메뉴 건너뛰기




Volumn 16, Issue 5, 2010, Pages 147-165

Uncovering the genetic architecture of multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD2 ANTIGEN; CD40 ANTIGEN; CD6 ANTIGEN; CELL CYCLE PROTEIN 37; CYCLIN DEPENDENT KINASE 4; HLA A ANTIGEN; HLA A3 ANTIGEN; HLA B ANTIGEN; HLA C ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; HLA DR15 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 3; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERLEUKIN 12P35; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; LYMPHOTOXIN; MESSENGER RNA; PROTEIN KINASE TYK2; STAT PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNINDEXED DRUG;

EID: 78650744485     PISSN: 10802371     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.CON.0000389939.15155.eb     Document Type: Article
Times cited : (1)

References (65)
  • 1
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996;273(5281):1516-1517.
    • (1996) Science , vol.273 , Issue.5281 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 2
    • 0023897491 scopus 로고
    • Multiple sclerosis: Updated risks for relatives
    • Sadovnick AD, Baird PA, Ward RH. Multiple sclerosis: Updated risks for relatives. Am J Med Genet 1988;29(3):533-541.
    • (1988) Am J Med Genet , vol.29 , Issue.3 , pp. 533-541
    • Sadovnick, A.D.1    Baird, P.A.2    Ward, R.H.3
  • 3
    • 0029121088 scopus 로고
    • A genetic basis for familial aggregation in multiple sclerosis
    • Canadian Collaborative Study Group
    • Ebers GC, Sadovnick AD, Risch NJ; Canadian Collaborative Study Group. A genetic basis for familial aggregation in multiple sclerosis. Nature 1995;377(6545):150-151.
    • (1995) Nature , vol.377 , Issue.6545 , pp. 150-151
    • Ebers, G.C.1    Sadovnick, A.D.2    Risch, N.J.3
  • 4
    • 0030007661 scopus 로고    scopus 로고
    • Evidence for genetic basis of multiple sclerosis
    • Canadian Collaborative Study Group
    • Sadovnick AD, Ebers GC, Dyment DA, et al. Canadian Collaborative Study Group. Evidence for genetic basis of multiple sclerosis. Lancet 1996;347(9017):1728-1730.
    • (1996) Lancet , vol.347 , Issue.9017 , pp. 1728-1730
    • Sadovnick, A.D.1    Ebers, G.C.2    Dyment, D.A.3
  • 5
    • 0015492877 scopus 로고
    • HL-A antigens and multiple sclerosis
    • Jersild C, Svejgaard A, Fog T. HL-A antigens and multiple sclerosis. Lancet 1972;1(7762):1240-1241.
    • (1972) Lancet , vol.1 , Issue.7762 , pp. 1240-1241
    • Jersild, C.1    Svejgaard, A.2    Fog, T.3
  • 7
    • 0015733713 scopus 로고
    • Histocompatibility determinants in multiple sclerosis, with special reference to clinical course
    • Jersild C, Fog T, Hansen GS, et al. Histocompatibility determinants in multiple sclerosis, with special reference to clinical course. Lancet 1973;2(7840):1221-1225.
    • (1973) Lancet , vol.2 , Issue.7840 , pp. 1221-1225
    • Jersild, C.1    Fog, T.2    Hansen, G.S.3
  • 8
    • 0024533562 scopus 로고
    • Extended major histocompatibility complex haplotypes in patients with multiple sclerosis
    • Hauser SL, Fleischnick E, Weiner HL, et al. Extended major histocompatibility complex haplotypes in patients with multiple sclerosis. Neurology 1989;39(2 pt 1):275-277.
    • (1989) Neurology , vol.39 , Issue.2 PART. 1 , pp. 275-277
    • Hauser, S.L.1    Fleischnick, E.2    Weiner, H.L.3
  • 9
    • 9144269888 scopus 로고    scopus 로고
    • Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans
    • Oksenberg JR, Barcellos LF, Cree BA, et al. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet 2004;74(1):160-167.
    • (2004) Am J Hum Genet , vol.74 , Issue.1 , pp. 160-167
    • Oksenberg, J.R.1    Barcellos, L.F.2    Cree, B.A.3
  • 10
    • 33748740746 scopus 로고    scopus 로고
    • Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
    • Barcellos LF, Sawcer S, Ramsay PP, et al. Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet 2006;15(18):2813-2824.
