메뉴 건너뛰기




Volumn 11, Issue , 2011, Pages

(R)-[11C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CARBON; DIAGNOSTIC AGENT; GLYCOPROTEIN P; KAINIC ACID; RADIOPHARMACEUTICAL AGENT; VERAPAMIL;

EID: 78650752621     PISSN: None     EISSN: 14712342     Source Type: Journal    
DOI: 10.1186/1471-2342-11-1     Document Type: Article
Times cited : (35)

References (58)
  • 1
    • 20544475805 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms
    • 10.1111/j.1528-1167.2005.54904.x, 15946327
    • Schmidt D, Löscher W. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 2005, 46(6):858-877. 10.1111/j.1528-1167.2005.54904.x, 15946327.
    • (2005) Epilepsia , vol.46 , Issue.6 , pp. 858-877
    • Schmidt, D.1    Löscher, W.2
  • 2
    • 0032918385 scopus 로고    scopus 로고
    • Clinical aspects and biological bases of drug-resistant epilepsies
    • 10.1016/S0920-1211(98)00106-5, 10210025
    • Regesta G, Tanganelli P. Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res 1999, 34(2-3):109-122. 10.1016/S0920-1211(98)00106-5, 10210025.
    • (1999) Epilepsy Res , vol.34 , Issue.2-3 , pp. 109-122
    • Regesta, G.1    Tanganelli, P.2
  • 3
    • 0000712439 scopus 로고
    • Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
    • 10.1073/pnas.86.2.695, 286540, 2563168
    • Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 1989, 86(2):695-698. 10.1073/pnas.86.2.695, 286540, 2563168.
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.2 , pp. 695-698
    • Cordon-Cardo, C.1    O'Brien, J.P.2    Casals, D.3    Rittman-Grauer, L.4    Biedler, J.L.5    Melamed, M.R.6    Bertino, J.R.7
  • 4
    • 0037457802 scopus 로고    scopus 로고
    • Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
    • 10.1016/S0169-409X(02)00169-2, 12535572
    • Schinkel AH, Jonker JW. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 2003, 55(1):3-29. 10.1016/S0169-409X(02)00169-2, 12535572.
    • (2003) Adv Drug Deliv Rev , vol.55 , Issue.1 , pp. 3-29
    • Schinkel, A.H.1    Jonker, J.W.2
  • 5
    • 33748792802 scopus 로고    scopus 로고
    • The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy
    • 10.1016/j.nbd.2006.06.014, 16928449
    • Brandt C, Bethmann K, Gastens AM, Loscher W. The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy. Neurobiol Dis 2006, 24(1):202-211. 10.1016/j.nbd.2006.06.014, 16928449.
    • (2006) Neurobiol Dis , vol.24 , Issue.1 , pp. 202-211
    • Brandt, C.1    Bethmann, K.2    Gastens, A.M.3    Loscher, W.4
  • 6
    • 72049093471 scopus 로고    scopus 로고
    • COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats
    • 10.1016/j.neuropharm.2009.09.012, 19786037
    • van Vliet EA, Zibell G, Pekcec A, Schlichtiger J, Edelbroek PM, Holtman L, Aronica E, Gorter JA, Potschka H. COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. Neuropharmacology 2009, 58(2):404-412. 10.1016/j.neuropharm.2009.09.012, 19786037.
    • (2009) Neuropharmacology , vol.58 , Issue.2 , pp. 404-412
    • van Vliet, E.A.1    Zibell, G.2    Pekcec, A.3    Schlichtiger, J.4    Edelbroek, P.M.5    Holtman, L.6    Aronica, E.7    Gorter, J.A.8    Potschka, H.9
  • 8
    • 33846580959 scopus 로고    scopus 로고
    • Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model
    • Epub 2007 Jan 2008, 10.1016/j.neulet.2006.11.075, 17240061
    • Hocht C, Lazarowski A, Gonzalez NN, Auzmendi J, Opezzo JA, Bramuglia GF, Taira CA, Girardi E. Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model. Neurosci Lett 2007, 413(2):168-172. Epub 2007 Jan 2008, 10.1016/j.neulet.2006.11.075, 17240061.
