메뉴 건너뛰기




Volumn 5, Issue 12, 2010, Pages

Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE; I KAPPA B KINASE COMPLEX ASSOCIATED PROTEIN; MESSENGER RNA; OMEGA 3 FATTY ACID; PHOSPHATIDYLSERINE; PROTEIN IKBKAP; UNCLASSIFIED DRUG; CARRIER PROTEIN; IKBKAP PROTEIN, HUMAN;

EID: 78650813785     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015884     Document Type: Article
Times cited : (37)

References (61)
  • 1
    • 1442328913 scopus 로고    scopus 로고
    • Familial dysautonomia
    • Axelrod FB (2004) Familial dysautonomia. Muscle Nerve 29: 352-363.
    • (2004) Muscle Nerve , vol.29 , pp. 352-363
    • Axelrod, F.B.1
  • 2
    • 41149144099 scopus 로고    scopus 로고
    • Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: Should the rationale for mutation choice for screening be reevaluated?
    • Fares F, Badarneh K, Abosaleh M, Harari-Shaham A, Diukman R, et al. (2008) Carrier frequency of autosomal-recessive disorders in the Ashkenazi Jewish population: should the rationale for mutation choice for screening be reevaluated? Prenat Diagn 28: 236-241.
    • (2008) Prenat Diagn , vol.28 , pp. 236-241
    • Fares, F.1    Badarneh, K.2    Abosaleh, M.3    Harari-Shaham, A.4    Diukman, R.5
  • 3
    • 0037815350 scopus 로고    scopus 로고
    • Screening for familial dysautonomia in Israel: Evidence for higher carrier rate among Polish Ashkenazi Jews
    • Lehavi O, Aizenstein O, Bercovich D, Pavzner D, Shomrat R, et al. (2003) Screening for familial dysautonomia in Israel: evidence for higher carrier rate among Polish Ashkenazi Jews. Genet Test 7: 139-142.
    • (2003) Genet Test , vol.7 , pp. 139-142
    • Lehavi, O.1    Aizenstein, O.2    Bercovich, D.3    Pavzner, D.4    Shomrat, R.5
  • 5
    • 0036799517 scopus 로고    scopus 로고
    • Survival in familial dysautonomia: Impact of early intervention
    • Axelrod FB, Goldberg JD, Ye XY, Maayan C (2002) Survival in familial dysautonomia: Impact of early intervention. J Pediatr 141: 518-523.
    • (2002) J Pediatr , vol.141 , pp. 518-523
    • Axelrod, F.B.1    Goldberg, J.D.2    Ye, X.Y.3    Maayan, C.4
  • 6
    • 39049183007 scopus 로고    scopus 로고
    • A world without pain or tears
    • Axelrod FB (2006) A world without pain or tears. Clin Auton Res 16: 90-97.
    • (2006) Clin Auton Res , vol.16 , pp. 90-97
    • Axelrod, F.B.1
  • 8
    • 58149198244 scopus 로고    scopus 로고
    • The molecular basis of familial dysautonomia: Overview, new discoveries and implications for directed therapies
    • Rubin BY, Anderson SL (2008) The molecular basis of familial dysautonomia: overview, new discoveries and implications for directed therapies. Neuromolecular Med 10: 148-156.
    • (2008) Neuromolecular Med , vol.10 , pp. 148-156
    • Rubin, B.Y.1    Anderson, S.L.2
  • 9
    • 0037371609 scopus 로고    scopus 로고
    • Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia
    • Cuajungco MP, Leyne M, Mull J, Gill SP, Lu W, et al. (2003) Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia. Am J Hum Genet 72: 749-758.
    • (2003) Am J Hum Genet , vol.72 , pp. 749-758
    • Cuajungco, M.P.1    Leyne, M.2    Mull, J.3    Gill, S.P.4    Lu, W.5
  • 10
    • 0035089807 scopus 로고    scopus 로고
    • Tissuespecific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia
    • Slaugenhaupt SA, Blumenfeld A, Gill SP, Leyne M, Mull J, et al. (2001) Tissuespecific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia. Am J Hum Genet 68: 598-605.
