Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats

Pharmacology Biochemistry and Behavior

Volumn 98, Issue 1, 2011, Pages 62-66

  Moradi Azani, Mahnaz ^a   Ahmadiani, Abolhassan ^b   Amini, Hossein ^a  

^a GOLESTAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BEHESHTI UNIVERSITY   (Iran)

Author keywords

5alpha reductase; Aromatase; Formalin test; Morphine; Ovariectomy

Indexed keywords

AROMATASE; FINASTERIDE; FORMALDEHYDE; LETROZOLE; MORPHINE SULFATE; STEROID 5ALPHA REDUCTASE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; NOCICEPTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT;

5-ALPHA REDUCTASE INHIBITORS; ANALGESICS, OPIOID; ANIMALS; AROMATASE INHIBITORS; DRUG SYNERGISM; FEMALE; FINASTERIDE; FORMALDEHYDE; MORPHINE; NITRILES; OVARIECTOMY; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR; TRIAZOLES;

ANIMALIA; RATTUS;

EID: 78650969020     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2010.12.016     Document Type: Article

References (50)

1. A.M. Aloisi, and M. Bonifazi Sex hormones, central nervous system and pain Horm Behav 50 2006 1 7
2. A.M. Aloisi, I. Ceccarelli, and C. Lupo Behavioral and hormonal effects of restraint stress and formalin test in male and female rats Brain Res Bull 74 1998 57 62
3. H. Amini, and A. Ahmadiani Increase in testosterone metabolism in the rat central nervous system by formalin-induced tonic pain Pharmacol Biochem Behav 74 2002 199 204
4. M. Aouad, A. Charlet, J.L. Rodeau, and P. Poisbeau Reduction and prevention of vincristine-induced neuropathic pain symptoms by the non-benzodiazepine anxiolytic etifoxine are mediated by 3a-reduced neurosteroids Pain 147 2009 54 59
5. M. Aydin, B. Yilmaz, E. Alcin, V.S. Nedzvetsky, Z. Sahin, and M. Tuzcu Effects of letrozole on hippocampal and cortical catecholaminergic neurotransmitter levels, neural cell adhesion molecule expression and spatial learning and memory in female rats Neuroscience 151 2008 186 194
6. F. Celotti, P. Negri-Cesi, and A. Polleti Steroid metabolism in the mammalian brain: 5a-reduction and aromatization Brain Res Bull 44 1997 365 375
7. R.E. Coleman, W.W. Bolten, M. Lansdown, S. Dale, C. Jackisch, and D. Merkel Aromatase inhibitor-induced arthralgia: clinical experience and treatment recommendations Cancer Treat Rev 34 2008 275 282
8. N.A. Compagnone, and S.H. Mellon Neurosteroids: biosynthesis and function of these novel neuromodulators Front Neuroendocrinol Rev 21 2000 1 56
9. D. Dubuisson, and S.G. Dennis The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats Pain 4 1977 161 174
10. H.C. Evrard Estrogen synthesis in the spinal dorsal horn: a new central mechanism for the hormonal regulation of pain Am J Physiol 291 2006 291 299
11. H.C. Evrard, and J. Balthazart Rapid regulation of pain by estrogens synthesized in spinal dorsal horn neurons J Neurosci 24 2004 7225 7229
12. N.C. Favaro-Moreira, K.E. Torres-Chavez, L. Fischer, and C.H. Tambeli Peripheral estradiol induces temporomandibular joint antinociception in rats by activating the nitric oxide/cyclic guanosine monophosphate signaling pathway Neuroscience 164 2009 724 732
13. D.T. Felson, and S. Cummings Aromatase inhibitors and the syndrome of arthralgias with estrogen deprivation Arth Rheum 52 2005 2594 2598
14. R.B. Fillingim, and T.J. Ness Sex-related hormonal influences on pain and analgesic responses Neurosci Biobehav Rev 24 2000 485 501
15. L. Fischer, K.E. Torres-Chavez, J.T. Clemente-Napimoga, D. Jorge, F. Arsati, and M.C. Arruda Veiga The influence of sex and ovarian hormones on temporomandibular joint nociception in rats J Pain 7 2008 630 638
16. C.A. Frye, K.R. Van Keuren, P.N. Rao, and M.S. Erskine Analgesic effects of the neurosteroid 3 alpha-androstanediol Brain Res 709 1996 1 9
17. C.A. Frye, D. Park, M. Tanaka, R. Rosellini, and B. Svare The testosterone metabolite and neurosteroid 3alpha-androstanediol may mediate the effects of testosterone on conditioned place preference Psychoneuroendocrinology 26 2001 731 750 (Pubitemid 32738997)
18. K.Y. Fu, A.R. Light, and W. Maixner Long-lasting inflammation and long-term hyperalgesia after subcutaneous formalin injection into the rat hindpaw J Pain 2 2001 2 11
19. M. Gasior, R.B. Carter, and J.M. Witkin Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders Trends Pharmacol Sci 20 1999 107 112
20. M.B. Herd, D. Belelli, and J.J. Lambert Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors Pharmacol Ther 116 2007 20 27
21. A.F. Keller, J.D. Breton, R. Schlichter, and P. Poisbeau Production of 5alpha-reduced neurosteroids is developmentally regulated and shapes GABA(A) miniature IPSCs in lamina II of the spinal cord J Neurosci 24 2004 907 915
22. C.K. Kellogg, and C.A. Frye Endogenous levels of 5 alpha-reduced progestins and androgens in fetal vs. adult rat brains Brain Res Dev 115 1999 17 24