    • (2007) Neurosci Lett , vol.413 , Issue.2 , pp. 168-172
    • Hocht, C.1    Lazarowski, A.2    Gonzalez, N.N.3    Auzmendi, J.4    Opezzo, J.A.5    Bramuglia, G.F.6    Taira, C.A.7    Girardi, E.8
  • 9
    • 60949089759 scopus 로고    scopus 로고
    • Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid
    • Epub 2009 Feb 2004, 10.1016/j.neulet.2009.01.079, 19429015
    • Hocht C, Lazarowski A, Gonzalez NN, Mayer MA, Opezzo JA, Taira CA, Girardi E. Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. Neurosci Lett 2009, 453(1):54-57. Epub 2009 Feb 2004, 10.1016/j.neulet.2009.01.079, 19429015.
    • (2009) Neurosci Lett , vol.453 , Issue.1 , pp. 54-57
    • Hocht, C.1    Lazarowski, A.2    Gonzalez, N.N.3    Mayer, M.A.4    Opezzo, J.A.5    Taira, C.A.6    Girardi, E.7
  • 10
    • 0036156280 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
    • 10.1093/brain/awf002, 11834590
    • Sisodiya SM, Lin WR, Harding BN, Squier MV, Thom M. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 2002, 125(Pt 1):22-31. 10.1093/brain/awf002, 11834590.
    • (2002) Brain , vol.125 , Issue.PART 1 , pp. 22-31
    • Sisodiya, S.M.1    Lin, W.R.2    Harding, B.N.3    Squier, M.V.4    Thom, M.5
  • 11
    • 0028895740 scopus 로고
    • MDR1 gene expression in brain of patients with medically intractable epilepsy
    • 10.1111/j.1528-1157.1995.tb01657.x, 8001500
    • Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 1995, 36(1):1-6. 10.1111/j.1528-1157.1995.tb01657.x, 8001500.
    • (1995) Epilepsia , vol.36 , Issue.1 , pp. 1-6
    • Tishler, D.M.1    Weinberg, K.I.2    Hinton, D.R.3    Barbaro, N.4    Annett, G.M.5    Raffel, C.6
  • 12
    • 0035669389 scopus 로고    scopus 로고
    • Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy
    • 10.1046/j.1528-1157.2001.12301.x, 11879359
    • Dombrowski SM, Desai SY, Marroni M, Cucullo L, Goodrich K, Bingaman W, Mayberg MR, Bengez L, Janigro D. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 2001, 42(12):1501-1506. 10.1046/j.1528-1157.2001.12301.x, 11879359.
    • (2001) Epilepsia , vol.42 , Issue.12 , pp. 1501-1506
    • Dombrowski, S.M.1    Desai, S.Y.2    Marroni, M.3    Cucullo, L.4    Goodrich, K.5    Bingaman, W.6    Mayberg, M.R.7    Bengez, L.8    Janigro, D.9
  • 13
    • 33645513798 scopus 로고    scopus 로고
    • Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats
    • 10.1111/j.1528-1167.2006.00496.x, 16650133
    • van Vliet EA, van Schaik R, Edelbroek PM, Redeker S, Aronica E, Wadman WJ, Marchi N, Vezzani A, Gorter JA. Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia 2006, 47(4):672-680. 10.1111/j.1528-1167.2006.00496.x, 16650133.
    • (2006) Epilepsia , vol.47 , Issue.4 , pp. 672-680
    • van Vliet, E.A.1    van Schaik, R.2    Edelbroek, P.M.3    Redeker, S.4    Aronica, E.5    Wadman, W.J.6    Marchi, N.7    Vezzani, A.8    Gorter, J.A.9
  • 14
    • 22744440362 scopus 로고    scopus 로고
    • Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
    • Löscher W, Potschka H. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol 2005, 76(1):22-76.
    • (2005) Prog Neurobiol , vol.76 , Issue.1 , pp. 22-76
    • Löscher, W.1    Potschka, H.2
  • 15
    • 79961129959 scopus 로고    scopus 로고
    • The Antiepileptic Drug Topiramate is a Substrate for Human P-glycoprotein but Not Multidrug Resistance Proteins
    • Luna-Tortos C, Rambeck B, Jurgens UH, Loscher W. The Antiepileptic Drug Topiramate is a Substrate for Human P-glycoprotein but Not Multidrug Resistance Proteins. Pharm Res 2009, 3:3.
