Evaluation of carotenoid extract from Dunaliella salina against cadmium-induced cytotoxicity and transforming growth factor β1 induced expression of smooth muscle α-actin with rat liver cell lines

Journal of Food and Drug Analysis

Volumn 18, Issue 5, 2010, Pages 301-306

  Lin, Jau Tien ^a   Lee, Ying Chung ^b   Hu, Chao Chin ^a   Shen, You Cheng ^a   Lu, Fung Jou ^a   Yang, Deng Jye ^a,c  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG CHOU INSTITUTE OF TECHNOLOGY   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

SMA; Cadmium; Carotenoid; Clone 9 cells; Cytotoxicity; Dunaliella salina; HPLC analysis; HSC T6 cells; Smooth muscle actin; TGF 1; Transforming growth factor 1

Indexed keywords

13 CIS BETA CAROTENE; 13' CIS BETA CAROTENE; 9 CIS ALPHA CAROTENE; 9 CIS BETA CAROTENE; 9' CIS ALPHA CAROTENE; 9' CIS BETA CAROTENE; ALGAL EXTRACT; ALL TRANS ALPHA CAROTENE; ALL TRANS BETA CAROTENE; ALL TRANS LUTEIN; ALL TRANS ZEAXANTHIN; CADMIUM CHLORIDE; DUNALIELLA SALINA EXTRACT; SMOOTH MUSCLE ACTIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CHLOROPHYCEAE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG SCREENING; DUNALIELLA SALINA; LIVER TOXICITY; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; STELLATE CELL;

ALGAE; DUNALIELLA SALINA; RATTUS;

