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Volumn 107, Issue 50, 2010, Pages 21529-21534

Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; GEMININ; HOXB4 PROTEIN; MESSENGER RNA; PROTEASOME; PROTEIN; REPLICATION LICENSING FACTOR CDT1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

EID: 78650747684     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1011054107     Document Type: Article
Times cited : (26)

References (30)
  • 1
    • 0029091845 scopus 로고
    • Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
    • Sauvageau G, et al. (1995) Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 9: 1753-1765.
    • (1995) Genes Dev , vol.9 , pp. 1753-1765
    • Sauvageau, G.1
  • 2
    • 0037023528 scopus 로고    scopus 로고
    • HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
    • Antonchuk J, Sauvageau G, Humphries RK (2002) HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 109:39-45.
    • (2002) Cell , vol.109 , pp. 39-45
    • Antonchuk, J.1    Sauvageau, G.2    Humphries, R.K.3
  • 3
    • 0036682496 scopus 로고    scopus 로고
    • Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells
    • Buske C, et al. (2002) Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells. Blood 100:862-868.
    • (2002) Blood , vol.100 , pp. 862-868
    • Buske, C.1
  • 4
    • 0037023544 scopus 로고    scopus 로고
    • HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors
    • Kyba M, Perlingeiro RC, Daley GQ (2002) HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell 109:29-37.
    • (2002) Cell , vol.109 , pp. 29-37
    • Kyba, M.1    Perlingeiro, R.C.2    Daley, G.Q.3
  • 5
    • 0345708270 scopus 로고    scopus 로고
    • Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein
    • Amsellem S, et al. (2003) Ex vivo expansion of human hematopoietic stem cells by direct delivery of the HOXB4 homeoprotein. Nat Med 9:1423-1427.
    • (2003) Nat Med , vol.9 , pp. 1423-1427
    • Amsellem, S.1
  • 6
    • 0344413639 scopus 로고    scopus 로고
    • In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
    • Krosl J, et al. (2003) In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med 9:1428-1432.
    • (2003) Nat Med , vol.9 , pp. 1428-1432
    • Krosl, J.1
  • 7
    • 0026504525 scopus 로고
    • Homeobox genes and axial patterning
    • McGinnis W, Krumlauf R (1992) Homeobox genes and axial patterning. Cell 68: 283-302.
    • (1992) Cell , vol.68 , pp. 283-302
    • McGinnis, W.1    Krumlauf, R.2
  • 8
    • 4944252717 scopus 로고    scopus 로고
    • Molecular interactions involved in HOXB4-induced activation of HSC self-renewal
    • Beslu N, et al. (2004) Molecular interactions involved in HOXB4-induced activation of HSC self-renewal. Blood 104:2307-2314.
    • (2004) Blood , vol.104 , pp. 2307-2314
    • Beslu, N.1
  • 9
    • 2942558501 scopus 로고    scopus 로고
    • Roles for c-Myc in self-renewal of hematopoietic stem cells
    • Satoh Y, et al. (2004) Roles for c-Myc in self-renewal of hematopoietic stem cells. J Biol Chem 279:24986-24993.
    • (2004) J Biol Chem , vol.279 , pp. 24986-24993
    • Satoh, Y.1
  • 10
    • 36749023976 scopus 로고    scopus 로고
    • HOXB4's road map to stem cell expansion
    • Schiedlmeier B, et al. (2007) HOXB4's road map to stem cell expansion. Proc Natl Acad Sci USA 104:16952-16957.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 16952-16957
    • Schiedlmeier, B.1
  • 11
    • 0037128662 scopus 로고    scopus 로고
    • Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells
    • Ohta H, et al. (2002) Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells. J Exp Med 195:759-770.
    • (2002) J Exp Med , vol.195 , pp. 759-770
    • Ohta, H.1
  • 12
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park IK, et al. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423:302-305.
    • (2003) Nature , vol.423 , pp. 302-305
    • Park, I.K.1
  • 13
    • 7244234099 scopus 로고    scopus 로고
    • Role of histone H2A ubiquitination in Polycomb silencing
    • Wang H, et al. (2004) Role of histone H2A ubiquitination in Polycomb silencing. Nature 431:873-878.
    • (2004) Nature , vol.431 , pp. 873-878
    • Wang, H.1
  • 14
    • 0030729636 scopus 로고    scopus 로고
    • Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects
    • Takihara Y, et al. (1997) Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development 124:3673-3682.
    • (1997) Development , vol.124 , pp. 3673-3682
    • Takihara, Y.1
  • 15
    • 33947134834 scopus 로고    scopus 로고
    • The Polycomb group proteins bind throughout the INK4AARF locus and are disassociated in senescent cells
    • Bracken AP, et al. (2007) The Polycomb group proteins bind throughout the INK4AARF locus and are disassociated in senescent cells. Genes Dev 21:525-530.
    • (2007) Genes Dev , vol.21 , pp. 525-530
