Rac GTPase-activating protein (Rac GAP) α1-chimaerin undergoes proteasomal degradation and is stabilized by diacylglycerol signaling in neurons

Journal of Biological Chemistry

Volumn 286, Issue 1, 2011, Pages 199-207

  Marland, Jamie R K ^a   Pan, DingXin ^a   Buttery, Philip C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BASAL CONDITIONS; C1 DOMAIN; CONSTITUTIVELY ACTIVES; DENDRITIC SPINE; DIACYLGLYCEROL; GTPASE-ACTIVATING PROTEIN; ISOFORMS; N-TERMINALS; NEW MODEL; OVER-EXPRESSION; PHORBOL ESTERS; PHOSPHOLIPASE C; PHYSIOLOGICAL CONDITION; PROTEASOMAL DEGRADATION;

DEGRADATION; ESTERIFICATION; ESTERS; GLYCEROL; NEURONS; OPTICAL COMMUNICATION; PHYSIOLOGICAL MODELS; SIGNALING;

PROTEINS;

ALPHA1 CHIMERIN; CHIMERIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAC GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DENDRITE; DENDRITIC SPINE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; NERVE CELL; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID SEQUENCE; ANIMALS; CHIMERIN 1; DIGLYCERIDES; HEK293 CELLS; HUMANS; NEURONS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN ISOFORMS; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RAC1 GTP-BINDING PROTEIN; RATS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TETRADECANOYLPHORBOL ACETATE; UBIQUITIN;

EID: 78650932889     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.166728     Document Type: Article

References (46)

