Direct ex vivo analysis of antigen-specific IFN-γ-secreting CD4 T cells in mycobacterium tuberculosis-infected individuals: Associations with clinical disease state and effect of treatment

Journal of Immunology

Volumn 167, Issue 9, 2001, Pages 5217-5225

  Pathan, A A ^a   Wilkinson, K A ^a   Klenerman, P ^a   McShane, H ^a   Davidson, R N ^a   Pasvol, G ^a   Hill, A V S ^a   Lalvani, A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CYTOKINE; EARLY SECRETORY ANTIGENIC TARGET 6; GAMMA INTERFERON; UNCLASSIFIED DRUG;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; CYTOKINE RELEASE; DISEASE ACTIVITY; DISEASE SEVERITY; FEMALE; HUMAN; IMMUNE RESPONSE; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL;

EID: 0035500638     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.9.5217     Document Type: Article

References (48)

1. Mice deficient in CD4 T cells have only transiently diminished levels of IFN-γ, yet succumb to tuberculosis
2. Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection
3. Susceptibility of mice deficient in CD1D or TAP1 to infection with mycobacterium tuberculosis
4. An essential role for interferon γ in resistance to Mycobacterium tuberculosis infection
5. Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice
6. Differential effects of cytolytic T cell subsets on intracellular infection
7. + T lymphocytes specific for Mycobacterium tuberculosis
8. + T cells reactive with Mycobacterium tuberculosis-infected antigen-presenting cells
9. + T lymphocytes derived from Mycobacterium tuberculosis-infected cells: Definition of antigenic specificity
10. CTL response to Mycobacterium tuberculosis: Identification of an immunogenic epitope in the 19-kDa lipoprotein
11. Immunology of tuberculosis
12. Relationship of the manifestations of tuberculosis to CD4 cell counts in patients with human immunodeficiency virus infection
13. Lymphocyte-dependent inhibition of growth of virulent Mycobacterium tuberculosis H37Rv within human monocytes: Requirement for CD4?? T cells in purified protein derivative-positive, but not in purified protein derivative-negative subjects
14. T cell mediated immunity to mycobacterium tuberculosis
15. Recall of long-lived immunity to mycobacterium tuberculosis infection in mice
16. Protective immunity against tuberculosis induced by vaccination with major extracellular proteins of Mycobacterium tuberculosis
17. ESAT-6 subunit vaccination against Mycobacterium tuberculosis
18. Efficient protection against Mycobacterium tuberculosis by vaccination with a single subdominant epitope from the ESAT-6 antigen
19. Human T cell responses to the ESAT-6 antigen from Mycobacterium tuberculosis
20. Rapid detection of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells
21. Use of ESAT-6 and CFP-10 antigens for diagnosis of extrapulmonary tuberculosis
22. Increased numbers of ESAT-6- and purified protein derivative-specific γ interferon-producing cells in subclinical and active tuberculosis infection
23. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis
24. Comparative genomics of BCG vaccines by whole-genome DNA microarray
25. Enhanced contact tracing and spatial tracking of Mycobacterium tuberculosis infection by enumeration of antigen-specific T cells
26. T-cell cytokine responses in human infection with Mycobacterium tuberculosis
27. Clinical correlates of interferon γ production in patients with tuberculosis
28. Cytokine profiles for peripheral blood lymphocytes from patients with active pulmonary tuberculosis and healthy household contacts in response to the 30-kilodalton antigen of Mycobacterium tuberculosis
29. Peptide-specific T cell response to Mycobacterium tuberculosis: Clinical spectrum, compartmentalization, and effect of chemotherapy
30. Depressed T-cell interferon-γ responses in pulmonary tuberculosis: Analysis of underlying mechanisms and modulation with therapy
31. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
32. Decay kinetics of human immunodeficiency virus-specific effector cytotoxic T lymphocytes after combination antiretroviral therapy
33. A new look at T cells
34. + T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
35. (+) cells in liver damage and viral control during persistent hepatitis B virus infection
36. + T cells specific for EBV in healthy virus carriers
37. + memory T cells
38. + T cells
39. High frequencies of circulating IFN-γ-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease
40. Differential T cell responses to Mycobacterium tuberculosis ESAT6 in tuberculosis patients and healthy donors
41. Numbers of IFN-γ-producing cells against ESAT-6 increase in tuberculosis patients during chemotherapy
42. Counting antigen -specific CD8 T cells: A reevaluation of bystander activation during viral infection
43. + T cell memory in vivo
44. Population dynamics of immune responses to persistent viruses
45. Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis
46. Protective effect of DNA immunization against mycobacterial infection is associated with the early emergence of interferon-γ-secreting lymphocytes
47. Multiple epitopes from the Mycobacterium tuberculosis ESAT-6 antigen are recognized by antigen-specific human T cell lines
48. Class II-restricted T cell function