HLA-class i markers and multiple sclerosis susceptibility in the Italian population

Genes and Immunity

Volumn 11, Issue 2, 2010, Pages 173-180

  Bergamaschi, L ^a   Leone, M A ^b   Fasano, M E ^c   Guerini, F R ^d   Ferrante, D ^a   Bolognesi, E ^a   Barizzone, N ^a   Corrado, L ^a   Naldi, P ^b   Agliardi, C ^d   Dametto, E ^c   Salvetti, M ^e   Visconti, A ^e   Galimberti, D ^f   Scarpini, E ^f   Vercellino, M ^c   Bergamaschi, R ^g   Monaco, F ^a,b   Caputo, D ^d   Momigliano Richiardi, P ^a   D'Alfonso, S ^a   more..

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b MAGGIORE DELLA CARITÀ HOSPITAL   (Italy)

^c MOLINETTE HOSPITAL   (Italy)

^d IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f UNIVERSITY OF MILAN   (Italy)

^g C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

Extended HLA haplotypes; Genetic association; HLA class I markers; Multiple sclerosis; Myelin Oligodendrocyte Glycoprotein

Indexed keywords

HLA ANTIGEN CLASS 1; HLA DR ANTIGEN;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; DISEASE PREDISPOSITION; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; MOLECULAR INTERACTION; MULTIPLE SCLEROSIS; POPULATION RESEARCH; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR;

ALLELES; DISEASE SUSCEPTIBILITY; GENETIC MARKERS; HAPLOTYPES; HLA-A ANTIGENS; HUMANS; ITALY; LINKAGE DISEQUILIBRIUM; MULTIPLE SCLEROSIS; MYELIN-ASSOCIATED GLYCOPROTEIN; ODDS RATIO; POPULATION GROUPS; RISK FACTORS;

EID: 77649342927     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2009.101     Document Type: Article

References (29)

1. Compston A, Coles A. Multiple sclerosis. Lancet 2008; 372: 1502-1517.
2. Ebers GC. Environmental factors and multiple sclerosis. Lancet Neurol 2008; 7: 268-277.
3. Ballerini C, Guerini FR, Rombolà G, Rosati E, Massacesi L, Ferrante P et al. HLA-multiple sclerosis association in continental Italy and correlation with disease prevalence in Europe. J Neuroimmunol 2004; 150: 178-185.
4. Fogdell A, Hillert J, Sachs C, Olerup O. The multiple sclerosis-and narcolepsy-associated HLA class II Haplotype incluse DRB5*0101 allele. Tissue Antigens 1995; 46: 333-336.
5. Olerup O, Hillert J. HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. Tissue Antigens 1991; 38: 1-15.
6. Barcellos LF, Sawcer S, Ramsay PP, Baranzini SE, Thomson G, Briggs F et al. Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet 2006; 15: 2813-2824.
7. Chao MJ, Barnardo MC, Lui GZ, Lincoln MR, Ramagopalan SV, Herrera BM et al. Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium. Hum Mol Genet 2007; 16: 1951-1958.
8. Lincoln MR, Montpetit A, Cader MZ, Saarela J, Dyment DA, Tiislar M et al. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet 2005; 37: 1108-1112.
9. Brynedal B, Duvefelt K, Jonasdottir G, Roos IM, Akesson E, Palmgren J et al. HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS One 2007; 7: e664.
10. Fogdell-Hahn A, Ligers A, Gronning M, Hillert J, Olerup O. Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease. Tissue Antigens 2000; 55: 140-148.
11. Yeo TW, De Jager PL, Gregory SG, Barcellos LF, Walton A, Goris A et al. A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol 2007; 61: 228-236.
12. D'Alfonso S, Bolognesi E, Guerini FR, Barizzone N, Bocca S, Ferrante D et al. A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy. Genes Immun 2008; 9: 7-15.
13. Burfoot RK, Jensen CJ, Field J, Stankovich J, Varney MD, Johnson LJ et al. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. Tissue Antigens 2008; 71: 42-50.
14. Cattley SK, Williamson JF, Tay GK, Martinez OP, Gaudieri S, Dawkins RL. Further characterization of MHC haplotypes demonstrates conservation telomeric of HLA-A: update of the 4AOH and 10IHW cell panels. Eur J Immunogenet 2000; 27: 397-426.
15. Alper CA, Larsen CE, Dubey DP, Awdeh ZL, Fici DA, Yunis EJ. The haplotype structure of the human major histocompat-ibility complex. Hum Immunol 2006; 67: 73-84.
16. Dorak MT, Shao W, Machulla HK, Lobashevsky ES, Tang J, Park MH et al. Conserved extended haplotypes of the major histocompatibility complex: further characterization. Genes Immun 2006; 7: 450-467.
17. Friese MA, Jakobsen KB, Friis L, Etzensperger R, Craner MJ, McMahon RM et al. Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis. Nat Med 2008; 14: 1227-1235.
18. Moretta L, Moretta A. Killer immunoglobulin-like receptors. Curr Opin Immunol 2004; 16: 626-633.
19. Thananchai H, Gillespie G, Martin MP, Bashirova A, Yawata N, Yawata M et al. Cutting edge: allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. J Immunol 2007; 178: 33-37.
20. Horton R, Gibson R, Coggill P, Miretti M, Allcock RJ, Almeida J et al. Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics 2008; 60: 1-18.
21. Baranzini SE, Wang J, Gibson RA, Galwey N, Naegelin Y, Barkhof F et al Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet 2009; 18: 767-778.
22. Howson JM, Walker NM, Clayton D, Todd JA, Diabetes Genetics Consortium. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab 2009; 11(Suppl 1): 31-45.
23. Eike MC, Becker T, Humphreys K, Olsson M, Lie BA. Conditional analyses on the T1DGC MHC dataset: novel associations with type 1 diabetes around HLA-G and confirmation of HLA-B. Genes Immun 2009; 10: 56-67.
24. Bolognesi E, Karell K, Percopo S, Coto I, Greco L, Mantovani V et al. Additional factor in some HLA DR3/DQ2 haplotypes confers a fourfold increased genetic risk of celiac disease. Tissue Antigens 2003; 61: 308-316.
25. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 50: 121-127.
26. Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996; 48: 907-911.
27. Tonks S, Marsh SGE, Bunce M, Moses JH, Krausa P, Sadler AM et al. HLA class I DNA typing study. In: D Charron (ed). Genetic Diversity of HLA: Functional and Medical Implications. EDK: Sevres, 1997, pp 199-215.
28. Dudbridge F Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003; 25: 115-121.
29. Mattiuz PL, Ihde D, Piazza A, Ceppellini R, Bodmer WD. New approaches to the population genetics and segregation analysis of the HLA system. In: P Terasaki (ed). Histocompatibility Testing. Munksgaard: Copenhagen, 1970, pp 193-205.