Fully automated high yield synthesis of (R)- and (S)-[11C]verapamil for measuring P-glycoprotein function with positron emission tomography

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 45, Issue 14, 2002, Pages 1199-1207

  Luurtsema, Gert ^a   Windhorst, Albert D ^b   Mooijer, Martien P J ^b   Herscheid, Jacobus D M ^b   Lammertsma, Adriaan A ^b   Franssen, Eric J F ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Enantiomers; P gp; Verapamil; 11C methyliodide; 11C methyltriflate

Indexed keywords

AUTOMATION; ENANTIOMERS; FUNCTION EVALUATION; GLYCOPROTEINS; METHYLATION; POSITRON EMISSION TOMOGRAPHY;

FREE BASIS; FULLY AUTOMATED; HIGH YIELD SYNTHESIS; IN-VIVO; METHYLATION REACTION; P-GLYCOPROTEIN; REACTION TEMPERATURE; VERAPAMIL; [11C]METHYLIODIDE; [11C]METHYLTRIFLATE;

ALKYLATION;

ACETONITRILE; BASE; GLYCOPROTEIN P; HYDROCHLORIC ACID; METHYL GROUP; METHYL IODIDE; SOLVENT; VERAPAMIL;

ARTICLE; AUTOMATION; DRUG SYNTHESIS; METHYLATION; POSITRON EMISSION TOMOGRAPHY; PROTEIN FUNCTION; RADIOCHEMISTRY; REACTION TIME; TEMPERATURE;

ANIMALIA;

EID: 0036937318     PISSN: 03624803     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlcr.632     Document Type: Article

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