Testosterone and progesterone metabolism in the central nervous system: Cellular localization and mechanism of control of the enzymes involved

Cellular and Molecular Neurobiology

Volumn 16, Issue 3, 1996, Pages 271-282

  Martini, L ^a,b   Celotti, F ^a   Melcangi, R C ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Istituto di Endocrinologia   (Italy)

Author keywords

5 reductase; glia; neurons; progesterone; testosterone

Indexed keywords

PROGESTERONE; STEROID 5ALPHA REDUCTASE; TESTOSTERONE;

ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; ENZYME LOCALIZATION; NONHUMAN; PRIORITY JOURNAL; PROGESTERONE METABOLISM; RAT; TESTOSTERONE METABOLISM;

ANDROSTANES; ANIMALS; CELL COMMUNICATION; CENTRAL NERVOUS SYSTEM; COCULTURE TECHNIQUES; DIHYDROTESTOSTERONE; NEUROGLIA; NEURONS; PROGESTERONE; RATS; TESTOSTERONE; TESTOSTERONE 5-ALPHA-REDUCTASE;

ANIMALIA;

EID: 0030011874     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02088095     Document Type: Article

References (24)

1. Andersson, S., and Russell, D. W. (1990). Structural and biochemical properties of cloned and expressed human and rat 5α-reductases. Proc, Natl. Acad. Sci. USA 87:3640-3644,
2. Andersson, S., Berman, D. M., Jenkins, E. P., and Russell, D. W. (1991). Deletion of steroid 5α-reductase-2 gene in male pseudohermaphroditism. Nature 354:159-161.
3. Banker, G. A. (1980). Trophic interactions between astroglial cells and hippocampal neurons in culture. Science 209:809-810.
4. Baulieu. E.-E., and Robel, P. (1990). Neurosteroids: A new brain function? J. Steroid Biochem. 37:395-403.
5. 3H)-testosterone and its metabolites by the brains of male and female macaque fetuses at 122 days of gestation. Neuroendocrinology 51:474-480.
6. Campbell, J. S., and Karavolas, H. J. (1989). The kinetic mechanism of the hypothalmic progesterone 5α-reductase. J. Steroid Biochem. 32:283-289.
7. Celotti, F., Melcangi, R. C., Negri-Cesi, P., and Poletti, A. (1991). Testosterone metabolism in brain cells and membranes. J. Steroid Biochem. Moi Biol. 40:673-678.
8. Celotti, F., Melcangi, R. C., and Martini, L. (1992). The 5α-reductase in the brain: Molecular aspects and relation to brain function. In Frontiers in Neuroendocrinology (L. Martini and W. F. Ganong, Eds.), Raven Press, New York, Vol. 13, pp. 163-215.
9. Cheng, K.-C. (1992). Molecular cloning of rat liver 3α-hydroxysteroid dehydrogenase and identification of structurally related proteins from rat lung and kidney. J. Steroid Biochem. Mol. Biol. 43:1083-1088.
10. Cheng, K.-C., White, P. C., and Quin, K.-N. (1991). Molecular cloning and expression of rat liver 3α-hydroxysteroid dehydrogenase. Mol. Endrocrinol. 5:823-828.
11. Corvalan, V., Cole, R., de Vellis, J., and Hagiwara, S. (1990). Neuronal modulation of calcium channel activity in cultured rat astrocytes. Proc. Nail. Acad. Sci. USA 87:4345-4348.
12. Frankfurt, M., Gould, F., Woolley, C. S., and McEwen, B. S. (1990). Gonadal steroids modify dendritic spine density in ventromedial hypothalamic neurons: A Golgi study in adult rat. Neuroendocrinology 51:530-535.
13. Frye, C. A., and DeBold, J. F. (1993). 3α-OH-DHP and 5α-THDOC implants to the ventral tegmental area facilitate sexual receptivity in hamsters after progesterone priming to the ventral medial hypothalamus. Brain Res. 612:130-137.
14. Gasser, U. E., and Hatten, M. E. (1990). Neuron-glia interactions of rat hippocampal cells in vitro: Glial-guided neuronal migration and neuronal regulation of glial differentiation. J. Neurosci. 10:1276-1285.
15. George, F. W., and Peterson, K. G. (1988). 5α-Dihydrotestosterone formation is necessary for embryogenesis of the rat prostate. Endrocrinology 122:1159-1164.
16. Hansson, E. (1989). Co-existence between receptors, carriers, and second messengers on astrocytes grown in primary cultures. Neurochem. Res. 14:811-819.
17. Harrison, N. L., Majewska, M. D., Harrington, J. W., and Barker, J. L. (1987). Structure-activity relationships for steroid interaction with the gamma-amminobutyric acid A receptor complex. J. Pharmacol Exp. Ther. 241:346-353.
18. Hatten, M. E., Lynch, M., Rydel, R. E., Sanchez, J., Joseph-Silverstein, J., Moscateli, D., and Rifkin, D. B. (1988). In vitro neurite extension by granule neurons is dependent upon astroglial-derived fibroblast growth factor. Dev. Biol. 125:280-289.
19. 21 5β/5α metabolite ratios in subjects treated with the 5α-reductase inhibitor Finasteride: Comparison of male pseudohermaphrodites with inherited 5α-reductase deficiency. J. Clin. Endocrinol. Metab. 70:777-78,
20. Jung-Testas, I., Renoir, M., Bugnard, H., Greene, G. L., and Baulieu, E. E. (1992). Demonstration of steroid hormone receptors and steroid action in primary cultures of rat glial cells. J. Steroid Biochem. Mol. Biol. 41:621-631.
21. Kabbadj, K., El-Etr, M., Baulieu, E.-E., and Robel, P. (1993). Pregnenolone metabolism in rodent embryonic neurons and astrocytes. Glia 7:170-175.
22. Kraulis, I., Foldes, G., Traikov, H., Dubrovsky, B., and Birmingham, M. K. (1975). Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system. Brain Res. 88:114.
23. Krieger, N. R., and Scott, R. G. (1989). Non-neuronal localization for steroid converting enzyme: 3α-Hydroxysteroid oxidoreductase in olfactory tubercule of rat brain. J. Neurochem. 52:1866-1870.
24. Langub, M. C., and Watson, R. E. (1992). Estrogen receptor-immunoreactive glia, endothelia, and ependyma in guinea pig preoptic area and median eminence: Electron microscopy. Endocrinology 130:364-372.