Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteria

Journal of Biological Chemistry

Volumn 286, Issue 2, 2011, Pages 1277-1282

  Zhang, Liyun ^a   Zheng, Yuchuan ^a   Callahan, Brian ^b   Belfort, Marlene ^b   Liu, Yangzhong ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANTI-MYCOBACTERIAL; ANTICANCER DRUG; CIS-PLATIN; CYSTEINE RESIDUES; GENETIC EXPERIMENTS; IN-VITRO; INHIBITION ACTIVITY; INHIBITORY EFFECT; INTEINS; M. TUBERCULOSIS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; OVER-EXPRESSION; PLATINUM COMPLEXES; PROTEIN-SPLICING; SMALL MOLECULES; THERAPEUTIC TARGETS;

AMINO ACIDS; BACTERIOLOGY; ESCHERICHIA COLI; PLATINUM; PROTEINS; TOXICITY;

PLATINUM COMPOUNDS;

CISPLATIN; INTEIN; RECA PROTEIN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BINDING AFFINITY; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG RESPONSE; ESCHERICHIA COLI; GROWTH INHIBITION; IC 50; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CISPLATIN; DRUG DESIGN; ESCHERICHIA COLI; GENE EXPRESSION REGULATION, BACTERIAL; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; INTEINS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PLATINUM COMPOUNDS; PROTEIN SPLICING; REC A RECOMBINASES;

CORYNEBACTERINEAE; ESCHERICHIA COLI; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS;

EID: 78651401666     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.171124     Document Type: Article

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