Toxicologic evaluation of humectants added to cigarette tobacco: 13-Week smoke inhalation study of glycerin and propylene glycol in fischer 344 rats

Inhalation Toxicology

Volumn 14, Issue 11, 2002, Pages 1135-1152

  Heck, J Daniel ^a   Gaworski, Charles L ^a   Rajendran, Narayanan ^b   Morrissey, Robert L ^c  

^a LORILLARD TOBACCO COMPANY   (United States)

^b IIT RESEARCH INSTITUTE   (United States)

^c Pathology Associates   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CARBOXYHEMOGLOBIN; CHOLESTEROL; CIGARETTE SMOKE; COTININE; GLUCOSE; GLYCEROL; NICOTINE; PROPYLENE GLYCOL;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BODY WEIGHT; BREATHING RATE; CELL HYPERPLASIA; CHOLESTEROL BLOOD LEVEL; CIGARETTE SMOKING; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; GLUCOSE BLOOD LEVEL; HEART WEIGHT; HISTOPATHOLOGY; INTERSTITIAL PNEUMONIA; LARYNX MUCOSA; LUNG ALVEOLUS MACROPHAGE; LUNG MINUTE VOLUME; LUNG WEIGHT; MALE; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; SQUAMOUS CELL METAPLASIA; TIDAL VOLUME; TOBACCO;

ADMINISTRATION, INHALATION; ALKALINE PHOSPHATASE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; EXCIPIENTS; FEMALE; GLYCEROL; LUNG DISEASES, INTERSTITIAL; MALE; ORGAN SIZE; PROPYLENE GLYCOL; RATS; RATS, INBRED F344; RESPIRATORY SYSTEM; SMOKING; TOXICITY TESTS;

ANIMALIA; NICOTIANA TABACUM;

EID: 0036845623     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370290084827     Document Type: Article

References (24)

1. Baumgartner, H., and Coggins, C. R. E. 1980. Description of a continuous-smoking inhalation machine for exposing small animals to tobacco smoke. Beit. Tabakforsch. 10(3):169-174.
2. Carmines, E. L. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 1: Cigarette design, testing approach, and review of results. Food Chem. Toxicol. 40:77-91.
3. Coggins, C. R. E. 1998. A review of chronic inhalation studies with mainstream cigarette smoke in rats and mice. Toxicol. Pathol. 26(3):307-314.
4. Coggins, C. R. E., Duchosal, F., Musy, C., and Ventrone, R. 1981. Measurement of respiratory patterns in rodents using whole-body plethysmography and a pneumotachograph. Lab. Anim. 15:137-140.
5. Coggins, C. R. E., Lam, R., and Morgan, K. T. 1982. Chronic inhalation study in rats using cigarettes containing different amounts of Cytrel tobacco supplement. Toxicology 22(4):287-296.
6. Dalbey, W. E., Nettesheim, P., Griesmer, R., Caton, J. E., and Guerin, M. R. 1980. Chronic inhalation of cigarette smoke by F344 rats. JNCI 64(2):383-390.
7. Doihara, T., Kobashi, U., Sugawara, S., and Kaburaki, Y. 1964. Studies of flavoring effect (IV). Pyrolysis of polyhydric alcohols. Nippon Senbai Kosha Chua Kenkyusho Kenkyn Hokuku 106:129-135.
8. Dungworth, D. L., Schwartz, L. W., and Tyler, W. S. 1976. Morphological methods for evaluation of pulmonary toxicity in animals. Ann. Rev. Pharmacol. Toxicol. 16:381-399.
9. Gaworski, C. L., Dozier, M. M., Gerhart, J. M., Rajendran, N., Brennecke, L. H., Aranyi, C., and Heck, J. D. 1997. 13-Week inhalation study of menthol cigarette smoke. Food Chem. Toxicol. 35:683-692.
10. Gaworski, C. L., Dozier, M. M., Heck, J. D., Gerhart, J. M., Rajendran, N., David, R. M., Brennecke, L. H., and Morrissey, R. 1998. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: 13-Week inhalation exposures in rats. Inhal. Toxicol. 10(4):357-381.
11. Gaworski, C. L., Heck, J. D., Bennett, M. B., and Wenk, M. L. 1999. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: Skin painting bioassay of cigarette smoke condensate in SENCAR mice. Toxicology 139:1-17.
12. Hoffmann, D., and Hoffmann, I. 1997. The changing cigarette 1950-1995. J. Toxicol. Environ. Health 50:307-364.
13. Kane, L. E., and Alarie, Y. 1977. Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice. Am. Ind. Hyg. Assoc. J. 38(10):509-522.
14. Kobashi, U., Doihara, T., Sugawara, S., and Kaburaki, Y. 1966. Changes in the chemical composition of smoke imparted with several polyols. Res. Inst. Jpn. Monopoly Corp. 107:319-323.
15. Laurene, A. H., Cundiff, R. H., and Greene, G. H. 1965. Determination of glycerol and propylene glycol in cigarette smoke. Tobacco Sci. 9:1-4.
16. National Cancer Institute. 1977. Toward Less Hazardous Cigarettes: Report No. 3, The Third Set of Experimental Cigarettes. Washington, DC: National Cancer Institute Smoking and Health Program.
17. Penney, D. G. 1993. Acute carbon monoxide poisoning in an animal model: The effects of altered glucose on morbidity and mortality. Toxicology 80:85-101.
18. Rustemeier, K., Sabbert R., Haussmann, H.-J., Roemer, E., and Carmines, E. L. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke. Food Chem. Toxicol. 40:93-104.
19. Sagartz, J. W., Madarasz, A. J., Forsell, M. A., Burger, G. T., Ayres, P. H., and Coggins, C. R. E. 1992. Histological sectioning of the rodent larynx for inhalation toxicity testing. Toxicol. Pathol. 20(1):118-121.
20. Stein, Y. S., and Antal, M. J. 1983. A study of the gas-phase pyrolysis of glycerol. J. Anal. Appl. Pyrol. 4(4):283-296.
21. Vanscheeuwijck, P. M., Teredesai, A., Terpstra, P. M., Verbeeck, J., Kuhl, P., Gerstenberg, B., Gebel, S., and Carmines, E. L. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 4: Subchronic inhalation toxicity. Food Chem. Toxicol. 40:113-131.
22. Van Vunakis, H., Gjika, H. B., and Langone, J. J. 1987. Environmental Carcinogens. Methods of Analysis and Exposure Measurement, Vol. 9, Passive Smoking. Lyon: IARC.
23. Wehner, A. P., Dagle, G. E., Millman, E. M., Phelps, D. W., Carr, D. B., Decker, J. R., and Filipy, R. E. 1981. Inhalation bioassay of cigarette smoke in rats. Toxicol. Appl. Pharmacol. 61(1):1-17.
24. Young, J. T. 1981. Histopathologic examination of the rat nasal cavity. Fundam. Appl. Toxicol. 61(1):309-312.