-
1
-
-
20544475805
-
Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms
-
10.1111/j.1528-1167.2005.54904.x, 15946327
-
Schmidt D, Löscher W. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 2005, 46(6):858-877. 10.1111/j.1528-1167.2005.54904.x, 15946327.
-
(2005)
Epilepsia
, vol.46
, Issue.6
, pp. 858-877
-
-
Schmidt, D.1
Löscher, W.2
-
2
-
-
0032918385
-
Clinical aspects and biological bases of drug-resistant epilepsies
-
10.1016/S0920-1211(98)00106-5, 10210025
-
Regesta G, Tanganelli P. Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res 1999, 34(2-3):109-122. 10.1016/S0920-1211(98)00106-5, 10210025.
-
(1999)
Epilepsy Res
, vol.34
, Issue.2-3
, pp. 109-122
-
-
Regesta, G.1
Tanganelli, P.2
-
3
-
-
0000712439
-
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
-
10.1073/pnas.86.2.695, 286540, 2563168
-
Cordon-Cardo C, O'Brien JP, Casals D, Rittman-Grauer L, Biedler JL, Melamed MR, Bertino JR. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 1989, 86(2):695-698. 10.1073/pnas.86.2.695, 286540, 2563168.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, Issue.2
, pp. 695-698
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Casals, D.3
Rittman-Grauer, L.4
Biedler, J.L.5
Melamed, M.R.6
Bertino, J.R.7
-
4
-
-
0037457802
-
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
-
10.1016/S0169-409X(02)00169-2, 12535572
-
Schinkel AH, Jonker JW. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. Adv Drug Deliv Rev 2003, 55(1):3-29. 10.1016/S0169-409X(02)00169-2, 12535572.
-
(2003)
Adv Drug Deliv Rev
, vol.55
, Issue.1
, pp. 3-29
-
-
Schinkel, A.H.1
Jonker, J.W.2
-
5
-
-
33748792802
-
The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy
-
10.1016/j.nbd.2006.06.014, 16928449
-
Brandt C, Bethmann K, Gastens AM, Loscher W. The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy. Neurobiol Dis 2006, 24(1):202-211. 10.1016/j.nbd.2006.06.014, 16928449.
-
(2006)
Neurobiol Dis
, vol.24
, Issue.1
, pp. 202-211
-
-
Brandt, C.1
Bethmann, K.2
Gastens, A.M.3
Loscher, W.4
-
6
-
-
72049093471
-
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats
-
10.1016/j.neuropharm.2009.09.012, 19786037
-
van Vliet EA, Zibell G, Pekcec A, Schlichtiger J, Edelbroek PM, Holtman L, Aronica E, Gorter JA, Potschka H. COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. Neuropharmacology 2009, 58(2):404-412. 10.1016/j.neuropharm.2009.09.012, 19786037.
-
(2009)
Neuropharmacology
, vol.58
, Issue.2
, pp. 404-412
-
-
van Vliet, E.A.1
Zibell, G.2
Pekcec, A.3
Schlichtiger, J.4
Edelbroek, P.M.5
Holtman, L.6
Aronica, E.7
Gorter, J.A.8
Potschka, H.9
-
7
-
-
0037101618
-
Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance
-
Rizzi M, Caccia S, Guiso G, Richichi C, Gorter JA, Aronica E, Aliprandi M, Bagnati R, Fanelli R, D'Incalci M, et al. Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. J Neurosci 2002, 22(14):5833-5839.
-
(2002)
J Neurosci
, vol.22
, Issue.14
, pp. 5833-5839
-
-
Rizzi, M.1
Caccia, S.2
Guiso, G.3
Richichi, C.4
Gorter, J.A.5
Aronica, E.6
Aliprandi, M.7
Bagnati, R.8
Fanelli, R.9
D'Incalci, M.10
-
8
-
-
33846580959
-
Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model
-
Epub 2007 Jan 2008, 10.1016/j.neulet.2006.11.075, 17240061
-
Hocht C, Lazarowski A, Gonzalez NN, Auzmendi J, Opezzo JA, Bramuglia GF, Taira CA, Girardi E. Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model. Neurosci Lett 2007, 413(2):168-172. Epub 2007 Jan 2008, 10.1016/j.neulet.2006.11.075, 17240061.
