-
1
-
-
78650730335
-
-
Chinese source
-
-
-
-
2
-
-
78650757390
-
-
Chinese source
-
-
-
-
3
-
-
4344650390
-
Marine natural products and related compounds in clinical and advanced preclinical trials [J]
-
Newman D J, Cragg C M. Marine natural products and related compounds in clinical and advanced preclinical trials [J]. J Nat Prod, 2004, 67, 1216-1238.
-
(2004)
J Nat Prod
, vol.67
, pp. 1216-1238
-
-
Newman, D.J.1
Cragg, C.M.2
-
4
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years [J]
-
Newman D J, Cragg G M. Natural products as sources of new drugs over the last 25 years [J]. J Nat Prod, 2007, 70, 461-477.
-
(2007)
J Nat Prod
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
5
-
-
0034082239
-
The influence of natural products upon drug discovery [J]
-
Newman D J, Cragg G M, Snader K M. The influence of natural products upon drug discovery [J]. Nat Prod Rep, 2000, 17, 215-234.
-
(2000)
Nat Prod Rep
, vol.17
, pp. 215-234
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
6
-
-
11344292132
-
The role of natural prodct chemistry in drug discovery [J]
-
Butler M S. The role of natural prodct chemistry in drug discovery [J]. J Nat Prod, 2004, 67, 2141-2153.
-
(2004)
J Nat Prod
, vol.67
, pp. 2141-2153
-
-
Butler, M.S.1
-
7
-
-
17844399025
-
Natural products to drugs, natural product compounds in clinical trials [J]
-
Butler M S. Natural products to drugs, natural product compounds in clinical trials [J]. Nat Prod Rep, 2005, 22, 162-195.
-
(2005)
Nat Prod Rep
, vol.22
, pp. 162-195
-
-
Butler, M.S.1
-
8
-
-
14944383798
-
The evolving role of natural products drug discovery [J]
-
Koethn F E, Carter G T. The evolving role of natural products drug discovery [J]. Nat Rev Drug Discov, 2005, 4, 206-220.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 206-220
-
-
Koethn, F.E.1
Carter, G.T.2
-
9
-
-
0042975166
-
Natural products, a simple model to explain chemical diversity [J]
-
Firn R D, Jones C G. Natural products, a simple model to explain chemical diversity [J]. Nat Prod Rep, 2003, 20, 382-391.
-
(2003)
Nat Prod Rep
, vol.20
, pp. 382-391
-
-
Firn, R.D.1
Jones, C.G.2
-
10
-
-
0032872173
-
How many leads from HTS? [J]
-
Lahana R. How many leads from HTS? [J]. Drug Discov Today, 1999, 4, 447-448.
-
(1999)
Drug Discov Today
, vol.4
, pp. 447-448
-
-
Lahana, R.1
-
11
-
-
0033961732
-
The role of natural products in a modern drug discovery program [J]
-
Strohl W R. The role of natural products in a modern drug discovery program [J]. Drug Discov Today, 2000. 5: 39-41.
-
(2000)
Drug Discov Today
, vol.5
, pp. 39-41
-
-
Strohl, W.R.1
-
12
-
-
78650722754
-
-
Chinese source
-
-
-
-
13
-
-
78650722337
-
-
Chinese source
-
-
-
-
14
-
-
67650436176
-
Drug discovery and natural products: end of an era or an eneless frontier? [J]
-
Li J W H, Vederas J C. Drug discovery and natural products: end of an era or an eneless frontier? [J]. Science, 2009, 325: 361-363.
-
(2009)
Science
, vol.325
, pp. 361-363
-
-
Li, J.W.H.1
Vederas, J.C.2
-
15
-
-
52449100159
-
Natural products as in-spiration for the development of asymmetric catalysis [J]
-
Mohr J T, Krout M R, Stoltzl B M. Natural products as in-spiration for the development of asymmetric catalysis [J]. Nature, 2008, 455, 323-332.