    • (2001) Am J Hum Genet , vol.68 , pp. 598-605
    • Slaugenhaupt, S.A.1    Blumenfeld, A.2    Gill, S.P.3    Leyne, M.4    Mull, J.5
  • 11
    • 77949904260 scopus 로고    scopus 로고
    • Nonsense-mediated mRNA decay in human cells: Mechanistic insights, functions beyond quality control and the double-life of NMD factors
    • Nicholson P, Yepiskoposyan H, Metze S, Zamudio Orozco R, Kleinschmidt N, et al. (2010) Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors. Cell Mol Life Sci 67: 677-700.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 677-700
    • Nicholson, P.1    Yepiskoposyan, H.2    Metze, S.3    Zamudio Orozco, R.4    Kleinschmidt, N.5
  • 13
  • 14
    • 0037200023 scopus 로고    scopus 로고
    • A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling
    • Holmberg C, Katz S, Lerdrup M, Herdegen T, Jaattela M, et al. (2002) A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling. J Biol Chem 277: 31918-31928.
    • (2002) J Biol Chem , vol.277 , pp. 31918-31928
    • Holmberg, C.1    Katz, S.2    Lerdrup, M.3    Herdegen, T.4    Jaattela, M.5
  • 15
    • 34250305505 scopus 로고    scopus 로고
    • Elongator complex: How many roles does it play?
    • Svejstrup JQ (2007) Elongator complex: how many roles does it play? Curr Opin Cell Biol 19: 331-336.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 331-336
    • Svejstrup, J.Q.1
  • 17
    • 33749078546 scopus 로고    scopus 로고
    • Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis
    • Esberg A, Huang B, Johansson MJ, Bystrom AS (2006) Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell 24: 139-148.
    • (2006) Mol Cell , vol.24 , pp. 139-148
    • Esberg, A.1    Huang, B.2    Johansson, M.J.3    Bystrom, A.S.4
  • 18
    • 15244355534 scopus 로고    scopus 로고
    • Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation
    • Rahl PB, Chen CZ, Collins RN (2005) Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Mol Cell 17: 841-853.
    • (2005) Mol Cell , vol.17 , pp. 841-853
    • Rahl, P.B.1    Chen, C.Z.2    Collins, R.N.3
  • 19
    • 42549137421 scopus 로고    scopus 로고
    • IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration
    • Johansen LD, Naumanen T, Knudsen A, Westerlund N, Gromova I, et al. (2008) IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci 121: 854-864.
    • (2008) J Cell Sci , vol.121 , pp. 854-864
    • Johansen, L.D.1    Naumanen, T.2    Knudsen, A.3    Westerlund, N.4    Gromova, I.5
  • 20
    • 33745034833 scopus 로고    scopus 로고
    • Transcription impairment and cell migration defects in elongator-depleted cells: Implication for familial dysautonomia
    • Close P, Hawkes N, Cornez I, Creppe C, Lambert CA, et al. (2006) Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia. Mol Cell 22: 521-531.
    • (2006) Mol Cell , vol.22 , pp. 521-531
    • Close, P.1    Hawkes, N.2    Cornez, I.3    Creppe, C.4    Lambert, C.A.5
  • 21
    • 34548457240 scopus 로고    scopus 로고
    • IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in down regulation of genes involved in oligodendrocyte differentiation and in myelination
    • Cheishvili D, Maayan C, Smith Y, Ast G, Razin A (2007) IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in down regulation of genes involved in oligodendrocyte differentiation and in myelination. Hum Mol Genet 16: 2097-2104.
    • (2007) Hum Mol Genet , vol.16 , pp. 2097-2104
    • Cheishvili, D.1    Maayan, C.2    Smith, Y.3    Ast, G.4    Razin, A.5
  • 22
    • 43049125074 scopus 로고    scopus 로고
    • Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells
    • Cornez I, Creppe C, Gillard M, Hennuy B, Chapelle JP, et al. (2008) Deregulated expression of pro-survival and pro-apoptotic p53-dependent genes upon Elongator deficiency in colon cancer cells. Biochem Pharmacol 75: 2122-2134.