EID: 78651382128     PISSN: 10219498     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Cresswell, R. C., Rees, T. V. A. and Shah, N. 1989. Algal and Cyanobacterial Biotechnology. pp. 90-114. Longman Scientific and Technical Press, Essex, England.
2. Raja, R., Hemaiswarya, S., Balasubramanyam, D. and Rengasamy, R. 2007. Protective effect of Dunaliella salina (Volvocales, Chlorophyta) against experimentally induced fibrosarcoma on wistar rat. Microbiol. Res. 162: 177-184.
3. Ben-Amotz A. and Avron, M. 1992. Dunaliella: Physiology, Biochemistry, and Biotechnology, CRC Press, Boca Raton, FL, U.S.A.
4. Denery, J. R., Dragull, K., Tang, C. S. and Li, Q. X. 2004. Pressurized fluid extraction of carotenoids from Haeatococcus pluvialis and Dunaliella salina and kavalactones from Piper methysticum. Anal. Chim. Acta 501: 175-181.
5. García-González, M., Moreno, J., Manzano, J. C., Florencio, F. J. and Guerrero, M. G. 2005. Production of Dunaliella salina biomass rich in 9-cis-β-carotene and lutein in a closed tubular photobioreactor. J. Biotechnol. 115: 81-90.
6. Johnson E. A. and Schroeder W. A. 1995. Microbial carotenoids. In "Advances in Biochemical Engineering and Biotechnology", pp. 119-178. Fiechter, A. ed. Springer-Verlag. Berlin, Germany.
7. Edge, R., McGarvey, D. J. and Truscott, T. G. 1997. The carotenoids as antioxidants - a review. J. Photochem. Photobiol. B, Biol. 41: 189-200.
8. Burton, G. W. and Ingold, K. U. 1984. β-Carotene - an usual type of lipid antioxidant. Science 224: 569-573.
9. Foote, C. S. and Denny, R. W. 1968. Chemistry of singlet oxygen. VII. Quenching by β-carotene. J. Am. Chem. Soc. 90: 6233-6235
10. Jimenez, C. and Pick, U. 1993. Differential reactivity of β-carotene isomers from Dunaliella bardawil toward oxygen radicals. Plant Physiol. 101: 385-390.
11. Ziegler, R. G. 1989. A review of epidemiologic evidence that carotenoids reduce the risk of cancer. J. Nutr. 119: 116-122.
12. Gester, H. 1993. Anticarcinogenic effect of common carotenoids. Int. J. Vitam. Nutr. Res. 63: 93-121.
13. Ben-Amotz, A. 1999. Dunaliella β-carotene: from science to commerce. In "Enigmatic Microorganisms and Life in Extreme Environments", pp. 401-410. Seckbach, J. ed. Kluwer Academic Publisher, Netherlands.
14. Kopsell, D. A. and Kopsell, D. E. 2006. Accumulation and bioavailability of dietary carotenoids in vegetable crops. Trends Plant Sci. 11: 499-507.
15. Yeum K. J. and Russell, R. M. 2002. Carotenoid bioavailability and bioconversion. Annu. Rev. Nutr. 22: 483-504.
16. Bruscalupi, G., Massimi, M., Devirgiliis, L. C. and Leoni, S. 2009. Multiple parameters are involved in the effects of cadmium on prenatal hepatocytes. Toxicol. In Vitro 23: 1311-1318.
17. Kawata, K., Shimazaki, R. and Okabe, S. 2009. Comparison of gene expression profiles in HepG2 cells exposed to arsenic, cadmium, nickel, and three model carcinogens for investigating the mechanisms of metal carcinogenesis. Environ. Mol. Mutagen. 50: 46-59.
18. Galán, A., Troyano, A., Vilaboa, N. E., Fernandez, C., de Blas, E. and Aller, P. 2001. Modulation of the stress response during apoptosis and necrosis induction in cadmium-treated U- 937 human promonocytic cells. Biochim. Biophys. Acta 1538: 38-46.
19. Shaikh, Z. A., Vu, T. T. and Zaman, K. 1999. Oxidative stress as a mechanism of chronic cadmium-induced hepatotoxicity and renal toxicity and protection by anti-oxidants. Toxicol. Appl. Pharmacol. 154: 256-263.
20. Li, D. and Friedman, S. L. 1999. Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy. J. Gastroenterol. Hepatol. 14: 618-633.
21. Cheng, K., Yang, N. and Mahato, R. I. 2009. TGF-β1 gene silencing for treating liver fibrosis. Mol. Pharm. 6: 772-779.
22. Bataller, R. and Brenner, D. A. 2005. Liver fibrosis. J. Clin. Invest. 115: 209-218.
23. Horie, T., Sakaida, I., Yokoya, F., Nakajo, M., Sonaka, I. and Okitab, K. 2003. L-Cysteine administration prevents liver fibrosis by suppressing hepatic stellate cell proliferation and activation. Biochem. Biophys. Res. Commun. 305: 94-100.
24. Hu, C. C., Lin, J. T., Lu, F. J., Chou, F. P. and Yang, D. J. 2008. Determination of carotenoids in Dunaliella salina cultivated in Taiwan and antioxidant capacity of the algal carotenoid extract. Food Chem. 109: 439-446.
25. Inbaraj, B. S., Chien, J. T. and Chen, B. H. 2006. Improved high performance liquid chromatographic method for determination of carotenoids in the microalga Chlorella pyrenoidosa. J. Chromatogr. A 1102: 193-199.
26. Liu, H. L., Kao, T. H. and Chen, B. H. 2004. Determination of carotenoids in the Chinese medical herb JiaoGu-Lan (Gynostemma Pentaphyllum MAKINO) by liquid chromatography. Chromatographia 60: 411-417.
27. Böhm, V., Puspitasari-Nienaber, L. N., Ferruzzi, M. G. and Schwartz, S. J. 2002. Trolox equivalent antioxidant capacity of different geometrical isomers of α-carotene, β-carotene, lycopene, and zeaxanthin. J. Agric. Food Chem. 50: 221-226.
28. Lin, C. H. and Chen, B. H. 2003. Determination of carotenoids in tomato juice by liquid chromatography. J. Chromatogr. A 1012: 103-109.
29. Chen, J. P., Tai, C. Y. and Chen, B. H. 2004. An improved HPLC method for determination of carotenoids in Taiwanese mango. J. Chromatogr. A 1054: 261-268.
30. Friedman, S. L. 1993. Isolation and culture of hepatic nonparenchymal cells. Methods Toxicol. 1: 292-310.
31. Lin J. K. and Chou, C. K. 1992. In vitro apoptosis in the human hepatoma cell line induced by transforming growth factor β1. Cancer Res. 52: 385-388.
32. Alley, M. C., Scudiero, D. A. and Monkds, A. 1988. Feasibility of drug screening with panels of human tumor cell lines using a micro-culture tetrazolium assay. Cancer Res. 48: 589-601.
33. Ben-Amotz, A., Katz, A. and Avron, M. 1982. Accumulation of β-carotene in halotolerant algae: purification and characterization of β-carotene rich globules from Dunaliella bardawil (chiorophyceae). J. Phycol. 18: 529-537.
34. Leivin, G., Yeshurun, M. and Mokady, S. 1997. In vivo peroxidative effect of 9-cis-β-carotene compared with that of the all-trans isomer. Nutr. Cancer 27: 293-297.
35. Ben-Amotz, A. and Fishier, R. 1998. Analysis of carotenoid with emphasis on 9-cis-β-carotene in vegetables and fruits commonly consumed in Israel. Food Chem. 62: 515-520. (Pubitemid 28398499)
36. Chen, A., Zhang, L., Xu, J. and Tang, J. 2002. The antioxidant (-)-epigallo-catechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression. Biochem. J. 368: 695-704. (Pubitemid 36042671)
37. Ali-Riza, S., Nurettin, A., Umit-Nusret, B., Semsi, A., Orhan, T., Nursal, G., Hasan, U., Ahmet, T., Gulbin, D., Huseyin, B., Mevlut, T., Kemal, K. and Kadir, K. 2006. Antioxidants vitamin E and C attenuate hepatic fibrosis in biliary-obstructed rats. World J. Gastroenterol. 12: 6835-6841.