Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D1 receptor dysfunction in obese rats

American Journal of Physiology - Renal Physiology

Volumn 300, Issue 1, 2011, Pages

  Muhammad, Abdul Bari ^a   Lokhandwala, Mustafa F ^a   Banday, Anees A ^a  

^a UNIVERSITY OF HOUSTON   (United States)

Author keywords

Hypertension; Insulin sensitivity; Natriuresis; Nuclear factor B; Reactive oxygen species

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; DOPAMINE 1 RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; SODIUM;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; EXERCISE; GENE TRANSLOCATION; HYPERINSULINEMIA; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; NATRIURESIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SODIUM EXCRETION; TREADMILL EXERCISE; URINARY EXCRETION;

EID: 78651335183     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00386.2010     Document Type: Article

References (74)

1. Aleixandre de Artinano A, Miguel Castro M. Experimental rat models to study the metabolic syndrome. Br J Nutr 102: 1246-1253, 2009.
2. Alexander ET, Tanaka M, Kono M, Saito H, Rader DJ, Phillips MC. Structural and functional consequences of the Milano mutation (R173C) in human apolipoprotein A-I. J Lipid Res 50: 1409-1419, 2009.
3. Ando K, Fujita T. Metabolic syndrome and oxidative stress. Free Radic Biol Med 47: 213-218, 2009.
4. Arvola P, Wu X, Kahonen M, Makynen H, Riutta A, Mucha I, Solakivi T, Kainulainen H, Porsti I. Exercise enhances vasorelaxation in experimental obesity associated hypertension. Cardiovasc Res 43: 992-1002, 1999. (Pubitemid 29413199)
5. 1 receptor function in old rats. Am J Physiol Renal Physiol 293: F914-F919, 2007.
6. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem 304: 93-99, 2007.
7. Banday AA, Fazili FR, Lokhandwala MF. Oxidative stress causes renal dopamine D1 receptor dysfunction and hypertension via mechanisms that involve nuclear factor-kappaB and protein kinase C. J Am Soc Nephrol 18: 1446-1457, 2007.
8. Banday AA, Lau YS, Lokhandwala MF. Oxidative stress causes renal dopamine D1 receptor dysfunction and salt-sensitive hypertension in Sprague-Dawley rats. Hypertension 51: 367-375, 2008.
9. Banday AA, Marwaha A, Tallam LS, Lokhandwala MF. Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Diabetes 54: 2219-2226, 2005.
10. Bonner G. Hyperinsulinemia, insulin resistance, hypertension. J Cardiovasc Pharmacol 24, Suppl 2: S39-S49, 1994.
11. Boor P, Celec P, Behuliak M, Grancic P, Kebis A, Kukan M, Pronayova N, Liptaj T, Ostendorf T, Sebekova K. Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats. Metabolism 58: 1669-1677, 2009.
12. Briel M, Ferreira-Gonzalez I, You JJ, Karanicolas PJ, Akl EA, Wu P, Blechacz B, Bassler D, Wei X, Sharman A, Whitt I, Alves da Silva S, Khalid Z, Nordmann AJ, Zhou Q, Walter SD, Vale N, Bhatnagar N, O'Regan C, Mills EJ, Bucher HC, Montori VM, Guyatt GH. Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and metaregression analysis. Br Med J 338: b92, 2009.
13. Chagnac A, Herman M, Zingerman B, Erman A, Rozen-Zvi B, Hirsh J, Gafter U. Obesity-induced glomerular hyperfiltration: its involvement in the pathogenesis of tubular sodium reabsorption. Nephrol Dial Transplant 23: 3946-3952, 2008.
14. Chang SP, Chen YH, Chang WC, Liu IM, Cheng JT. Increase of anti-oxidation by exercise in the liver of obese Zucker rats. Clin Exp Pharmacol Physiol 31: 506-511, 2004.