-
(2008)
Nature
, vol.455
, pp. 323-332
-
-
Mohr, J.T.1
Krout, M.R.2
Stoltzl, B.M.3
-
16
-
-
27144547510
-
The renaissance of natural products as drug candidates [J]
-
Paterson I, Anderson E A. The renaissance of natural products as drug candidates [J]. Science, 2005, 310: 451-453.
-
(2005)
Science
, vol.310
, pp. 451-453
-
-
Paterson, I.1
Anderson, E.A.2
-
17
-
-
33947717002
-
Anticancer drugs from nature-natural products as a unique source of new nicrotubule-stabilizing agents [J]
-
Altmann K H, Gertsch J. Anticancer drugs from nature-natural products as a unique source of new nicrotubule-stabilizing agents [J]. Nat Prod Rep, 2007, 24, 327-357.
-
(2007)
Nat Prod Rep
, vol.24
, pp. 327-357
-
-
Altmann, K.H.1
Gertsch, J.2
-
18
-
-
39149137869
-
Plant-derived compounds in clinical trials [J]
-
Saklani A, Kutty S K. Plant-derived compounds in clinical trials [J]. Drug Discov Today, 2008, 13: 161-171.
-
(2008)
Drug Discov Today
, vol.13
, pp. 161-171
-
-
Saklani, A.1
Kutty, S.K.2
-
19
-
-
3042634937
-
Natural products in drug discovery-creating a new vision [J]
-
Cordell G A. Natural products in drug discovery-Creating a new vision [J]. Phytochem Rev, 2002, 1, 261-273.
-
(2002)
Phytochem Rev
, vol.1
, pp. 261-273
-
-
Cordell, G.A.1
-
20
-
-
42949160050
-
Natural products as leads to potential drugs: An old process or the hoper for drug disvocery? [J]
-
Newman D J. Natural products as leads to potential drugs: an old process or the hoper for drug disvocery? [J]. Med Chem, 2008, 51: 2589-2599.
-
(2008)
Med Chem
, vol.51
, pp. 2589-2599
-
-
Newman, D.J.1
-
21
-
-
52049109838
-
Natural prodccts in drug discovery [J]
-
Harvey A L. Natural prodccts in drug discovery [J]. Drug Discov Today, 2008, 13: 894-901.
-
(2008)
Drug Discov Today
, vol.13
, pp. 894-901
-
-
Harvey, A.L.1
-
22
-
-
44249098800
-
Natural products to drugs natural product-de-rived compounds in clinical trials [J]
-
Butler M S. Natural products to drugs, natural product-de-rived compounds in clinical trials [J]. Nat Prod Rep, 2008, 25: 475-516.
-
(2008)
Nat Prod Rep
, vol.25
, pp. 475-516
-
-
Butler, M.S.1
-
23
-
-
14944383798
-
The evolving role of natural products in drug discovery [J]
-
Koehn F E, Carter C T. The evolving role of natural products in drug discovery [J]. Na Rev Drug Discov, 2005, 4: 206-220.
-
(2005)
Na Rev Drug Discov
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, C.T.2
-
24
-
-
42949174608
-
Natural products, small molecules, and genetics in tuberculosis drug development [J]
-
Gutierrez-Lugo M T, Bewley C A. Natural products, small molecules, and genetics in tuberculosis drug development [J]. J Med Chem, 2008, 51: 2606-2612.
-
(2008)
J Med Chem
, vol.51
, pp. 2606-2612
-
-
Gutierrez-Lugo, M.T.1
Bewley, C.A.2
-
25
-
-
34249811180
-
New aspects of natural products in drug discovery [J]
-
Lam K S. New aspects of natural products in drug discovery [J]. Trends Microbiol, 2007, 15: 279-289.