1. Alvarez, V. A., and Sabatini, B. L. (2007) Annu. Rev. Neurosci. 30, 79-97
2. Cingolani, L. A., and Goda, Y. (2008) Nat. Rev. Neurosci. 9, 344-356
3. Jaffe, A. B., and Hall, A. (2005) Annu. Rev. Cell Dev. Biol. 21, 247-269
4. Tashiro, A., and Yuste, R. (2004) Mol. Cell. Neurosci. 26, 429-440
5. Nakayama, A. Y., Harms, M. B., and Luo, L. (2000) J. Neurosci. 20, 5329-5338
6. Buttery, P., Beg, A. A., Chih, B., Broder, A., Mason, C. A., and Scheiffele, P. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 1924-1929
7. Yang, C., and Kazanietz, M. G. (2007) Biochem. J. 403, 1-12
8. Takeuchi, S., Yamaki, N., Iwasato, T., Negishi, M., and Katoh, H. (2009) FEBS Lett. 583, 1237-1242
9. Wegmeyer, H., Egea, J., Rabe, N., Gezelius, H., Filosa, A., Enjin, A., Varoqueaux, F., Deininger, K., Schnütgen, F., Brose, N., Klein, R., Kullander, K., and Betz, A. (2007) Neuron 55, 756-767
10. Shi, L., Fu, W. Y., Hung, K. W., Porchetta, C., Hall, C., Fu, A. K., and Ip, N. Y. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 16347-16352
11. Iwasato, T., Katoh, H., Nishimaru, H., Ishikawa, Y., Inoue, H., Saito, Y. M., Ando, R., Iwama, M., Takahashi, R., Negishi, M., and Itohara, S. (2007) Cell 130, 742-753
12. Beg, A. A., Sommer, J. E., Martin, J. H., and Scheiffele, P. (2007) Neuron 55, 768-778
13. Caloca, M. J., Wang, H., and Kazanietz, M. G. (2003) Biochem. J. 375, 313-321
14. Manser, E., Leung, T., Monfries, C., Teo, M., Hall, C., and Lim, L. (1992) J. Biol. Chem. 267, 16025-16028
15. Colón-González, F., and Kazanietz, M. G. (2006) Biochim. Biophys. Acta 1761, 827-837
16. Wang, H., Yang, C., Leskow, F. C., Sun, J., Canagarajah, B., Hurley, J. H., and Kazanietz, M. G. (2006) EMBO J. 25, 2062-2074
17. Sosa, M. S., Lewin, N. E., Choi, S. H., Blumberg, P. M., and Kazanietz, M. G. (2009) Biochemistry 48, 8171-8178
18. Colón-González, F., Leskow, F. C., and Kazanietz, M. G. (2008) J. Biol. Chem. 283, 35247-35257
19. Canagarajah, B., Leskow, F. C., Ho, J. Y., Mischak, H., Saidi, L. F., Kazanietz, M. G., and Hurley, J. H. (2004) Cell 119, 407-418
20. Brewer, G. J., Torricelli, J. R., Evege, E. K., and Price, P. J. (1993) J. Neurosci. Res. 35, 567-576
21. Michaelson, D., Abidi, W., Guardavaccaro, D., Zhou, M., Ahearn, I., Pagano, M., and Philips, M. R. (2008) J. Cell Biol. 181, 485-496
22. Michaelson, D., Silletti, J., Murphy, G., D'Eustachio, P., Rush, M., and Philips, M. R. (2001) J. Cell Biol. 152, 111-126
23. Storm, E. E., Rubenstein, J. L., and Martin, G. R. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 1757-1762
24. Niwa, H., Yamamura, K., and Miyazaki, J. (1991) Gene 108, 193-199
25. Lennon, G., Auffray, C., Polymeropoulos, M., and Soares, M. B. (1996) Genomics 33, 151-152
26. Graham, D. R., Garnham, C. P., Fu, Q., Robbins, J., and Van Eyk, J. E. (2005) Proteomics 5, 2309-2314
27. Arbuzova, A., Schmitz, A. A., and Vergères, G. (2002) Biochem. J. 362, 1-12
28. Kazanietz, M. G., Wang, S., Milne, G. W., Lewin, N. E., Liu, H. L., and Blumberg, P. M. (1995) J. Biol. Chem. 270, 21852-21859
29. Harden, T. K., Hicks, S. N., and Sondek, J. (2009) J. Lipid Res. 50, S243-S248
30. Miyake, N., Chilton, J., Psatha, M., Cheng, L., Andrews, C., Chan, W. M., Law, K., Crosier, M., Lindsay, S., Cheung, M., Allen, J., Gutowski, N. J., Ellard, S., Young, E., Iannaccone, A., Appukuttan, B., Stout, J. T., Christiansen, S., Ciccarelli, M. L., Baldi, A., Campioni, M., Zenteno, J. C., Davenport, D., Mariani, L. E., Sahin, M., Guthrie, S., and Engle, E. C. (2008) Science 321, 839-843
31. Hall, C., Michael, G. J., Cann, N., Ferrari, G., Teo, M., Jacobs, T., Monfries, C., and Lim, L. (2001) J. Neurosci. 21, 5191-5202
32. Chen, F., Hasegawa, H., Schmitt-Ulms, G., Kawarai, T., Bohm, C., Katayama, T., Gu, Y., Sanjo, N., Glista, M., Rogaeva, E., Wakutani, Y., Pardossi-Piquard, R., Ruan, X., Tandon, A., Checler, F., Marambaud, P., Hansen, K., Westaway, D., St George-Hyslop, P., and Fraser, P. (2006) Nature 440, 1208-1212
33. Wang, H., and Kazanietz, M. G. (2010) Mol. Biol. Cell 21, 1398-1408
34. Wang, H., and Kazanietz, M. G. (2002) J. Biol. Chem. 277, 4541-4550
35. Van de Ven, T. J., VanDongen, H. M., and VanDongen, A. M. (2005) J. Neurosci. 25, 9488-9496
36. Bingol, B., Wang, C. F., Arnott, D., Cheng, D., Peng, J., and Sheng, M. (2010) Cell 140, 567-578
37. Bingol, B., and Schuman, E. M. (2006) Nature 441, 1144-1148
38. Ehlers, M. D. (2003) Nat. Neurosci. 6, 231-242
39. Pickart, C. M., and Eddins, M. J. (2004) Biochim. Biophys. Acta 1695, 55-72
40. Kawabe, H., Neeb, A., Dimova, K., Young, S. M., Jr., Takeda, M., Katsurabayashi, S., Mitkovski, M., Malakhova, O. A., Zhang, D. E., Umikawa, M., Kariya, K., Goebbels, S., Nave, K. A., Rosenmund, C., Jahn, O., Rhee, J., and Brose, N. (2010) Neuron 65, 358-372
41. Hung, A. Y., Sung, C. C., Brito, I. L., and Sheng, M. (2010) PLoS One 5, e9842
42. Dindot, S. V., Antalffy, B. A., Bhattacharjee, M. B., and Beaudet, A. L. (2008) Hum. Mol. Genet. 17, 111-118
43. Ang, X. L., Seeburg, D. P., Sheng, M., and Harper, J. W. (2008) J. Biol. Chem. 283, 29424-29432
44. Lu, Z., Liu, D., Hornia, A., Devonish, W., Pagano, M., and Foster, D. A. (1998) Mol. Cell. Biol. 18, 839-845
45. Holtmaat, A. J., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., and Svoboda, K. (2005) Neuron 45, 279-291
46. Knobloch, M., and Mansuy, I. M. (2008) Mol. Neurobiol. 37, 73-82