    • (2006) Hum Mol Genet , vol.15 , Issue.18 , pp. 2813-2824
    • Barcellos, L.F.1    Sawcer, S.2    Ramsay, P.P.3
  • 11
    • 0030822571 scopus 로고    scopus 로고
    • Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles
    • Marrosu MG, Murru MR, Costa G, et al. Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles. Am J Hum Genet 1997;61(2):454-457.
    • (1997) Am J Hum Genet , vol.61 , Issue.2 , pp. 454-457
    • Marrosu, M.G.1    Murru, M.R.2    Costa, G.3
  • 12
    • 43249119095 scopus 로고    scopus 로고
    • Defining the role of the MHC in autoimmunity: A review and pooled analysis
    • Fernando MM, Stevens CR, Walsh EC, et al. Defining the role of the MHC in autoimmunity: A review and pooled analysis. PLoS Genet 2008;4(4):e1000024.
    • (2008) PLoS Genet , vol.4 , Issue.4
    • Fernando, M.M.1    Stevens, C.R.2    Walsh, E.C.3
  • 13
    • 38549083107 scopus 로고    scopus 로고
    • HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis
    • Brynedal B, Duvefelt K, Jonasdottir G, et al. HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS One 2007;2(7):e664.
    • (2007) PLoS One , vol.2 , Issue.7
    • Brynedal, B.1    Duvefelt, K.2    Jonasdottir, G.3
  • 14
    • 0033975139 scopus 로고    scopus 로고
    • Multiple sclerosis: A modifying influence of HLA class I genes in an HLA class II associated autoimmune disease
    • Fogdell-Hahn A, Ligers A, Gronning M, et al. Multiple sclerosis: A modifying influence of HLA class I genes in an HLA class II associated autoimmune disease. Tissue Antigens 2000;55(2):140-148.
    • (2000) Tissue Antigens , vol.55 , Issue.2 , pp. 140-148
    • Fogdell-Hahn, A.1    Ligers, A.2    Gronning, M.3
  • 15
    • 77649342927 scopus 로고    scopus 로고
    • HLA-class I markers and multiple sclerosis susceptibility in the Italian population
    • Bergamaschi L, Leone MA, Fasano ME, et al. HLA-class I markers and multiple sclerosis susceptibility in the Italian population. Genes Immun 2010;11(2):173-180.
    • (2010) Genes Immun , vol.11 , Issue.2 , pp. 173-180
    • Bergamaschi, L.1    Leone, M.A.2    Fasano, M.E.3
  • 16
    • 34147167634 scopus 로고    scopus 로고
    • A second major histocompatibility complex susceptibility locus for multiple sclerosis
    • Yeo TW, De Jager PL, Gregory SG, et al. A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol 2007;61(3):228-236.
    • (2007) Ann Neurol , vol.61 , Issue.3 , pp. 228-236
    • Yeo, T.W.1    De Jager, P.L.2    Gregory, S.G.3
  • 17
    • 67649876123 scopus 로고    scopus 로고
    • Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
    • De Jager PL, Jia X, Wang J, et al. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet 2009;41(7):776-782.
    • (2009) Nat Genet , vol.41 , Issue.7 , pp. 776-782
    • De Jager, P.L.1    Jia, X.2    Wang, J.3
  • 18
    • 73249122274 scopus 로고    scopus 로고
    • Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
    • International MHC Autoimmunity Genetics Network (IMAGEN)
    • International MHC and Autoimmunity Genetics Network (IMAGEN), Rioux JD, Goyette P, et al. Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A 2009;106(44):18680-18685.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.44 , pp. 18680-18685
    • Rioux, J.D.1    Goyette, P.2
  • 19
    • 7344223861 scopus 로고    scopus 로고
    • Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity
    • Haines JL, Terwedow HA, Burgess K, et al. Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. Hum Mol Genet 1998;7(8):1229-1234.
    • (1998) Hum Mol Genet , vol.7 , Issue.8 , pp. 1229-1234
    • Haines, J.L.1    Terwedow, H.A.2    Burgess, K.3
  • 20
    • 23944499790 scopus 로고    scopus 로고
    • A high-density screen for linkage in multiple sclerosis
    • Sawcer S, Ban M, Maranian M, et al. A high-density screen for linkage in multiple sclerosis. Am J Hum Genet 2005;77(3):454-467.
