Effect of leukotriene D4 on mouse embryonic stem cell migration and proliferation: Involvement of PI3K/Akt as well as GSK-3β/β-catenin signaling pathways

Journal of Cellular Biochemistry

Volumn 111, Issue 3, 2010, Pages 686-698

  Kim, Min Hee ^a   Lee, Yu Jin ^b   Kim, Mi Ok ^b   Kim, Jin Sang ^a   Han, Ho Jae ^b  

^a Daegu University   (South Korea)

^b Chonnam National University   (South Korea)

Author keywords

Embryonic Stem Cell; Leukotriene; Migration; Proliferation

Indexed keywords

BETA CATENIN; CALCINEURIN; CALCIUM ION; FOCAL ADHESION KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; LEUKOTRIENE D4; PAXILLIN; PEPTIDOLEUKOTRIENE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REGULATOR PROTEIN; SMALL INTERFERING RNA; STAT3 PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL COUNT; CELL MIGRATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; DNA SYNTHESIS; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MOUSE; MOUSE EMBRYO; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; SIGNAL TRANSDUCTION; ANIMAL; CELL MOTION; CYTOLOGY; DRUG EFFECT; METABOLISM; PHYSIOLOGY;

ANIMALS; BETA CATENIN; CALCINEURIN; CELL MOVEMENT; CELL PROLIFERATION; EMBRYONIC STEM CELLS; GLYCOGEN SYNTHASE KINASE 3; LEUKOTRIENE D4; MICE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 78651327668     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22755     Document Type: Article

References (54)

