GABAA receptor open-state conformation determines non-competitive antagonist binding

Toxicology and Applied Pharmacology

Volumn 250, Issue 3, 2011, Pages 221-228

  Chen, Ligong ^a,c   Xue, Ling ^b   Giacomini, Kathleen M ^c   Casida, John E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California   (United States)

Author keywords

3H EBOB; Chimeragenesis; GABAA receptor; Insecticide; Mutagenesis; Non competitive antagonist

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; RADIOLIGAND;

ALPHA CHAIN; ARTICLE; BETA CHAIN; BINDING AFFINITY; BINDING SITE; CHIMERA; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG BINDING; GENE MUTATION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MUTAGENESIS; PROTEIN CONFORMATION; PROTEIN DOMAIN;

ANESTHETICS, GENERAL; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOMIDATE; GABA-A RECEPTOR AGONISTS; GABA-A RECEPTOR ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; PROTEIN SUBUNITS; RADIOLIGAND ASSAY; RECEPTORS, GABA-A; RECOMBINANT FUSION PROTEINS;

EID: 78651433716     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.11.010     Document Type: Article

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