The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions

Nature

Volumn 427, Issue 6976, 2004, Pages 749-753

  Luo, Lingfel ^a   Yang, Xiaoping ^a   Takihara, Yoshihiro ^b   Knoetgen, Hendrik ^a   Kessel, Michael ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DNA; PROTEINS;

PROLIFERATIVE CONTROL; TRANSCRIPTIONAL ACTIVATION;

GENETIC ENGINEERING;

GEMININ; HOMEODOMAIN PROTEIN; HOX PROTEIN; PROTEIN; REPLICATION LICENSING FACTOR CDT1; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; DNA; DNA BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 2; GMNN PROTEIN, MOUSE; HOXB9 PROTEIN, HUMAN; HOXB9 PROTEIN, MOUSE; NUCLEAR PROTEIN; ONCOPROTEIN; POLYCOMB GROUP PROTEINS; REPRESSOR PROTEIN; TLX1 PROTEIN, MOUSE;

BIOLOGY;

ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA BINDING; EMBRYO DEVELOPMENT; GENE CLUSTER; GENETIC TRANSCRIPTION; HUMAN; NEURAL TUBE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; ANIMAL; BINDING COMPETITION; CHICK EMBRYO; DNA RESPONSIVE ELEMENT; DRUG ANTAGONISM; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; TUMOR CELL LINE;

MURINAE;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CHICK EMBRYO; DNA; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; ONCOGENE PROTEINS; PROTEIN BINDING; REPRESSOR PROTEINS; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC;

EID: 1442305333     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02305     Document Type: Article

References (29)

1. Krumlauf, R. Hox genes in vertebrate development. Cell 78, 191-200 (1994).
2. Kessel, M. & Gruss, P. Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell 67, 89-104 (1991).
3. Schumacher, A. & Magnuson, T. Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends Genet. 13, 167-170 (1997).
4. Abate-Shen, C. Deregulated homeobox gene expression in cancer: cause or consequence? Nature Rev. Cancer 2, 777-785 (2002).
5. Wohlschlegel, J. A. et al. Inhibition of eukaryotic DNA replication by Geminin binding to Cdt1. Science 290, 2309-2312 (2000).
6. Tada, S., Li, A., Maiorano, D., Méchali, M. & Blow, J. J. Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by Geminin. Nature Cell Biol. 3, 107-113 (2001).
7. Kroll, K. L., Salic, A. N., Evans, L. M. & Kirschner, M. W. Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development 125, 3247-3258 (1998).
8. Bornemann, D., Miller, E. & Simon, J. The Drosophila Polycomb group gene Sex comb on midleg (Scm) encodes a zinc finger protein with similarity to polyhomeotic protein. Development 122, 1621-1630 (1996).
9. Tomotsune, D. et al. A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with Rae28/Mph1 in vitro. Differentiation 65, 229-239 (1999).
10. Takihara, Y. et al. Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects. Development 124, 3673-3682 (1997).
11. Akasaka, T. et al. A role of mel-18, a Polycomb group-related vertebrate gene, during the anteroposterior specification of the axial skeleton. Development 122, 1513-1522 (1996).
12. Kulartz, M. et al. Expression and phosphorylation of the replication regulator protein geminin. Biochem. Biophys. Res. Commun. 305, 412-420 (2003).
13. Barna, M. et al. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev. Cell 3, 499-510 (2002).
14. Pekarik, V. et al. Screening for gene function in chicken embryo using RNAi and electroporation. Nature Biotechnol. 21, 93-96 (2003).
15. McGarry, T. J. & Kirschner, M. W. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93, 1043-1053 (1998).
16. Del Bene, F., Tessmar-Raible, K. & Wittbrodt, J. Direct interaction of geminin and Six3 in eye development. Nature 427, 745-749 (2004).
17. Care, A. et al. HoxB7 constitutively activates basic fibroblast growth factor in melanomas. Mol. Cell. Biol. 16, 4842-4851 (1996).
18. Duboule, D. Vertebrate Hox genes and proliferation: an alternative pathway to homeosis? Curr. Opin. Genet. Dev. 5, 525-528 (1995).
19. Tetsu, O. et al. Mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Immunity 9, 439-448 (1998).
20. Krosl, J. et al. Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1. Oncogene 16, 3403-3412 (1998).
21. Thorsteinsdottir, U. et al. Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. Mol. Cell. Biol. 17, 495-505 (1997).
22. Wohlschlegel, J. A., Kutok, J. L., Weng, A. P. & Dutta, A. Expression of geminin as a marker of cell proliferation in normal tissues and malignancies. Am. J. Pathol. 161, 267-273 (2002).
23. Gabellini, D. et al. Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. EMBO J. 22, 3715-3724 (2003).
24. Suzuki, M. et al. Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice. Development 129, 4171-4183 (2002).
25. Saurin, A. J. et al. The human Polycomb group complex associates with pericentromeric heterochromatin to form a novel nuclear domain. J. Cell Biol. 142, 887-898 (1998).
26. Megason, S. G. & McMahon, A. P. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 129, 2087-2098 (2002).
27. Shen, W.-F. et al. AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. Mol. Cell. Biol. 17, 6448-6458 (1997).
28. Semenza, G. L., Wang, G. L. & Kundu, R. DNA binding and transcriptional properties of wild-type and mutant forms of the homeodomain protein Msx2. Biochem. Biophys. Res. Commun. 209, 257-262 (1995).
29. Elbashir, S. M., Harborth, J., Weber, K. & Tuschl, T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26, 199-213 (2002).