Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release

Journal of Biological Chemistry

Volumn 286, Issue 1, 2011, Pages 391-402

  Kuehn, Hye Sun ^a   Jung, Mi Yeon ^a   Beaven, Michael A ^b   Metcalfe, Dean D ^a   Gilfillan, Alasdair M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN POLYMERIZATION; BASEMENT MEMBRANE; BONE MARROW-DERIVED MAST CELLS; CHEMOATTRACTANTS; CHEMOKINES; DOWN-REGULATION; DOWNSTREAM TARGET; KEY REGULATORS; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MAST CELLS; PHOSPHATIDYLINOSITOL 3-KINASE; PROSTAGLANDINE; RAPAMYCIN; SELECTIVE INHIBITION; SIGNALING PATHWAYS;

ANTIBIOTICS; BIOLOGICAL MEMBRANES; MAMMALS; PHOSPHORYLATION; PROTEINS; SIGNALING;

BIOCHEMISTRY;

CYCLOOXYGENASE 1; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROTEIN KINASE B; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; S6 KINASE; SERINE; SHORT HAIRPIN RNA; ACTIN; CHEMOKINE; MTORC1 COMPLEX, MOUSE; PROSTAGLANDIN E RECEPTOR 3; PROTEIN; TORC2 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CELL ADHESION; CELL MIGRATION; CHEMOTAXIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE SILENCING; GENETICS; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SECRETION;

MAMMALIA; RAPTORES;

ACTINS; ANIMALS; BONE MARROW CELLS; CHEMOKINE CCL2; CHEMOKINES; CHEMOTAXIS; DINOPROSTONE; GENE KNOCKDOWN TECHNIQUES; MAST CELLS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PROSTAGLANDIN D2; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEINS; RECEPTORS, PROSTAGLANDIN E, EP3 SUBTYPE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 78650941515     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.164772     Document Type: Article

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