    • (2005) Am J Hum Genet , vol.77 , Issue.3 , pp. 454-467
    • Sawcer, S.1    Ban, M.2    Maranian, M.3
  • 21
    • 9444295337 scopus 로고    scopus 로고
    • Gene map of the extended human MHC
    • Horton R, Wilming L, Rand V, et al. Gene map of the extended human MHC. Nat Rev Genet 2004;5(12):889-899.
    • (2004) Nat Rev Genet , vol.5 , Issue.12 , pp. 889-899
    • Horton, R.1    Wilming, L.2    Rand, V.3
  • 22
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • International Multiple Sclerosis Genetics Consortium (IMSGC)
    • International Multiple Sclerosis Genetics Consortium (IMSGC), Hafler DA, Compston A, et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007;357(9):851-862.
    • (2007) N Engl J Med , vol.357 , Issue.9 , pp. 851-862
    • Hafler, D.A.1    Compston, A.2
  • 23
    • 34548368541 scopus 로고    scopus 로고
    • Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
    • Lundmark F, Duvefelt K, Iacobaeus E, et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 2007;39(9): 1108-1113.
    • (2007) Nat Genet , vol.39 , Issue.9 , pp. 1108-1113
    • Lundmark, F.1    Duvefelt, K.2    Iacobaeus, E.3
  • 24
    • 34548351247 scopus 로고    scopus 로고
    • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    • Gregory SG, Schmidt S, Seth P, et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 2007;39(9):1083-1091.
    • (2007) Nat Genet , vol.39 , Issue.9 , pp. 1083-1091
    • Gregory, S.G.1    Schmidt, S.2    Seth, P.3
  • 25
    • 49849091315 scopus 로고    scopus 로고
    • Refining genetic associations in multiple sclerosis
    • International Multiple Sclerosis Genetics Consortium (IMSGC)
    • International Multiple Sclerosis Genetics Consortium (IMSGC). Refining genetic associations in multiple sclerosis. Lancet Neurol 2008;7(7):567-569.
    • (2008) Lancet Neurol , vol.7 , Issue.7 , pp. 567-569
  • 26
    • 0031587826 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    • Akashi K, Kondo M, von Freeden-Jeffry U, et al. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 1997;89(7):1033-1041.
    • (1997) Cell , vol.89 , Issue.7 , pp. 1033-1041
    • Akashi, K.1    Kondo, M.2    Von Freeden-Jeffry, U.3
  • 27
    • 77951626389 scopus 로고    scopus 로고
    • Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility
    • Zuvich RL, McCauley JL, Oksenberg JR, et al. Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. Hum Genet 2010;127(5):525-535.
    • (2010) Hum Genet , vol.127 , Issue.5 , pp. 525-535
    • Zuvich, R.L.1    McCauley, J.L.2    Oksenberg, J.R.3
  • 28
    • 58949100205 scopus 로고    scopus 로고
    • IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production
    • Maier LM, Lowe CE, Cooper J, et al. IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet 2009;5(1):e1000322.
    • (2009) PLoS Genet , vol.5 , Issue.1
    • Maier, L.M.1    Lowe, C.E.2    Cooper, J.3
  • 29
    • 34548367511 scopus 로고    scopus 로고
    • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    • Lowe CE, Cooper JD, Brusko T, et al. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet 2007;39(9):1074-1082.
    • (2007) Nat Genet , vol.39 , Issue.9 , pp. 1074-1082
    • Lowe, C.E.1    Cooper, J.D.2    Brusko, T.3
  • 30
    • 33947274768 scopus 로고    scopus 로고
    • Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs
    • Brand OJ, Lowe CE, Heward JM, et al. Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf) 2007;66(4):508-512.
    • (2007) Clin Endocrinol (Oxf) , vol.66 , Issue.4 , pp. 508-512
    • Brand, O.J.1    Lowe, C.E.2    Heward, J.M.3
  • 31
    • 38649125210 scopus 로고    scopus 로고
    • Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
    • Harley JB, Alarcon-Riquelme ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 2008;40(2):204-210.
    • (2008) Nat Genet , vol.40 , Issue.2 , pp. 204-210
    • Harley, J.B.1    Alarcon-Riquelme, M.E.2    Criswell, L.A.3
  • 32
    • 52949131340 scopus 로고    scopus 로고
    • Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
    • Barton A, Thomson W, Ke X, et al. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet 2008;40(10):1156-1159.