-
(2007)
Trends Microbiol
, vol.15
, pp. 279-289
-
-
Lam, K.S.1
-
26
-
-
44949134801
-
The impact of natural products upon modern drug discovery [J]
-
Ganesan A. The impact of natural products upon modern drug discovery [J]. Curr Opin Chem Biol, 2008, 13: 306-317.
-
(2008)
Curr Opin Chem Biol
, vol.13
, pp. 306-317
-
-
Ganesan, A.1
-
27
-
-
43049183607
-
Natural products as a robust source of new drugs and drug leads, past successes and present day issues [J]
-
Rishton G M. Natural products as a robust source of new drugs and drug leads, past successes and present day issues [J]. Am J Cardiol, 2008, 101(Suppl), 43D-49D.
-
(2008)
Am J Cardiol
, vol.101
, Issue.SUPPL.
-
-
Rishton, G.M.1
-
28
-
-
77955948967
-
Challenges in research and development of traditional Chinese medicines [J]
-
Liu C X, Xiao P G, Peng Y, et al. Challenges in research and development of traditional Chinese medicines [J]. Chin Herb Med, 2009, 1(1): 1-28.
-
(2009)
Chin Herb Med
, vol.1
, Issue.1
, pp. 1-28
-
-
Liu, C.X.1
Xiao, P.G.2
Peng, Y.3
-
29
-
-
0032569205
-
Stereoselective synthesis of over two million compounds having structural fea-tures both reminiscent of natural products and compatible with miniaturized cell-based assays [J]
-
Tan D S, Foley M A, Shair M D, et al. Stereoselective synthesis of over two million compounds having structural fea-tures both reminiscent of natural products and compatible with miniaturized cell-based assays [J]. J Am Chem Soc, 1998, 120: 8565-8566.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 8565-8566
-
-
Tan, D.S.1
Foley, M.A.2
Shair, M.D.3
-
30
-
-
0030667760
-
Will combinatorial chemistry deliver real medicines? [J]
-
Myers P L. Will combinatorial chemistry deliver real medicines? [J]. Curr Opin Biotechnol, 1997, 8: 701-707.
-
(1997)
Curr Opin Biotechnol
, vol.8
, pp. 701-707
-
-
Myers, P.L.1
-
31
-
-
78650747048
-
-
Chinese source
-
-
-
-
32
-
-
78650746242
-
-
Chinese source
-
-
-
-
33
-
-
78650732283
-
-
Chinese source
-
-
-
-
34
-
-
58149189779
-
Drug development form marine natural products [J]
-
Molinski T F, Dalisay D S, Lievens S L, et al. Drug development form marine natural products [J]. Nat Rev Drug Discov, 2009, 8: 69-85.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 69-85
-
-
Molinski, T.F.1
Dalisay, D.S.2
Lievens, S.L.3
-
35
-
-
0038461995
-
Drugs from the deep: Marine natural products as drug candidates [J]
-
Haefner B. Drugs from the deep: marine natural products as drug candidates [J]. Drug Discov Today, 2003, 8(12): 536-544.
-
(2003)
Drug Discov Today
, vol.8
, Issue.12
, pp. 536-544
-
-
Haefner, B.1
-
36
-
-
12344255038
-
Marine natural products [J]
-
Hill R A. Marine natural products [J]. Annu Rep Prog Chem Sec B, 2004, 100: 169-189.
-
(2004)
Annu Rep Prog Chem Sec B
, vol.100
, pp. 169-189
-
-
Hill, R.A.1
-
37
-
-
78650735684
-
-
Chinese source
-
-
-
-
38
-
-
78650745182
-
-
Chinese source
-
-
-
-
39
-
-
33646056420
-
Drug discovery from natural sources [J]
-
Chin Y W, Balunas M J, Chai H B, et al. Drug discovery from natural sources [J]. AAPS J, 2006, 8: E239-E253.