    • (2008) Biochem Pharmacol , vol.75 , pp. 2122-2134
    • Cornez, I.1    Creppe, C.2    Gillard, M.3    Hennuy, B.4    Chapelle, J.P.5
  • 23
    • 59249093238 scopus 로고    scopus 로고
    • Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP
    • Chen YT, Hims MM, Shetty RS, Mull J, Liu L, et al. (2009) Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP. Mol Cell Biol 29: 736-744.
    • (2009) Mol Cell Biol , vol.29 , pp. 736-744
    • Chen, Y.T.1    Hims, M.M.2    Shetty, R.S.3    Mull, J.4    Liu, L.5
  • 24
    • 33846574156 scopus 로고    scopus 로고
    • Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia
    • Hims MM, Ibrahim EC, Leyne M, Mull J, Liu L, et al. (2007) Therapeutic potential and mechanism of kinetin as a treatment for the human splicing disease familial dysautonomia. J Mol Med 85: 149-161.
    • (2007) J Mol Med , vol.85 , pp. 149-161
    • Hims, M.M.1    Ibrahim, E.C.2    Leyne, M.3    Mull, J.4    Liu, L.5
  • 25
    • 22144463880 scopus 로고    scopus 로고
    • Metabolism and functions of phosphatidylserine
    • Vance JE, Steenbergen R (2005) Metabolism and functions of phosphatidylserine. Prog Lipid Res 44: 207-234.
    • (2005) Prog Lipid Res , vol.44 , pp. 207-234
    • Vance, J.E.1    Steenbergen, R.2
  • 26
    • 0030087583 scopus 로고    scopus 로고
    • A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain?
    • Pepeu G, Pepeu IM, Amaducci L (1996) A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain? Pharmacol Res 33: 73-80.
    • (1996) Pharmacol Res , vol.33 , pp. 73-80
    • Pepeu, G.1    Pepeu, I.M.2    Amaducci, L.3
  • 27
    • 78650830504 scopus 로고    scopus 로고
    • U.S. Food and Drug administration website. Available, Accessed Dec 8
    • U.S. Food and Drug administration website. Available: http://www.fda.gov/Food/LabelingNutrition/LabelClaims/QualifiedHealthClaims/ucm072999. htm. Accessed 2010 Dec 8.
    • (2010)
  • 28
  • 29
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • da Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 31
    • 0037276810 scopus 로고    scopus 로고
    • Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: A multicenter, double-blind, randomized, placebo-controlled trial
    • De Jesus Moreno Moreno M (2003) Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial. Clin Ther 25: 178-193.
    • (2003) Clin Ther , vol.25 , pp. 178-193
    • De Jesus Moreno Moreno, M.1
  • 32
    • 11244306637 scopus 로고    scopus 로고
    • Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia
    • Bunea R, El Farrah K, Deutsch L (2004) Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia. Altern Med Rev 9: 420-428.
    • (2004) Altern Med Rev , vol.9 , pp. 420-428
    • Bunea, R.1    El Farrah, K.2    Deutsch, L.3
  • 33
    • 0037673946 scopus 로고    scopus 로고
    • Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea
    • Sampalis F, Bunea R, Pelland MF, Kowalski O, Duguet N, et al. (2003) Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea. Altern Med Rev 8: 171-179.
    • (2003) Altern Med Rev , vol.8 , pp. 171-179
    • Sampalis, F.1    Bunea, R.2    Pelland, M.F.3    Kowalski, O.4    Duguet, N.5
  • 34
    • 34547454243 scopus 로고    scopus 로고
    • A humanized IKBKAP transgenic mouse models a tissue-specific human splicing defect
    • Hims MM, Shetty RS, Pickel J, Mull J, Leyne M, et al. (2007) A humanized IKBKAP transgenic mouse models a tissue-specific human splicing defect. Genomics 90: 389-396.
