-
1
-
-
0033306082
-
Changes in free insulin-like growth factor-1 and leptin concentrations during acute metabolic decompensation in insulin withdrawn patients with type 1 diabetes
-
Attia N, Caprio S, Jones TW, Heptulla R, Holcombe J, Silver D, Sherwin RS, Tamborlane WV (1999) Changes in free insulin-like growth factor-1 and leptin concentrations during acute metabolic decompensation in insulin withdrawn patients with type 1 diabetes. J Clin Endocrinol Metab 84: 2324-2328
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 2324-2328
-
-
Attia, N.1
Caprio, S.2
Jones, T.W.3
Heptulla, R.4
Holcombe, J.5
Silver, D.6
Sherwin, R.S.7
Tamborlane, W.V.8
-
2
-
-
0029747031
-
Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children
-
Bereket A, Lang CH, Blethen SL, Ng LC, Wilson TA (1996) Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children. Clin Endocrinol (Oxf) 45: 321-326
-
(1996)
Clin Endocrinol (Oxf)
, vol.45
, pp. 321-326
-
-
Bereket, A.1
Lang, C.H.2
Blethen, S.L.3
Ng, L.C.4
Wilson, T.A.5
-
4
-
-
47549110969
-
Normal values of circulating insulinlike growth factor-I bioactivity in the healthy population: Comparison with five widely used IGF-1 immunoassays
-
Brugts MP, Ranke MB, Hofland LJ, van der Wansem K, Weber K, Frystyk J, Lamberts SW, Janssen JA (2008a) Normal values of circulating insulinlike growth factor-I bioactivity in the healthy population: comparison with five widely used IGF-1 immunoassays. J Clin Endocrinol Metab 93: 2539-2545
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 2539-2545
-
-
Brugts, M.P.1
Ranke, M.B.2
Hofland, L.J.3
Van Der Wansem, K.4
Weber, K.5
Frystyk, J.6
Lamberts, S.W.7
Janssen, J.A.8
-
5
-
-
47549088668
-
Low circulating insulinlike growth factor i bioactivity in elderly men is associated with increased mortality
-
BrugtsMP, van den Beld AW, Hofland LJ, van derWansemK, van Koetsveld PM, Frystyk J, Lamberts SW, Janssen JA (2008b) Low circulating insulinlike growth factor I bioactivity in elderly men is associated with increased mortality. J Clin Endocrinol Metab 93: 2515-2522
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 2515-2522
-
-
Brugts, M.P.1
Van Den Beld, A.W.2
Hofland, L.J.3
Van Der Wansem, K.4
Van Koetsveld, P.M.5
Frystyk, J.6
Lamberts, S.W.7
Janssen, J.A.8
-
6
-
-
77449084191
-
Igf-I bioactivity in an elderly population: Relation to insulin sensitivity, insulin levels, and the metabolic syndrome
-
Brugts MP, van Duijn CM, Hofland LJ, Witteman JC, Lamberts SW, Janssen JA (2010) Igf-I bioactivity in an elderly population: relation to insulin sensitivity, insulin levels, and the metabolic syndrome. Diabetes 59: 505-508
-
(2010)
Diabetes
, vol.59
, pp. 505-508
-
-
Brugts, M.P.1
Van Duijn, C.M.2
Hofland, L.J.3
Witteman, J.C.4
Lamberts, S.W.5
Janssen, J.A.6
-
7
-
-
0036899977
-
Clinical significance of insulin-like growth factor-binding protein-3 expression in stage i non-small cell lung cancer
-
Chang YS, Kong G, Sun S, Liu D, El-Naggar AK, Khuri FR, Hong WK, Lee HY (2002) Clinical significance of insulin-like growth factor-binding protein-3 expression in stage I non-small cell lung cancer. Clin Cancer Res 8: 3796-3802
