Molecular investigation of resistance to the antituberculous drug ethionamide in multidrug-resistant clinical isolates of Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 1, 2011, Pages 355-360

  Brossier, F ^a,b   Veziris, N ^a,b   Truffot Pernot, C ^b   Jarlier, V ^a,b   Sougakoff, W ^a,b,c  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ETHIONAMIDE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; DNA SEQUENCE; ETHA BACTERIAL GENE; ETHR BACTERIAL GENE; GENE MUTATION; INHA BACTERIAL GENE; KATG BACTERIAL GENE; MSHA BACTERIAL GENE; MYCOBACTERIUM TUBERCULOSIS; NDH BACTERIAL GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION;

ANTITUBERCULAR AGENTS; ETHIONAMIDE; HUMANS; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 78650654727     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01030-10     Document Type: Article

References (33)

1. Argyrou, A., M. W. Vetting, B. Aladegbami, and J. S. Blanchard. 2006. Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid. Nat. Struct. Mol. Biol. 13:408-413. (Pubitemid 43881580)
2. Banerjee, A., E. Dubnau, A. Quemard, V. Balasubramanian, K. S. Um, T. Wilson, D. Collins, G. de Lisle, and W. R. Jacobs Jr. 1994. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science 263:227-230.
3. Baulard, A. R., J. C. Betts, J. Engohang-Ndong, S. Quan, R. A. McAdam, P. J. Brennan, C. Locht, and G. S. Besra. 2000. Activation of the pro-drug ethionamide is regulated in mycobacteria. J. Biol. Chem. 275:28326-28331.
4. Boonaiam, S., A. Chaiprasert, T. Prammananan, and M. Leechawengwongs. 2010. Genotypic analysis of genes associated with isoniazid and ethionamide resistance in MDR-TB isolates from Thailand. Clin. Microbiol. Infect. 16: 396-399.
5. Brossier, F., N. Veziris, C. Truffot-Pernot, V. Jarlier, and W. Sougakoff. 2006. Performance of the Genotype MTBDR line probe assay for detection of resistance to rifampin and isoniazid in strains of Mycobacterium tuberculosis with low-and high-level resistance. J. Clin. Microbiol. 44:3659-3664.
6. Canetti, G. 1965. Present aspects of bacterial resistance in tuberculosis. Am. Rev. Respir. Dis. 92:687-703.
7. Canetti, G., B. Kreis, R. Thibier, P. Gay, and M. Le Lirzin. 1967. Current data on primary resistance in pulmonary tuberculosis in adults in France. 2d survey of the Centre d'Etudes sur la Resistance Primaire: 1965-1966. Rev. Tuberc. Pneumol. (Paris) 31:433-474. (In French.)
8. Canetti, G., N. Rist, and J. Grosset. 1963. Measurement of sensitivity of the tuberculous bacillus to antibacillary drugs by the method of proportions. Methodology, resistance criteria, results and interpretation. Rev. Tuberc. Pneumol. (Paris) 27:217-272. (In French.)
9. Cardoso, R. F., M. A. Cardoso, C. Q. Leite, D. N. Sato, E. M. Mamizuka, R. D. Hirata, F. F. de Mello, and M. H. Hirata. 2007. Characterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazil. Mem. Inst. Oswaldo Cruz 102:59-61.
10. DeBarber, A. E., K. Mdluli, M. Bosman, L. G. Bekker, and C. E. Barry III. 2000. Ethionamide activation and sensitivity in multidrug-resistant Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 97:9677-9682.
11. Engohang-Ndong, J., D. Baillat, M. Aumercier, F. Bellefontaine, G. S. Besra, C. Locht, and A. R. Baulard. 2004. EthR, a repressor of the TetR/CamR family implicated in ethionamide resistance in mycobacteria, octamerizes cooperatively on its operator. Mol. Microbiol. 51:175-188.
12. Frénois, F., A. R. Baulard, and V. Villeret. 2006. Insights into mechanisms of induction and ligands recognition in the transcriptional repressor EthR from Mycobacterium tuberculosis. Tuberculosis (Edinb.) 86:110-114.
13. Guo, H., Q. Seet, S. Denkin, L. Parsons, and Y. Zhang. 2006. Molecular characterization of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis from the USA. J. Med. Microbiol. 55:1527-1531.