    • (2007) Genomics , vol.90 , pp. 389-396
    • Hims, M.M.1    Shetty, R.S.2    Pickel, J.3    Mull, J.4    Leyne, M.5
  • 35
    • 61949408123 scopus 로고    scopus 로고
    • Kinetin in familial dysautonomia carriers: Implications for a new therapeutic strategy targeting mRNA splicing
    • Gold-von Simson G, Goldberg JD, Rolnitzky LM, Mull J, Leyne M, et al. (2009) Kinetin in familial dysautonomia carriers: implications for a new therapeutic strategy targeting mRNA splicing. Pediatr Res 65: 341-346.
    • (2009) Pediatr Res , vol.65 , pp. 341-346
    • Gold-von Simson, G.1    Goldberg, J.D.2    Rolnitzky, L.M.3    Mull, J.4    Leyne, M.5
  • 36
    • 0038392607 scopus 로고    scopus 로고
    • Tocotrienols induce IKBKAP expression: A possible therapy for familial dysautonomia
    • Anderson SL, Qiu J, Rubin BY (2003) Tocotrienols induce IKBKAP expression: a possible therapy for familial dysautonomia. Biochem Biophys Res Commun 306: 303-309.
    • (2003) Biochem Biophys Res Commun , vol.306 , pp. 303-309
    • Anderson, S.L.1    Qiu, J.2    Rubin, B.Y.3
  • 37
    • 24344501293 scopus 로고    scopus 로고
    • Tocotrienols reverse IKAP and monoamine oxidase deficiencies in familial dysautonomia
    • Anderson SL, Rubin BY (2005) Tocotrienols reverse IKAP and monoamine oxidase deficiencies in familial dysautonomia. Biochem Biophys Res Commun 336: 150-156.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 150-156
    • Anderson, S.L.1    Rubin, B.Y.2
  • 38
    • 0141681935 scopus 로고    scopus 로고
    • EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia
    • Anderson SL, Qiu J, Rubin BY (2003) EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia. Biochem Biophys Res Commun 310: 627-633.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 627-633
    • Anderson, S.L.1    Qiu, J.2    Rubin, B.Y.3
  • 39
    • 70349301819 scopus 로고    scopus 로고
    • Modelling pathogenesis and treatment of familial dysautonomia using patientspecific iPSCs
    • Lee G, Papapetrou EP, Kim H, Chambers SM, Tomishima MJ, et al. (2009) Modelling pathogenesis and treatment of familial dysautonomia using patientspecific iPSCs. Nature 461: 402-406.
    • (2009) Nature , vol.461 , pp. 402-406
    • Lee, G.1    Papapetrou, E.P.2    Kim, H.3    Chambers, S.M.4    Tomishima, M.J.5
  • 40
    • 43549118650 scopus 로고    scopus 로고
    • Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: Effect of dietary n-3 fatty acids containing phospholipids
    • Vaisman N, Kaysar N, Zaruk-Adasha Y, Pelled D, Brichon G, et al. (2008) Correlation between changes in blood fatty acid composition and visual sustained attention performance in children with inattention: effect of dietary n-3 fatty acids containing phospholipids. Am J Clin Nutr 87: 1170-1180.
    • (2008) Am J Clin Nutr , vol.87 , pp. 1170-1180
    • Vaisman, N.1    Kaysar, N.2    Zaruk-Adasha, Y.3    Pelled, D.4    Brichon, G.5
  • 41
    • 0034565097 scopus 로고    scopus 로고
    • An open trial of plant-source derived phosphatydilserine for treatment of agerelated cognitive decline
    • Schreiber S, Kampf-Sherf O, Gorfine M, Kelly D, Oppenheim Y, et al. (2000) An open trial of plant-source derived phosphatydilserine for treatment of agerelated cognitive decline. Isr J Psychiatry Relat Sci 37: 302-307.
