메뉴 건너뛰기




Volumn 4, Issue 1, 2011, Pages 47-52

Down-regulation of zinc transporter 8 in the pancreas of db/db mice is rescued by Exendin-4 administration

Author keywords

Adipose tissue; Exendin 4; Pancreas; Type 2 diabetes mellitus; Zinc transporter 8

Indexed keywords

EXENDIN 4; MESSENGER RNA; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER 8;

EID: 78651407871     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2010.392     Document Type: Article
Times cited : (8)

References (31)
  • 1
    • 33751183948 scopus 로고    scopus 로고
    • In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion
    • Chimienti F, Devergnas S, Pattou F, et al: In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J Cell Sci 119: 4199-4206, 2006.
    • (2006) J Cell Sci , vol.119 , pp. 4199-4206
    • Chimienti, F.1    Devergnas, S.2    Pattou, F.3
  • 2
    • 4344665860 scopus 로고    scopus 로고
    • Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules
    • Chimienti F, Devergnas S, Favier A and Seve M: Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 53: 2330-2337, 2004.
    • (2004) Diabetes , vol.53 , pp. 2330-2337
    • Chimienti, F.1    Devergnas, S.2    Favier, A.3    Seve, M.4
  • 3
    • 24744451161 scopus 로고    scopus 로고
    • ZnT-8, a pancreatic beta-cell-specific zinc transporter
    • Chimienti F, Favier A and Seve M: ZnT-8, a pancreatic beta-cell-specific zinc transporter. Biometals 18: 313-317, 2005.
    • (2005) Biometals , vol.18 , pp. 313-317
    • Chimienti, F.1    Favier, A.2    Seve, M.3
  • 4
    • 33846195047 scopus 로고    scopus 로고
    • Zinc-transporter genes in human visceral and subcutaneous adipocytes: Lean versus obese
    • Smidt K, Pedersen SB, Brock B, et al: Zinc-transporter genes in human visceral and subcutaneous adipocytes: lean versus obese. Mol Cell Endocrinol 264: 68-73, 2007.
    • (2007) Mol Cell Endocrinol , vol.264 , pp. 68-73
    • Smidt, K.1    Pedersen, S.B.2    Brock, B.3
  • 5
    • 38949175970 scopus 로고    scopus 로고
    • Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9
    • Overbeck S, Uciechowski P, Ackland ML, Ford D and Rink L: Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukocyte Biol 83: 368-380, 2008.
    • (2008) J Leukocyte Biol , vol.83 , pp. 368-380
    • Overbeck, S.1    Uciechowski, P.2    Ackland, M.L.3    Ford, D.4    Rink, L.5
  • 6
    • 67349256742 scopus 로고    scopus 로고
    • Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands
    • Murgia C, Devirgiliis C, Mancini E, Donadel G, Zalewski P and Perozzi G: Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands. Nutr Metab Cardiovasc Dis 19: 431-439, 2009.
    • (2009) Nutr Metab Cardiovasc Dis , vol.19 , pp. 431-439
    • Murgia, C.1    Devirgiliis, C.2    Mancini, E.3    Donadel, G.4    Zalewski, P.5    Perozzi, G.6
  • 7
    • 34249828965 scopus 로고    scopus 로고
    • A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    • Steinthorsdottir V, Thorleifsson G, Reynisdottir I, et al: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39: 770-775, 2007.
    • (2007) Nat Genet , vol.39 , pp. 770-775
    • Steinthorsdottir, V.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 8
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J, et al: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 445: 881-885, 2007.
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 9
    • 39849107884 scopus 로고    scopus 로고
    • Analysis of novel risk loci for type 2 diabetes in a general French population: The D.E.S.I.R. study
    • Cauchi S, Proenca C, Choquet H, et al: Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study. J Mol Med 86: 341-348, 2008.
    • (2008) J Mol Med , vol.86 , pp. 341-348
    • Cauchi, S.1    Proenca, C.2    Choquet, H.3
  • 10
    • 38849129636 scopus 로고    scopus 로고
    • Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function
    • Staiger H, Machicao F, Stefan N, et al: Polymorphisms within novel risk loci for type 2 diabetes determine beta-cell function. PLoS One 2: e832, 2007.
    • (2007) PLoS One , vol.2
    • Staiger, H.1    Machicao, F.2    Stefan, N.3
  • 11
    • 41149178492 scopus 로고    scopus 로고
    • Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion
    • Kirchhoff K, Machicao F, Haupt A, et al: Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 51: 597-601, 2008.
    • (2008) Diabetologia , vol.51 , pp. 597-601
    • Kirchhoff, K.1    Machicao, F.2    Haupt, A.3
  • 12
    • 36749011882 scopus 로고    scopus 로고
    • The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
    • Wenzlau JM, Juhl K, Yu L, et al: The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci USA 104: 17040-17045, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17040-17045
    • Wenzlau, J.M.1    Juhl, K.2    Yu, L.3
  • 14
    • 48249136253 scopus 로고    scopus 로고
    • Association analysis of type 2 diabetes Loci in type 1 diabetes
    • Qu HQ, Grant SF, Bradfield JP, et al: Association analysis of type 2 diabetes Loci in type 1 diabetes. Diabetes 57: 1983-1986, 2008.
    • (2008) Diabetes , vol.57 , pp. 1983-1986
    • Qu, H.Q.1    Grant, S.F.2    Bradfield, J.P.3
  • 15
    • 44649196388 scopus 로고    scopus 로고
    • A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population
    • Brorsson C, Bergholdt R, Sjogren M, et al: A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population. Mol Genet Metab 94: 386-388, 2008.
    • (2008) Mol Genet Metab , vol.94 , pp. 386-388