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3796-3802
-
-
Chang, Y.S.1
Kong, G.2
Sun, S.3
Liu, D.4
El-Naggar, A.K.5
Khuri, F.R.6
Hong, W.K.7
Lee, H.Y.8
-
8
-
-
56749110996
-
The type 1 insulin-like growth factor receptor pathway
-
Chitnis MM, Yuen JS, Protheroe AS, Pollak M, Macaulay VM (2008) The type 1 insulin-like growth factor receptor pathway. Clin Cancer Res 14: 6364-6370
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6364-6370
-
-
Chitnis, M.M.1
Yuen, J.S.2
Protheroe, A.S.3
Pollak, M.4
MacAulay, V.M.5
-
9
-
-
20144386856
-
Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871
-
Cohen BD, Baker DA, Soderstrom C, Tkalcevic G, Rossi AM, Miller PE, Tengowski MW, Wang F, Gualberto A, Beebe JS, Moyer JD (2005) Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin-like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res 11: 2063-2073
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2063-2073
-
-
Cohen, B.D.1
Baker, D.A.2
Soderstrom, C.3
Tkalcevic, G.4
Rossi, A.M.5
Miller, P.E.6
Tengowski, M.W.7
Wang, F.8
Gualberto, A.9
Beebe, J.S.10
Moyer, J.D.11
-
10
-
-
0033580610
-
Total alanine-scanning mutagenesis of insulin-like growth factor i (IGF-1) identifies differential binding epitopes for IGFBP-1 and IGFBP-3
-
Dubaquié Y, Lowman HB (1999) Total alanine-scanning mutagenesis of insulin-like growth factor I (IGF-1) identifies differential binding epitopes for IGFBP-1 and IGFBP-3. Biochemistry 38: 6386-6396
-
(1999)
Biochemistry
, vol.38
, pp. 6386-6396
-
-
Dubaquié, Y.1
Lowman, H.B.2
-
11
-
-
17744369458
-
Binding protein-3-selective insulin-like growth factor i variants: Engineering, biodistributions, and clearance
-
Dubaquié Y, Mortensen DL, Intintoli A, Hogue DA, Nakamura G, Rancatore P, Lester P, Sadick MD, Filvaroff E, Fielder PJ, Lowman HB (2001) Binding protein-3-selective insulin-like growth factor I variants: engineering, biodistributions, and clearance. Endocrinology 142: 165-173
-
(2001)
Endocrinology
, vol.142
, pp. 165-173
-
-
Dubaquié, Y.1
Mortensen, D.L.2
Intintoli, A.3
Hogue, D.A.4
Nakamura, G.5
Rancatore, P.6
Lester, P.7
Sadick, M.D.8
Filvaroff, E.9
Fielder, P.J.10
Lowman, H.B.11
-
12
-
-
0028293446
-
Expression and function of the insulin like growth factor 1 system in human non small cell lung cancer and normal lung cell lines
-
Favoni RE, de Cupis A, Ravera F, Cantoni C, Pirani P, Ardizzoni A, Noonan D, Biassoni R (1994) Expression and function of the insulin like growth factor 1 system in human non small cell lung cancer and normal lung cell lines. Int J Cancer 56: 858-866
-
(1994)
Int J Cancer
, vol.56
, pp. 858-866
-
-
Favoni, R.E.1
De Cupis, A.2
Ravera, F.3
Cantoni, C.4
Pirani, P.5
Ardizzoni, A.6
Noonan, D.7
Biassoni, R.8
-
13
-
-
34249930520
-
Utility of free IGF-1 measurements
-
Frystyk J (2007) Utility of free IGF-1 measurements. Pituitary 10: 181-187
-
(2007)
Pituitary
, vol.10
, pp. 181-187
-
-
Frystyk, J.1
-
14
-
-
77949448133
-
Figitumumab (CP-751, 871) for cancer therapy
-
Gualberto A (2010) Figitumumab (CP-751,871) for cancer therapy. Expert Opin Biol Ther 10: 575-585
-
(2010)
Expert Opin Biol Ther
, vol.10
, pp. 575-585
-
-
Gualberto, A.1
-
15
-
-