    • (2000) Isr J Psychiatry Relat Sci , vol.37 , pp. 302-307
    • Schreiber, S.1    Kampf-Sherf, O.2    Gorfine, M.3    Kelly, D.4    Oppenheim, Y.5
  • 42
    • 0006869295 scopus 로고    scopus 로고
    • Phosphatidylserine; Membrane nutrient for Memory
    • A clinical and mechanistic assesment
    • Kidd PM (1996) Phosphatidylserine; Membrane nutrient for Memory. A clinical and mechanistic assesment. Altern Med Rev 1: 70-84.
    • (1996) Altern Med Rev , vol.1 , pp. 70-84
    • Kidd, P.M.1
  • 43
    • 77951059311 scopus 로고    scopus 로고
    • Administration of DHA-PS to aged mice was suitable for increasing hippocampal PS and DHA ratio
    • Ohkubo T, Tanaka Y (2010) Administration of DHA-PS to aged mice was suitable for increasing hippocampal PS and DHA ratio. J Oleo Sci 59: 247-253.
    • (2010) J Oleo Sci , vol.59 , pp. 247-253
    • Ohkubo, T.1    Tanaka, Y.2
  • 44
    • 33746768939 scopus 로고    scopus 로고
    • Effects of phosphatidylserine supplementation on exercising humans
    • Kingsley M (2006) Effects of phosphatidylserine supplementation on exercising humans. Sports Med 36: 657-669.
    • (2006) Sports Med , vol.36 , pp. 657-669
    • Kingsley, M.1
  • 46
    • 42149159461 scopus 로고    scopus 로고
    • The tumourassociated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched microdomains: Implication for tumour cell motility
    • Lekishvili T, Fromm E, Mujoomdar M, Berditchevski F (2008) The tumourassociated antigen L6 (L6-Ag) is recruited to the tetraspanin-enriched microdomains: implication for tumour cell motility. J Cell Sci 121: 685-694.
    • (2008) J Cell Sci , vol.121 , pp. 685-694
    • Lekishvili, T.1    Fromm, E.2    Mujoomdar, M.3    Berditchevski, F.4
  • 47
    • 0035879096 scopus 로고    scopus 로고
    • Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes
    • Storim J, Friedl P, Schaefer BM, Bechtel M, Wallich R, et al. (2001) Molecular and functional characterization of the four-transmembrane molecule l6 in epidermal keratinocytes. Exp Cell Res 267: 233-242.
    • (2001) Exp Cell Res , vol.267 , pp. 233-242
    • Storim, J.1    Friedl, P.2    Schaefer, B.M.3    Bechtel, M.4    Wallich, R.5
  • 48
    • 0027459938 scopus 로고
    • Sequence-specific transcriptional activation by Myc and repression by Max
    • Amin C, Wagner AJ, Hay N (1993) Sequence-specific transcriptional activation by Myc and repression by Max. Mol Cell Biol 13: 383-390.
    • (1993) Mol Cell Biol , vol.13 , pp. 383-390
    • Amin, C.1    Wagner, A.J.2    Hay, N.3
  • 49
    • 0141506887 scopus 로고    scopus 로고
    • Valproic acid increases the SMN2 protein level: A well-known drug as a potential therapy for spinal muscular atrophy
    • Brichta L, Hofmann Y, Hahnen E, Siebzehnrubl FA, Raschke H, et al. (2003) Valproic acid increases the SMN2 protein level: a well-known drug as a potential therapy for spinal muscular atrophy. Hum Mol Genet 12: 2481-2489.
    • (2003) Hum Mol Genet , vol.12 , pp. 2481-2489
    • Brichta, L.1    Hofmann, Y.2    Hahnen, E.3    Siebzehnrubl, F.A.4    Raschke, H.5
  • 51
    • 23244458683 scopus 로고    scopus 로고
    • Hydroxyurea enhances SMN2 gene expression in spinal muscular atrophy cells
    • Grzeschik SM, Ganta M, Prior TW, Heavlin WD, Wang CH (2005) Hydroxyurea enhances SMN2 gene expression in spinal muscular atrophy cells. Ann Neurol 58: 194-202.