15. Chen C, Beach RE, Lokhandwala MF. Dopamine fails to inhibit renal tubular sodium pump in hypertensive rats. Hypertension 21: 364-372, 1993.
16. Chen CJ, Lokhandwala MF. An impairment of renal tubular DA-1 receptor function as the causative factor for diminished natriuresis to volume expansion in spontaneously hypertensive rats. Clin Exp Hypertens A 14: 615-628, 1992.
17. Chiasera JM, Ward-Cook KM, McCune SA, Wardlaw GM. Effect of aerobic training on diabetic nephropathy in a rat model of type 2 diabetes mellitus. Ann Clin Lab Sci 30: 346-353, 2000.
18. Cortez MY, Torgan CE, Brozinick JT Jr, Ivy JL. Insulin resistance of obese Zucker rats exercise trained at two different intensities. Am J Physiol Endocrinol Metab 261: E613-E619, 1991.
19. Deb S, Martin RJ. Effects of exercise and of food restriction on the development of spontaneous obesity in rats. J Nutr 105: 543-549, 1975.
20. Dornfeld LP, Maxwell MH, Waks A, Tuck M. Mechanisms of hypertension in obesity. Kidney Int Suppl 22: S254-S258, 1987.
21. Fardoun RZ, Asghar M, Lokhandwala M. Role of nuclear factor kappa B (NF-kappaB) in oxidative stress-induced defective dopamine D1 receptor signaling in the renal proximal tubules of Sprague-Dawley rats. Free Radic Biol Med 42: 756-764, 2007.
22. Fardoun RZ, Asghar M, Lokhandwala M. Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats. Am J Physiol Renal Physiol 291: F945-F951, 2006. (Pubitemid 44772027)
23. Felder RA, Seikaly MG, Cody P, Eisner GM, Jose PA. Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats. Hypertension 15: 560-569, 1990.
24. Frisbee JC, Samora JB, Peterson J, Bryner R. Exercise training blunts microvascular rarefaction in the metabolic syndrome. Am J Physiol Heart Circ Physiol 291: H2483-H2492, 2006.
25. 1 receptor function in old rats. Am J Physiol Renal Physiol 297: F1174-F1180, 2009.
26. Gordon T, Castelli WP, Hjortland MC, Kannel WB, Dawber TR. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study Am J Med 62: 707-714, 1977.
27. Hansell P. In vivo evidence for a defect in the dopamine DA1 receptor in the prehypertensive Dahl salt-sensitive rat. Exp Nephrol 3: 15-22, 1995.
28. Haynes WG, Morgan DA, Walsh SA, Sivitz WI, Mark AL. Cardiovascular consequences of obesity: role of leptin. Clin Exp Pharmacol Physiol 25: 65-69, 1998.
29. Hedrick CC, Thorpe SR, Fu MX, Harper CM, Yoo J, Kim SM, Wong H, Peters AL. Glycation impairs high-density lipoprotein function. Diabetologia 43: 312-320, 2000.
30. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 67: 968-977, 1983. (Pubitemid 13080473)
31. Hussain T, Becker M, Beheray S, Lokhandwala MF. Dopamine fails to inhibit Na,H-exchanger in proximal tubules of obese Zucker rats. Clin Exp Hypertens 23: 591-601, 2001.
32. Hussain T, Beheray SA, Lokhandwala MF. Defective dopamine receptor function in proximal tubules of obese zucker rats. Hypertension 34: 1091-1096, 1999.
33. Ip TY, Peterson J, Byrner R, Tou JC. Bone responses to body weight and moderate treadmill exercising in growing male obese (fa/fa) and lean Zucker rats. J Musculoskelet Neuronal Interact 9: 155-166, 2009.
34. Jose PA, Eisner GM, Felder RA. Renal dopamine receptors in health and hypertension. Pharmacol Ther 80: 149-182, 1998.
