Selective COX-2 inhibitors modulate cellular senescence in human dermal fibroblasts in a catalytic activity-independent manner

Mechanisms of Ageing and Development

Volumn 129, Issue 12, 2008, Pages 706-713

  Kim, So Ra ^a   Park, Jung Hae ^a   Lee, Mi Eun ^a   Park, Jeong Soo ^b   Park, Sang Chul ^c   Han, Jeong A ^a  

^a Kangwon National University College of Medicine   (South Korea)

^b Dankook University College of Medicine   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

Caveolin 1; Cyclooxygenase 2; Fibroblast; Inhibitor; Senescence

Indexed keywords

ACETYLSALICYLIC ACID; BETA GALACTOSIDASE; CAVEOLIN 1; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FLURBIPROFEN; GLUTATHIONE PEROXIDASE 1; IBUPROFEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NIMESULIDE; PROSTAGLANDIN E2; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ARTICLE; CATALYSIS; CELL AGING; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE;

ASPIRIN; CAVEOLIN 1; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FIBROBLASTS; FLURBIPROFEN; HUMANS; IBUPROFEN; KINETICS; MODELS, BIOLOGICAL; NF-KAPPA B; NITROBENZENES; PYRAZOLES; REACTIVE OXYGEN SPECIES; SKIN; SKIN AGING; SULFONAMIDES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 56949107189     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2008.09.003     Document Type: Article

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