1. Akino K, Mineda T, Mori N, Hirano A, Imaizumi T, Akita S. 2006. Attenuation of cysteinyl leukotrienes induces human mesenchymal stem cell differentiation. Wound Repair Regen 14:343-349.
2. 4-induced, epithelial cell-derived transforming growth factor b1 in human bronchial smooth muscle cell proliferation. Clin Exp Allergy 38:113-121.
3. Braccioni F, Dorman SC, O'Byrne PM, Inman MD, Denburg JA, Parameswaran K, Baatjes AJ, Foley R, Gauvreau GM. 2002. The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects. J Allergy Clin Immunol 110:96-101.
4. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. 2+/calcineurin/NFAT signaling in cancerogenesis. Cell Cycle 6:16-19.
6. Capra V. 2004. Molecular and functional aspects of human cysteinyl leukotriene receptors. Pharmacol Res 50:1-11.
7. Chase LG, Firpo MT. 2007. Development of serum-free culture systems for human embryonic stem cells. Curr Opin Chem Biol 11:367-372.
8. Chen CH, Ho ML, Chang JK, Hung SH, Wang GJ. 2005. Green tea catechin enhances osteogenesis in a bone marrow mesenchymal stem cell line. Osteoporos Int 16:2039-2045.
9. Chow W, Hou G, Bendeck MP. 2008. Glycogen synthase kinase 3b regulation of nuclear factor of activated T-cells isoform c1 in the vascular smooth muscle cell response to injury. Exp Cell Res 314:2919-2929.
10. 4 pathway regulates the fate of the hematopoietic stem cells. Exp Mol Med 37:45-50.
11. Evans JF. 2003. The cysteinyl leukotriene receptors. Prostaglandins Leukotrienes Essent. Fatty Acids 69:117-122.
12. Fashena SJ, Thomas SM. 2000. Signalling by adhesion receptors. Nat Cell Biol 2:E225-E229.
13. Guasch G, Fuchs E. 2005. Mice in the world of stem cell biology. Nat Genet 37:1201-1206.
14. 2+/PKC as well as EGF receptor-dependent PI3K/Akt/mTOR/p70S6K1 signal pathways in mouse embryonic stem cells. J Cell Physiol 211:618-629.
15. Hanks SK, Ryzhova L, Shin NY, Brabek J. 2003. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci 8:d982-d996.
16. Hayashi Y, Furue MK, Okamoto T, Ohnuma K, Myoishi Y, Fukuhara Y, Abe T, Sato JD, Hata R, Asashima M. 2007. Integrins regulate mouse embryonic stem cell self-renewal. Stem Cells 25:3005-3015.
17. Hsu JH, Shi Y, Frost P, Yan H, Hoang B, Sharma S, Gera J, Lichtenstein A. 2004. Interleukin-6 activates phosphoinositol-30 kinase in multiple myeloma tumor cells by signaling through RAS-dependent and, separately, through p85-dependent pathways. Oncogene 23:3368-3375.
18. 4 potentiates fibronectin-induced migration of human lung fibroblasts. Clin Immunol 117:177-181.
19. Kim YH, Han HJ. 2008. Synergistic effect of high glucose and ANG II on proliferation of mouse embryonic stem cells: Involvement of PKC and MAPKs as well as AT1 receptor. J Cell Physiol 215:374-382.
20. 2+/PKC, PI3K/Akt, and MAPKs. Cell Physiol Biochem 23:53-64.
21. Kim MO, Lee YJ, Han HJ. 2010. Involvement of Cx43 phosphorylation in 50- N-ethylcarboxamide-induced migration and proliferation of mouse embryonic stem cells. J Cell Physiol 224:187-194.
22. Lee YJ, Heo JS, Suh HN, Lee MY, Han HJ. 2007. Interleukin-6 stimulates a- MG uptake in renal proximal tubule cells: Involvement of STAT3, PI3K/Akt, MAPKs, and NF-kB. Am J Physiol Renal Physiol 293:F1036-F1046.
23. Lewis RA, Austen KF, Soberman RJ. 1990. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 323:645-655.
24. Lipskaia L, Pourci ML, Delomenie C, Combettes L, Goudouneche D, Paul JL, Capiod T, Lompre AM. 2003. Phosphatidylinositol 3-kinase and calciumactivated transcription pathways are required for VLDL-induced smooth muscle cell proliferation. Circ Res 92:1115-1122.
25. Liu TJ, LaFortune T, Honda T, Ohmori O, Hatakeyama S, Meyer T, Jackson D, de Groot J, Yung WK. 2007. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther 6:1357-1367.
26. Lu Y, Zhou J, Xu C, Lin H, Xiao J, Wang Z, Yang B. 2008. JAK/STAT and PI3K/AKT pathways form a mutual transactivation loop and afford resistance to oxidative stress-induced apoptosis in cardiomyocytes. Cell Physiol Biochem 21:305-314.
27. Luo M, Guan JL. 2010. Focal adhesion kinase: A prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett 289:127-139.
28. Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, Greig GM, Kargman S, Hooks SB, Hosfield E, Williams DL, Jr., Ford-Hutchinson AW, Caskey CT, Evans JF. 1999. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399:789-793.
