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Volumn 138, Issue 1-2, 2003, Pages 1-8

Mechanistic and toxicokinetic data reducing uncertainty in risk assessment

Author keywords

Chlorobenzene; Covalent binding; Ethylene; Risk assessment; Styrene; Toxicokinetic modeling

Indexed keywords

CHLOROBENZENE; CYTOCHROME P450; ETHYLENE; ETHYLENE OXIDE; GLUTATHIONE TRANSFERASE; HYDROLASE; STYRENE;

EID: 0037452435     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(02)00408-3     Document Type: Article
Times cited : (12)

References (37)
  • 1
    • 0012771942 scopus 로고    scopus 로고
    • ACGIH: American Conference of Governmental Indusrial Hygienists
    • ACGIH, Technical Affairs Office, Cincinnati, OH 45240
    • ACGIH: American Conference of Governmental Indusrial Hygienists, 2002. Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs). ACGIH, Technical Affairs Office, Cincinnati, OH 45240.
    • (2002) Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs)
  • 2
    • 0033804464 scopus 로고    scopus 로고
    • Quantification of DNA adducts formed in liver, lungs, and isolated lung cells of rats and mice exposed to (14)C-styrene by nose-only inhalation
    • Boogaard P.J., de Kloe K.P., Wong B.A., Sumner S.C., Watson W.P., van Sittert N.J. Quantification of DNA adducts formed in liver, lungs, and isolated lung cells of rats and mice exposed to (14)C-styrene by nose-only inhalation. Toxicol. Sci. 57:2000;203-216.
    • (2000) Toxicol. Sci. , vol.57 , pp. 203-216
    • Boogaard, P.J.1    De Kloe, K.P.2    Wong, B.A.3    Sumner, S.C.4    Watson, W.P.5    Van Sittert, N.J.6
  • 6
    • 0001932687 scopus 로고
    • Carcinogenic risk estimates for inhaled styrene based on the body burden of its metabolite styrene-7,8-oxide
    • Csanády G.A., Kessler W., Filser J.G. Carcinogenic risk estimates for inhaled styrene based on the body burden of its metabolite styrene-7,8-oxide. Naunyn-Schmiedeberg's Arch. Pharmacol. (Suppl. 351):1995;122.
    • (1995) Naunyn-Schmiedeberg's Arch. Pharmacol. , Issue.SUPPL. 351 , pp. 122
    • Csanády, G.A.1    Kessler, W.2    Filser, J.G.3
  • 7
    • 0343133887 scopus 로고    scopus 로고
    • A physiological toxicokinetic model for exogenous and endogenous ethylene and ethylene oxide in rat, mouse, and human: Formation of 2-hydroxyethyl adducts with hemoglobin and DNA
    • Csanády G.A., Denk B., Pütz C., Kreuzer P.E., Kessler W., Baur C., Gargas M.L., Filser J.G. A physiological toxicokinetic model for exogenous and endogenous ethylene and ethylene oxide in rat, mouse, and human: Formation of 2-hydroxyethyl adducts with hemoglobin and DNA. Toxicol. Appl. Pharmacol. 165:2000;1-26.
    • (2000) Toxicol. Appl. Pharmacol. , vol.165 , pp. 1-26
    • Csanády, G.A.1    Denk, B.2    Pütz, C.3    Kreuzer, P.E.4    Kessler, W.5    Baur, C.6    Gargas, M.L.7    Filser, J.G.8
  • 8
    • 0034463201 scopus 로고    scopus 로고
    • The relevance of physical activity for the kinetics of inhaled gaseous substances
    • Csanády G.A., Filser J.G. The relevance of physical activity for the kinetics of inhaled gaseous substances. Arch. Toxicol. 74:2001;663-672.
    • (2001) Arch. Toxicol. , vol.74 , pp. 663-672
    • Csanády, G.A.1    Filser, J.G.2
  • 9
    • 0035819912 scopus 로고    scopus 로고
    • Investigation of the role of the 2′,3′-epoxidation pathway in the bioactivation and genotoxicity of dietary allylbenzene analogs
    • Guenthner T.M., Luo G. Investigation of the role of the 2′,3′-epoxidation pathway in the bioactivation and genotoxicity of dietary allylbenzene analogs. Toxicology. 160:2001;47-58.
    • (2001) Toxicology , vol.160 , pp. 47-58
    • Guenthner, T.M.1    Luo, G.2
  • 10
    • 0017665036 scopus 로고
    • Evaluation of genetic risks of alkylating agents. III. Alkylation of hemoglobin after metabolic conversion of ethene to ethene oxide in vivo
