Highly conserved histidine plays a dual catalytic role in protein splicing: A pKa shift mechanism

Journal of the American Chemical Society

Volumn 131, Issue 32, 2009, Pages 11581-11589

  Du, Zhenming ^a   Shemella, Philip T ^a   Liu, Yangzhong ^b   McCallum, Scott A ^a   Pereira, Brian ^c,d   Nayak, Saroj K ^a   Belfort, Georges ^d   Belfort, Marlene ^c   Wang, Chunyu ^a  

^a Research Rensselaer Polytechnic Institute   (United States)

^b UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^c WADSWORTH CENTER   (United States)

^d RENSSELAER POLYTECHNIC INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-BASE CATALYSIS; ACTIVE SITE RESIDUES; AUTOCATALYTIC PROCESS; BIOCHEMICAL DATA; CATALYTIC ROLE; CONSERVED RESIDUES; DUAL ROLE; FLANKING SEQUENCE; GENERAL BASE; INTEINS; IONIZATION STATE; MYCOBACTERIUM TUBERCULOSIS; N-TERMINALS; PROTEIN-SPLICING; REACTION MECHANISM; SCISSILE BOND; SEQUENCE CONSERVATION; SHIFT MECHANISM; SHIFT-AND;

ACIDS; CATALYSIS;

MOLECULAR MECHANICS;

HISTIDINE; INTEIN;

ACID BASE BALANCE; ARTICLE; BIOENGINEERING; CATALYSIS; MOLECULAR MECHANICS; MYCOBACTERIUM TUBERCULOSIS; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PURIFICATION; QUANTUM MECHANICS;

AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HISTIDINE; HYDROGEN-ION CONCENTRATION; INTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN SPLICING; SEQUENCE ALIGNMENT;

EID: 68849086984     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja904318w     Document Type: Article

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