Changes in cortical activation during retrieval of clock time representations in patients with mild cognitive impairment and early Alzheimer's disease

Dementia and Geriatric Cognitive Disorders

Volumn 27, Issue 2, 2009, Pages 117-132

  Leyhe, Thomas ^a   Erb, Michael ^b   Milian, Monika ^a   Eschweiler, Gerhard W ^a   Ethofer, Thomas ^a,c   Grodd, Wolfgang ^b   Saur, Ralf ^a,b  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Clock test; Default network; Dementia; Functional magnetic resonance imaging; Left fusiform gyrus; Semantic memory

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; BRAIN MAPPING; BRAIN REGION; CLINICAL ARTICLE; CLOCK DRAWING TEST; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; MILD COGNITIVE IMPAIRMENT; NERVE DEGENERATION; NEUROIMAGING; NEUROPSYCHOLOGICAL TEST; OCCIPITAL LOBE; PARIETAL LOBE; PRIORITY JOURNAL; SEMANTIC MEMORY; SPATIAL MEMORY; TASK PERFORMANCE; TEMPORAL LOBE; TIME PERCEPTION;

AGED; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; CEREBRAL CORTEX; COGNITION DISORDERS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NERVE NET; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; REACTION TIME;

EID: 58949085861     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000197930     Document Type: Article

References (52)