    • (2008) Nat Genet , vol.40 , Issue.10 , pp. 1156-1159
    • Barton, A.1    Thomson, W.2    Ke, X.3
  • 33
    • 67649881102 scopus 로고    scopus 로고
    • Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
    • The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene)
    • The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene). Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet 2009;41(7):824-828.
    • (2009) Nat Genet , vol.41 , Issue.7 , pp. 824-828
  • 34
    • 56749098072 scopus 로고    scopus 로고
    • Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
    • Aulchenko YS, Hoppenbrouwers IA, Ramagopalan SV, et al. Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. Nat Genet 2008;40(12):1402-1403.
    • (2008) Nat Genet , vol.40 , Issue.12 , pp. 1402-1403
    • Aulchenko, Y.S.1    Hoppenbrouwers, I.A.2    Ramagopalan, S.V.3
  • 35
    • 76049083598 scopus 로고    scopus 로고
    • Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene
    • Jakkula E, Leppa V, Sulonen AM, et al. Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am J Hum Genet 2010;86(2):285-291.
    • (2010) Am J Hum Genet , vol.86 , Issue.2 , pp. 285-291
    • Jakkula, E.1    Leppa, V.2    Sulonen, A.M.3
  • 36
    • 77950544633 scopus 로고    scopus 로고
    • Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci
    • International Multiple Sclerosis Genetics Consortium (IMSGC)
    • International Multiple Sclerosis Genetics Consortium (IMSGC). Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci. Hum Mol Genet 2010;19(5):953-962.
    • (2010) Hum Mol Genet , vol.19 , Issue.5 , pp. 953-962
  • 37
    • 59149098926 scopus 로고    scopus 로고
    • CD226 Gly307Ser association with multiple autoimmune diseases
    • Hafler JP, Maier LM, Cooper JD, et al. CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun 2009;10(1):5-10.
    • (2009) Genes Immun , vol.10 , Issue.1 , pp. 5-10
    • Hafler, J.P.1    Maier, L.M.2    Cooper, J.D.3
  • 38
    • 22544455033 scopus 로고    scopus 로고
    • CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions
    • Dardalhon V, Schubart AS, Reddy J, et al. CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions. J Immunol 2005;175(3):1558-1565.
    • (2005) J Immunol , vol.175 , Issue.3 , pp. 1558-1565
    • Dardalhon, V.1    Schubart, A.S.2    Reddy, J.3
  • 40
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004;199(7):971-979.
    • (2004) J Exp Med , vol.199 , Issue.7 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 41
    • 0242660096 scopus 로고    scopus 로고
    • Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis
    • Chitnis T, Khoury SJ. Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis. J Allergy Clin Immunol 2003;112(5):837-849.
    • (2003) J Allergy Clin Immunol , vol.112 , Issue.5 , pp. 837-849
    • Chitnis, T.1    Khoury, S.J.2
  • 42
    • 77952884985 scopus 로고    scopus 로고
    • Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis
    • Sanna S, Pitzalis M, Zoledziewska M, et al. Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis. Nat Genet 2010;42:495-497.
    • Nat Genet , vol.2010 , Issue.42 , pp. 495-497
    • Sanna, S.1    Pitzalis, M.2    Zoledziewska, M.3
  • 43
    • 70349577982 scopus 로고    scopus 로고
    • Activation of T cells: Releasing the brakes by proteolytic elimination of Cbl-b
    • Schmitz ML. Activation of T cells: Releasing the brakes by proteolytic elimination of Cbl-b. Sci Signal 2009;2(76):pe38.
    • (2009) Sci Signal , vol.2 , Issue.76
    • Schmitz, M.L.1
  • 44
    • 0034642534 scopus 로고    scopus 로고
    • Cbl-b regulates the CD28 dependence of T-cell activation
    • Chiang YJ, Kole HK, Brown K, et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 2000;403(6766):216-220.
    • (2000) Nature , vol.403 , Issue.6766 , pp. 216-220
    • Chiang, Y.J.1    Kole, H.K.2    Brown, K.3
  • 45
    • 70349629969 scopus 로고    scopus 로고
    • Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor
    • Ban M, Goris A, Lorentzen AR, et al. Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. Eur J Hum Genet 2009;17(10):1309-1313.
