Cortical activation during clock reading as a quadratic function of dementia state

Journal of Alzheimer's Disease

Volumn 22, Issue 1, 2010, Pages 267-284

  Saur, Ralf ^a,b   Milian, Monika ^a   Erb, Michael ^b   Eschweiler, Gerhard W ^a   Grodd, Wolfgang ^b   Leyhe, Thomas ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Alzheimer's disease; clock test; correlation analysis; functional magnetic resonance imaging; mild cognitive impairment

Indexed keywords

AGED; ARTICLE; BOLD SIGNAL; BRAIN CORTEX; BRAIN FUNCTION; BRAIN REGION; CLINICAL ARTICLE; CLOCK READING TASK; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; CUNEUS; DEMENTIA; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUSIFORM GYRUS; HUMAN; INFERIOR FRONTAL GYRUS; INFERIOR TEMPORAL GYRUS; LINGUAL GYRUS; MALE; MENTAL TASK; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROIMAGING; NEUROMODULATION; OCCIPITAL GYRUS; PRECUNEUS; PRIORITY JOURNAL; READING; SPATIAL CONTROL TASK;

EID: 78650648942     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-091390     Document Type: Article

References (76)

1. Petersen RC, Negash S (2008) Mild cognitive impairment: an overview. CNSSpectr 13, 45-53.
2. Amieva H, Le Goff M, Millet X, Orgogozo JM, Peres K, Barberger-Gateau P, Jacqmin-Gadda H, Dartigues JF (2008) Prodromal Alzheimer's disease: successive emergence of the clinical symptoms. Ann Neurol 64, 492-498.
3. Dickerson BC (2007) Advances in functional magnetic resonance imaging: technology and clinical applications. Neu-rotherapeutics 4, 360-370.
4. Vannini P, Almkvist O, Franck A, Jonsson T, Volpe U, Kristoffersen Wiberg M, Wahlund LO, Dierks T (2004) Task demand modulations of visuospatial processing measured with functional magnetic resonance imaging. Neuroimage 21, 58-68.
5. Dickerson BC, Sperling RA (2008) Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies. Neuropsychologia 46, 1624-1635.
6. Machulda MM, Ward HA, Borowski B, Gunter JL, Cha RH, O'Brien PC, Petersen RC, Boeve BF, Knopman D, Tang-Wai DF, Ivnik RJ, Smith GE, Tangalos EG, Jack CR, Jr. (2003) Comparison of memory fMRI response among normal, MCI, and Alzheimer's patients. Neurology 61, 500-506.
7. Small SA, Perera GM, DeLaPaz R, Mayeux R, Stern Y (1999) Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer's disease. Ann Neurol 45, 466-472.
8. Sperling R (2007) Functional MRI studies of associative encoding in normal aging, mild cognitive impairment, and Alzheimer's disease. Ann NY Acad Sci 1097, 146-155.
9. Vannini P, Lehmann C, Dierks T, Jann K, Viitanen M, Wahlund LO, Almkvist O (2008) Failure to modulate neural response to increased task demand in mild Alzheimer's disease: fMRI study of visuospatial processing. Neurobiol Dis 31, 287-297.
10. Petrella JR, Wang L, Krishnan S, Slavin MJ, Prince SE, Tran TT, Doraiswamy PM (2007) Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging. Radiology 245, 224-235. (Pubitemid 47417806)
11. Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA (2006) Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. JNeurosci 26, 10222-10231.
12. Dickerson BC, Salat DH, Bates JF, Atiya M, Killiany RJ, Greve DN, Dale AM, Stern CE, Blacker D, Albert MS, Sperling RA (2004) Medial temporal lobe function and structure in mild cognitive impairment. Ann Neurol 56, 27-35.
13. Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA (2005) Increased hip-pocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology 65, 404-411.
14. Hamalainen A, Pihlajamaki M, Tanila H, Hanninen T, Niska-nen E, Tervo S, Karjalainen PA, Vanninen RL, Soininen H (2007) Increased fMRI responses during encoding in mild cognitive impairment. Neurobiol Aging 28, 1889-1903.
15. Gronholm P, Rinne JO, Vorobyev VA, Laine M (2007) Neural correlates of naming newly learned objects in MCI. Neuropsychologia 45, 2355-2368.
16. Kircher TT, Weis S, Freymann K, Erb M, Jessen F, Grodd W, Heun R, Leube DT (2007) Hippocampal activation in patients with mild cognitive impairment is necessary for successful memory encoding. J Neurol Neurosurg Psychiatry 78, 812-818.
17. Miller SL, Fenstermacher E, Bates J, Blacker D, Sperling RA, Dickerson BC (2008) Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. J Neurol Neurosurg Psychiatry 79, 630-635.
18. Rouleau I, Salmon DP, Butters N (1996) Longitudinal analysis of clock drawing in Alzheimer's disease patients. Brain Cogn 31, 17-34.
19. Shulman KI (2000) Clock-drawing: is it the ideal cognitive screening test? Int J Geriatr Psychiatry 15, 548-561.
20. Shulman KI, Shedletsky P, Silver IJ (1986) The challenge of time: Clock-drawing and cognitive function in elderly. Int J Geriatr Psych 1, 135-140.
