Mechanisms of cardiodepression by an Na+-H+ exchange inhibitor methyl-N-isobutyl amiloride (MIA) on the heart: Lack of beneficial effects in ischemia-reperfusion injury

Canadian Journal of Physiology and Pharmacology

Volumn 85, Issue 1, 2007, Pages 67-78

  Saini, Harjot K ^b   Elimban, Vijayan ^b   Ozcelikay, A Tanju ^a   Dhalla, N S ^b  

^a ANKARA UNIVERSITY   (Turkey)

^b NONE

Author keywords

Calcium handling proteins; Calcium paradox; Ischemia reperfusion; Sodium hydrogen exchanger

Indexed keywords

AMILORIDE DERIVATIVE; CALCIUM; HYDROGEN PEROXIDE; METHYL N ISOBUTYL AMILORIDE; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG; 5 (N ISOBUTYL N METHYL)AMILORIDE; 5-(N-METHYL-N-ISOBUTYL)AMILORIDE; ADENOSINE TRIPHOSPHATASE (CALCIUM); AMILORIDE; ANTIARRHYTHMIC AGENT; BICARBONATE; CARDIOTONIC AGENT; DRUG DERIVATIVE; ENZYME INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEART MUSCLE ISCHEMIA; MITOCHONDRION; MUSCLE FIBRIL; NONHUMAN; PRIORITY JOURNAL; RAT; SARCOLEMMA; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HEART; HEART CONTRACTION; HEART LEFT VENTRICLE FUNCTION; HEART MITOCHONDRION; HEART MUSCLE; HEART MUSCLE CELL; IN VITRO STUDY; MALE; METABOLISM; PATHOPHYSIOLOGY; PH; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

AMILORIDE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BICARBONATES; CALCIUM; CALCIUM-TRANSPORTING ATPASES; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HEART; HYDROGEN-ION CONCENTRATION; MALE; MITOCHONDRIA, HEART; MYOCARDIAL CONTRACTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; MYOFIBRILS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-HYDROGEN ANTIPORTER; VENTRICULAR FUNCTION, LEFT;

EID: 34250829193     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y06-099     Document Type: Article

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