35. Kibenge MT, Chan CB. The effects of high-fat diet on exercise-induced changes in metabolic parameters in Zucker fa/fa rats. Metabolism 51: 708-715, 2002.
36. Lash JM, Sherman WM, Betts JJ, Hamlin RL. Training-induced vascular and metabolic adaptations in normo(11 week)- and hyper(18 week)-glycemic obese Zucker rats. Int J Obes 13: 777-789, 1989.
37. Lokhandwala MF, Hussain T. Defective renal dopamine D1-like receptor signal transduction in obese hypertensive rats. Acta Physiol Scand 168: 251-255, 2000.
38. Lurbe E, Alvarez V, Redon J. Obesity, body fat distribution, and ambulatory blood pressure in children and adolescents. J Clin Hypertens (Greenwich) 3: 362-367, 2001.
39. Marwaha A, Lokhandwala MF. Diminished natriuretic response to dopamine D1 receptor agonist, SKF-38393 in obese Zucker rats. Clin Exp Hypertens 25: 509-515, 2003.
40. Marwaha A, Lokhandwala MF. Tempol reduces oxidative stress and restores renal dopamine D1-like receptor-G protein coupling and function in hyperglycemic rats. Am J Physiol Renal Physiol 291: F58-F66, 2006.
41. Metzger BL. The effect of a genetic variant for obesity and Type 2 Diabetes on the therapeutic potential of exercise and calorie restrictive diets in Zucker rats. Res Theory Nurs Pract 17: 321-333, 2003.
42. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86: 271-278, 1978. (Pubitemid 9050395)
43. Muniyappa R, Lee S, Chen H, Quon MJ. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage. Am J Physiol Endocrinol Metab 294: E15-E26, 2008.
44. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Dietz WH. The disease burden associated with overweight and obesity. J Am Med Assoc 282: 1523-1529, 1999.
45. Navab M, Hama SY, Anantharamaiah GM, Hassan K, Hough GP, Watson AD, Reddy ST, Sevanian A, Fonarow GC, Fogelman AM. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3. J Lipid Res 41: 1495-1508, 2000.
46. Navab M, Hama SY, Cooke CJ, Anantharamaiah GM, Chaddha M, Jin L, Subbanagounder G, Faull KF, Reddy ST, Miller NE, Fogelman AM. Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: step 1. J Lipid Res 41: 1481-1494, 2000.
47. Navab M, Reddy ST, Van Lenten BJ, Anantharamaiah GM, Fogelman AM. The role of dysfunctional HDL in atherosclerosis. J Lipid Res Suppl 50: S145-S149, 2009.
48. Nicholls SJ, Zheng L, Hazen SL. Formation of dysfunctional high-density lipoprotein by myeloperoxidase. Trends Cardiovasc Med 15: 212-219, 2005.
49. Norris SL, Zhang X, Avenell A, Gregg E, Schmid CH, Lau J. Long-term non-pharmacological weight loss interventions for adults with prediabetes. Cochrane Database Syst Rev CD005270, 2005.
50. Pagano C, Marzolo M, Granzotto M, Ricquier D, Federspil G, Vettor R. Acute effects of exercise on circulating leptin in lean and genetically obese fa/fa rats. Biochem Biophys Res Commun 255: 698-702, 1999.
51. Persegol L, Foissac M, Lagrost L, Athias A, Gambert P, Verges B, Duvillard L. HDL particles from type 1 diabetic patients are unable to reverse the inhibitory effect of oxidised LDL on endothelium-dependent vasorelaxation. Diabetologia 50: 2384-2387, 2007.
52. Persegol L, Verges B, Foissac M, Gambert P, Duvillard L. Inability of HDL from type 2 diabetic patients to counteract the inhibitory effect of oxidised LDL on endothelium-dependent vasorelaxation. Diabetologia 49: 1380-1386, 2006.
53. Persegol L, Verges B, Gambert P, Duvillard L. Inability of HDL from abdominally obese subjects to counteract the inhibitory effect of oxidized LDL on vasorelaxation. J Lipid Res 48: 1396-1401, 2007.