21. O'Rourke N, Tuokko H, Hayden S, Lynn Beattie B (1997) Early identification of dementia: predictive validity of the clock test. Arch Clin Neuropsychol 12, 257-267.
22. Schmidtke K, Olbrich S (2007) The Clock Reading Test: validation of an instrument for the diagnosis of dementia and disorders of visuo-spatial cognition. Int Psychogeriatr 19, 307321.
23. Tuokko H, Hadjistavropoulos T, Miller JA, Beattie BL (1992) The Clock Test: a sensitive measure to differentiate normal elderly from those with Alzheimer disease. J Am Geriatr Soc 40, 579-584.
24. Kleist K (1912) Der Gang und der gegenwartige Stand der Apraxieforschung. Neurologie und Psychiatrie 1, 342-352.
25. Mendez MF, Ala T, Underwood KL (1992) Development of scoring criteria for the clock drawing task in Alzheimer's disease. J Am Geriatr Soc 40, 1095-1099.
26. Sunderland T, Hill JL, Mellow AM, Lawlor BA, Gunder-sheimer J, Newhouse PA, Grafman JH (1989) Clock drawing in Alzheimer's disease. A novel measure of dementia severity. J Am Geriatr Soc 37, 725-729.
27. Juby A, Tench S, Baker V (2002) The value of clock drawing in identifying executive cognitive dysfunction in people with a normal Mini-Mental State Examination score. Cmaj 167, 859-864.
28. Libon DJ, Swenson RA, Barnoski EJ, Sands LP (1993) Clock drawing as an assessment tool for dementia. Arch Clin Neuropsychol 8, 405-415.
29. Royall DR, Cordes JA, Polk M (1998) CLOX: an executive clock drawing task. J Neurol Neurosurg Psychiatry 64, 588594.
30. Cahn-Weiner DA, Sullivan EV, Shear PK, Fama R, Lim KO, Yesavage JA, Tinklenberg JR, Pfefferbaum A (1999) Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease. J Int Neuropsychol Soc 5, 502509.
31. Leyhe T, Milian M, Muller S, Eschweiler GW, Saur R (2009) The minute hand phenomenon in the Clock Test of patients with early Alzheimer disease. J Geriatr Psychiatry Neurol 22, 119-129.
32. Leyhe T, Saur R, Eschweiler GW, Milian M (2009) Clock Test Deficits Are Associated With Semantic Memory Impairment in Alzheimer Disease. J Geriatr Psychiatry Neurol 22, 24642469.
33. Leyhe T, Erb M, Milian M, Eschweiler GW, Ethofer T, Grodd W, Saur R (2009) Changes in cortical activation during retrieval of clock time representations in patients with mild cognitive impairment and early Alzheimer's disease. Dement Geriatr Cogn Disord 27, 117-132.
34. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. JPsychiatr Res 12, 189-198.
35. Ashford JW (2008) Screening for memory disorders, dementia and Alzheimer's disease. Aging Health 4, 399-432.
36. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C (1989) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39, 1159-1165.
37. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56, 303-308. (Pubitemid 29120227)
38. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th edn., APA Press, Washington DC.
39. World Health Organization (1992) Tenth revision of the International Classification of Diseases. Chapter 5 (F): Mental and behavioural disorders (including disorders of psychological development). Clinical Descriptions and Diagnostic Guidelines, Geneva.
40. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
41. Reisberg B, Ferris SH, de Leon MJ, Crook T (1988) Global Deterioration Scale (GDS). Psychopharmacol Bull 24, 661663.
42. Akaike H (1974) A new look at the statistical model identification. IEEE TAutomat Contr 19, 716-723.
43. Genovese CR, Lazar NA, Nichols T (2002) Thresholding of statistical maps in functional neuroimaging using the false discovery rate. Neuroimage 15, 870-878.
44. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15, 273-289.
45. Milner AD, Goodale MA (2008) Two visual systems reviewed. Neuropsychologia 46, 774-785.
46. Ungerleider LG, Haxby JV (1994) 'What' and 'where' in the human brain. Curr Opin Neurobiol 4, 157-165.
47. Buckner RL, Andrews-Hanna JR, Schacter DL (2008) The brain's default network: anatomy, function, and relevance to disease. Ann NY Acad Sci 1124, 1-38.
48. Gusnard DA, Raichle ME, Raichle ME (2001) Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci 2, 685-694.
49. Martin A (2007) The representation of object concepts in the brain. Annu Rev Psychol 58, 25-45.
50. Thompson-Schill SL (2003) Neuroimaging studies of semantic memory: inferring "how" from "where". Neuropsycholo-gia 41, 280-292.
51. Martin A, Chao LL (2001) Semantic memory and the brain: structure and processes. Curr Opin Neurobiol 11, 194-201.