    • Bracken, A.P.1
  • 16
    • 33746626042 scopus 로고    scopus 로고
    • E4F1: A novel candidate factor for mediating BMI1 function in primitive hematopoietic cells
    • Chagraoui J, et al. (2006) E4F1: A novel candidate factor for mediating BMI1 function in primitive hematopoietic cells. Genes Dev 20:2110-2120.
    • (2006) Genes Dev , vol.20 , pp. 2110-2120
    • Chagraoui, J.1
  • 17
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz J, et al. (1998) The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92:713-723.
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1
  • 18
    • 33750834640 scopus 로고    scopus 로고
    • E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation
    • Le Cam L, et al. (2006) E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell 127:775-788.
    • (2006) Cell , vol.127 , pp. 775-788
    • Le Cam, L.1
  • 19
    • 0036470433 scopus 로고    scopus 로고
    • Replication licensing: Defining the proliferative state?
    • Blow JJ, Hodgson B (2002) Replication licensing: Defining the proliferative state? Trends Cell Biol 12:72-78.
    • (2002) Trends Cell Biol , vol.12 , pp. 72-78
    • Blow, J.J.1    Hodgson, B.2
  • 20
    • 48749092149 scopus 로고    scopus 로고
    • Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity
    • Ohtsubo M, et al. (2008) Polycomb-group complex 1 acts as an E3 ubiquitin ligase for Geminin to sustain hematopoietic stem cell activity. Proc Natl Acad Sci USA 105: 10396-10401.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10396-10401
    • Ohtsubo, M.1
  • 21
    • 22944448744 scopus 로고    scopus 로고
    • Geminin regulates neuronal differentiation by antagonizing Brg1 activity
    • Seo S, et al. (2005) Geminin regulates neuronal differentiation by antagonizing Brg1 activity. Genes Dev 19:1723-1734.
    • (2005) Genes Dev , vol.19 , pp. 1723-1734
    • Seo, S.1
  • 22
    • 1442305333 scopus 로고    scopus 로고
    • The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions
    • Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M (2004) The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature 427:749-753.
    • (2004) Nature , vol.427 , pp. 749-753
    • Luo, L.1    Yang, X.2    Takihara, Y.3    Knoetgen, H.4    Kessel, M.5
  • 23
    • 33748350491 scopus 로고    scopus 로고
    • A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells
    • Kim MY, et al. (2006) A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc Natl Acad Sci USA 103:13074-13079.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13074-13079
    • Kim, M.Y.1
  • 24
    • 34948910184 scopus 로고    scopus 로고
    • Cul4A is required for hematopoietic stem-cell engraftment and selfrenewal
    • Li B, et al. (2007) Cul4A is required for hematopoietic stem-cell engraftment and selfrenewal. Blood 110:2704-2707.
    • (2007) Blood , vol.110 , pp. 2704-2707
    • Li, B.1
  • 25
    • 0344442841 scopus 로고    scopus 로고
    • CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein
    • Zhang Y, et al. (2003) CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein. EMBO J 22:6057-6067.
    • (2003) EMBO J , vol.22 , pp. 6057-6067
    • Zhang, Y.1
  • 26
    • 0032511148 scopus 로고    scopus 로고
    • Geminin, an inhibitor of DNA replication, is degraded during mitosis
    • McGarry TJ, Kirschner MW (1998) Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93:1043-1053.
    • (1998) Cell , vol.93 , pp. 1043-1053
    • McGarry, T.J.1    Kirschner, M.W.2
  • 27
    • 0033120027 scopus 로고    scopus 로고
    • ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
    • Ohta T, Michel JJ, Schottelius AJ, Xiong Y (1999) ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell 3:535-541.
    • (1999) Mol Cell , vol.3 , pp. 535-541
    • Ohta, T.1    Michel, J.J.2    Schottelius, A.J.3    Xiong, Y.4
  • 28
    • 0028892480 scopus 로고
    • Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site
    • Schulze A, et al. (1995) Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc Natl Acad Sci USA 92:11264-11268.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11264-11268
    • Schulze, A.1
  • 29
    • 2342542322 scopus 로고    scopus 로고
    • Regulation of Geminin and Cdt1 expression by E2F transcription factors
    • Yoshida K, Inoue I (2004) Regulation of Geminin and Cdt1 expression by E2F transcription factors. Oncogene 23:3802-3812.
    • (2004) Oncogene , vol.23 , pp. 3802-3812
    • Yoshida, K.1    Inoue, I.2
  • 30
    • 0034646660 scopus 로고    scopus 로고
    • Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type i
    • Ohtani K, et al. (2000) Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I. J Biol Chem 275:11154-11163.
    • (2000) J Biol Chem , vol.275 , pp. 11154-11163
    • Ohtani, K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.