    • Brorsson, C.1    Bergholdt, R.2    Sjogren, M.3
  • 16
    • 66249128300 scopus 로고    scopus 로고
    • Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion
    • Fu Y, Tian W, Pratt EB, Dirling LB, Shyng SL, Meshul CK and Cohen DM: Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. PLoS One 4: e5679, 2009.
    • (2009) PLoS One , vol.4
    • Fu, Y.1    Tian, W.2    Pratt, E.B.3    Dirling, L.B.4    Shyng, S.L.5    Meshul, C.K.6    Cohen, D.M.7
  • 17
    • 69249226366 scopus 로고    scopus 로고
    • Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion
    • Pound LD, Sarkar SA, Benninger RK, et al: Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion. Biochem J 421: 371-376, 2009.
    • (2009) Biochem J , vol.421 , pp. 371-376
    • Pound, L.D.1    Sarkar, S.A.2    Benninger, R.K.3
  • 18
    • 70349280000 scopus 로고    scopus 로고
    • Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
    • Lemaire K, Ravier MA, Schraenen A, et al: Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci USA 106: 14872-14877, 2009.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14872-14877
    • Lemaire, K.1    Ravier, M.A.2    Schraenen, A.3
  • 19
    • 0141953908 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 synthetic analogs: New therapeutic agents for use in the treatment of diabetes mellitus
    • Holz GG and Chepurny OG: Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus. Curr Med Chem 10: 2471-2483, 2003.
    • (2003) Curr Med Chem , vol.10 , pp. 2471-2483
    • Holz, G.G.1    Chepurny, O.G.2
  • 20
    • 62349127266 scopus 로고    scopus 로고
    • The long-acting GLP-1 analogue liraglutide regulates zinc transporter mRNA in β cells
    • Magnusson N, Bjerre KL, Wogensen L, et al: The long-acting GLP-1 analogue liraglutide regulates zinc transporter mRNA in β cells. Diabetologia 50 (Suppl 1): 65, 2007.
    • (2007) Diabetologia , vol.50 , Issue.SUPPL. 1 , pp. 65
    • Magnusson, N.1    Bjerre, K.L.2    Wogensen, L.3
  • 21
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ and Nauck MA: The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368: 1696-1705, 2006.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 22
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ: The biology of incretin hormones. Cell Metab 3: 153-165, 2006.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 23
    • 0036381989 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 treatment delays the onset of diabetes in 8-week-old db/db mice
    • Wang Q and Brubaker PL: Glucagon-like peptide-1 treatment delays the onset of diabetes in 8-week-old db/db mice. Diabetologia 45: 1263-1273, 2002.
    • (2002) Diabetologia , vol.45 , pp. 1263-1273
    • Wang, Q.1    Brubaker, P.L.2
  • 24
    • 77955514154 scopus 로고    scopus 로고
    • Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion
    • Wijesekara N, Dai FF, Hardy AB, et al: Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion. Diabetologia 53: 1656-1668, 2010.
    • (2010) Diabetologia , vol.53 , pp. 1656-1668
    • Wijesekara, N.1    Dai, F.F.2    Hardy, A.B.3
  • 25
    • 70349113136 scopus 로고    scopus 로고
    • Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants
    • Nicolson TJ, Bellomo EA, Wijesekara N, et al: Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes 58: 2070-2083, 2009.
    • (2009) Diabetes , vol.58 , pp. 2070-2083
    • Nicolson, T.J.1    Bellomo, E.A.2    Wijesekara, N.3
  • 26
    • 67649339727 scopus 로고    scopus 로고
    • ZnT-8 regulates insulin and glucagon seretion in Min6 and aTC1-9 pancreatic cell lines
    • Souza SC, Qiu L and Inouye KE: ZnT-8 regulates insulin and glucagon seretion in Min6 and aTC1-9 pancreatic cell lines. Diabetologia 51 (Suppl 1): 501, 2009.
    • (2009) Diabetologia , vol.51 , Issue.SUPPL. 1 , pp. 501
    • Souza, S.C.1    Qiu, L.2    Inouye, K.E.3
  • 27
    • 0034697329 scopus 로고    scopus 로고
    • Zinc may be a mediator of leptin production in humans
    • Chen MD, Song YM and Lin PY: Zinc may be a mediator of leptin production in humans. Life Sci 66: 2143-2149, 2000.
    • (2000) Life Sci , vol.66 , pp. 2143-2149
    • Chen, M.D.1    Song, Y.M.2    Lin, P.Y.3
  • 28
    • 0035680494 scopus 로고    scopus 로고
    • Zinc deficiency reduces leptin gene expression and leptin secretion in rat adipocytes
    • Ott ES and Shay NF: Zinc deficiency reduces leptin gene expression and leptin secretion in rat adipocytes. Exp Biol Med 226: 841-846, 2001.
    • (2001) Exp Biol Med , vol.226 , pp. 841-846
    • Ott, E.S.1    Shay, N.F.2
  • 30
    • 18744376312 scopus 로고    scopus 로고
    • Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypoz-incemia of the acute-phase response
    • Liuzzi JP, Lichten LA, Rivera S, et al: Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypoz-incemia of the acute-phase response. Proc Natl Acad Sci USA 102: 6843-6848, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6843-6848
    • Liuzzi, J.P.1    Lichten, L.A.2    Rivera, S.3
  • 31
    • 0034032317 scopus 로고    scopus 로고
    • Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas
    • Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF and Egan JM: Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes 49: 741-748, 2000.
    • (2000) Diabetes , vol.49 , pp. 741-748
    • Stoffers, D.A.1    Kieffer, T.J.2    Hussain, M.A.3    Drucker, D.J.4    Bonner-Weir, S.5    Habener, J.F.6    Egan, J.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.