-
(2007)
Neurosci Lett
, vol.413
, Issue.2
, pp. 168-172
-
-
Hocht, C.1
Lazarowski, A.2
Gonzalez, N.N.3
Auzmendi, J.4
Opezzo, J.A.5
Bramuglia, G.F.6
Taira, C.A.7
Girardi, E.8
-
9
-
-
60949089759
-
Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid
-
Epub 2009 Feb 2004, 10.1016/j.neulet.2009.01.079, 19429015
-
Hocht C, Lazarowski A, Gonzalez NN, Mayer MA, Opezzo JA, Taira CA, Girardi E. Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid. Neurosci Lett 2009, 453(1):54-57. Epub 2009 Feb 2004, 10.1016/j.neulet.2009.01.079, 19429015.
-
(2009)
Neurosci Lett
, vol.453
, Issue.1
, pp. 54-57
-
-
Hocht, C.1
Lazarowski, A.2
Gonzalez, N.N.3
Mayer, M.A.4
Opezzo, J.A.5
Taira, C.A.6
Girardi, E.7
-
10
-
-
0036156280
-
Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
-
10.1093/brain/awf002, 11834590
-
Sisodiya SM, Lin WR, Harding BN, Squier MV, Thom M. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain 2002, 125(Pt 1):22-31. 10.1093/brain/awf002, 11834590.
-
(2002)
Brain
, vol.125
, Issue.PART 1
, pp. 22-31
-
-
Sisodiya, S.M.1
Lin, W.R.2
Harding, B.N.3
Squier, M.V.4
Thom, M.5
-
11
-
-
0028895740
-
MDR1 gene expression in brain of patients with medically intractable epilepsy
-
10.1111/j.1528-1157.1995.tb01657.x, 8001500
-
Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C. MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 1995, 36(1):1-6. 10.1111/j.1528-1157.1995.tb01657.x, 8001500.
-
(1995)
Epilepsia
, vol.36
, Issue.1
, pp. 1-6
-
-
Tishler, D.M.1
Weinberg, K.I.2
Hinton, D.R.3
Barbaro, N.4
Annett, G.M.5
Raffel, C.6
-
12
-
-
0035669389
-
Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy
-
10.1046/j.1528-1157.2001.12301.x, 11879359
-
Dombrowski SM, Desai SY, Marroni M, Cucullo L, Goodrich K, Bingaman W, Mayberg MR, Bengez L, Janigro D. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 2001, 42(12):1501-1506. 10.1046/j.1528-1157.2001.12301.x, 11879359.
-
(2001)
Epilepsia
, vol.42
, Issue.12
, pp. 1501-1506
-
-
Dombrowski, S.M.1
Desai, S.Y.2
Marroni, M.3
Cucullo, L.4
Goodrich, K.5
Bingaman, W.6
Mayberg, M.R.7
Bengez, L.8
Janigro, D.9
-
13
-
-
33645513798
-
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats
-
10.1111/j.1528-1167.2006.00496.x, 16650133
-
van Vliet EA, van Schaik R, Edelbroek PM, Redeker S, Aronica E, Wadman WJ, Marchi N, Vezzani A, Gorter JA. Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia 2006, 47(4):672-680. 10.1111/j.1528-1167.2006.00496.x, 16650133.
-
(2006)
Epilepsia
, vol.47
, Issue.4
, pp. 672-680
-
-
van Vliet, E.A.1
van Schaik, R.2
Edelbroek, P.M.3
Redeker, S.4
Aronica, E.5
Wadman, W.J.6
Marchi, N.7
Vezzani, A.8
Gorter, J.A.9
-
14
-
-
22744440362
-
Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases
-
Löscher W, Potschka H. Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol 2005, 76(1):22-76.
-
(2005)
Prog Neurobiol
, vol.76
, Issue.1
, pp. 22-76
-
-
Löscher, W.1
Potschka, H.2
-
15
-
-
79961129959
-
The Antiepileptic Drug Topiramate is a Substrate for Human P-glycoprotein but Not Multidrug Resistance Proteins
-
Luna-Tortos C, Rambeck B, Jurgens UH, Loscher W. The Antiepileptic Drug Topiramate is a Substrate for Human P-glycoprotein but Not Multidrug Resistance Proteins. Pharm Res 2009, 3:3.