70349476392
-
Molecular basis for sensitivity to figitumumab (CP-751, 871) in NSCLC
-
abstract 8091
-
Gualberto A, Dolled-Filhart MP, Hixon ML, Christensen J, Rimm DL, Lee AV, Wang Y, Pollak M, Paz-Ares LG, Karp DD (2009) Molecular basis for sensitivity to figitumumab (CP-751,871) in NSCLC. J Clin Oncol 27: 15s (abstract 8091
-
(2009)
J Clin Oncol
, vol.27
-
-
Gualberto, A.1
Dolled-Filhart, M.P.2
Hixon, M.L.3
Christensen, J.4
Rimm, D.L.5
Lee, A.V.6
Wang, Y.7
Pollak, M.8
Paz-Ares, L.G.9
Karp, D.D.10
-
16
-
-
69449097339
-
Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
-
Gualberto A, Pollak M (2009) Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene 28: 3009-3021
-
(2009)
Oncogene
, vol.28
, pp. 3009-3021
-
-
Gualberto, A.1
Pollak, M.2
-
17
-
-
33751076856
-
The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer
-
Han JY, Choi BG, Choi JY, Lee SY, Ju SY (2006) The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer. Lung Cancer 54: 227-234
-
(2006)
Lung Cancer
, vol.54
, pp. 227-234
-
-
Han, J.Y.1
Choi, B.G.2
Choi, J.Y.3
Lee, S.Y.4
Ju, S.Y.5
-
18
-
-
0031862937
-
Serum total IGF-1, free IGF-1, and IGFB-1 levels in an elderly population: Relation to cardiovascular risk factors and disease
-
Janssen JA, Stolk RP, Pols HA, Grobbee DE, Lamberts SW (1998) Serum total IGF-1, free IGF-1, and IGFB-1 levels in an elderly population: relation to cardiovascular risk factors and disease. Arterioscler Thromb Vasc Biol 18: 277-282
-
(1998)
Arterioscler Thromb Vasc Biol
, vol.18
, pp. 277-282
-
-
Janssen, J.A.1
Stolk, R.P.2
Pols, H.A.3
Grobbee, D.E.4
Lamberts, S.W.5
-
19
-
-
77956227862
-
Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
-
abstract 7500
-
Jassem J, Langer CJ, Karp DD, Mok T, Benner RJ, Green SJ, Park K, Novello S, Strausz J, Gualberto A (2010) Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol 28: 15s (abstract 7500
-
(2010)
J Clin Oncol
, vol.28
-
-
Jassem, J.1
Langer, C.J.2
Karp, D.D.3
Mok, T.4
Benner, R.J.5
Green, S.J.6
Park, K.7
Novello, S.8
Strausz, J.9
Gualberto, A.10
-
20
-
-
77956682418
-
The role of insulin-like growth factors in the epithelial to mesenchymal transition
-
Eurekah/Landes Bioscience: Georgetown
-
Julien-Grille S, Moore R, Denat L, Morali OG, Delmas V, Bellacosa A, Laure L (eds(2005) The role of insulin-like growth factors in the epithelial to mesenchymal transition. In: Rise and Fall of Epithelial Phenotype: Concepts of Epithelial. Eurekah/Landes Bioscience: Georgetown
-
(2005)
Rise and Fall of Epithelial Phenotype: Concepts of Epithelial
-
-
Julien-Grille, S.1
Moore, R.2
Denat, L.3
Morali, O.G.4
Delmas, V.5
Bellacosa, A.6
Laure, L.7
-
21
-
-
0030876829
-
Free insulin-like growth factor i serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency
-
Juul A, Holm K, Kastrup KW, Pedersen SA, Michaelsen KF, Scheike T, Rasmussen S, Müller J, Skakkebaek NE (1997) Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency. J Clin Endocrinol Metab 82: 2497-2502
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 2497-2502
-
-
Juul, A.1
Holm, K.2
Kastrup, K.W.3
Pedersen, S.A.4
Michaelsen, K.F.5
Scheike, T.6
Rasmussen, S.7
Müller, J.8
Skakkebaek, N.E.9