14. Hazbón, M. H., M. Brimacombe, M. Bobadilla del Valle, M. Cavatore, M. I. Guerrero, M. Varma-Basil, H. Billman-Jacobe, C. Lavender, J. Fyfe, L. García-García, C. I. León, M. Bose, F. Chaves, M. Murray, K. D. Eisenach, J. Sifuentes-Osornio, M. D. Cave, A. Ponce de León, and D. Alland. 2006. Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 50:2640-2649.
15. Ho, Y. M., Y. J. Sun, S. Y. Wong, and A. S. Lee. 2009. Contribution of dfrA and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates. Antimicrob. Agents Chemother. 53:4010-4012.
16. Larsen, M. H., C. Vilchèze, L. Kremer, G. S. Besra, L. Parsons, M. Salfinger, L. Heifets, M. H. Hazbon, D. Alland, J. C. Sacchettini, and W. R. Jacobs, Jr. 2002. Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis. Mol. Microbiol. 46:453-466.
17. Lee, H., S. N. Cho, H. E. Bang, J. H. Lee, G. H. Bai, S. J. Kim, and J. D. Kim. 2000. Exclusive mutations related to isoniazid and ethionamide resistance among Mycobacterium tuberculosis isolates from Korea. Int. J. Tuber. Lung Dis. 4:441-447.
18. Lee, A. S., A. S. Teo, and S. Y. Wong. 2001. Novel mutations in ndh in isoniazid-resistant Mycobacterium tuberculosis isolates. Antimicrob. Agents Chemother. 45:2157-2159.
19. Marrakchi, H., G. Lanéelle, and A. Quémard. 2000. InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II. Microbiology 146:289-296.
20. Miesel, L., T. R. Weisbrod, J. A. Marcinkeviciene, R. Bittman, and W. R. Jacobs, Jr. 1998. NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis. J. Bacteriol. 180:2459-2467.
21. Morlock, G. P., B. Metchock, D. Sikes, J. T. Crawford, and R. C. Cooksey. 2003. ethA, inhA, and katG loci of ethionamide-resistant clinical Mycobacterium tuberculosis isolates. Antimicrob. Agents Chemother. 47:3799-3805.
22. Juréen, P., J. Werngren, J. C. Toro, and S. Hoffner. 2008. Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 52:1852-1854.
23. Ramaswamy, S. V., R. Reich, S. J. Dou, L. Jasperse, X. Pan, A. Wanger, T. Quitugua, and E. A. Graviss. 2003. Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 47:1241-1250.
24. Schaaf, H. S., T. C. Victor, A. Venter, W. Brittle, A. M. Jordaan, A. C. Hesseling, B. J. Marais, P. D. van Helden, and P. R. Donald. 2009. Ethionamide cross-and co-resistance in children with isoniazid-resistant tuberculosis. Int. J. Tuber. Lung Dis. 13:1355-1359.
25. Tahaoǧlu, K., T. Törün, T. Sevim, G. Ataç, A. Kir, L. Karasulu, I. Ozmen, and N. Kapakli. 2001. The treatment of multidrug-resistant tuberculosis in Turkey. N. Engl. J. Med. 345:170-174.
26. van Ingen, J., S. Simons, R. de Zwaan, T. van der Laan, M. Kamst-van Agterveld, M. J. Boeree, and D. van Soolingen. 2010. Comparative study on genotypic and phenotypic second-line drug resistance testing of Mycobacterium tuberculosis complex isolates. J. Clin. Microbiol. 48:2749-2753.
27. Vannelli, T. A., A. Dykman, and P. R. Ortiz de Montellano. 2002. The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J. Biol. Chem. 277:12824-12829.
28. Vilchèze, C., Y. Av-Gay, R. Attarian, Z. Liu, M. H. Hazbón, R. Colangeli, B. Chen, W. Liu, D. Alland, J. C. Sacchettini, and W. R. Jacobs, Jr. 2008. Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis. Mol. Microbiol. 69:1316-1329.
29. Vilchèze, C., F. Wang, M. Arai, M. H. Hazbón, R. Colangeli, L. Kremer, T. R. Weisbrod, D. Alland, J. C. Sacchettini, and W. R. Jacobs, Jr. 2006. Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat. Med. 12:1027-1029.
30. + ratio mediates coresistance to isoniazid and ethionamide in mycobacteria. Antimicrob. Agents Chemother. 49:708-720.
31. World Health Organization. 2001. Guidelines for drug susceptibility testing for second-line anti-tuberculosis drugs for DOTS-Plus. WHO/CDS/TB/ 2001.288. World Health Organization, Geneva, Switzerland.
32. World Health Organization. 2008. Guidelines for the programmatic management of drug-resistant tuberculosis. Emergency update 2008. WHO/HTM/2008.402. World Health Organization, Geneva, Switzerland.
33. Zhang, Y., B. Heym, B. Allen, D. Young, and S. Cole. 1992. The catalaseperoxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature 358:591-593