23. T. Kuba, H.B. Wu, A. Nazarian, E.D. Festa, G.A. Barr, and S. Jenab Estradiol and progesterone differentially regulate formalin-induced nociception in ovariectomized female rats Horm Behav 49 2006 441 449
24. D.R. Ladle, N.A. Jacobson, and E.D. Lephart Hypothalamic aromatase cytochrome P450 and 5alpha-reductase enzyme activities in pregnant and female rats Life Sci 61 1997 2017 2026
25. M.S. Mahendroo, K.M. Cala, and D.P. Landrum Fetal death in mice lacking 5alpha-Reductase type 1 caused by estrogen excess Mol Endocrinol 11 1997 917 927
26. L. Martini, F. Celotti, and R.C. Melcangi Testosterone and progesterone metabolism in the central nervous system: cellular localization and mechanism of control of the enzymes involved Cell Mol Neurobiol 16 1996 271 282
27. B.K. Matthies, and K.B.J. Franklin Formalin pain is expressed in decerebrate rats but not attenuated by morphine Pain 51 1992 199 206
28. A.G. Mensah-nyagan, C. Kibaly, V. Schaeffer, C. Venard, L. Meyre, and C. Patte-Mensah Endogenous steroids production in the spinal cord and the potential involvement in neuropathic pain modulation J Steroid Biochem Mol Biol 109 2008 286 293
29. L. Meyer, C. Venard, V. Schaeffer, P.C. Mensah, and M.A.G. Nyagan The biological activity of 3α-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury Neurobiol Dis 30 2008 30 41
30. G. Munro Pharmacological assessment of the rat formalin test utilizing the clinically used analgesic drugs gabapentin, lamotrigine, morphine, duloxetine, tramadol and ibuprofen: influence of low and high formalin concentrations Eur J Pharmacol 605 2009 95 102
31. A.R. Nayebi, and A. Ahmadiani Involvement of the spinal serotonergic system in analgesia produced by castration Pharmacol Biochem Behav 64 1999 467 471
32. A.R. Nayebi, and H. Rezazadeh Involvement of serotoninergic mechanism in analgesia by castration and flutamide, a testosterone antagonist, in the rat formalin test Pharmacol Biochem Behav 77 2004 9 14
33. E.G. Occhiato, A. Guarna, G. Danza, and M. Serio Selective non-steroidal inhibitors of 5α-reductase type 1 J Steroid Biochem Mol Biol 88 2004 1 16
34. R. Ocvirk, B.E. Pearson Murphy, K.B.J. Franklin, and F.V. Abbott Antinociceptive profile of ring A-reduced progesterone metabolites in the formalin test Pain 138 2008 402 409
35. C. Patte-Mensah, S. Li, and A.G. Mensah-Nyagan Impact of neuropathic pain on the gene expression and activity of Cytochrome P450side-chain-cleavage in sensory neural networks Cell Mol Life Sci 61 2004 2274 2284
36. C. Patte-Mensah, C. Kibaly, D. Boudard, V. Schaeffer, A. Begle, and S. Saredi Neurogenic pain and steroid synthesis in the spinal cord J Mol Neurosci 28 2006 17 32
37. S.M. Paul, and R.H. Purdy Neuroactive steroids Faseb J 6 1992 2311 2322
38. P. Poisbeau, P.C. Mensah, A.F. Keller, M. Barrot, J.D. Breton, and O.E. Luis-Delgado Inflammatory pain upregulates spinal inhibition via endogenous neurosteroid production J Neurosci 14 2005 11768 11776
39. D.S. Pradhan, Y. Yu, and K.K. Soma Rapid estrogen regulation of DHEA metabolism in the male and female songbird brain J Neurochem 104 2008 244 253
40. C.M. Ribeiro, and O.C. Pereira 5alpha-reductase 2 inhibition impairs brain defeminization of male rats: reproductive aspects Pharmacol Biochem Behav 82 2005 228 235
41. P. Sanchez, J.M. Torres, P. Vilchez, R.G. Moral, and E. Ortega Effects of sulpiride on mRNA levels of steroid 5a-reductase isozymes in adult rat brain Neurochem Res 33 2008 820 825
42. V. Schaeffer, L. Meyer, C. Patte-Mensah, A. Eckert, and A.G. Mensah-Nyagan Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons Glia 58 2010 169 180
43. R. Schlichter, A.F. Keller, M.D. Roo, J.D. Breton, P. Inquimbert, and P. Poisbeau Fast nongenomic effects of steroids on synaptic transmission and role of endogenous neurosteroids in spinal pain pathways J Mol Neurosci 28 2006 33 51
44. B. Stoffel-Wagner Neurosteroid metabolism in the human brain Eur J Endocrinol Rev 145 2001 669 679
45. B. Stoffel-Wagner Neurosteroid biosynthesis in the human brain and its clinical implications Ann NY Acad Sci 1007 2003 64 78
46. A.E. Thigpen, R.I. Silver, J.M. Guileyardo, M.L. Casey, M.J.D. Connell, and D.W. Russell Tissue distribution and ontogeny of steroid 5a-reductase isozyme expression J Clin Invest 92 1993 903 910
47. A. Tjolsen, O.G. Berge, S. Hunskaar, J.H. Rosland, and K. Hole The formalin test: an evaluation of the method Pain 51 1992 5 17
48. J.M. Torres, and E. Ortega Differential regulation of steroid 5a-reductase isozymes expression by androgens in the adult rat brain Faseb J 17 2003 1428 1433
49. C.M. Tsao, C.M. Ho, S.K. Tsai, and T.Y. Lee Effects of estrogen on autotomy in normal and ovariectomized rats Pharmacology 59 1999 142 148
50. G.S. Watson, K.J. Sufka, and T.J. Coderre Optimal scoring strategies and weights for the formalin test in rats Pain 70 1997 53 58