Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer 77:147-152
6. Kamai T et al (2003) Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 9:2632-2641
7. Wang W, Yang LY, Yang ZL, Huang GW, Lu WQ (2003) Expression and significance of RhoC gene in hepatocellular carcinoma. World J Gastroenterol 9:1950-1953
8. Boguski MS, McCormick F (1993) Proteins regulating Ras and its relatives. Nature 366:643-654
9. Kimura K, Tsuji T, Takada Y, Miki T, Narumiya S (2000) Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J Biol Chem 275:17233-17236
10. Schnelzer A et al (2000) Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 19:3013-3020
11. Liu CA, Wang MJ, Chi CW, Wu CW, Chen JY (2004) Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis. Oncogene 23(54):8731-8742
12. Vasiliev JM, Omelchenko T, Gelfand IM, Feder HH, Bonder EM (2004) Rho overexpression leads to mitosis-associated detachment of cells from epithelial sheets: a link to the mechanism of cancer dissemination. Proc Natl Acad Sci USA 101:12526-12530
13. McNicholas MM et al (1994) Magnetic resonance imaging of rectal carcinoma: a prospective study. Br J Surg 81:911-914
14. Saitoh N et al (1986) Evaluation of echographic diagnosis of rectal cancer using intrarectal ultrasonic examination. Dis Colon Rectum 29:234-242
15. Beynon J et al (1989) Preoperative assessment of mesorectal lymph node involvement in rectal cancer. Br J Surg 76:276-279