-
22
-
-
67650999875
-
The basics of epithelial-mesenchymal transition
-
Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428
-
(2009)
J Clin Invest
, vol.119
, pp. 1420-1428
-
-
Kalluri, R.1
Weinberg, R.A.2
-
23
-
-
66349091290
-
Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
-
Karp DD, Paz-Ares LG, Novello S, Haluska P, Garland L, Cardenal F, Blakely LJ, Eisenberg PD, Langer CJ, Blumenschein Jr G, Johnson FM, Green S, Gualberto A (2009) Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 27: 2516-2522
-
(2009)
J Clin Oncol
, vol.27
, pp. 2516-2522
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Novello, S.3
Haluska, P.4
Garland, L.5
Cardenal, F.6
Blakely, L.J.7
Eisenberg, P.D.8
Langer, C.J.9
Blumenschein Jr., G.10
Johnson, F.M.11
Green, S.12
Gualberto, A.13
-
24
-
-
0029930716
-
Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics
-
Kelley KM, Oh Y, Gargosky SE, Gucev Z, Matsumoto T, Hwa V, Ng L, Simpson DM, Rosenfeld RG (1996) Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics. Int J Biochem Cell Biol 28: 619-637
-
(1996)
Int J Biochem Cell Biol
, vol.28
, pp. 619-637
-
-
Kelley, K.M.1
Oh, Y.2
Gargosky, S.E.3
Gucev, Z.4
Matsumoto, T.5
Hwa, V.6
Ng, L.7
Simpson, D.M.8
Rosenfeld, R.G.9
-
25
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Koivunen JP, Mermel C, Zejnullahu K, Murphy C, Lifshits E, Holmes AJ, Choi HG, Kim J, Chiang D, Thomas R, Lee J, Richards WG, Sugarbaker DJ, Ducko C, Lindeman N, Marcoux JP, Engelman JA, Gray NS, Lee C, Meyerson M, Jänne PA (2008) EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 14: 4275-4283
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullahu, K.3
Murphy, C.4
Lifshits, E.5
Holmes, A.J.6
Choi, H.G.7
Kim, J.8
Chiang, D.9
Thomas, R.10
Lee, J.11
Richards, W.G.12
Sugarbaker, D.J.13
Ducko, C.14
Lindeman, N.15
Marcoux, J.P.16
Engelman, J.A.17
Gray, N.S.18
Lee, C.19
Meyerson, M.20
Jänne, P.A.21
more..
-
26
-
-
0027320012
-
Regulation and function of insulinlike growth factor binding protein-1
-
Lee PD, Conover CA, Powell DR (1993) Regulation and function of insulinlike growth factor binding protein-1. Proc Soc Exp Biol Med 204: 4-29
-
(1993)
Proc Soc Exp Biol Med
, vol.204
, pp. 4-29
-
-
Lee, P.D.1
Conover, C.A.2
Powell, D.R.3
-
27
-
-
0035899466
-
IGF-2 induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition
-
Morali OG, Delmas V, Moore R, Jeanney C, Thiery JP, Larue L (2001) IGF-2 induces rapid beta-catenin relocation to the nucleus during epithelium to mesenchyme transition. Oncogene 20: 4942-4950
-
(2001)
Oncogene
, vol.20
, pp. 4942-4950
-
-
Morali, O.G.1
Delmas, V.2
Moore, R.3
Jeanney, C.4
Thiery, J.P.5
Larue, L.6
-
28
-
-
0035157508
-
Physiological differences in insulin-like growth factor binding protein-1 (IGFBP-1) phosphorylation in IGFBP-1 transgenic mice
-
Sakai K, D'Ercole AJ, Murphy LJ, Clemmons DR (2001) Physiological differences in insulin-like growth factor binding protein-1 (IGFBP-1) phosphorylation in IGFBP-1 transgenic mice. Diabetes 50: 32-38
-
(2001)
Diabetes
, vol.50
, pp. 32-38
-
-
Sakai, K.1
D'Ercole, A.J.2
Murphy, L.J.3
Clemmons, D.R.4
-
29
-
-
0034710915
-
Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin
