Hypoxia induces an immunodominant target of tuberculosis specific T cells absent from common BCG vaccines

PLoS Pathogens

Volumn 6, Issue 12, 2010, Pages

  Gideon, Hannah Priyadarshini ^a   Wilkinson, Katalin Andrea ^a,b   Rustad, Tige R ^c   Oni, Tolu ^a,d   Guio, Heinner ^d   Kozak, Robert Andrew ^e   Sherman, David R ^c   Meintjes, Graeme ^a   Behr, Marcel A ^e   Vordermeier, Hans Martin ^f   Young, Douglas Brownlee ^b,d   Wilkinson, Robert John ^a,b,d  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^f VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BCG VACCINE; CULTURE FILTRATE PROTEIN 10; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; INTERLEUKIN 2; BACTERIAL ANTIGEN; EPITOPE; T LYMPHOCYTE RECEPTOR;

ARTICLE; BCG VACCINATION; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPOXIA; MEMORY T LYMPHOCYTE; NONHUMAN; SUPERINFECTION; T LYMPHOCYTE; TUBERCULOSIS; ANOXIA; BIOSYNTHESIS; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; TRANSCRIPTION INITIATION;

BACILLI (CLASS); MYCOBACTERIUM TUBERCULOSIS;

ANOXIA; ANTIGENS, BACTERIAL; BCG VACCINE; GENE EXPRESSION PROFILING; HUMANS; IMMUNODOMINANT EPITOPES; IMMUNOLOGIC MEMORY; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTES; TRANSCRIPTIONAL ACTIVATION; TUBERCULOSIS;

EID: 78651261228     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001237     Document Type: Article

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