Characterization of lymphocyte subsets in patients with common variable immunodeficiency reveals subsets of naive human B cells marked by CD24 expression

Journal of Immunology

Volumn 185, Issue 11, 2010, Pages 6431-6438

  Vlková, Marcela ^a   Froňková, Eva ^b   Kanderová, Veronika ^b   Janda, Aleš ^b   Růžičková, Šárka ^c   Litzman, Jiří ^a   Šediva, Anna ^b   Kalina, Tomáš ^b  

^a MASARYK UNIVERSITY   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF BIOTECHNOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CD24 ANTIGEN; CD27 ANTIGEN; CD38 ANTIGEN; IMMUNOGLOBULIN M;

ADOLESCENT; ADULT; AGED; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL ACTIVITY; CELL DIVISION; CHILD; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; OVARY FOLLICLE CELL; PHENOTYPE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD24; B-LYMPHOCYTE SUBSETS; CELL DIFFERENTIATION; CELL PROLIFERATION; CHILD; COMMON VARIABLE IMMUNODEFICIENCY; FEMALE; G0 PHASE; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PHENOTYPE; YOUNG ADULT;

EID: 78650661461     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903876     Document Type: Article

References (34)

1. Cunningham-Rundles, C., and C. Bodian. 1999. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin. Immunol. 92:34-48.
2. Chapel, H., M. Lucas, M. Lee, J. Bjorkander, D. Webster, B. Grimbacher, C. Fieschi, V. Thon, M. R. Abedi, and L. Hammarstrom. 2008. Common variable immunodeficiency disorders: division into distinct clinical phenotypes. Blood 112:277-286.
3. North, M. E., A. D. Webster, and J. Farrant. 1998. Primary defect in CD8+ lymphocytes in the antibody deficiency disease (common variable immunodeficiency): abnormalities in intracellular production of interferon-gamma (IFN-gamma) in CD28+ ('cytotoxic') and CD28-('suppressor') CD8+ subsets. Clin. Exp. Immunol. 111:70-75.
4. Thon, V., H. M. Wolf, M. Sasgary, J. Litzman, A. Samstag, I. Hauber, J. Lokaj, and M. M. Eibl. 1997. Defective integration of activating signals derived from the T cell receptor (TCR) and costimulatory molecules in both CD4+ and CD8+ T lymphocytes of common variable immunodeficiency (CVID) patients. Clin. Exp. Immunol. 110:174-181.
5. Vlková, M., V. Thon, M. Sárfyová, L. Bláha, A. Svobodník, J. Lokaj, and J. Litzman. 2006. Age dependency and mutual relations in T and B lymphocyte abnormalities in common variable immunodeficiency patients. Clin. Exp. Immunol. 143:373-379.
6. Ferrer, J. M., J. Iglesias, M. Hernández, and N. Matamoros. 1995. Alterations in interleukin secretion (IL-2 and IL-4) by CD4 and CD4 CD45RO cells from common variable immunodeficiency (CVI) patients. Clin. Exp. Immunol. 102:286-289.
7. Piqueras, B., C. Lavenu-Bombled, L. Galicier, F. Bergeron-van der Cruyssen, L. Mouthon, S. Chevret, P. Debré, C. Schmitt, and E. Oksenhendler. 2003. Common variable immunodeficiency patient classification based on impaired B cell memory differentiation correlates with clinical aspects. J. Clin. Immunol. 23:385-400.
8. Park, M. A., J. T. Li, J. B. Hagan, D. E. Maddox, and R. S. Abraham. 2008. Common variable immunodeficiency: a new look at an old disease. Lancet 372:489-502.
9. Brouet, J. C., A. Chedeville, J. P. Fermand, and B. Royer. 2000. Study of the B cell memory compartment in common variable immunodeficiency. Eur. J. Immunol. 30:2516-2520.
10. Agematsu, K., T. Futatani, S. Hokibara, N. Kobayashi, M. Takamoto, S. Tsukada, H. Suzuki, S. Koyasu, T. Miyawaki, K. Sugane, et al. 2002. Absence of memory B cells in patients with common variable immunodeficiency. Clin. Immunol. 103:34-42.
11. Warnatz, K., C. Wehr, R. Dräger, S. Schmidt, H. Eibel, M. Schlesier, and H. H. Peter. 2002. Expansion of CD19 (hi) CD21 (lo/neg) B cells in common variable immunodeficiency (CVID) patients with autoimmune cytopenia. Immunobiology 206:502-513.
12. Moratto, D., A. V. Gulino, S. Fontana, L. Mori, S. Pirovano, A. Soresina, A. Meini, L. Imberti, L. D. Notarangelo, A. Plebani, and R. Badolato. 2006. Combined decrease of defined B and T cell subsets in a group of common variable immunodeficiency patients. Clin. Immunol. 121:203-214.
13. Taubenheim, N., M. von Hornung, A. Durandy, K. Warnatz, L. Corcoran, H. H. Peter, and H. Eibel. 2005. Defined blocks in terminal plasma cell differentiation of common variable immunodeficiency patients. J. Immunol. 175:5498-5503.