-
Playford MP, Bicknell D, Bodmer WF, Macaulay VM (2000) Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc Natl Acad Sci USA 9: 12103-12108
-
(2000)
Proc Natl Acad Sci USA
, vol.9
, pp. 12103-12108
-
-
Playford, M.P.1
Bicknell, D.2
Bodmer, W.F.3
MacAulay, V.M.4
-
30
-
-
56749184290
-
Insulin and insulin-like growth factor signalling in neoplasia
-
Pollak M (2008) Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 8: 915-928
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 915-928
-
-
Pollak, M.1
-
31
-
-
70349939382
-
Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
-
Siena S, Sartore-Bianchi A, Di Nicolantonio F, Balfour J, Bardelli A (2009) Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J Natl Cancer Inst 101: 1308-1324
-
(2009)
J Natl Cancer Inst
, vol.101
, pp. 1308-1324
-
-
Siena, S.1
Sartore-Bianchi, A.2
Di Nicolantonio, F.3
Balfour, J.4
Bardelli, A.5
-
32
-
-
62449090881
-
Guidelines for human epidermal growth factor receptor 2 testing: Biologic and methodologic considerations
-
Sauter G, Lee J, Bartlett JM, Slamon DJ, Press MF (2009) Guidelines for human epidermal growth factor receptor 2 testing: biologic and methodologic considerations. J Clin Oncol 27: 1323-1333
-
(2009)
J Clin Oncol
, vol.27
, pp. 1323-1333
-
-
Sauter, G.1
Lee, J.2
Bartlett, J.M.3
Slamon, D.J.4
Press, M.F.5
-
33
-
-
77949902069
-
Epidermal growth factor receptor biomarkers in non-small-cell lung cancer: A riddle, wrapped in a mystery, inside an enigma
-
Shepherd FA, Tsao MS (2010) Epidermal growth factor receptor biomarkers in non-small-cell lung cancer: a riddle, wrapped in a mystery, inside an enigma. J Clin Oncol 28: 903-905
-
(2010)
J Clin Oncol
, vol.28
, pp. 903-905
-
-
Shepherd, F.A.1
Tsao, M.S.2
-
34
-
-
0036847606
-
Serum insulin like growth factor (IGF) and IGF binding protein levels and risk of lung cancer: A case control study nested in the beta carotene and retinol efficacy trial cohort
-
Spitz MR, Barnett MJ, Goodman GE, Thornquist MD, Wu X, Pollak M (2002) Serum insulin like growth factor (IGF) and IGF binding protein levels and risk of lung cancer: a case control study nested in the beta carotene and retinol efficacy trial cohort. Cancer Epidemiol Biomarkers Prev 11: 1413-1418
-
(2002)
Cancer Epidemiol Biomarkers Prev
, vol.11
, pp. 1413-1418
-
-
Spitz, M.R.1
Barnett, M.J.2
Goodman, G.E.3
Thornquist, M.D.4
Wu, X.5
Pollak, M.6
-
35
-
-
58249092146
-
-
Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, Pollak MN, Giovannucci EL, Fuchs CS (2009) Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. 27: 176-185
-
(2009)
Insulin, the Insulin-like Growth Factor Axis, and Mortality in Patients with Nonmetastatic Colorectal Cancer
, vol.27
, pp. 176-185
-
-
Wolpin, B.M.1
Meyerhardt, J.A.2
Chan, A.T.3
Ng, K.4
Chan, J.A.5
Wu, K.6
Pollak, M.N.7
Giovannucci, E.L.8
Fuchs, C.S.9
-
36
-
-
0027457620
-
Receiver-operating characteristic (ROC) plots: A fundamental evaluation tool in clinical medicine
-
Zweig MH, Campbell G (1993) Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 39: 561-577
-
(1993)
Clin Chem
, vol.39
, pp. 561-577
-
-
Zweig, M.H.1
Campbell, G.2
|