Plant flavonol quercetin and isoflavone biochanin A differentially induce protection against oxidative stress and inflammation in ARPE-19 cells

Food Research International

Volumn 44, Issue 1, 2011, Pages 109-113

  Saviranta, Niina M M ^a   Veeroos, Laura ^a   Granlund, Lars J ^a   Hassinen, Viivi H ^a   Kaarniranta, Kai ^a   Karjalainen, Reijo O ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b FINNISH FOREST RESEARCH INSTITUTE   (Finland)

Author keywords

Biochanin A; Eye health; Functional ingredients; Inflammation; Oxidative stress; Quercetin

Indexed keywords

BIOCHANIN A; EYE HEALTH; FUNCTIONAL INGREDIENTS; INFLAMMATION; QUERCETIN;

ALDEHYDES; CELL DEATH; FOOD PRODUCTS; GENE EXPRESSION; HEALTH RISKS; IMMUNOLOGY; OPHTHALMOLOGY; OXIDATIVE STRESS; PATHOLOGY; PHENOLS;

FATTY ACIDS;

EID: 78651439493     PISSN: 09639969     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodres.2010.10.056     Document Type: Article

References (35)

1. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001, 119:1417-1436. Age-Related Eye Disease Study Group.
2. Boots A.W., Haenen G.R., Bast A. Health effects of quercetin: From antioxidant to nutraceutical. Eur J Pharmacol 2008, 585:325-337.
3. Braun S., Hanselmann C., Gassmann M.G., auf dem Keller U., Born-Berclaz C., Chan K., et al. Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol Cell Biol 2002, 22:5492-5505.
4. Cao X., Liu M., Tuo J., Shen D., Chan C.-C. The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res 2010, 91:15-25.
5. Chung H.Y., Cesari M., Anton S., Marzetti E., Giovannini S., Seo A.Y., et al. Molecular inflammation: Underpinnings of aging and age-related diseases. Ageing Res Rev 2009, 8:18-30.
6. Dussault A.A., Pouliot M. Rapid and simple comparison of messenger RNA levels using real-time PCR. Biol Proced Online 2006, 8:1-10.
7. Gehrs K.M., Anderson D.H., Johnson L.V., Hageman G.S. Age-related macular degeneration-Emerging pathogenetic and therapeutic concepts. Ann Med 2006, 38:450-471.
8. González-Molina E., Moreno D.A., García-Viguera C. A new drink rich in healthy bioactives combining lemon and pomegranate juices. Food Chem 2009, 115:1364-1372.
9. Hanneken A., Lin F.-F., Johnson J., Maher P. Flavonoids protect human retinal pigment epithelial cells from oxidative stress-induced death. Investig Ophthalmol Vis Sci 2006, 47:3164-3177.
10. Hansen M.B., Nielsen S.E., Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Meth 1989, 119:203-210.
11. Heinonen S.M., Wähälä K., Adlercreutz H. Identification of urinary metabolites of the red clover isoflavones formononetin and biochanin A in human subjects. J Agric Food Chem 2004, 52:6802-6809.
12. Ho L., Chen L.H., Wang J., Zhao W., Talcott S.T., Ono K., et al. Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration. J Alzheimers Dis JAD 2009, 16:59-72.
13. Iyer S.S., Pulskens W.P., Sadler J.J., Butter L.M., Teske G.J., Ulland T.K., et al. Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci USA 2009, 106:20388-20393.
14. Johnson J., Maher P., Hanneken A. The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression. Investig Ophthalmol Vis Sci 2009, 50:2398-2406.
15. Kaarniranta K., Salminen A. Age-related macular degeneration: Activation of innate immunity system via pattern recognition receptors. J Mol Med 2009, 87:117-123.
16. Kaarniranta K., Hyttinen J., Ryhänen T., Viiri J., Paimela T., Toropainen E., et al. Mechanisms of protein aggregation in the retinal pigment epithelial cells. Front biosci Elite edition 2010, 2:1374-1384.