    • (2009) Pharm Res , vol.3 , pp. 3
    • Luna-Tortos, C.1    Rambeck, B.2    Jurgens, U.H.3    Loscher, W.4
  • 16
    • 0032693058 scopus 로고    scopus 로고
    • Over-expression of P-glycoprotein in malformations of cortical development
    • 10.1097/00001756-199911080-00032, 10599858
    • Sisodiya SM, Heffernan J, Squier MV. Over-expression of P-glycoprotein in malformations of cortical development. Neuroreport 1999, 10(16):3437-3441. 10.1097/00001756-199911080-00032, 10599858.
    • (1999) Neuroreport , vol.10 , Issue.16 , pp. 3437-3441
    • Sisodiya, S.M.1    Heffernan, J.2    Squier, M.V.3
  • 17
    • 0036128985 scopus 로고    scopus 로고
    • Role of multidrug transporters in pharmacoresistance to antiepileptic drugs
    • Löscher W, Potschka H. Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther 2002, 301(1):7-14.
    • (2002) J Pharmacol Exp Ther , vol.301 , Issue.1 , pp. 7-14
    • Löscher, W.1    Potschka, H.2
  • 18
    • 42449134059 scopus 로고    scopus 로고
    • P-glycoprotein--a clinical target in drug-refractory epilepsy?
    • 10.1124/mol.108.046680, 18314494
    • Robey RW, Lazarowski A, Bates SE. P-glycoprotein--a clinical target in drug-refractory epilepsy?. Mol Pharmacol 2008, 73(5):1343-1346. 10.1124/mol.108.046680, 18314494.
    • (2008) Mol Pharmacol , vol.73 , Issue.5 , pp. 1343-1346
    • Robey, R.W.1    Lazarowski, A.2    Bates, S.E.3
  • 19
    • 58849093964 scopus 로고    scopus 로고
    • Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus
    • 10.1016/j.eplepsyres.2008.10.010, 19059762
    • Pekcec A, Unkruer B, Stein V, Bankstahl JP, Soerensen J, Tipold A, Baumgartner W, Potschka H. Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus. Epilepsy Res 2009, 83(2-3):144-151. 10.1016/j.eplepsyres.2008.10.010, 19059762.
    • (2009) Epilepsy Res , vol.83 , Issue.2-3 , pp. 144-151
    • Pekcec, A.1    Unkruer, B.2    Stein, V.3    Bankstahl, J.P.4    Soerensen, J.5    Tipold, A.6    Baumgartner, W.7    Potschka, H.8
  • 20
    • 64149098897 scopus 로고    scopus 로고
    • Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus
    • 10.1016/j.eplepsyres.2008.07.007, 18760905
    • Bankstahl JP, Löscher W. Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus. Epilepsy Res 2008, 82(1):70-85. 10.1016/j.eplepsyres.2008.07.007, 18760905.
    • (2008) Epilepsy Res , vol.82 , Issue.1 , pp. 70-85
    • Bankstahl, J.P.1    Löscher, W.2
  • 21
    • 33847613348 scopus 로고    scopus 로고
    • How to explain multidrug resistance in epilepsy?
    • 1198632, 16145617
    • Löscher W. How to explain multidrug resistance in epilepsy?. Epilepsy Curr 2005, 5:107-112. 1198632, 16145617.
    • (2005) Epilepsy Curr , vol.5 , pp. 107-112
    • Löscher, W.1
  • 22
    • 36949025921 scopus 로고    scopus 로고
    • Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?
    • 10.1111/j.1528-1167.2007.01260_3.x, 18088270
    • Anderson GD, Shen DD. Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?. Epilepsia 2007, 48(12):2372-2374. 10.1111/j.1528-1167.2007.01260_3.x, 18088270.
    • (2007) Epilepsia , vol.48 , Issue.12 , pp. 2372-2374
    • Anderson, G.D.1    Shen, D.D.2
  • 23
    • 0031747177 scopus 로고    scopus 로고
    • Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy
    • 10.1016/S0920-1211(98)00017-5, 9696302
    • Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE. Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res 1998, 31(1):73-84. 10.1016/S0920-1211(98)00017-5, 9696302.