-
(2009)
Pharm Res
, vol.3
, pp. 3
-
-
Luna-Tortos, C.1
Rambeck, B.2
Jurgens, U.H.3
Loscher, W.4
-
16
-
-
0032693058
-
Over-expression of P-glycoprotein in malformations of cortical development
-
10.1097/00001756-199911080-00032, 10599858
-
Sisodiya SM, Heffernan J, Squier MV. Over-expression of P-glycoprotein in malformations of cortical development. Neuroreport 1999, 10(16):3437-3441. 10.1097/00001756-199911080-00032, 10599858.
-
(1999)
Neuroreport
, vol.10
, Issue.16
, pp. 3437-3441
-
-
Sisodiya, S.M.1
Heffernan, J.2
Squier, M.V.3
-
17
-
-
0036128985
-
Role of multidrug transporters in pharmacoresistance to antiepileptic drugs
-
Löscher W, Potschka H. Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther 2002, 301(1):7-14.
-
(2002)
J Pharmacol Exp Ther
, vol.301
, Issue.1
, pp. 7-14
-
-
Löscher, W.1
Potschka, H.2
-
18
-
-
42449134059
-
P-glycoprotein--a clinical target in drug-refractory epilepsy?
-
10.1124/mol.108.046680, 18314494
-
Robey RW, Lazarowski A, Bates SE. P-glycoprotein--a clinical target in drug-refractory epilepsy?. Mol Pharmacol 2008, 73(5):1343-1346. 10.1124/mol.108.046680, 18314494.
-
(2008)
Mol Pharmacol
, vol.73
, Issue.5
, pp. 1343-1346
-
-
Robey, R.W.1
Lazarowski, A.2
Bates, S.E.3
-
19
-
-
58849093964
-
Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus
-
10.1016/j.eplepsyres.2008.10.010, 19059762
-
Pekcec A, Unkruer B, Stein V, Bankstahl JP, Soerensen J, Tipold A, Baumgartner W, Potschka H. Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus. Epilepsy Res 2009, 83(2-3):144-151. 10.1016/j.eplepsyres.2008.10.010, 19059762.
-
(2009)
Epilepsy Res
, vol.83
, Issue.2-3
, pp. 144-151
-
-
Pekcec, A.1
Unkruer, B.2
Stein, V.3
Bankstahl, J.P.4
Soerensen, J.5
Tipold, A.6
Baumgartner, W.7
Potschka, H.8
-
20
-
-
64149098897
-
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus
-
10.1016/j.eplepsyres.2008.07.007, 18760905
-
Bankstahl JP, Löscher W. Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus. Epilepsy Res 2008, 82(1):70-85. 10.1016/j.eplepsyres.2008.07.007, 18760905.
-
(2008)
Epilepsy Res
, vol.82
, Issue.1
, pp. 70-85
-
-
Bankstahl, J.P.1
Löscher, W.2
-
21
-
-
33847613348
-
How to explain multidrug resistance in epilepsy?
-
1198632, 16145617
-
Löscher W. How to explain multidrug resistance in epilepsy?. Epilepsy Curr 2005, 5:107-112. 1198632, 16145617.
-
(2005)
Epilepsy Curr
, vol.5
, pp. 107-112
-
-
Löscher, W.1
-
22
-
-
36949025921
-
Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?
-
10.1111/j.1528-1167.2007.01260_3.x, 18088270
-
Anderson GD, Shen DD. Where is the evidence that p-glycoprotein limits brain uptake of antiepileptic drug and contributes to drug resistance in epilepsy?. Epilepsia 2007, 48(12):2372-2374. 10.1111/j.1528-1167.2007.01260_3.x, 18088270.
-
(2007)
Epilepsia
, vol.48
, Issue.12
, pp. 2372-2374
-
-
Anderson, G.D.1
Shen, D.D.2
-
23
-
-
0031747177
-
Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy
-
10.1016/S0920-1211(98)00017-5, 9696302
-
Hellier JL, Patrylo PR, Buckmaster PS, Dudek FE. Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy. Epilepsy Res 1998, 31(1):73-84. 10.1016/S0920-1211(98)00017-5, 9696302.