17. Kang H.J., Lee S.H., Price J.E., Kim L.S. Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB in breast cancer cells and potentiates the growth inhibitory effect of paclitaxel in a breast cancer nude mice model. Breast J 2009, 15:223-229.
18. Kimura S., Warabi E., Yanagawa T., Ma D., Itoh K., Ishii Y., et al. Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun 2009, 387:109-114.
19. Knekt P., Kumpulainen J., Järvinen R., Rissanen H., Heliövaara M., Reunanen A., et al. Flavonoid intake and risk of chronic diseases. Am J Clin Nutr 2002, 76:560-568.
20. Kokot A., Metze D., Mouchet N., Galibert M., Schiller M., Luger T.A., et al. α-Melanocyte-stimulating hormone counteracts the suppressive effect of UVB on Nrf2 and Nrf2-dependent gene-expression in human skin. Endocrinology 2009, 150:3197-3206.
21. Kook D., Wolf A.H., Yu A.L., Neubauer A.S., Priglinger S.G., Kampik A., et al. The protective effect of quercetin against oxidative stress in the human RPE in vitro. Investig Ophthalmol Vis Sci 2008, 49:1712-1720.
22. Li W., Khor T.O., Xu C., Shen G., Jeong W.S., Yu S., et al. Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol 2008, 76:1485-1489.
23. Liu R.H. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. Am J Clin Nutr 2003, 78:517S-520S.
24. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods 2001, 25:402-408.
25. Maher P., Hanneken A. Flavonoids protect retinal ganglion cells from oxidative stress-induced death. Investig Ophthalmol Vis Sci 2005, 46:4796-4803.
26. Malinen M., Saramäki A., Ropponen A., Degenhardt T., Väisänen S., Carlberg C. Distinct HDACs regulate the transcriptiona response of human cyclin-dependent kinase inhibitor genes to trichostatin A and 1 1 α, 25-dihydroxyvitamin D3. Nucleic Acids Res 2008, 36:121-132.
27. Milbury P., Graf P., Curran-Celentano J., Blumberg J. Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in APRE-19 cells. Investig Ophthalmol Vis Sci 2007, 48:2343-2349.
28. Miyamura N., Ogawa T., Boylan S., Morse L.S., Handa J.T., Hjelmeland L.M. Topographic and age-dependent expression of heme oxygenase-1 and catalase in the human retinal pigment epithelium. Investig Ophthalmol Vis Sci 2004, 45:1562-1565.
29. Nguyen T., Nioi P., Pickett C.B. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 2009, 284:13291-13295.
30. Occhiuto F., Palumbo D.R., Samperi S., Zangla G., Pino A., De Pasquale R., et al. The isoflavones mixture from Trifolium pratense L. protects HCN 1-A neurons from oxidative stress. Phytother Res PTR 2009, 23:192-196.
31. Park H.J., Yang J.Y., Ambati S., Della-Fera M.A., Hausman D.B., Rayalam S., et al. Combined effects of genistein, quercetin, and resveratrol in human and 3T3-L1 adipocytes. J Med Food 2008, 11:773-783.
32. Reiterer G., Toborek M., Hennig B. Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction. J Nutr 2004, 134:771-775.
33. Saviranta N.M.M., Anttonen M.J., von Wright A., Karjalainen R.O. Red clover (Trifolium pratense L.) isoflavones: Determination of concentrations by plant stage, flower colour, plant part and cultivar. J Sci Food Agric 2008, 88:125-132.
34. Surh Y.J., Na H.K. NF-kappaB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals. Genes Nutr 2008, 2:313-317.
35. Zafrilla P., Morillas J.M., Rubio-Perez J.M., Cantos Villar E. Ingredients for functional drinks in neurodegenerative diseases: A review. Nat Prod Commun 2009, 4:719-740.