    • (1998) Epilepsy Res , vol.31 , Issue.1 , pp. 73-84
    • Hellier, J.L.1    Patrylo, P.R.2    Buckmaster, P.S.3    Dudek, F.E.4
  • 24
    • 8444250735 scopus 로고    scopus 로고
    • Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats
    • 10.1016/j.eplepsyres.2004.06.005, 15380564
    • van Vliet E, Aronica E, Redeker S, Marchi N, Rizzi M, Vezzani A, Gorter J. Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. Epilepsy Res 2004, 60(2-3):203-213. 10.1016/j.eplepsyres.2004.06.005, 15380564.
    • (2004) Epilepsy Res , vol.60 , Issue.2-3 , pp. 203-213
    • van Vliet, E.1    Aronica, E.2    Redeker, S.3    Marchi, N.4    Rizzi, M.5    Vezzani, A.6    Gorter, J.7
  • 25
    • 0344121138 scopus 로고    scopus 로고
    • Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET
    • 10.1016/S1053-8119(03)00405-1, 14642487
    • Bart J, Willemsen AT, Groen HJ, van der Graaf WT, Wegman TD, Vaalburg W, de Vries EG, Hendrikse NH. Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET. Neuroimage 2003, 20(3):1775-1782. 10.1016/S1053-8119(03)00405-1, 14642487.
    • (2003) Neuroimage , vol.20 , Issue.3 , pp. 1775-1782
    • Bart, J.1    Willemsen, A.T.2    Groen, H.J.3    van der Graaf, W.T.4    Wegman, T.D.5    Vaalburg, W.6    de Vries, E.G.7    Hendrikse, N.H.8
  • 26
    • 48749106993 scopus 로고    scopus 로고
    • Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET
    • 10.2967/jnumed.108.051235, 18632828
    • Bankstahl JP, Kuntner C, Abrahim A, Karch R, Stanek J, Wanek T, Wadsak W, Kletter K, Muller M, Löscher W, et al. Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. J Nucl Med 2008, 49(8):1328-1335. 10.2967/jnumed.108.051235, 18632828.
    • (2008) J Nucl Med , vol.49 , Issue.8 , pp. 1328-1335
    • Bankstahl, J.P.1    Kuntner, C.2    Abrahim, A.3    Karch, R.4    Stanek, J.5    Wanek, T.6    Wadsak, W.7    Kletter, K.8    Muller, M.9    Löscher, W.10
  • 29
    • 20444480695 scopus 로고    scopus 로고
    • Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography
    • 10.1016/j.clpt.2005.01.022, 15961982
    • Sasongko L, Link JM, Muzi M, Mankoff DA, Yang X, Collier AC, Shoner SC, Unadkat JD. Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography. Clin Pharmacol Ther 2005, 77(6):503-514. 10.1016/j.clpt.2005.01.022, 15961982.
    • (2005) Clin Pharmacol Ther , vol.77 , Issue.6 , pp. 503-514
    • Sasongko, L.1    Link, J.M.2    Muzi, M.3    Mankoff, D.A.4    Yang, X.5    Collier, A.C.6    Shoner, S.C.7    Unadkat, J.D.8
  • 30
    • 31144434780 scopus 로고    scopus 로고
    • In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil
    • 10.1124/jpet.105.088328, 16293715
    • Lee YJ, Maeda J, Kusuhara H, Okauchi T, Inaji M, Nagai Y, Obayashi S, Nakao R, Suzuki K, Sugiyama Y, et al. In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil. J Pharmacol Exp Ther 2006, 316(2):647-653. 10.1124/jpet.105.088328, 16293715.
    • (2006) J Pharmacol Exp Ther , vol.316 , Issue.2 , pp. 647-653
    • Lee, Y.J.1    Maeda, J.2    Kusuhara, H.3    Okauchi, T.4    Inaji, M.5    Nagai, Y.6    Obayashi, S.7    Nakao, R.8    Suzuki, K.9    Sugiyama, Y.10
  • 31
    • 33744936006 scopus 로고    scopus 로고
    • Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography
    • 10.1016/j.clpt.2006.02.004, 16765142
    • Toornvliet R, van Berckel BN, Luurtsema G, Lubberink M, Geldof AA, Bosch TM, Oerlemans R, Lammertsma AA, Franssen EJ. Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography. Clin Pharmacol Ther 2006, 79(6):540-548. 10.1016/j.clpt.2006.02.004, 16765142.