    • (2005) Ann Neurol , vol.58 , pp. 194-202
    • Grzeschik, S.M.1    Ganta, M.2    Prior, T.W.3    Heavlin, W.D.4    Wang, C.H.5
  • 52
    • 0035891862 scopus 로고    scopus 로고
    • Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients
    • Andreassi C, Jarecki J, Zhou J, Coovert DD, Monani UR, et al. (2001) Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients. Hum Mol Genet 10: 2841-2849.
    • (2001) Hum Mol Genet , vol.10 , pp. 2841-2849
    • Andreassi, C.1    Jarecki, J.2    Zhou, J.3    Coovert, D.D.4    Monani, U.R.5
  • 53
    • 33745686137 scopus 로고    scopus 로고
    • The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells
    • Riessland M, Brichta L, Hahnen E, Wirth B (2006) The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells. Hum Genet 120: 101-110.
    • (2006) Hum Genet , vol.120 , pp. 101-110
    • Riessland, M.1    Brichta, L.2    Hahnen, E.3    Wirth, B.4
  • 54
    • 77749301118 scopus 로고    scopus 로고
    • Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy
    • Hastings ML, Berniac J, Liu YH, Abato P, Jodelka FM, et al. (2009) Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy. Sci Transl Med 1: 5ra12.
    • (2009) Sci Transl Med , vol.1
    • Hastings, M.L.1    Berniac, J.2    Liu, Y.H.3    Abato, P.4    Jodelka, F.M.5
  • 56
    • 0036094055 scopus 로고    scopus 로고
    • N6-Furfuryladenine (Kinetin) as a potential Anti-Aging Molecule
    • Rattan S (2002) N6-Furfuryladenine (Kinetin) as a potential Anti-Aging Molecule. Journal of Anti-Aging Medicine 5: 113-116.
    • (2002) Journal of Anti-Aging Medicine , vol.5 , pp. 113-116
    • Rattan, S.1
  • 57
    • 33847782088 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 7-azaindole derivatives, synthetic cytokinin analogues
    • Guillard J, Decrop M, Gallay N, Espanel C, Boissier E, et al. (2007) Synthesis and biological evaluation of 7-azaindole derivatives, synthetic cytokinin analogues. Bioorg Med Chem Lett 17: 1934-1937.
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 1934-1937
    • Guillard, J.1    Decrop, M.2    Gallay, N.3    Espanel, C.4    Boissier, E.5
  • 58
    • 0028800205 scopus 로고
    • Plant growth hormone kinetin delays ageing, prolongs the lifespan and slows down development of the fruitfly Zaprionus paravittiger
    • Sharma SP, Kaur P, Rattan SI (1995) Plant growth hormone kinetin delays ageing, prolongs the lifespan and slows down development of the fruitfly Zaprionus paravittiger. Biochem Biophys Res Commun 216: 1067-1071.
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 1067-1071
    • Sharma, S.P.1    Kaur, P.2    Rattan, S.I.3
  • 59
    • 35448976819 scopus 로고    scopus 로고
    • Tocotrienols in health and disease: The other half of the natural vitamin E family
    • Sen CK, Khanna S, Roy S (2007) Tocotrienols in health and disease: the other half of the natural vitamin E family. Mol Aspects Med 28: 692-728.
    • (2007) Mol Aspects Med , vol.28 , pp. 692-728
    • Sen, C.K.1    Khanna, S.2    Roy, S.3
  • 61
    • 17744382360 scopus 로고    scopus 로고
    • Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression
    • Wood LD, Halvorsen TL, Dhar S, Baur JA, Pandita RK, et al. (2001) Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression. Oncogene 20: 278-288.
    • (2001) Oncogene , vol.20 , pp. 278-288
    • Wood, L.D.1    Halvorsen, T.L.2    Dhar, S.3    Baur, J.A.4    Pandita, R.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.