Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 1, 2002, Pages 385-392

  Smith, Terry J ^a   Koumas, Laura ^b   Gagnon, Annemarie ^c   Bell, Andrea ^d   Sempowski, Gregory D ^b   Phipps, Richard P ^d   Sorisky, Alexander ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Cancer Center   (United States)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; THY 1 ANTIGEN;

ADIPOCYTE; ARTICLE; CELL DIFFERENTIATION; CONNECTIVE TISSUE; CONTROLLED STUDY; ENDOCRINE OPHTHALMOPATHY; EXTRAOCULAR MUSCLE; FIBROBLAST; HUMAN; HUMAN CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYROID GLAND;

EID: 0036149915     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.87.1.8164     Document Type: Article

References (49)

1. Fibroblasts as sentinel cells: Synthesis of chemokines and regulation of inflammation
2. Cultured human fibroblasts express constitutive IL-16 mRNA: Cytokine induction of active IL-16 protein synthesis through a caspase-3-dependent mechanism
3. Human orbital fibroblasts in culture bind and respond to endothelin
4. Human orbital fibroblasts in culture express ganglioside profiles distinct from those in dermal fibroblasts
5. Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production
6. Stimulation of glycosaminoglycan accumulation by interferon gamma in cultured human retroocular fibroblasts
7. Leukoregulin is a potent inducer of hyaluronan synthesis in cultured human orbital fibroblasts
8. Leukoregulin induction of prostaglandin-endoperoxide H synthase-2 in human orbital fibroblasts: An in vitro model for connective tissue inflammation
9. Leukoregulin induction of protein expression in human orbital fibroblasts: Evidence for anatomical site-restricted cytokine-target cell interactions
10. Leukoregulin upregulation of prostaglandin endoperoxide H synthase-2 expression in human orbital fibroblasts
11. Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression
12. 2 elicits a morphological change in cultured orbital fibroblasts from patients with Graves ophthalmopathy
13. 2 alters human orbital fibroblast shape through a mechanism involving the generation of cyclic adenosine monophosphate
14. Assessment of rapid morphological changes associated with elevated cAMP levels in human orbital fibroblasts
15. Connective tissue, glycosaminoglycans, and diseases of the thyroid
16. Immunohistochemical and ultrastructural studies on the exenterated orbital tissues of a patient with Graves' disease
17. Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy
18. Evidence of adipocyte differentiation in human orbital fibroblasts in primary culture
19. Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts
20. Association of Thy-1 cell surface differentiation antigen with certain connective tissues in vivo
21. Differential expression of interleukin 1α by Thy-1+ and Thy-1- lung fibroblast subpopulations: Enhancement of interleukin 1α production by tumor necrosis factor-α
22. Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis
23. Dysthyroid optic neuropathy without extraocular muscle involvement
24. The ocular muscle cell is a target of the immune system in endocrine ophthalmopathy
25. n-Butyrate inhibition of hyaluronate synthesis in cultured human fibroblasts
26. Angiotensin II receptors in human preadipocytes: Role in cell cycle regulation
27. Bone morphogenetic protein-2 stimulates adipogenic differentiation of mesenchymal precursor cells in synergy with BRL 49653 (rosiglitazone)
28. PPAR gamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
29. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
30. Hormonal regulation of hyaluronate synthesis in cultured human fibroblasts: Evidence for differences between retroocular and dermal fibroblasts
31. 2 and hyaluronan synthesis
32. Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium
33. Lipid deposition within the extra-ocular muscles of a patient with dysthyroid ophthalmopathy
34. Stimulation of glycosaminoglycan accumulation by interferon gamma in cultured human retroocular fibroblasts
35. Molecular cloning and characterization of the human and mouse UDP-glucose dehydrogenase genes
36. Expression of hyaluronan synthase messenger ribonucleic acids and their induction by interleukin-1β in human orbital fibroblasts: Potential insight into the molecular pathogenesis of thyroid-associated ophthalmopathy
37. Cytochemical studies on the fibroblast-preadipocyte relationships in cultured fibroblast cell lines
38. 15- deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR-gamma
39. Improved insulin sensitivity in mice heterozygous for PPAR-gamma deficiency
40. Differential activation of adipogenesis by multiple PPAR isoforms
41. PPAR gamma is required for placental, cardiac, and adipose tissue development
42. Molecular regulation of adipogenesis
43. Differentiation of human orbital preadipocyte fibroblasts induces expression of functional thyrotropin receptor
44. Adipogenesis in thyroid eye disease
45. Functional expression of thyrotropin receptor in differentiated 3T3-L1 cells: A possible model cell line of extrathyroidal expression of thyrotropin receptor
46. Differentiation of rat preadipocytes is accompanied by expression of thyrotropin receptors
47. Effects of thyrotropin on the proliferation and differentiation of cultured rat preadipocytes
48. Functional TSH receptor in human abdominal preadipocytes and orbital fibroblasts
49. Presence of thyrotropin receptor in infant adipocytes