    • (2006) Clin Pharmacol Ther , vol.79 , Issue.6 , pp. 540-548
    • Toornvliet, R.1    van Berckel, B.N.2    Luurtsema, G.3    Lubberink, M.4    Geldof, A.A.5    Bosch, T.M.6    Oerlemans, R.7    Lammertsma, A.A.8    Franssen, E.J.9
  • 32
  • 34
    • 34548413773 scopus 로고    scopus 로고
    • Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil
    • 10.1111/j.1528-1167.2007.01116.x, 17484754
    • Langer O, Bauer M, Hammers A, Karch R, Pataraia E, Koepp MJ, Abrahim A, Luurtsema G, Brunner M, Sunder-Plassmann R, et al. Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia 2007, 48(9):1774-1784. 10.1111/j.1528-1167.2007.01116.x, 17484754.
    • (2007) Epilepsia , vol.48 , Issue.9 , pp. 1774-1784
    • Langer, O.1    Bauer, M.2    Hammers, A.3    Karch, R.4    Pataraia, E.5    Koepp, M.J.6    Abrahim, A.7    Luurtsema, G.8    Brunner, M.9    Sunder-Plassmann, R.10
  • 35
    • 0015306706 scopus 로고
    • Modification of seizure activity by electrical stimulation. 3. Mechanisms
    • 10.1016/0013-4694(72)90178-2, 4110398
    • Racine R, Okujava V, Chipashvili S. Modification of seizure activity by electrical stimulation. 3. Mechanisms. Electroencephalogr Clin Neurophysiol 1972, 32(3):295-299. 10.1016/0013-4694(72)90178-2, 4110398.
    • (1972) Electroencephalogr Clin Neurophysiol , vol.32 , Issue.3 , pp. 295-299
    • Racine, R.1    Okujava, V.2    Chipashvili, S.3
  • 36
    • 0036937318 scopus 로고    scopus 로고
    • Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring the P-glycoprotein function with positron emission tomography
    • Luurtsema G, Windhorst AD, J MP, Herscheid JDM, Lammertsma AA, Franssen EJ. Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring the P-glycoprotein function with positron emission tomography. J Labelled Compd Radiopharm 2002, 45:1199-1207.
    • (2002) J Labelled Compd Radiopharm , vol.45 , pp. 1199-1207
    • Luurtsema, G.1    Windhorst, A.D.2    J., M.P.3    Herscheid, J.D.M.4    Lammertsma, A.A.5    Franssen, E.J.6
  • 37
    • 34247203132 scopus 로고    scopus 로고
    • Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner
    • 10.1088/0031-9155/52/5/019, 17301468
    • de Jong HW, van Velden FH, Kloet RW, Buijs FL, Boellaard R, Lammertsma AA. Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner. Phys Med Biol 2007, 52(5):1505-1526. 10.1088/0031-9155/52/5/019, 17301468.
    • (2007) Phys Med Biol , vol.52 , Issue.5 , pp. 1505-1526
    • de Jong, H.W.1    van Velden, F.H.2    Kloet, R.W.3    Buijs, F.L.4    Boellaard, R.5    Lammertsma, A.A.6
  • 38
    • 38049054734 scopus 로고    scopus 로고
    • Impact of attenuation correction strategies on the quantification of High Resolution Research Tomograph PET studies
    • 10.1088/0031-9155/53/1/007, 18182690
    • van Velden FH, Kloet RW, van Berckel BN, Molthoff CF, de Jong HW, Lammertsma AA, Boellaard R. Impact of attenuation correction strategies on the quantification of High Resolution Research Tomograph PET studies. Phys Med Biol 2008, 53(1):99-118. 10.1088/0031-9155/53/1/007, 18182690.
