Decreased cardiac activity of AMP deaminase in subjects with the AMPD1 mutation - A potential mechanism of protection in heart failure

Cardiovascular Research

Volumn 59, Issue 3, 2003, Pages 678-684

  Kalsi, Kameljit K ^a   Yuen, Ada H Y ^a   Rybakowska, Iwona M ^b   Johnson, Philip H ^a   Slominska, Ewa ^b   Birks, Emma J ^a   Kaletha, Krystian ^b   Yacoub, Magdi H ^a   Smolenski, Ryszard T ^a  

^a HAREFIELD HOSPITAL   (United Kingdom)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Adenosine; Gene expression; Heart failure

Indexed keywords

ADENOSINE; ADENOSINE MONOPHOSPHATE DEAMINASE;

ADULT; ALLELE; ARTICLE; CLINICAL ARTICLE; DNA POLYMORPHISM; ENZYME ACTIVITY; EXERCISE; FEMALE; GENE MUTATION; GENOTYPE; HEART FAILURE; HEART PROTECTION; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MEASUREMENT; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; STATISTICAL SIGNIFICANCE; VENOUS BLOOD; WILD TYPE;

ADENOSINE; ADULT; AMP DEAMINASE; BACTERIAL PROTEINS; EXERCISE TEST; FEMALE; HEART FAILURE, CONGESTIVE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; MUTATION; MYOCARDIUM; N-ACETYLMURAMOYL-L-ALANINE AMIDASE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEIN ISOFORMS;

EID: 1642299985     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00497-8     Document Type: Article

References (29)

1. Loh E., Rebbeck T.R., Mahoney P.D., et al. Common variant in AMPD1 gene predicts improved clinical outcome in patients with heart failure. Circulation. 99:1999;1422-1425.
2. Anderson J.L., Habashi J., Carlquist J.F., et al. A common variant of the AMPD1 gene predicts improved cardiovascular survival in patients with coronary artery disease. J. Am. Coll. Cardiol. 36:2000;1248-1252.
3. Berne R.M. Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am. J Physiol. 204:1963;317-322.
4. Edwards N.L., Gelfand E.W., Burk L., Dosch H.M., Fox I.H. Distribution of 5′-nucleotidase in human lymphoid tissues. Proc. Natl. Acad. Sci. USA. 76:1979;3474-3476.
5. Morisaki T., Gross M., Morisaki H., et al. Molecular basis of AMP deaminase deficiency in skeletal muscle. Proc. Natl. Acad. Sci. USA. 89:1992;6457-6461.
6. Sabina R.L., Swain J.L., Olanow C.W., et al. Myoadenylate deaminase deficiency. Functional and metabolic abnormalities associated with disruption of the purine nucleotide cycle. J. Clin. Invest. 73:1984;720-730.
7. Smolenski R.T., Yacoub M.H. Liquid chromatographic evaluation of purine production in the donor human heart during transplantation. Biomed. Chromatogr. 7:1993;189-195.
8. Kochan Z., Smolenski R.T., Yacoub M.H., Seymour A.-M.L. Nucleotide and adenosine metabolism in different cell types in human and rat heart. J. Mol. Cell. Cardiol. 26:1994;1497-1503.
9. Smolenski R.T., Lachno D.R., Ledingham S.J.M., Yacoub M.H. Determination of sixteen nucleotides, nucleosides and bases using high-performance liquid chromatography and its application to the study of purine metabolism in hearts for transplantation. J. Chromatogr. 527:1990;414-420.
10. Fishbein W.N., Sabina R.L., Ogasawara N., Holmes E.W. Immunologic evidence for three isoforms of AMP deaminase (AMPD) in mature skeletal muscle. Biochim. Biophys. Acta. 1163:1993;97-104.
11. Bausch-Jurken M.T., Mahnke-Zizelman D.K., Morisaki T., Sabina R.L. Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA. J. Biol. Chem. 267:1992;22407-22413.
12. Mahnke Zizelman D.K., Sabina R.L. Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5′-exons. J. Biol. Chem. 267:1992;20866-20877.
13. Altschuld R.A., Gamelin L.M., Kelley R.E., et al. Degradation and resynthesis of adenine nucleotides in adult rat heart myocytes. J. Biol. Chem. 262:1987;13527-13533.
14. Ogasawara N., Goto H., Yamada Y., Watanabe T., Asano T. AMP deaminase isozymes in human tissues. Biochim. Biophys. Acta. 714:1982;298-306.
15. Thakkar J.K., Janero D.R., Sharif H.M., Yarwood C. Mammalian-heart adenylate deaminase: cross-species immunoanalysis of tissue distribution with a cardiac-directed antibody. Mol. Cell Biochem. 145:1995;177-183.
16. Norman B., Mahnke-Zizelman D.K., Vallis A., Sabina R.L. Genetic and other determinants of AMP deaminase activity in healthy adult skeletal muscle. J. Appl. Physiol. 85:1998;1273-1278.
17. Norman B., Sabina R.L., Jansson E. Regulation of skeletal muscle ATP catabolism by AMPD1 genotype during sprint exercise in asymptomatic subjects. J. Appl. Physiol. 91:2001;258-264.
18. Tarnopolsky M., Parise G., Gibala M., Graham T., Rush J. Myoadenylate deaminase deficiency does not affect muscle anaplerosis during exhaustive exercise in humans. J. Physiol. 533:2001;881-889.
19. Fortuin F.D., Morisaki T., Holmes E.W. Subunit composition of AMPD varies in response to changes in AMPD1 and AMPD3 gene expression in skeletal muscle. Proc. Assoc. Am. Physicians. 108:1996;329-333.
20. Lowes B.D., Minobe W., Abraham W.T., et al. Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium. J. Clin. Invest. 100:1997;2315-2324.
21. Daval J.L., Nehlig A., Nicolas F. Physiological and pharmacological properties of adenosine: therapeutic implications. Life Sci. 49:1991;1435-1453.
22. Kitakaze M., Hori M., Kamada T. Role of adenosine and its interaction with alpha adrenoceptor activity in ischaemic and reperfusion injury of the myocardium. Cardiovasc. Res. 27:1993;18-27.
23. Le Hir M., Kaissling B. Distribution and regulation of renal ecto-5′-nucleotidase: implications for physiological functions of adenosine. Am. J. Physiol. 264:1993;F377-F387.
24. Deguchi H., Takeya H., Urano H., et al. Adenosine regulates tissue factor expression on endothelial cells. Thromb. Res. 91:1998;57-64.
25. Feoktistov I., Ryzhov S., Goldstein A.E., Biaggioni I. Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. Circ. Res. 92:2003;485-492.
26. Cohen G., Shirai T., Weisel R.D., et al. Optimal myocardial preconditioning in humans. Ann. N.Y. Acad. Sci. 874:1999;306-319.
27. Pell T.J., Baxter G.F., Yellon D.M., Drew G.M. Renal ischemia preconditions myocardium: role of adenosine receptors and ATP-sensitive potassium channels. Am. J. Physiol. 275:1998;H1542-H1547.
28. Liem D.A., Verdouw P.D., Ploeg H., Kazim S., Duncker D.J. Sites of action of adenosine in interorgan preconditioning of the heart. Am. J. Physiol Heart Circ. Physiol. 283:2002;H29-H37.
29. Moser G.H., Schrader J., Deussen A. Turnover of adenosine in plasma of human and dog blood. Am. J. Physiol. 256:1989;C799-C806.