-
(1998)
Epilepsy Res
, vol.31
, Issue.1
, pp. 73-84
-
-
Hellier, J.L.1
Patrylo, P.R.2
Buckmaster, P.S.3
Dudek, F.E.4
-
24
-
-
8444250735
-
Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats
-
10.1016/j.eplepsyres.2004.06.005, 15380564
-
van Vliet E, Aronica E, Redeker S, Marchi N, Rizzi M, Vezzani A, Gorter J. Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. Epilepsy Res 2004, 60(2-3):203-213. 10.1016/j.eplepsyres.2004.06.005, 15380564.
-
(2004)
Epilepsy Res
, vol.60
, Issue.2-3
, pp. 203-213
-
-
van Vliet, E.1
Aronica, E.2
Redeker, S.3
Marchi, N.4
Rizzi, M.5
Vezzani, A.6
Gorter, J.7
-
25
-
-
0344121138
-
Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET
-
10.1016/S1053-8119(03)00405-1, 14642487
-
Bart J, Willemsen AT, Groen HJ, van der Graaf WT, Wegman TD, Vaalburg W, de Vries EG, Hendrikse NH. Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET. Neuroimage 2003, 20(3):1775-1782. 10.1016/S1053-8119(03)00405-1, 14642487.
-
(2003)
Neuroimage
, vol.20
, Issue.3
, pp. 1775-1782
-
-
Bart, J.1
Willemsen, A.T.2
Groen, H.J.3
van der Graaf, W.T.4
Wegman, T.D.5
Vaalburg, W.6
de Vries, E.G.7
Hendrikse, N.H.8
-
26
-
-
48749106993
-
Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET
-
10.2967/jnumed.108.051235, 18632828
-
Bankstahl JP, Kuntner C, Abrahim A, Karch R, Stanek J, Wanek T, Wadsak W, Kletter K, Muller M, Löscher W, et al. Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. J Nucl Med 2008, 49(8):1328-1335. 10.2967/jnumed.108.051235, 18632828.
-
(2008)
J Nucl Med
, vol.49
, Issue.8
, pp. 1328-1335
-
-
Bankstahl, J.P.1
Kuntner, C.2
Abrahim, A.3
Karch, R.4
Stanek, J.5
Wanek, T.6
Wadsak, W.7
Kletter, K.8
Muller, M.9
Löscher, W.10
-
27
-
-
0033563120
-
A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier
-
Hendrikse NH, de Vries EG, Eriks-Fluks L, van der Graaf WT, Hospers GA, Willemsen AT, Vaalburg W, Franssen EJ. A new in vivo method to study P-glycoprotein transport in tumors and the blood-brain barrier. Cancer Res 1999, 59(10):2411-2416.
-
(1999)
Cancer Res
, vol.59
, Issue.10
, pp. 2411-2416
-
-
Hendrikse, N.H.1
de Vries, E.G.2
Eriks-Fluks, L.3
van der Graaf, W.T.4
Hospers, G.A.5
Willemsen, A.T.6
Vaalburg, W.7
Franssen, E.J.8
-
28
-
-
33747786976
-
Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET
-
Syvänen S, Blomquist G, Sprycha M, Höglund AU, Roman M, Eriksson O, Hammarlund-Udenaes M, Långström B, Bergström M. Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET. Neuroimage 2006, 32(3):1134-1141.
-
(2006)
Neuroimage
, vol.32
, Issue.3
, pp. 1134-1141
-
-
Syvänen, S.1
Blomquist, G.2
Sprycha, M.3
Höglund, A.U.4
Roman, M.5
Eriksson, O.6
Hammarlund-Udenaes, M.7
Långström, B.8
Bergström, M.9
-
29
-
-
20444480695
-
Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography
-
10.1016/j.clpt.2005.01.022, 15961982
-
Sasongko L, Link JM, Muzi M, Mankoff DA, Yang X, Collier AC, Shoner SC, Unadkat JD. Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography. Clin Pharmacol Ther 2005, 77(6):503-514. 10.1016/j.clpt.2005.01.022, 15961982.
-
(2005)
Clin Pharmacol Ther
, vol.77
, Issue.6
, pp. 503-514
-
-
Sasongko, L.1
Link, J.M.2
Muzi, M.3
Mankoff, D.A.4
Yang, X.5
Collier, A.C.6
Shoner, S.C.7
Unadkat, J.D.8
-
30
-
-
31144434780
-
In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil
-
10.1124/jpet.105.088328, 16293715
-
Lee YJ, Maeda J, Kusuhara H, Okauchi T, Inaji M, Nagai Y, Obayashi S, Nakao R, Suzuki K, Sugiyama Y, et al. In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil. J Pharmacol Exp Ther 2006, 316(2):647-653. 10.1124/jpet.105.088328, 16293715.