    • (2008) Phys Med Biol , vol.53 , Issue.1 , pp. 99-118
    • van Velden, F.H.1    Kloet, R.W.2    van Berckel, B.N.3    Molthoff, C.F.4    de Jong, H.W.5    Lammertsma, A.A.6    Boellaard, R.7
  • 40
    • 13244258485 scopus 로고    scopus 로고
    • Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat
    • 10.1016/j.nucmedbio.2004.06.007, 15691665
    • Luurtsema G, Molthoff CF, Schuit RC, Windhorst AD, Lammertsma AA, Franssen EJ. Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat. Nucl Med Biol 2005, 32(1):87-93. 10.1016/j.nucmedbio.2004.06.007, 15691665.
    • (2005) Nucl Med Biol , vol.32 , Issue.1 , pp. 87-93
    • Luurtsema, G.1    Molthoff, C.F.2    Schuit, R.C.3    Windhorst, A.D.4    Lammertsma, A.A.5    Franssen, E.J.6
  • 41
    • 16244367423 scopus 로고    scopus 로고
    • Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables
    • 10.1369/jhc.4A6451.2005, 15805426
    • Volk H, Potschka H, Loscher W. Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables. J Histochem Cytochem 2005, 53(4):517-531. 10.1369/jhc.4A6451.2005, 15805426.
    • (2005) J Histochem Cytochem , vol.53 , Issue.4 , pp. 517-531
    • Volk, H.1    Potschka, H.2    Loscher, W.3
  • 42
    • 0003717437 scopus 로고
    • The Rat Brain in stereotaxic coordinates
    • New York: Academic Press, 2
    • Paxinos G, Watson C. The Rat Brain in stereotaxic coordinates. 1986, New York: Academic Press, 2.
    • (1986)
    • Paxinos, G.1    Watson, C.2
  • 44
    • 0242409499 scopus 로고    scopus 로고
    • AMIDE: A free software tool for multimodality medical image analysis
    • 10.1162/153535003322556877, 14649056
    • Loening AM, Gambhir SS. AMIDE: A free software tool for multimodality medical image analysis. Mol Imaging 2003, 2:131-137. 10.1162/153535003322556877, 14649056.
    • (2003) Mol Imaging , vol.2 , pp. 131-137
    • Loening, A.M.1    Gambhir, S.S.2
  • 45
    • 0026774071 scopus 로고
    • Cerebral blood flow, blood volume, and brain tissue hematocrit during isovolemic hemodilution with hetastarch in rats
    • Todd MM, Weeks JB, Warner DS. Cerebral blood flow, blood volume, and brain tissue hematocrit during isovolemic hemodilution with hetastarch in rats. Am J Physiol 1992, 263(1 Pt 2):H75-82.
    • (1992) Am J Physiol , vol.263 , Issue.1 PART 2
    • Todd, M.M.1    Weeks, J.B.2    Warner, D.S.3
  • 48
    • 0034986870 scopus 로고    scopus 로고
    • Positron emission tomography compartmental models
    • 10.1097/00004647-200106000-00002, 11488533
    • Gunn RN, Gunn SR, Cunningham VJ. Positron emission tomography compartmental models. J Cereb Blood Flow Metab 2001, 21(6):635-652. 10.1097/00004647-200106000-00002, 11488533.
    • (2001) J Cereb Blood Flow Metab , vol.21 , Issue.6 , pp. 635-652
    • Gunn, R.N.1    Gunn, S.R.2    Cunningham, V.J.3
  • 49
    • 0016355478 scopus 로고
    • A new look at the statistical model identification
    • Akaike H. A new look at the statistical model identification. IEEE Trans Autom Control 1974, 19:716-723.
    • (1974) IEEE Trans Autom Control , vol.19 , pp. 716-723
    • Akaike, H.1
  • 50
    • 0002322365 scopus 로고    scopus 로고
    • Xpose - an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM
    • 10.1016/S0169-2607(98)00067-4, 10195646
    • Jonsson EN, Karlsson MO. Xpose - an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM. Computer Methods and Programs in Biomedicine 1999, 58(1):51-64. 10.1016/S0169-2607(98)00067-4, 10195646.