1. Fagan AM, Csernansky CA, Morris JC, Holtzman DM: The search for antecedent biomarkers of Alzheimer's disease. J Alzheimers Dis 2005;8:347-358.
2. Mendez MF, Ala T, Underwood KL: Development of scoring criteria for the clock drawing task in Alzheimer's disease. J Am Geriatr Soc 1992;40:1095-1099.
3. Sunderland T, Hill JL, Mellow AM: Clock drawing in Alzheimer disease: a novel measure of dementia severity. J Am Geriatr Soc 1989;37:725-729.
4. Kleist K: Der Gang und der gegenwärtige Stand der Apraxieforschung. Neurol Psychiatrie 1912;1:342-352.
5. Juby A: Correlation between the Folstein Mini-Mental State Examination and three methods of clock drawing scoring. J Geriatr Psychiatry Neurol 1999;12:87-91.
6. Royall DR, Cordes JA, Polk M: CLOX: an executive clock drawing task. J Neurol Neurosurg Psychiatry 1998;64:588-594.
7. Libon DJ, Swenson R, Barnoski E, Sands LT: Clock drawing as an assessment tool in dementia. Arch Clin Neuropsychol 1993;8:405-415.
8. Cahn-Weiner DA, Sullivan EV, Shear PK, Fama R, Lim Q, Yesavage JA, Trinklenberg JR, Pfefferbaum A: Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease. J Int Neuropsychol Soc 1999;5:502-509.
9. Rouleau I, Salmon DP, Butters N: Longitudinal analysis of clock drawing in Alzheimer's disease patients. Brain Cogn 1996;31:17-34.
10. Tuokko H, Hadjistavropoulus T, Miller JA, Beattie BL: The Clock Test: a sensitive measure to differentiate normal elderly from those with Alzheimer disease. J Am Geriatr Soc 1992;40:579-584.
11. Freedman M, Leach L, Kaplan E, Winocur G, Shulman K, Delis DC: Clock drawing: a neuropsychological analysis. New York, Oxford University Press, 1994.
12. Rouleau I, Salmon DP, Butters N, Kennedy C, McGuire K: Quantitative and qualitative analyses of clock drawings in Alzheimer's and Huntington's disease. Brain Cogn 1992;18:70-87.
13. Shulman KI, Shedletsky P, Silver IJ: The challenge of time: clock-drawing and cognitive function in elderly. Int J Geriatr Psychiatry 1986;1:135-140.
14. Reisberg B, Ferris SH, de Leon MJ, Crook T: The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 1982;139:1136-1139.
15. Leyhe T, Milian M, Müller S, Eschweiler GW, Saur R: The minute hand phenomenon in the Clock Test of patients with early Alzheimer's disease. J Geriatr Psychiatry Neurol. In press.
16. Trojano L, Grossi D, Linden DE, Formisano E, Goebel R, Cirillo S, Elefante R, Di Salle F: Coordinate and categorical judgments in spatial imagery. An fMRI study. Neuropsychologia 2002;40:1666-1674.
17. Ino T, Asada T, Ito J, Kimura T, Fukuyama H: Parieto-frontal networks for clock drawing revealed with fMRI. Neurosci Res 2003;45:71-77.
18. Thomann PA, Toro P, Dos Santos V, Essig M, Schröder J: Clock drawing performance and brain morphology in mild cognitive impairment and Alzheimer's disease. Brain Cogn 2008;67:88-93
19. Nagahama Y, Okina T, Suzuki N, Nabatame H, Matsuda M: Neural correlates of impaired performance on the clock drawing test in Alzheimer's disease. Dement Geriatr Cogn Disord 2005;19:390-396.
20. Ueda H, Kitabayashi Y, Narumoto J, Nakamura K, Kita H, Kishikawa Y, Fukui K: Relationship between clock drawing test performance and regional cerebral blood flow in Alzheimer's disease: a single photon emission computed tomography study. Psychiat Clin Neurosci 2002;56:25-29.
21. Martin A: The representation of object concepts in the brain. Annu Rev Psychol 2007;58:25-45.
22. Gusard DA, Raichle ME: Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci 2001;2:685-694.
23. Wermke M, Sorg C, Wohlschläger AM, Drzezga A: A new itegrative model of cerebral activation, deactivation and default mode function in Alzheimer's disease. Eur J Nucl Med Mol Imaging 2008;35(suppl 1):812-824.
24. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum G, Mellits ED, Clark C: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD-NP). Part 1. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 1989;39:1159-1165.
25. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E: Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;56:303-308.
26. American Psychiatric Association: Diagnostic and Statistical Manual Of Mental Disorders, ed 4. Washington, American Psychiatric Association, 1994.
27. World Health Organization: The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. Geneva, WHO, 1992.
28. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan E: Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services task force on Alzheimer's disease. Neurology 1984;34:939-944.
29. Folstein MF, Folstein SE, Mc Hugh PR: 'Mini-Mental State'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
30. Genovese CR, Lazar NA, Nichols T: Thresholding of statistical maps in functional neuroimaging using the false discovery rate. NeuroImage 2002;15:870-878.
31. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M: Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage 2002;15:273-289.
32. Milner D, Goodale M: The vision brain in action. New York, Oxford University Press, 2006.
33. Ungerleider LG, Haxby JV: 'What' and 'where' in the human brain. Curr Opin Neurobiol 1994;4:157-165.
34. Trojano L, Grossi D, Linden DEJ, Formisano E, Hacker H, Zanella FE, Goebel R, Di Salle F: Matching two imagined clocks: the functional anatomy of spatial analysis in the absence of visual stimulation. Cereb Cortex 2000;10:473-481.
35. Goebel R, Linden DEJ, Lanfermann H, Zanella FE, Singer W: Functional imaging of mirror and inverse reading reveals separate coactivated networks for oculomotion and spatial transformations. Neuroreport 1998;9:713-719.
36. Patterson K, Nestor PJ, Rogers TT: Where do you know what you know? The representation of semantic knowledge in the human brain. Nat Rev Neurosci 2007;8:976-987.
37. Poeppel D, Hickok G: Towards a new functional anatomy of language. Cognition 2004;92:1-12.
38. Thompson-Schill SL: Neuroimaging studies of semantic memory: inferring 'how' from 'where'. Neuropsychologia 2003;41:280-292.
39. Martin A, Chao LL: Semantic memory and the brain: structure and processes. Curr Opin Neurobiol 2001;11:194-201.
40. Sevostianov A, Horwitz B, Nechaev V, Williams R, Fromm S, Braun AR: fMRI study comparing names versus pictures of objects. Hum Brain Mapp 2002;16:168-175.
41. Mosconi L, Tsui WH, De Santi S, Li J, Rusinek H, Convit A, Li Y, Boppana M, de Leon MJ: Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis. Neurology 2005;64:1860-1867.
42. 18F]fluoro-2-deoxy-D-glucose/ positron-emission tomography (FDG/PET). Proc Natl Acad Sci USA 2001;98:10966-10971.
43. Herholz K, Salmon E, Perani D, Baron JC, Holthoff V, Frölich L, Schönknecht P, Ito K, Mielke R, Kalbe E, Zündorf G, Delbeuck X, Pelati O, Anchisi D, Fazio F, Kerrouche N, Desgranges B, Eustache F, Beuthien-Baumann B, Menzel C, Schröder J, Kato T, Arahata Y, Henze M, Heiss WD: Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. NeuroImage 2002;17:302-316.
44. Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE: Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85-94.
45. Nestor PJ, Fryer TD, Smielewski P, Hodges JR: Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment. Ann Neurol 2003;54:343-351.
46. Chételat G, Landeau B, Eustache F, Mézenge F, Viader F, de la Sayette V, Desgranges B, Baron JC: Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: a longitudinal MRI study. NeuroImage 2005;27:934-946.
47. Poettrich K, Weiss PH, Werner A, Lux S, Donix M, Gerber J, von Kummer R, Fink GR, Holthoff VA: Altered neural network supporting declarative long-term memory in mild cognitive impairment. Neurobiol Aging 2009;30:284-298.
48. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thal L, Winblad B: Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985-1992.
49. Grill-Spector K, Malach R: The human visual cortex. Annu Rev Neurosci 2004;27:649-677.
50. Caroli A, Testa C, Geroldi C, Nobili F, Barnden LR, Guerra UG, Bonetti M, Frisoni GB: Cerebral perfusion correlates of conversion to Alzheimer's disease in amnestic mild cognitive impairment. J Neurol 2007;254:1698-1707.
51. Cavanna AE, Trimble MR: The precuneus: a review of its functional anatomy and behavioural correlates. Brain 2006;129:564-583.
52. Gardini S, De Beni R, Cornoldi C, Bromiley A, Venneric A: Different neuronal pathways support the generation of general and specific mental images. NeuroImage 2005;27:544-552.