Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 5, 2008, Pages 1852-1854

  Juréen, Pontus ^a,b,c   Werngren, Jim ^a   Toro, Juan Carlos ^a   Hoffner, Sven ^a  

^a SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c NONE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BACTERIAL PROTEIN; BIOLOGICAL MARKER; NUCLEOTIDE;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; FRAMESHIFT MUTATION; GENE DELETION; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; MULTIDRUG RESISTANCE; MUTATIONAL ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PNCA GENE; PRIORITY JOURNAL;

AMIDOHYDROLASES; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; DNA MUTATIONAL ANALYSIS; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PYRAZINAMIDE; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 42949150821     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00110-08     Document Type: Article

References (23)

1. Aragon, L. M., M. Garrigo, C. Moreno, M. Espanol, and P. Coll. 2007. Evaluation of the BacT/ALERT PZA kit in comparison with the BACTEC 460TB PZA for testing Mycobacterium tuberculosis susceptibility to pyrazinamide. J. Antimicrob. Chemother. 60:655-657.
2. Barco, P., R. F. Cardoso, R. D. Hirata, C. Q. Leite, J. R. Pandolfi, D. N. Sato, M. L. Shikama, F. F. de Melo, E. M. Mamizuka, P. A. Campanerut, and M. H. Hirata. 2006. pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates from the southeast region of Brazil. J. Antimicrob. Chemother. 58:930-935.
3. Bemer, P., T. Bodmer, J. Munzinger, M. Perrin, V. Vincent, and H. Drugeon. 2004. Multicenter evaluation of the MB/BACT system for susceptibility testing of Mycobacterium tuberculosis. J. Clin. Microbiol. 42:1030-1034.
4. Cheng, S. J., L. Thibert, T. Sanchez, L. Heifets, and Y. Zhang. 2000. pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada. Antimicrob. Agents Chemother. 44:528-532.
5. Dormandy, J., A. Somoskovi, B. N. Kreiswirth, J. R. Driscoll, D. Ashkin, and M. Salfinger. 2007. Discrepant results between pyrazinamide susceptibility testing by the reference BACTEC 460TB method and pncA DNA sequencing in patients infected with multidrug-resistant W-Beijing Mycobacterium tuberculosis strains. Chest 131:497-501.
6. Hirano, K., M. Takahashi, Y. Kazumi, Y. Fukasawa, and C. Abe. 1997. Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis. Tuber. Lung Dis. 78:117-122.
7. Hou, L., D. Osei-Hyiaman, Z. Zhang, B. Wang, A. Yang, and K. Kano. 2000. Molecular characterization of pncA gene mutations in Mycobacterium tuberculosis clinical isolates from China. Epidemiol. Infect. 124:227-232.
8. Kruuner, A., M. D. Yates, and F. A. Drobniewski. 2006. Evaluation of MGIT 960-based antimicrobial testing and determination of critical concentrations of first- and second-line antimicrobial drugs with drug-resistant clinical strains of Mycobacterium tuberculosis. J. Clin. Microbiol. 44:811-818.
9. Lee, K. W., J. M. Lee, and K. S. Jung. 2001. Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Korea. J. Korean Med. Sci. 16:537-543.
10. Lemaitre, N., W. Sougakoff, C. Truffot-Pernot, and V. Jarlier. 1999. Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA. Antimicrob. Agents Chemother. 43:1761-1763.
11. Martin, A., A. Cubillos-Ruiz, A. Von Groll, P. Del Portillo, F. Portaels, and J. C. Palomino. 2008. Nitrate reductase assay for the rapid detection of pyrazinamide resistance in Mycobacterium tuberculosis using nicotinamide. J. Antimicrob. Chemother. 61:123-127.
12. Marttila, H. J., M. Marjamaki, E. Vyshnevskaya, B. I. Vyshnevskiy, T. F. Otten, A. V. Vasilyef, and M. K. Viljanen. 1999. pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia. Antimicrob. Agents Chemother. 43:1764-1766.
13. Mestdagh, M., P. A. Fonteyne, L. Realini, R. Rossau, G. Jannes, W. Mijs, K. A. De Smet, F. Portaels, and E. Van den Eeckhout. 1999. Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 43:2317-2319.
14. O'Sullivan, D. M., T. D. McHugh, and S. H. Gillespie. 2005. Analysis of rpoB and pncA mutations in the published literature: an insight into the role of oxidative stress in Mycobacterium tuberculosis evolution? J. Antimicrob. Chemother. 55:674-679.
15. Rodrigues Vde, F., M. A. Telles, M. O. Ribeiro, P. I. Cafrune, M. L. Rossetti, and A. Zaha. 2005. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil. Antimicrob. Agents Chemother. 49:444-446.
16. Sachais, B. S., I. I. Nachamkindagger, J. K. Mills, and D. G. Leonard. 1998. Novel pncA mutations in pyrazinamide-resistant isolates of Mycobacterium tuberculosis. Mol. Diagn. 3:229-231.
17. Scarparo, C., P. Ricordi, G. Ruggiero, and P. Piccoli. 2004. Evaluation of the fully automated BACTEC MGIT 960 system for testing susceptibility of Mycobacterium tuberculosis to pyrazinamide, streptomycin, isoniazid, rifampin, and ethambutol and comparison with the radiometric BACTEC 460TB method. J. Clin. Microbiol. 42:1109-1114.
18. Scorpio, A., P. Lindholm-Levy, L. Heifets, R. Gilman, S. Siddiqi, M. Cynamon, and V. Zhang. 1997. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 41:540-543.
19. Scorpio, A., and Y. Zhang. 1996. Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus. Nat. Med. 2:662-667.
20. Sreevatsan, S., X. Pan, Y. Zhang, B. N. Kreiswirth, and J. M. Musser. 1997. Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms. Antimicrob. Agents Chemother. 41: 636-640.
21. Zhang, H., J. Y. Deng, L. J. Bi, Y. F. Zhou, Z. P. Zhang, C. G. Zhang, Y. Zhang, and X. E. Zhang. 2008. Characterization of Mycobacterium tuberculosis nicotinamidase/pyrazinamidase. FEBS J. 275:753-762.
22. Zhang, Y., and D. Mitchison. 2003. The curious characteristics of pyrazinamide: a review. Int. J. Tuberc. Lung Dis. 7:6-21.
23. Zhang, Y., S. Permar, and Z. Sun. 2002. Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide. J. Med. Microbiol. 51:42-49.