-
(2006)
AAPS J
, vol.8
-
-
Chin, Y.W.1
Balunas, M.J.2
Chai, H.B.3
-
40
-
-
33646499702
-
Natural products in drug discovery-concepts and approaches for tracking bioactivity [J]
-
Potterat O, Hamburger M. Natural products in drug discovery-concepts and approaches for tracking bioactivity [J]. Curr Org Chem, 2006, 10: 899-920.
-
(2006)
Curr Org Chem
, vol.10
, pp. 899-920
-
-
Potterat, O.1
Hamburger, M.2
-
41
-
-
22844441647
-
Rediscovery of known natural compounds: Nuisance or goldmine?
-
DOI 10.1016/j.bmc.2005.05.067, PII S0968089605005250
-
Tulpa M, Bohlin L. Rediscovery of known natural compounds, Nurisance or goldmine? [J]. Bioorg Med Chem, 2005, 13: 5274-5282. (Pubitemid 41039989)
-
(2005)
Bioorganic and Medicinal Chemistry
, vol.13
, Issue.17
, pp. 5274-5282
-
-
Tulp, M.1
Bohlin, L.2
-
42
-
-
48149108752
-
Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries [J]
-
Cordier C, Morton D, Murrison S, et al. Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries [J]. Nat Prod Rep, 2008, 25: 719-737.
-
(2008)
Nat Prod Rep
, vol.25
, pp. 719-737
-
-
Cordier, C.1
Morton, D.2
Murrison, S.3
-
43
-
-
52449100159
-
Natural products as in-spiration for the development of asymmetric catalysis [J]
-
Mohr J T, Krout M R, Stoltzl B M. Natural products as in-spiration for the development of asymmetric catalysis [J]. Nature, 2008, 455: 323-332.
-
(2008)
Nature
, vol.455
, pp. 323-332
-
-
Mohr, J.T.1
Krout, M.R.2
Stoltzl, B.M.3
-
44
-
-
38949083855
-
The chemical versatility of natural-product assembly lines [J]
-
Walsh C T. The chemical versatility of natural-product assembly lines [J]. Accou Chem Res, 2008, 41: 4-10.
-
(2008)
Accou Chem Res
, vol.41
, pp. 4-10
-
-
Walsh, C.T.1
-
45
-
-
0042975166
-
Natural products, a simple model to explain chemical diversity [J]
-
Firn R D, Jones C G. Natural products, a simple model to explain chemical diversity [J]. Nat Prod Rep, 2003, 20, 382-391.
-
(2003)
Nat Prod Rep
, vol.20
, pp. 382-391
-
-
Firn, R.D.1
Jones, C.G.2
-
46
-
-
23044471389
-
Bioguided isoation of pharmacologically active plant components, still a valuable strategy for the finding of new lead compounds [J]
-
Pieters L, Vlietinck A J. Bioguided isoation of pharmacologically active plant components, still a valuable strategy for the finding of new lead compounds [J]. J Ethno pharma, 2005, 100: 57-60.
-
(2005)
J Ethno pharma
, vol.100
, pp. 57-60
-
-
Pieters, L.1
Vlietinck, A.J.2
-
47
-
-
27844474247
-
Drug discovery from medicinal plants [J]
-
Balunas M J, Douglas Kinghorn A. Drug discovery from medicinal plants [J]. Life Sci, 2005, 78: 431-441.
-
(2005)
Life Sci
, vol.78
, pp. 431-441
-
-
Balunas, M.J.1
Douglas Kinghorn, A.2
-
48
-
-
0036488643
-
Natural products in cancer chemotherapy, past, present and future [J]
-
Mann J, Natural products in cancer chemotherapy, past, present and future [J]. Nat Rew Cancer, 2002, 2, 143-148.
-
(2002)
Nat Rew Cancer
, vol.2
, pp. 143-148
-
-
Mann, J.1
-
49
-
-
0035135713
-
Marine btoprospecting-trawling for treasure and pleasure [J]
-
Capon R J. Marine btoprospecting-trawling for treasure and pleasure [J]. Eur J Org Chem, 2001, 4, 633-645.