    • Ehrenberg L., Ostermann-Golkar S., Segerbäck D., Svenson K., Calleman C.J. Evaluation of genetic risks of alkylating agents. III. Alkylation of hemoglobin after metabolic conversion of ethene to ethene oxide in vivo. Mutat. Res. 45:1977;175-184.
    • (1977) Mutat. Res. , vol.45 , pp. 175-184
    • Ehrenberg, L.1    Ostermann-Golkar, S.2    Segerbäck, D.3    Svenson, K.4    Calleman, C.J.5
  • 11
    • 0006111328 scopus 로고    scopus 로고
    • Office of Research and Development. US Environmental Protection Agency. Washington, DC. EPA/600/P-92/003C, April 1996, Federal. Register 61, 17960-18011.
    • EPA: Environmental Protection Agency: Proposed Guidelines for Carcinogenic Risk Assessment., 1996. Office of Research and Development. US Environmental Protection Agency. Washington, DC. EPA/600/P-92/003C, April 1996, Federal. Register 61, 17960-18011.
    • (1996) EPA: Environmental Protection Agency: Proposed Guidelines for Carcinogenic Risk Assessment
  • 13
    • 0021162019 scopus 로고
    • Inhalation pharmacokinetics based on gas uptake studies. VI. Comparative evaluation of ethylene oxide and butadiene monoxide as exhaled reactive metabolites of ethylene and 1,3-butadiene in rats
    • Filser J., Bolt H.M. Inhalation pharmacokinetics based on gas uptake studies. VI. Comparative evaluation of ethylene oxide and butadiene monoxide as exhaled reactive metabolites of ethylene and 1,3-butadiene in rats. Arch. Toxicol. 55:1984;219-223.
    • (1984) Arch. Toxicol. , vol.55 , pp. 219-223
    • Filser, J.1    Bolt, H.M.2
  • 14
    • 0026593234 scopus 로고
    • Pharmacokinetics of ethylene in man: Body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene
    • Filser J.G., Denk B., Törnquist M., Kessler W., Ehrenberg L. Pharmacokinetics of ethylene in man: body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene. Arch. Toxicol. 66:1992;157-163.
    • (1992) Arch. Toxicol. , vol.66 , pp. 157-163
    • Filser, J.G.1    Denk, B.2    Törnquist, M.3    Kessler, W.4    Ehrenberg, L.5
  • 15
    • 0003004242 scopus 로고
    • Different approaches to estimate the carcinogenic risk of styrene based on animal studies
    • Filser, J.G., Kessler, W., Csanády, G.A., 1993. Different approaches to estimate the carcinogenic risk of styrene based on animal studies. The SIRC Review 3, 54.
    • (1993) The SIRC Review , vol.3 , pp. 54
    • Filser, J.G.1    Kessler, W.2    Csanády, G.A.3
  • 16
    • 0037021810 scopus 로고    scopus 로고
    • Estimation of a possible tumorigenic risk of styrene from daily intake via food and ambient air
    • Filser J.G., Kessler W., Csanády G.A. Estimation of a possible tumorigenic risk of styrene from daily intake via food and ambient air. Toxicol. Lett. 126:2002;1-18.
    • (2002) Toxicol. Lett. , vol.126 , pp. 1-18
    • Filser, J.G.1    Kessler, W.2    Csanády, G.A.3
  • 17
    • 0014664711 scopus 로고
    • Hémopathies graves et exposition à des dérivés chlorés du bezène (à propos de 7 cas)
    • Girard M.M.R., Tolot F., Martin P., Bourret J. Hémopathies graves et exposition à des dérivés chlorés du bezène (à propos de 7 cas). J. Med. Lyon. 50:1969;771-773.
    • (1969) J. Med. Lyon. , vol.50 , pp. 771-773
    • Girard, M.M.R.1    Tolot, F.2    Martin, P.3    Bourret, J.4
  • 18
    • 0012784575 scopus 로고    scopus 로고
    • Greim H. Weinheim: Wiley-VCH
    • Greim H. Ethylene. Occupational Toxicants. 10:1998;91-107 Wiley-VCH, Weinheim.
    • (1998) Ethylene. Occupational Toxicants , vol.10 , pp. 91-107
  • 19
    • 0012870935 scopus 로고    scopus 로고
    • Greim H. Weinheim: Wiley-VCH
    • Greim H. Chlorobenzene. Occupational Toxicants. 12:1999;103-127 Wiley-VCH, Weinheim.
    • (1999) Chlorobenzene. Occupational Toxicants , vol.12 , pp. 103-127
  • 21
    • 0032720864 scopus 로고    scopus 로고