54. Porsti I, Kahonen M, Wu X, Arvola P, Ruskoaho H. Long-term physical exercise and atrial natriuretic peptide in obese Zucker rats. Pharmacol Toxicol 91: 8-12, 2002.
55. Redon J. Hypertension in obesity. Nutr Metab Cardiovasc Dis 11: 344-353, 2001.
56. Reinehr T, Kleber M, de Sousa G, Andler W. Leptin concentrations are a predictor of overweight reduction in a lifestyle intervention. Int J Pediatr Obes 4: 215-223, 2009.
57. Roberts CK, Ng C, Hama S, Eliseo AJ, Barnard RJ. Effect of a short-term diet and exercise intervention on inflammatory/anti-inflammatory properties of HDL in overweight/obese men with cardiovascular risk factors. J Appl Physiol 101: 1727-1732, 2006.
58. Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sci 84: 705-712, 2009.
59. Rocchini AP. Obesity hypertension, salt sensitivity and insulin resistance. Nutr Metab Cardiovasc Dis 10: 287-294, 2000.
60. Rocchini AP. The relationship of sodium sensitivity to insulin resistance. Am J Med Sci 307, Suppl 1: S75-S80, 1994.
61. Santti E, Huupponen R, Rouru J, Hanninen V, Pesonen U, Jhanwar-Uniyal M, Koulu M. Potentiation of the anti-obesity effect of the selective beta 3-adrenoceptor agonist BRL 35135 in obese Zucker rats by exercise. Br J Pharmacol 113: 1231-1236, 1994.
62. Shaw K, Gennat H, O'Rourke P, Del Mar C. Exercise for overweight or obesity. Cochrane Database Syst Rev CD003817, 2006.
63. Stern JS, Johnson PR. Spontaneous activity and adipose cellularity in the genetically obese Zucker rat (fafa). Metabolism 26: 371-380, 1977.
64. Thomas DE, Elliott EJ, Naughton GA. Exercise for type 2 diabetes mellitus. Cochrane Database Syst Rev 3: CD002968, 2006.
65. Trivedi M, Lokhandwala MF. Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylation in obese rats. Am J Physiol Renal Physiol 289: F298-F304, 2005.
66. Trivedi M, Marwaha A, Lokhandwala M. Rosiglitazone restores Gprotein coupling, recruitment, and function of renal dopamine D1A receptor in obese Zucker rats. Hypertension 43: 376-382, 2004.
67. Umrani DN, Banday AA, Hussain T, Lokhandwala MF. Rosiglitazone treatment restores renal dopamine receptor function in obese Zucker rats. Hypertension 40: 880-885, 2002. (Pubitemid 35434910)
68. Van Lenten BJ, Hama SY, de Beer FC, Stafforini DM, McIntyre TM, Prescott SM, La Du BN, Fogelman AM, Navab M. Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. J Clin Invest 96: 2758-2767, 1995.
69. Van Vliet BN, Chafe LL, Antic V, Schnyder-Candrian S, Montani JP. Direct and indirect methods used to study arterial blood pressure. J Pharmacol Toxicol Methods 44: 361-373, 2000.
70. Walberg JL, Mole PA, Stern JS. Effect of swim training on development of obesity in the genetically obese rat. Am J Physiol Regul Integr Comp Physiol 242: R204-R211, 1982.
71. Walberg JL, Upton D, Stern JS. Exercise training improves insulin sensitivity in the obese Zucker rat. Metabolism 33: 1075-1079, 1984.
72. Ward KM, Mahan JD, Sherman WM. Aerobic training and diabetic nephropathy in the obese Zucker rat. Ann Clin Lab Sci 24: 266-277, 1994.
73. Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta-analysis of randomized, controlled trials. Ann Intern Med 136: 493-503, 2002.
74. Xiang L, Naik J, Hester RL. Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 288: R987-R991, 2005.