-
(2001)
Eur J Org Chem
, vol.4
, pp. 633-645
-
-
Capon, R.J.1
-
50
-
-
34547265045
-
Properties and architecture of drugs and natural products revisited [J]
-
Grabowski K, Schneider G. Properties and architecture of drugs and natural products revisited [J]. Curr Chem Biol, 2007, 1: 115-127.
-
(2007)
Curr Chem Biol
, vol.1
, pp. 115-127
-
-
Grabowski, K.1
Schneider, G.2
-
51
-
-
35349020474
-
Natural product drug discovery, the times have never been better [J]
-
Galm U, Shen B. Natural product drug discovery, the times have never been better [J]. Chem Biol, 2007, 14: 1098-1104.
-
(2007)
Chem Biol
, vol.14
, pp. 1098-1104
-
-
Galm, U.1
Shen, B.2
-
52
-
-
27144547510
-
The renaissance of natural products as drug candidates [J]
-
Paterson I, Anderson F A. The renaissance of natural products as drug candidates [J]. Science, 2005, 310: 451-453.
-
(2005)
Science
, vol.310
, pp. 451-453
-
-
Paterson, I.1
Anderson, F.A.2
-
53
-
-
34249811180
-
New aspects of natural products in drug discovery [J]
-
Lam K S, New aspects of natural products in drug discovery [J]. Trends Microbiol, 2007, 15: 279-289.
-
(2007)
Trends Microbiol
, vol.15
, pp. 279-289
-
-
Lam, K.S.1
-
54
-
-
3042617137
-
Advanced preclinical and clinical trials of natural products and related compounds from marine sources [J]
-
Newman D J, Cragg G M. Advanced preclinical and clinical trials of natural products and related compounds from marine sources [J]. Curr Med Chem, 2004, 11: 1693-1713.
-
(2004)
Curr Med Chem
, vol.11
, pp. 1693-1713
-
-
Newman, D.J.1
Cragg, G.M.2
-
55
-
-
33645816334
-
The role of pharmacognosy in modern medicine and pharmacy [J]
-
Jones W P, Chin Y W, Kinghorn A D. The role of pharmacognosy in modern medicine and pharmacy [J]. Curr Drug Targets, 2006, 7: 247-264.
-
(2006)
Curr Drug Targets
, vol.7
, pp. 247-264
-
-
Jones, W.P.1
Chin, Y.W.2
Kinghorn, A.D.3
-
56
-
-
38549100141
-
Natural products, chemical instruments to apprehend biological symphony [J]
-
Pucheault M. Natural products, chemical instruments to apprehend biological symphony [J]. Org Biomol Chem, 2008, 6: 424-432.
-
(2008)
Org Biomol Chem
, vol.6
, pp. 424-432
-
-
Pucheault, M.1
-
57
-
-
37549071045
-
Drug discovery beyond the 'rule-of-five' [J]
-
Zhang M Q, Wilkinson B. Drug discovery beyond the 'rule-of-five' [J]. Curr Opin Biotechnol, 2007, 18: 478-488.
-
(2007)
Curr Opin Biotechnol
, vol.18
, pp. 478-488
-
-
Zhang, M.Q.1
Wilkinson, B.2
-
58
-
-
78650740978
-
-
Chinese source
-
-
-
-
59
-
-
78650756417
-
-
Chinese source
-
-
-
-
60
-
-
34347388239
-
Biological screening of natural products and drug innovation in China [J]
-
Wang M W, Hao X J, Chen K X. Biological screening of natural products and drug innovation in China [J]. Phil Trans R Soc B, 2007, 362, 1093-1105.
-
(2007)
Phil Trans R Soc B
, vol.362
, pp. 1093-1105
-
-
Wang, M.W.1
Hao, X.J.2
Chen, K.X.3
|