An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 52, 2007, Pages 20896-20901

  DeLuca, G C ^a,c   Ramagopalan, S V ^a,c   Herrera, B M ^a,c   Dyment, D A ^a,c   Lincoln, M R ^a,c   Montpetit, A ^d   Pugliatti, M ^e   Barnardo, M C N ^b   Risch, N J ^f   Sadovnick, A D ^g   Chao, M ^a,c   Sotgiu, S ^e   Hudson, T J ^h   Ebers, G C ^a,c  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF SASSARI   (Italy)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^h ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN;

ADULT; ALLELE; ANTIGENIC VARIATION; ARTICLE; COHORT ANALYSIS; DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE PREDISPOSITION; DISEASE SEVERITY; EPISTASIS; FEMALE; GENE LOCUS; GENOTYPE; HUMAN; IMMUNOPATHOGENESIS; MAJOR CLINICAL STUDY; MALE; MOLECULAR INTERACTION; MULTIPLE SCLEROSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALLELES; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HLA-DR ANTIGENS; HUMANS; ITALY; MALE; MIDDLE AGED; MODELS, GENETIC; MULTIPLE SCLEROSIS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; TREATMENT OUTCOME;

EID: 38049170558     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0707731105     Document Type: Article

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