-
(2006)
J Pharmacol Exp Ther
, vol.316
, Issue.2
, pp. 647-653
-
-
Lee, Y.J.1
Maeda, J.2
Kusuhara, H.3
Okauchi, T.4
Inaji, M.5
Nagai, Y.6
Obayashi, S.7
Nakao, R.8
Suzuki, K.9
Sugiyama, Y.10
-
31
-
-
33744936006
-
Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography
-
10.1016/j.clpt.2006.02.004, 16765142
-
Toornvliet R, van Berckel BN, Luurtsema G, Lubberink M, Geldof AA, Bosch TM, Oerlemans R, Lammertsma AA, Franssen EJ. Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography. Clin Pharmacol Ther 2006, 79(6):540-548. 10.1016/j.clpt.2006.02.004, 16765142.
-
(2006)
Clin Pharmacol Ther
, vol.79
, Issue.6
, pp. 540-548
-
-
Toornvliet, R.1
van Berckel, B.N.2
Luurtsema, G.3
Lubberink, M.4
Geldof, A.A.5
Bosch, T.M.6
Oerlemans, R.7
Lammertsma, A.A.8
Franssen, E.J.9
-
32
-
-
33750588234
-
Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function
-
Ikoma Y, Takano A, Ito H, Kusuhara H, Sugiyama Y, Arakawa R, Fukumura T, Nakao R, Suzuki K, Suhara T. Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function. J Nucl Med 2006, 47(9):1531-1537.
-
(2006)
J Nucl Med
, vol.47
, Issue.9
, pp. 1531-1537
-
-
Ikoma, Y.1
Takano, A.2
Ito, H.3
Kusuhara, H.4
Sugiyama, Y.5
Arakawa, R.6
Fukumura, T.7
Nakao, R.8
Suzuki, K.9
Suhara, T.10
-
33
-
-
13144255682
-
Blood-brain barrier dysfunction in parkinsonian midbrain in vivo
-
10.1002/ana.20369, 15668963
-
Kortekaas R, Leenders KL, van Oostrom JC, Vaalburg W, Bart J, Willemsen AT, Hendrikse NH. Blood-brain barrier dysfunction in parkinsonian midbrain in vivo. Ann Neurol 2005, 57(2):176-179. 10.1002/ana.20369, 15668963.
-
(2005)
Ann Neurol
, vol.57
, Issue.2
, pp. 176-179
-
-
Kortekaas, R.1
Leenders, K.L.2
van Oostrom, J.C.3
Vaalburg, W.4
Bart, J.5
Willemsen, A.T.6
Hendrikse, N.H.7
-
34
-
-
34548413773
-
Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil
-
10.1111/j.1528-1167.2007.01116.x, 17484754
-
Langer O, Bauer M, Hammers A, Karch R, Pataraia E, Koepp MJ, Abrahim A, Luurtsema G, Brunner M, Sunder-Plassmann R, et al. Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil. Epilepsia 2007, 48(9):1774-1784. 10.1111/j.1528-1167.2007.01116.x, 17484754.
-
(2007)
Epilepsia
, vol.48
, Issue.9
, pp. 1774-1784
-
-
Langer, O.1
Bauer, M.2
Hammers, A.3
Karch, R.4
Pataraia, E.5
Koepp, M.J.6
Abrahim, A.7
Luurtsema, G.8
Brunner, M.9
Sunder-Plassmann, R.10
-
35
-
-
0015306706
-
Modification of seizure activity by electrical stimulation. 3. Mechanisms
-
10.1016/0013-4694(72)90178-2, 4110398
-
Racine R, Okujava V, Chipashvili S. Modification of seizure activity by electrical stimulation. 3. Mechanisms. Electroencephalogr Clin Neurophysiol 1972, 32(3):295-299. 10.1016/0013-4694(72)90178-2, 4110398.
-
(1972)
Electroencephalogr Clin Neurophysiol
, vol.32
, Issue.3
, pp. 295-299
-
-
Racine, R.1
Okujava, V.2
Chipashvili, S.3
-
36
-
-
0036937318
-
Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring the P-glycoprotein function with positron emission tomography
-
Luurtsema G, Windhorst AD, J MP, Herscheid JDM, Lammertsma AA, Franssen EJ. Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring the P-glycoprotein function with positron emission tomography. J Labelled Compd Radiopharm 2002, 45:1199-1207.