14. Thon, V., H. Eggenbauer, H. M. Wolf, M. B. Fischer, J. Litzman, J. Lokaj, and M. M. Eibl. 1997. Antigen presentation by common variable immunodeficiency (CVID) B cells and monocytes is unimpaired. Clin. Exp. Immunol. 108:1-8.
15. Cambronero, R., W. A. Sewell, M. E. North, A. D. Webster, and J. Farrant. 2000. Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency. J. Immunol. 164:488-494.
16. Bayry, J., S. Lacroix-Desmazes, M. D. Kazatchkine, L. Galicier, Y. Lepelletier, D. Webster, Y. Lévy, M. M. Eibl, E. Oksenhendler, O. Hermine, and S. V. Kaveri. 2004. Common variable immunodeficiency is associated with defective functions of dendritic cells. Blood 104:2441-2443.
17. Loder, F., B. Mutschler, R. J. Ray, C. J. Paige, P. Sideras, R. Torres, M. C. Lamers, and R. Carsetti. 1999. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190:75-89.
18. Klein, U., K. Rajewsky, and R. Küppers. 1998. Human immunoglobulin (Ig) M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188:1679-1689.
19. Warnatz, K., A. Denz, R. Dräger, M. Braun, C. Groth, G. Wolff-Vorbeck, H. Eibel, M. Schlesier, and H. H. Peter. 2002. Severe deficiency of switched memory B cells (CD27 (+) IgM (-) IgD (-)) in subgroups of patients with common variable immunodeficiency: a new approach to classify a heterogeneous disease. Blood 99:1544-1551.
20. Wehr, C., T. Kivioja, C. Schmitt, B. Ferry, T. Witte, E. Eren, M. Vlkova, M. Hernandez, D. Detkova, P. R. Bos, et al. 2008. The EUROclass trial: defining subgroups in common variable immunodeficiency. Blood 111:77-85.
21. Wehr, C., H. Eibel, M. Masilamani, H. Illges, M. Schlesier, H. H. Peter, and K. Warnatz. 2004. A new CD21low B cell population in the peripheral blood of patients with SLE. Clin. Immunol. 113:161-171.
22. Moir, S., J. Ho, A. Malaspina, W. Wang, A. C. DiPoto, M. A. O'Shea, G. Roby, S. Kottilil, J. Arthos, M. A. Proschan, et al. 2008. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J. Exp. Med. 205:1797-1805.
23. Rakhmanov, M., B. Keller, S. Gutenberger, C. Foerster, M. Hoenig, G. Driessen, M. van der Burg, J. J. van Dongen, E. Wiech, M. Visentini, et al. 2009. Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells. Proc. Natl. Acad. Sci. USA 106:13451-13456.
24. Cuss, A. K., D. T. Avery, J. L. Cannons, L. J. Yu, K. E. Nichols, P. J. Shaw, and S. G. Tangye. 2006. Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity. J. Immunol. 176:1506-1516.
25. Cariappa, A., C. Boboila, S. T. Moran, H. Liu, H. N. Shi, and S. Pillai. 2007. The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations. J. Immunol. 179:2270-2281.
26. Carey, J. B., C. S. Moffatt-Blue, L. C. Watson, A. L. Gavin, and A. J. Feeney. 2008. Repertoire-based selection into the marginal zone compartment during B cell development. J. Exp. Med. 205:2043-2052.
27. van Zelm, M. C., T. Szczepanski, M. van der Burg, and J. J. van Dongen. 2007. Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion. J. Exp. Med. 204:645-655.
28. Kalina, T., J. Stuchlý, A. Janda, O. Hrusák, S. Růzicková, A. Sedivá, J. Litzman, and M. Vlková. 2009. Profiling of polychromatic flow cytometry data on B-cells reveals patients' clusters in common variable immunodeficiency. Cytometry A 75:902-909.
29. Viau, M., B. Cholley, L. Björck, and M. Zouali. 2004. Down-modulation of the antigen receptor by a superantigen for human B cells. Immunol. Lett. 92:91-96.
30. Galibert, L., N. Burdin, B. de Saint-Vis, P. Garrone, C. Van Kooten, J. Banchereau, and F. Rousset. 1996. CD40 and B cell antigen receptor dual triggering of resting B lymphocytes turns on a partial germinal center phenotype. J. Exp. Med. 183:77-85.
31. Pillai, S., and A. Cariappa. 2009. The follicular versus marginal zone B lymphocyte cell fate decision. Nat. Rev. Immunol. 9:767-777.
32. Liu, Y., G. Y. Chen, and P. Zheng. 2009. CD24-Siglec G/10 discriminates danger-from pathogen-associated molecular patterns. Trends Immunol. 30:557-561.
33. Groth, C., R. Drager, K. Warnatz, G. Wolff-Vorbeck, S. Schmidt, H. Eibel, M. Schlesier, and H. H. Peter. 2002. Impaired up-regulation of CD70 and CD86 in naive (CD27-) B cells from patients with common variable immunodeficiency (CVID). Clin. Exp. Immunol. 129:133-139.
34. Carroll, M. C. 1998. CD21/CD35 in B cell activation. Semin. Immunol. 10:279-286.