52. Goebel R, Linden DE, Lanfermann H, Zanella FE, Singer W (1998) Functional imaging of mirror and inverse reading reveals separate coactivated networks for oculomotion and spatial transformations. Neuroreport 9, 713-719.
53. Trojano L, Grossi D, Linden DE, Formisano E, Hacker H, Zanella FE, Goebel R, Di Salle F (2000) Matching two imagined clocks: the functional anatomy of spatial analysis in the absence of visual stimulation. Cereb Cortex 10, 473-481.
54. Cavanna AE, Trimble MR (2006) The precuneus: a review of its functional anatomy and behavioural correlates. Brain 129, 564-583.
55. Gardini S, De Beni R, Cornoldi C, Bromiley A, Venneri AC, Different neuronal pathways support the generation of general and specific mental images. Neuroimage 27, 544-552.
56. Robbins TW (2007) Shifting and stopping: fronto-striatal substrates, neurochemical modulation and clinical implications. Philos Trans R Soc LondB Biol Sci 362, 917-932.
57. Bookheimer S, Burggren A (2009) APOE-4 genotype and neurophysiological vulnerability to Alzheimer's and cognitive aging. Annu Rev Clin Psychol 5, 343-362.
58. Trivedi MA, Wichmann AK, Torgerson BM, Ward MA, Schmitz TW, Ries ML, Koscik RL, Asthana S, Johnson SC (2006) Structural MRI discriminates individuals with Mild Cognitive Impairment from age-matched controls: A combined neuropsychological and voxel based morphometry study. Alzheimers Dement 2, 296-302.
59. Smith CD, Andersen AH, Kryscio RJ, Schmitt FA, Kindy MS, Blonder LX, Avison MJ (1999) Altered brain activation in cognitively intact individuals at high risk for Alzheimer's disease. Neurology 53, 1391-1396.
60. Lind J, Persson J, Ingvar M, Larsson A, Cruts M, Van Broeck-hoven C, Adolfsson R, Backman L, Nilsson LG, Petersson KM, Nyberg L (2006) Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers. Brain 129, 1240-1248.
61. Bassett SS, Yousem DM, Cristinzio C, Kusevic I, Yassa MA, Caffo BS, Zeger SL (2006) Familial risk for Alzheimer's disease alters fMRI activation patterns. Brain 129, 1229-1239.
62. Bondi MW, Houston WS, Eyler LT, Brown GG (2005) fM-RI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease. Neurology 64, 501-508.
63. Bookheimer SY, Strojwas MH, Cohen MS, Saunders AM, Pericak-Vance MA, Mazziotta JC, Small GW (2000) Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med 343, 450-456.
64. Wishart HA, Saykin AJ, Rabin LA, Santulli RB, Flashman LA, Guerin SJ, Mamourian AC, Belloni DR, Rhodes CH, McAllister TW (2006) Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele. Am J Psychiatry 163, 1603-1610.
65. Wermke M, Sorg C, Wohlschlager AM, Drzezga A (2008) A new integrative model of cerebral activation, deactivation and default mode function in Alzheimer's disease. Eur J Nucl Med Mol Imaging 35 Suppl 1, S12-24.
66. Johnson SC, Schmitz TW, Moritz CH, Meyerand ME, Rowley HA, Alexander AL, Hansen KW, Gleason CE, Carlsson CM, Ries ML, Asthana S, Chen K, Reiman EM, Alexander GEE, Activation of brain regions vulnerable to Alzheimer's disease: the effect of mild cognitive impairment. Neurobiol Aging 27, 1604-1612.
67. Ries ML, Schmitz TW, Kawahara TN, Torgerson BM, Trivedi MA, Johnson SC (2006) Task-dependent posterior cingulate activation in mild cognitive impairment. Neuroimage 29, 485-492.
68. Bokde AL, Lopez-Bayo P, Meindl T, Pechler S, Born C, Fal-traco F, Teipel SJ, Moller HJ, Hampel H (2006) Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment. Brain 129, 1113-1124.
69. Wandell BA, Dumoulin SO, Brewer AA (2007) Visual field maps in human cortex. Neuron 56, 366-383.
70. Beckmann M, Johansen-Berg H, Rushworth MF (2009) Connectivity-based parcellation of human cingulate cortex and its relation to functional specialization. J Neurosci 29, 1175-1190.
71. Palop JJ, Chin J, Mucke L (2006) A network dysfunction perspective on neurodegenerative diseases. Nature 443, 768773.
72. Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791.
73. Hildebrandt H, Haldenwanger A, Eling P (2009) False recognition correlates with amyloid-beta (1-42) but not with total tau in cerebrospinal fluid of patients with dementia and mild cognitive impairment. JAlzheimers Dis 16, 157-165.
74. Kojima N, Shirao T (2007) Synaptic dysfunction and disruption of postsynaptic drebrin-actin complex: a study of neurological disorders accompanied by cognitive deficits. Neurosci Res 58, 1-5.
75. Petrella JR, Prince SE, Wang L, Hellegers C, Doraiswamy PM (2007) Prognostic value of posteromedial cortex deactivation in mild cognitive impairment. PLoS One 2, e1104.
76. Ashford JW, Shan M, Butler S, Rajasekar A, Schmitt FA (1995) Temporal quantification of Alzheimer's disease severity: 'time index' model. Dementia 6, 269-280.