-
(2002)
J Labelled Compd Radiopharm
, vol.45
, pp. 1199-1207
-
-
Luurtsema, G.1
Windhorst, A.D.2
J., M.P.3
Herscheid, J.D.M.4
Lammertsma, A.A.5
Franssen, E.J.6
-
37
-
-
34247203132
-
Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner
-
10.1088/0031-9155/52/5/019, 17301468
-
de Jong HW, van Velden FH, Kloet RW, Buijs FL, Boellaard R, Lammertsma AA. Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner. Phys Med Biol 2007, 52(5):1505-1526. 10.1088/0031-9155/52/5/019, 17301468.
-
(2007)
Phys Med Biol
, vol.52
, Issue.5
, pp. 1505-1526
-
-
de Jong, H.W.1
van Velden, F.H.2
Kloet, R.W.3
Buijs, F.L.4
Boellaard, R.5
Lammertsma, A.A.6
-
38
-
-
38049054734
-
Impact of attenuation correction strategies on the quantification of High Resolution Research Tomograph PET studies
-
10.1088/0031-9155/53/1/007, 18182690
-
van Velden FH, Kloet RW, van Berckel BN, Molthoff CF, de Jong HW, Lammertsma AA, Boellaard R. Impact of attenuation correction strategies on the quantification of High Resolution Research Tomograph PET studies. Phys Med Biol 2008, 53(1):99-118. 10.1088/0031-9155/53/1/007, 18182690.
-
(2008)
Phys Med Biol
, vol.53
, Issue.1
, pp. 99-118
-
-
van Velden, F.H.1
Kloet, R.W.2
van Berckel, B.N.3
Molthoff, C.F.4
de Jong, H.W.5
Lammertsma, A.A.6
Boellaard, R.7
-
39
-
-
66149120313
-
HRRT Versus HR+ Human Brain PET Studies: An Interscanner Test-Retest Study
-
10.2967/jnumed.108.058628, 19372482
-
van Velden FH, Kloet RW, van Berckel BN, Buijs FL, Luurtsema G, Lammertsma AA, Boellaard R. HRRT Versus HR+ Human Brain PET Studies: An Interscanner Test-Retest Study. J Nucl Med 2009, 50(5):693-702. 10.2967/jnumed.108.058628, 19372482.
-
(2009)
J Nucl Med
, vol.50
, Issue.5
, pp. 693-702
-
-
van Velden, F.H.1
Kloet, R.W.2
van Berckel, B.N.3
Buijs, F.L.4
Luurtsema, G.5
Lammertsma, A.A.6
Boellaard, R.7
-
40
-
-
13244258485
-
Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat
-
10.1016/j.nucmedbio.2004.06.007, 15691665
-
Luurtsema G, Molthoff CF, Schuit RC, Windhorst AD, Lammertsma AA, Franssen EJ. Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat. Nucl Med Biol 2005, 32(1):87-93. 10.1016/j.nucmedbio.2004.06.007, 15691665.
-
(2005)
Nucl Med Biol
, vol.32
, Issue.1
, pp. 87-93
-
-
Luurtsema, G.1
Molthoff, C.F.2
Schuit, R.C.3
Windhorst, A.D.4
Lammertsma, A.A.5
Franssen, E.J.6
-
41
-
-
16244367423
-
Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables
-
10.1369/jhc.4A6451.2005, 15805426
-
Volk H, Potschka H, Loscher W. Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables. J Histochem Cytochem 2005, 53(4):517-531. 10.1369/jhc.4A6451.2005, 15805426.
-
(2005)
J Histochem Cytochem
, vol.53
, Issue.4
, pp. 517-531
-
-
Volk, H.1
Potschka, H.2
Loscher, W.3
-
42
-
-
0003717437
-
The Rat Brain in stereotaxic coordinates
-
New York: Academic Press, 2
-
Paxinos G, Watson C. The Rat Brain in stereotaxic coordinates. 1986, New York: Academic Press, 2.