    • (2009) Eur J Hum Genet , vol.17 , Issue.10 , pp. 1309-1313
    • Ban, M.1    Goris, A.2    Lorentzen, A.R.3
  • 46
    • 68949131070 scopus 로고    scopus 로고
    • STAT3 in CD4+ T helper cell differentiation and inflammatory diseases
    • Egwuagu CE. STAT3 in CD4+ T helper cell differentiation and inflammatory diseases. Cytokine 2009;47(3):149-156.
    • (2009) Cytokine , vol.47 , Issue.3 , pp. 149-156
    • Egwuagu, C.E.1
  • 47
    • 44449136105 scopus 로고    scopus 로고
    • Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases
    • Liu X, Lee YS, Yu CR, Egwuagu CE. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases. J Immunol 2008;180(9):6070- 6076.
    • (2008) J Immunol , vol.180 , Issue.9 , pp. 6070-6076
    • Liu, X.1    Lee, Y.S.2    Yu, C.R.3    Egwuagu, C.E.4
  • 48
    • 24744458604 scopus 로고    scopus 로고
    • Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages
    • Tamura T, Thotakura P, Tanaka TS, et al. Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages. Blood 2005;106(6):1938-1947.
    • (2005) Blood , vol.106 , Issue.6 , pp. 1938-1947
    • Tamura, T.1    Thotakura, P.2    Tanaka, T.S.3
  • 49
    • 49249124418 scopus 로고    scopus 로고
    • Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: A novel germinal center marker
    • Martinez A, Pittaluga S, Rudelius M, et al. Expression of the interferon regulatory factor 8/ICSBP-1 in human reactive lymphoid tissues and B-cell lymphomas: A novel germinal center marker. Am J Surg Pathol 2008;32(8):1190- 1200.
    • (2008) Am J Surg Pathol , vol.32 , Issue.8 , pp. 1190-1200
    • Martinez, A.1    Pittaluga, S.2    Rudelius, M.3
  • 50
    • 72149112759 scopus 로고    scopus 로고
    • Autoimmune diseases induced by biological agents: A double-edged sword?
    • Ramos-Casals M, Roberto Perez A, Diaz-Lagares C, et al. Autoimmune diseases induced by biological agents: A double-edged sword? Autoimmun Rev 2010;9(3):188-193.
    • (2010) Autoimmun Rev , vol.9 , Issue.3 , pp. 188-193
    • Ramos-Casals, M.1    Roberto Perez, A.2    Diaz-Lagares, C.3
  • 51
    • 0034633542 scopus 로고    scopus 로고
    • Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis
    • Suvannavejh GC, Lee HO, Padilla J, et al. Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis. Cell Immunol 2000;205(1):24-33.
    • (2000) Cell Immunol , vol.205 , Issue.1 , pp. 24-33
    • Suvannavejh, G.C.1    Lee, H.O.2    Padilla, J.3
  • 52
    • 0033812142 scopus 로고    scopus 로고
    • The occurrence of autoimmune diseases in patients with multiple sclerosis and their families
    • Henderson RD, Bain CJ, Pender MP. The occurrence of autoimmune diseases in patients with multiple sclerosis and their families. J Clin Neurosci 2000;7(5):434-437.
    • (2000) J Clin Neurosci , vol.7 , Issue.5 , pp. 434-437
    • Henderson, R.D.1    Bain, C.J.2    Pender, M.P.3
  • 53
    • 33749653103 scopus 로고    scopus 로고
    • Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: A descriptive study
    • Barcellos LF, Kamdar BB, Ramsay PP, et al. Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: A descriptive study. Lancet Neurol 2006;5(11):924-931.
    • (2006) Lancet Neurol , vol.5 , Issue.11 , pp. 924-931
    • Barcellos, L.F.1    Kamdar, B.B.2    Ramsay, P.P.3
  • 54
    • 41349103493 scopus 로고    scopus 로고
    • Newly identified genetic risk variants for celiac disease related to the immune response
    • Hunt KA, Zhernakova A, Turner G, et al. Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet 2008;40(4):395-402.
    • (2008) Nat Genet , vol.40 , Issue.4 , pp. 395-402
    • Hunt, K.A.1    Zhernakova, A.2    Turner, G.3
  • 55
    • 54949143968 scopus 로고    scopus 로고
    • Alemtuzumab vs. interferon beta-1a in early multiple sclerosis
    • Coles AJ, Compston DA, Selmaj KW, et al. Alemtuzumab vs. interferon beta-1a in early multiple sclerosis. N Engl J Med 2008;359(7):1786-1801.