    • Metabolism of styrene by mouse and rat isolated lung cells
    • Hynes D.E., DeNicola D.B., Carlson G.P. Metabolism of styrene by mouse and rat isolated lung cells. Toxicol. Sci. 51:1999;195-201.
    • (1999) Toxicol. Sci. , vol.51 , pp. 195-201
    • Hynes, D.E.1    DeNicola, D.B.2    Carlson, G.P.3
  • 24
    • 0033754904 scopus 로고    scopus 로고
    • Human toxicokinetics of inhaled monochlorobenzene: Latest experimental findings regarding re-evaluation of the biological tolerance value
    • Knecht U., Woitowitz H.J. Human toxicokinetics of inhaled monochlorobenzene: latest experimental findings regarding re-evaluation of the biological tolerance value. Int. Arch. Occup. Environ. Health. 73:2000;543-554.
    • (2000) Int. Arch. Occup. Environ. Health , vol.73 , pp. 543-554
    • Knecht, U.1    Woitowitz, H.J.2
  • 25
    • 0029044089 scopus 로고
    • Exposure to styrene and chronic health effects: Mortality and incidence of solid cancers in the Danish reinforced plastics industry
    • Kolstad H.A., Juel K., Olsen J., Lynge E. Exposure to styrene and chronic health effects: mortality and incidence of solid cancers in the Danish reinforced plastics industry. Occup. Environ. Med. 52:1995;320-327.
    • (1995) Occup. Environ. Med. , vol.52 , pp. 320-327
    • Kolstad, H.A.1    Juel, K.2    Olsen, J.3    Lynge, E.4
  • 26
    • 0021261696 scopus 로고
    • Drug metabolism in man and its relationship to that in three rodent species: Monooxygenase, epoxide hydrolase and glutathione S-transferase activities in subcellular fractions of lung and liver
    • Lorenz J., Glatt H.R., Fleischmann R., Ferlinz R., Oesch F. Drug metabolism in man and its relationship to that in three rodent species: monooxygenase, epoxide hydrolase and glutathione S-transferase activities in subcellular fractions of lung and liver. Biochem. Med. 32:1984;43-56.
    • (1984) Biochem. Med. , vol.32 , pp. 43-56
    • Lorenz, J.1    Glatt, H.R.2    Fleischmann, R.3    Ferlinz, R.4    Oesch, F.5
  • 31
    • 0003879687 scopus 로고
    • Prepared by Norway and The Netherlands. Oslo and Bilthoven, Final Report, September, 1995
    • OECD, Organisation for Economic Co-operation and Development, 1995a. Classification Systems on Carcinogens in OECD Countries-Similarities and Differences. Prepared by Norway and The Netherlands. Oslo and Bilthoven, Final Report, September, 1995.
    • (1995) Classification Systems on Carcinogens in OECD Countries-Similarities and Differences
  • 33
    • 0029654358 scopus 로고
    • Dosimetry of styrene 7,8-oxide in styrene- and styrene oxide-exposed mice and rats by quantification of haemoglobin adducts
    • Osterman-Golkar S., Christakopoulos A., Zorec V., Svensson K. Dosimetry of styrene 7,8-oxide in styrene- and styrene oxide-exposed mice and rats by quantification of haemoglobin adducts. Chem-Biol. Interact. 95:1995;79-87.
    • (1995) Chem-Biol. Interact. , vol.95 , pp. 79-87
    • Osterman-Golkar, S.1    Christakopoulos, A.2    Zorec, V.3    Svensson, K.4
  • 36
    • 0029032680 scopus 로고
    • Biomarkers of styrene exposure in lamination workers: Levels of O6-guanine DNA adducts, DNA strand breaks and mutant frequencies in the hypoxanthine guanine phosphoribosyltransferase gene in T-lymphocytes
    • Vodicka P., Bastlova T., Vodickova I., Peterkova K., Lambert B., Hemminki K. Biomarkers of styrene exposure in lamination workers: levels of O6-guanine DNA adducts, DNA strand breaks and mutant frequencies in the hypoxanthine guanine phosphoribosyltransferase gene in T-lymphocytes. Carcinogenesis. 16:1995;1473-1481.
    • (1995) Carcinogenesis , vol.16 , pp. 1473-1481
    • Vodicka, P.1    Bastlova, T.2    Vodickova, I.3    Peterkova, K.4    Lambert, B.5    Hemminki, K.6


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