-
(1986)
-
-
Paxinos, G.1
Watson, C.2
-
44
-
-
0242409499
-
AMIDE: A free software tool for multimodality medical image analysis
-
10.1162/153535003322556877, 14649056
-
Loening AM, Gambhir SS. AMIDE: A free software tool for multimodality medical image analysis. Mol Imaging 2003, 2:131-137. 10.1162/153535003322556877, 14649056.
-
(2003)
Mol Imaging
, vol.2
, pp. 131-137
-
-
Loening, A.M.1
Gambhir, S.S.2
-
45
-
-
0026774071
-
Cerebral blood flow, blood volume, and brain tissue hematocrit during isovolemic hemodilution with hetastarch in rats
-
Todd MM, Weeks JB, Warner DS. Cerebral blood flow, blood volume, and brain tissue hematocrit during isovolemic hemodilution with hetastarch in rats. Am J Physiol 1992, 263(1 Pt 2):H75-82.
-
(1992)
Am J Physiol
, vol.263
, Issue.1 PART 2
-
-
Todd, M.M.1
Weeks, J.B.2
Warner, D.S.3
-
46
-
-
33846405283
-
Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET
-
10.1038/sj.jcbfm.9600349, 16757979
-
Lubberink M, Luurtsema G, van Berckel BN, Boellaard R, Toornvliet R, Windhorst AD, Franssen EJ, Lammertsma AA. Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET. J Cereb Blood Flow Metab 2007, 27(2):424-433. 10.1038/sj.jcbfm.9600349, 16757979.
-
(2007)
J Cereb Blood Flow Metab
, vol.27
, Issue.2
, pp. 424-433
-
-
Lubberink, M.1
Luurtsema, G.2
van Berckel, B.N.3
Boellaard, R.4
Toornvliet, R.5
Windhorst, A.D.6
Franssen, E.J.7
Lammertsma, A.A.8
-
47
-
-
0025127930
-
Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects
-
Logan J, Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer DJ, MacGregor RR, Hitzemann R, Bendriem B, Gatley SJ, et al. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab 1990, 10(5):740-747.
-
(1990)
J Cereb Blood Flow Metab
, vol.10
, Issue.5
, pp. 740-747
-
-
Logan, J.1
Fowler, J.S.2
Volkow, N.D.3
Wolf, A.P.4
Dewey, S.L.5
Schlyer, D.J.6
MacGregor, R.R.7
Hitzemann, R.8
Bendriem, B.9
Gatley, S.J.10
-
48
-
-
0034986870
-
Positron emission tomography compartmental models
-
10.1097/00004647-200106000-00002, 11488533
-
Gunn RN, Gunn SR, Cunningham VJ. Positron emission tomography compartmental models. J Cereb Blood Flow Metab 2001, 21(6):635-652. 10.1097/00004647-200106000-00002, 11488533.
-
(2001)
J Cereb Blood Flow Metab
, vol.21
, Issue.6
, pp. 635-652
-
-
Gunn, R.N.1
Gunn, S.R.2
Cunningham, V.J.3
-
49
-
-
0016355478
-
A new look at the statistical model identification
-
Akaike H. A new look at the statistical model identification. IEEE Trans Autom Control 1974, 19:716-723.
-
(1974)
IEEE Trans Autom Control
, vol.19
, pp. 716-723
-
-
Akaike, H.1
-
50
-
-
0002322365
-
Xpose - an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM
-
10.1016/S0169-2607(98)00067-4, 10195646
-
Jonsson EN, Karlsson MO. Xpose - an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM. Computer Methods and Programs in Biomedicine 1999, 58(1):51-64. 10.1016/S0169-2607(98)00067-4, 10195646.
-
(1999)
Computer Methods and Programs in Biomedicine
, vol.58
, Issue.1
, pp. 51-64
-
-
Jonsson, E.N.1
Karlsson, M.O.2
-
51
-
-
19344376876
-
NONMEMory: a run management tool for NONMEM
-
10.1016/j.cmpb.2005.02.003, 15899310
-
Wilkins JJ. NONMEMory: a run management tool for NONMEM. Comput Methods Programs Biomed 2005, 78(3):259-267. 10.1016/j.cmpb.2005.02.003, 15899310.