29. Marikawa Y. 2006. Wnt/b-catenin signaling and body plan formation in mouse embryos. Semin Cell Dev Biol 17:175-184.
30. Mayatepek E, Badiou S, Bellet H, Lehmann WD. 2005. A patient with neurological symptoms and abnormal leukotriene metabolism: A new defect in leukotriene biosynthesis. Ann Neurol 58:968-970.
31. McMahon B, Mitchell D, Shattock R, Martin F, Brady HR, Godson C. 2002. Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation. FASEB J 16:1817-1819.
32. 4 induces transcriptional activity of potentially oncogenic genes. Biochem Soc Trans 33:698-700.
33. 4 induces b-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells. J Biol Chem 281:6776-6784.
34. Mitra SK, Schlaepfer DD. 2006. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18:516-523.
35. Nguyen T, Di Giovanni S. 2008. NFAT signaling in neural development and axon growth. Int J Dev Neurosci 26:141-145.
36. Ohd JF, Wikstrom K, Sjolander A. 2000. Leukotrienes induce cell-survival signaling in intestinal epithelial cells. Gastroenterology 119:1007-1018.
37. Park JH, Han HJ. 2009. Caveolin-1 plays important role in EGF-induced migration and proliferation of mouse embryonic stem cells: Involvement of PI3K/Akt and ERK. Am J Physiol Cell Physiol 297:C935-C944.
38. 4 mediates survival and proliferation via separate but parallel pathways in the human intestinal epithelial cell line Int 407. J Biol Chem 278:45577-45585.
39. 4 activates MAPK through a Ras-independent but PKCedependent pathway in intestinal epithelial cells. J Cell Sci 115:1883-1893.
40. Profita M, Sala A, Bonanno A, Siena L, Ferraro M, Di Giorgi R, Montalbano AM, Albano GD, Gagliardo R, Gjomarkaj M. 2008. Cysteinyl leukotriene-1 receptor activation in a human bronchial epithelial cell line leads to signal transducer and activator of transcription 1-mediated eosinophil adhesion. J Pharmacol Exp Ther 325:1024-1030.
41. 4-induced Rhomediated actin reorganization in human bronchial smooth muscle cells. Eur J Pharmacol 413:163-171.
42. Sarau HM, Ames RS, Chambers J, Ellis C, Elshourbagy N, Foley JJ, Schmidt DB, Muccitelli RM, Jenkins O, Murdock PR, Herrity NC, Halsey W, Sathe G, Muir AI, Nuthulaganti P, Dytko GM, Buckley PT, Wilson S, Bergsma DJ, Hay DW. 1999. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol Pharmacol 56:657-663.
43. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH. 2004. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10:55-63.
44. Sato K, Chisaka H, Okamura K, Challis JR. 2008. Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts. Biol Reprod 78:514-520.
45. Schafer WR, Zahradnik HP, Arbogast E, Wetzka B, Werner K, Breckwoldt M. 1996. Arachidonate metabolism in human placenta, fetal membranes, decidua and myometrium: Lipoxygenase and cytochrome P450 metabolites as main products in HPLC profiles. Placenta 17:231-238.
46. Schulz RA, Yutzey KE. 2004. Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Dev Biol 266:1-16.
47. Semb H. 2005. Human embryonic stem cells: Origin, properties and applications. APMIS 113:743-750. (Pubitemid 43934217)
48. Sonoda Y, Hada N, Kaneda T, Suzuki T, Ohshio T, Takeda T, Kasahara T. 2008. A synthetic glycosphingolipid-induced antiproliferative effect in melanoma cells is associated with suppression of FAK, Akt, and Erk activation. Biol Pharm Bull 31:1279-1283.
49. Tanaka M, Abe T, Hara Y. 2009. Roles of focal adhesions and fibronectinmediated cohesion in proliferation of confluent fibroblasts. J Cell Physiol 219:194-201.
50. Vannella KM, McMillan TR, Charbeneau RP, Wilke CA, Thomas PE, Toews GB, Peters-Golden M, Moore BB. 2007. Cysteinyl leukotrienes are autocrine and paracrine regulators of fibrocyte function. J Immunol 179:7883-7890.
51. 4 are regulatory signals for neural stem cell proliferation and differentiation. FASEB J 20:1785-1792.
52. 4 stimulates the migration but not proliferation of endothelial cells mediated by the cysteinyl leukotriene CysLT1 receptor via the extracellular signal-regulated kinase pathway. J Pharmacol Sci 109:285-292.
53. Zelenka PS, Arpitha P. 2008. Coordinating cell proliferation and migration in the lens and cornea. Semin Cell Dev Biol 19:113-124.
54. Zhang E, Li X, Zhang S, Chen L, Zheng X. 2005. Cell cycle synchronization of embryonic stem cells: Effect of serum deprivation on the differentiation of embryonic bodies in vitro. Biochem Biophys Res Commun 333:1171-1177.