    • (2008) N Engl J Med , vol.359 , Issue.7 , pp. 1786-1801
    • Coles, A.J.1    Compston, D.A.2    Selmaj, K.W.3
  • 56
    • 51249089462 scopus 로고    scopus 로고
    • HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis
    • Cournu-Rebeix I, Genin E, Leray E, et al. HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis. Genes Immun 2008;9(6):570-574.
    • (2008) Genes Immun , vol.9 , Issue.6 , pp. 570-574
    • Cournu-Rebeix, I.1    Genin, E.2    Leray, E.3
  • 57
    • 58849146101 scopus 로고    scopus 로고
    • Genotype-phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures
    • Okuda DT, Srinivasan R, Oksenberg JR, et al. Genotype-phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. Brain 2009;132(pt 1):250-259.
    • (2009) Brain , vol.132 , Issue.PART. 1 , pp. 250-259
    • Okuda, D.T.1    Srinivasan, R.2    Oksenberg, J.R.3
  • 58
    • 73549090822 scopus 로고    scopus 로고
    • HLA-DRB1 1501 and spinal cord magnetic resonance imaging lesions in multiple sclerosis
    • Sombekke MH, Lukas C, Crusius JB, et al. HLA-DRB1 1501 and spinal cord magnetic resonance imaging lesions in multiple sclerosis. Arch Neurol 2009;66(12):1531-1536.
    • (2009) Arch Neurol , vol.66 , Issue.12 , pp. 1531-1536
    • Sombekke, M.H.1    Lukas, C.2    Crusius, J.B.3
  • 59
    • 58949099391 scopus 로고    scopus 로고
    • Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis
    • Baranzini SE, Wang J, Gibson RA, et al. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 2009;18(4):767-778.
    • (2009) Hum Mol Genet , vol.18 , Issue.4 , pp. 767-778
    • Baranzini, S.E.1    Wang, J.2    Gibson, R.A.3
  • 60
    • 38049170558 scopus 로고    scopus 로고
    • An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus
    • DeLuca GC, Ramagopalan SV, Herrera BM, et al. An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus. Proc Natl Acad Sci U S A 2007;104(52):20896- 20901.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.52 , pp. 20896-20901
    • DeLuca, G.C.1    Ramagopalan, S.V.2    Herrera, B.M.3
  • 61
    • 40849094272 scopus 로고    scopus 로고
    • Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis
    • Byun E, Caillier SJ, Montalban X, et al. Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. Arch Neurol 2008;65(3):337-344.
    • (2008) Arch Neurol , vol.65 , Issue.3 , pp. 337-344
    • Byun, E.1    Caillier, S.J.2    Montalban, X.3
  • 62
    • 68549085471 scopus 로고    scopus 로고
    • Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis
    • Comabella M, Craig DW, Morcillo-Suarez C, et al. Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon beta therapy in multiple sclerosis. Arch Neurol 2009;66(8):972-978.
    • (2009) Arch Neurol , vol.66 , Issue.8 , pp. 972-978
    • Comabella, M.1    Craig, D.W.2    Morcillo-Suarez, C.3
  • 63
    • 71849098862 scopus 로고    scopus 로고
    • Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: A weighted genetic risk score
    • De Jager PL, Chibnik LB, Cui J, et al. Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: A weighted genetic risk score. Lancet Neurol 2009;8(12):1111-1119.
    • (2009) Lancet Neurol , vol.8 , Issue.12 , pp. 1111-1119
    • De Jager, P.L.1    Chibnik, L.B.2    Cui, J.3
  • 64
    • 77649289047 scopus 로고    scopus 로고
    • What role for genetics in the prediction of multiple sclerosis?
    • Sawcer S, Ban M, Wason J, Dudbridge F. What role for genetics in the prediction of multiple sclerosis? Ann Neurol 2010;67(1):3-10.
    • (2010) Ann Neurol , vol.67 , Issue.1 , pp. 3-10
    • Sawcer, S.1    Ban, M.2    Wason, J.3    Dudbridge, F.4
  • 65
    • 65549084289 scopus 로고    scopus 로고
    • Pathway and network-based analysis of genome-wide association studies in multiple sclerosis
    • Baranzini SE, Galwey NW, Wang J, et al. Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet 2009;18(11):2078-2090.
    • (2009) Hum Mol Genet , vol.18 , Issue.11 , pp. 2078-2090
    • Baranzini, S.E.1    Galwey, N.W.2    Wang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.