-
(2005)
Comput Methods Programs Biomed
, vol.78
, Issue.3
, pp. 259-267
-
-
Wilkins, J.J.1
-
52
-
-
63049137118
-
Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition
-
10.1016/j.neuropharm.2009.01.009, 19371577
-
Zibell G, Unkruer B, Pekcec A, Hartz AM, Bauer B, Miller DS, Potschka H. Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition. Neuropharmacology 2009, 56(5):849-855. 10.1016/j.neuropharm.2009.01.009, 19371577.
-
(2009)
Neuropharmacology
, vol.56
, Issue.5
, pp. 849-855
-
-
Zibell, G.1
Unkruer, B.2
Pekcec, A.3
Hartz, A.M.4
Bauer, B.5
Miller, D.S.6
Potschka, H.7
-
53
-
-
72049119592
-
Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach
-
10.1016/j.pharmthera.2009.10.004, 19896502
-
Potschka H. Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach. Pharmacol Ther 2009, 125(1):118-127. 10.1016/j.pharmthera.2009.10.004, 19896502.
-
(2009)
Pharmacol Ther
, vol.125
, Issue.1
, pp. 118-127
-
-
Potschka, H.1
-
54
-
-
8444220834
-
The role of positron emission tomography with [18F]fluorodeoxyglucose in the evaluation of the epilepsies
-
ix, 10.1016/j.nic.2004.04.011, 15324862
-
Henry TR, Votaw JR. The role of positron emission tomography with [18F]fluorodeoxyglucose in the evaluation of the epilepsies. Neuroimaging Clin N Am 2004, 14(3):517-535. ix, 10.1016/j.nic.2004.04.011, 15324862.
-
(2004)
Neuroimaging Clin N Am
, vol.14
, Issue.3
, pp. 517-535
-
-
Henry, T.R.1
Votaw, J.R.2
-
55
-
-
57349085135
-
Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier
-
Syvänen S, Hooker A, Rahman O, Wilking H, Blomquist G, Långström B, Bergström M, Hammarlund-Udenaes M. Pharmacokinetics of P-glycoprotein inhibition in the rat blood-brain barrier. J Pharm Sci 2008, 97(12):5386-5400.
-
(2008)
J Pharm Sci
, vol.97
, Issue.12
, pp. 5386-5400
-
-
Syvänen, S.1
Hooker, A.2
Rahman, O.3
Wilking, H.4
Blomquist, G.5
Långström, B.6
Bergström, M.7
Hammarlund-Udenaes, M.8
-
56
-
-
62149143407
-
Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection
-
10.1002/glia.20725, 18649402
-
Ronaldson PT, Persidsky Y, Bendayan R. Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection. Glia 2008, 56(16):1711-1735. 10.1002/glia.20725, 18649402.
-
(2008)
Glia
, vol.56
, Issue.16
, pp. 1711-1735
-
-
Ronaldson, P.T.1
Persidsky, Y.2
Bendayan, R.3
-
57
-
-
53549134294
-
Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function
-
10.1021/jm800510m, 2646255, 18783208
-
Lazarova N, Zoghbi SS, Hong J, Seneca N, Tuan E, Gladding RL, Liow JS, Taku A, Innis RB, Pike VW. Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function. J Med Chem 2008, 51(19):6034-6043. 10.1021/jm800510m, 2646255, 18783208.
-
(2008)
J Med Chem
, vol.51
, Issue.19
, pp. 6034-6043
-
-
Lazarova, N.1
Zoghbi, S.S.2
Hong, J.3
Seneca, N.4
Tuan, E.5
Gladding, R.L.6
Liow, J.S.7
Taku, A.8
Innis, R.B.9
Pike, V.W.10
-
58
-
-
77956316385
-
Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy
-
10.1111/j.1528-1167.2010.02671.x, 20633036
-
Bartmann H, Fuest C, La Fougere C, Xiong G, Just T, Schlichtiger J, Winter P, Boning G, Wangler B, Pekcec A, et al. Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: Proof-of-concept in a chronic rat model of temporal lobe epilepsy. Epilepsia 2010, 51(9):1780-1790. 10.1111/j.1528-1167.2010.02671.x, 20633036.
-
(2010)
Epilepsia
, vol.51
, Issue.9
, pp. 1780-1790
-
-
Bartmann, H.1
Fuest, C.2
La Fougere, C.3
Xiong, G.4
Just, T.5
Schlichtiger, J.6
Winter, P.7
Boning, G.8
Wangler, B.9
Pekcec, A.10
|