    • (1999) Computer Methods and Programs in Biomedicine , vol.58 , Issue.1 , pp. 51-64
    • Jonsson, E.N.1    Karlsson, M.O.2
  • 51
    • 19344376876 scopus 로고    scopus 로고
    • NONMEMory: a run management tool for NONMEM
    • 10.1016/j.cmpb.2005.02.003, 15899310
    • Wilkins JJ. NONMEMory: a run management tool for NONMEM. Comput Methods Programs Biomed 2005, 78(3):259-267. 10.1016/j.cmpb.2005.02.003, 15899310.
    • (2005) Comput Methods Programs Biomed , vol.78 , Issue.3 , pp. 259-267
    • Wilkins, J.J.1
  • 52
    • 63049137118 scopus 로고    scopus 로고
    • Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition
    • 10.1016/j.neuropharm.2009.01.009, 19371577
    • Zibell G, Unkruer B, Pekcec A, Hartz AM, Bauer B, Miller DS, Potschka H. Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. Neuropharmacology 2009, 56(5):849-855. 10.1016/j.neuropharm.2009.01.009, 19371577.
    • (2009) Neuropharmacology , vol.56 , Issue.5 , pp. 849-855
    • Zibell, G.1    Unkruer, B.2    Pekcec, A.3    Hartz, A.M.4    Bauer, B.5    Miller, D.S.6    Potschka, H.7
  • 53
    • 72049119592 scopus 로고    scopus 로고
    • Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach
    • 10.1016/j.pharmthera.2009.10.004, 19896502
    • Potschka H. Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach. Pharmacol Ther 2009, 125(1):118-127. 10.1016/j.pharmthera.2009.10.004, 19896502.
    • (2009) Pharmacol Ther , vol.125 , Issue.1 , pp. 118-127
    • Potschka, H.1
  • 54
    • 8444220834 scopus 로고    scopus 로고
    • The role of positron emission tomography with [18F]fluorodeoxyglucose in the evaluation of the epilepsies
    • ix, 10.1016/j.nic.2004.04.011, 15324862
    • Henry TR, Votaw JR. The role of positron emission tomography with [18F]fluorodeoxyglucose in the evaluation of the epilepsies. Neuroimaging Clin N Am 2004, 14(3):517-535. ix, 10.1016/j.nic.2004.04.011, 15324862.
    • (2004) Neuroimaging Clin N Am , vol.14 , Issue.3 , pp. 517-535
    • Henry, T.R.1    Votaw, J.R.2
  • 56
    • 62149143407 scopus 로고    scopus 로고
    • Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection
    • 10.1002/glia.20725, 18649402
    • Ronaldson PT, Persidsky Y, Bendayan R. Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection. Glia 2008, 56(16):1711-1735. 10.1002/glia.20725, 18649402.
    • (2008) Glia , vol.56 , Issue.16 , pp. 1711-1735
    • Ronaldson, P.T.1    Persidsky, Y.2    Bendayan, R.3
  • 57
    • 53549134294 scopus 로고    scopus 로고
    • Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function
    • 10.1021/jm800510m, 2646255, 18783208
    • Lazarova N, Zoghbi SS, Hong J, Seneca N, Tuan E, Gladding RL, Liow JS, Taku A, Innis RB, Pike VW. Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. J Med Chem 2008, 51(19):6034-6043. 10.1021/jm800510m, 2646255, 18783208.
    • (2008) J Med Chem , vol.51 , Issue.19 , pp. 6034-6043
    • Lazarova, N.1    Zoghbi, S.S.2    Hong, J.3    Seneca, N.4    Tuan, E.5    Gladding, R.L.6    Liow, J.S.7    Taku, A.8    Innis, R.B.9    Pike, V.W.10
  • 58
    • 77956316385 scopus 로고    scopus 로고
    • Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy
    • 10.1111/j.1528-1167.2010.02671.x, 20633036
    • Bartmann H, Fuest C, La Fougere C, Xiong G, Just T, Schlichtiger J, Winter P, Boning G, Wangler B, Pekcec A, et al. Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy. Epilepsia 2010, 51(9):1780-1790. 10.1111/j.1528-1167.2010.02671.x, 20633036.
    • (2010) Epilepsia , vol.51 , Issue.9 , pp. 1780-1790
    • Bartmann, H.1    Fuest, C.2    La Fougere, C.3    Xiong, G.4    Just, T.5    Schlichtiger, J.6    Winter, P.7    Boning, G.8    Wangler, B.9    Pekcec, A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.