-
1
-
-
0034485142
-
Estrogen receptor alpha in human breast cancer: Occurrence and significance
-
Ali S, Coombes RC (2000) Estrogen receptor alpha in human breast cancer: Occurrence and significance. J Mammary Gland Biol Neoplasia 5: 271-281
-
(2000)
J Mammary Gland Biol Neoplasia
, vol.5
, pp. 271-281
-
-
Ali, S.1
Coombes, R.C.2
-
2
-
-
67849122320
-
MEME SUITE: Tools for motif discovery and searching
-
Bailey TL, Boden M, Buske FA, Frith M, Grant CE, Clementi L, Ren J, Li WW, Noble WS (2009) MEME SUITE: tools for motif discovery and searching. Nucleic Acids Res 37: W202-W208
-
(2009)
Nucleic Acids Res
, vol.37
-
-
Bailey, T.L.1
Boden, M.2
Buske, F.A.3
Frith, M.4
Grant, C.E.5
Clementi, L.6
Ren, J.7
Li, W.W.8
Noble, W.S.9
-
3
-
-
0035282458
-
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
-
Bannister AJ, Zegerman P, Partridge JF, Miska EA, Thomas JO, Allshire RC, Kouzarides T (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410: 120-124
-
(2001)
Nature
, vol.410
, pp. 120-124
-
-
Bannister, A.J.1
Zegerman, P.2
Partridge, J.F.3
Miska, E.A.4
Thomas, J.O.5
Allshire, R.C.6
Kouzarides, T.7
-
4
-
-
8444245244
-
Global nucleosome occupancy in yeast
-
Bernstein BE, Liu CL, Humphrey EL, Perlstein EO, Schreiber SL (2004) Global nucleosome occupancy in yeast. Genome Biol 5: R62
-
(2004)
Genome Biol
, vol.5
-
-
Bernstein, B.E.1
Liu, C.L.2
Humphrey, E.L.3
Perlstein, E.O.4
Schreiber, S.L.5
-
5
-
-
35848958821
-
Chromatin remodeling: Insights and intrigue from single-molecule studies
-
Cairns BR (2007) Chromatin remodeling: insights and intrigue from single-molecule studies. Nat Struct Mol Biol 14: 989-996
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 989-996
-
-
Cairns, B.R.1
-
6
-
-
22144486551
-
Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1
-
Carroll JS, Liu XS, Brodsky AS, LiW, Meyer CA, Szary AJ, Eeckhoute J, Shao W, Hestermann EV, Geistlinger TR, Fox EA, Silver PA, Brown M (2005) Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 122: 33-43
-
(2005)
Cell
, vol.122
, pp. 33-43
-
-
Carroll, J.S.1
Liu, X.S.2
Brodsky, A.S.3
Li, W.4
Meyer, C.A.5
Szary, A.J.6
Eeckhoute, J.7
Shao, W.8
Hestermann, E.V.9
Geistlinger, T.R.10
Fox, E.A.11
Silver, P.A.12
Brown, M.13
-
7
-
-
33750442923
-
Genome-wide analysis of estrogen receptor binding sites
-
Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF,Wang Q, Bekiranov S, Sementchenko V, Fox EA, Silver PA, Gingeras TR, Liu XS, Brown M (2006) Genome-wide analysis of estrogen receptor binding sites. Nature Genetics 38: 1289-1297
-
(2006)
Nature Genetics
, vol.38
, pp. 1289-1297
-
-
Carroll, J.S.1
Meyer, C.A.2
Song, J.3
Li, W.4
Geistlinger, T.R.5
Eeckhoute, J.6
Brodsky, A.S.7
Keeton, E.K.8
Fertuck, K.C.9
Hall Gfwang, Q.10
Bekiranov, S.11
Sementchenko, V.12
Fox, E.A.13
Silver, P.A.14
Gingeras, T.R.15
Liu, X.S.16
Brown, M.17
-
8
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, Wong E, Orlov YL, ZhangW, Jiang J, Loh YH, Yeo HC, Yeo ZX, Narang V, Govindarajan KR, Leong B, Shahab A, Ruan Y, Bourque G, Sung WK et al (2008) Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133: 1106-1117
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
Fang, F.4
Huss, M.5
Vega, V.B.6
Wong, E.7
Orlov, Y.L.8
Zhangw Jiang, J.9
Loh, Y.H.10
Yeo, H.C.11
Yeo, Z.X.12
Narang, V.13
Govindarajan, K.R.14
Leong, B.15
Shahab, A.16
Ruan, Y.17
Bourque, G.18
Sung, W.K.19
-
9
-
-
31544465230
-
Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters
-
Cheng AS, Jin VX, Fan M, Smith LT, Liyanarachchi S, Yan PS, Leu YW, Chan MW, Plass C, Nephew KP, Davuluri RV, Huang TH (2006) Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters. Mol Cell 21: 393-404
-
(2006)
Mol Cell
, vol.21
, pp. 393-404
-
-
Cheng, A.S.1
Jin, V.X.2
Fan, M.3
Smith, L.T.4
Liyanarachchi, S.5
Yan, P.S.6
Leu, Y.W.7
Chan, M.W.8
Plass, C.9
Nephew, K.P.10
Davuluri, R.V.11
Huang, T.H.12
-
10
-
-
70449696134
-
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression
-
Cheng Y,WuW, Kumar SA, Yu D, DengW, Tripic T, King DC, Chen KB, Zhang Y, Drautz D, Giardine B, Schuster SC, MillerW, Chiaromonte F, Zhang Y, Blobel GA, Weiss MJ, Hardison RC (2009) Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res 19: 2172-2184
-
(2009)
Genome Res
, vol.19
, pp. 2172-2184
-
-
Ywuw, C.1
Kumar, S.A.2
Yu, D.3
Dengw Tripic, T.4
King, D.C.5
Chen, K.B.6
Zhang, Y.7
Drautz, D.8
Giardine, B.9
Schuster, S.C.10
Miller, W.11
Chiaromonte, F.12
Zhang, Y.13
Blobel, G.A.14
Weiss, M.J.15
Hardison, R.C.16
-
11
-
-
70350754328
-
Jmjd3 contributes to the control of gene expression in LPS-activated macrophages
-
De Santa F, Narang V, Yap ZH, , Tusi BK, , Burgold T, Austenaa L, Bucci G, CaganovaM, Notarbartolo S, Casola S, Testa G, SungWK,Wei CL, Natoli G (2009) Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. The EMBO J 28: 3341-3352
-
(2009)
The EMBO J
, vol.28
, pp. 3341-3352
-
-
De Santa, F.1
Narang, V.2
Yap, Z.H.3
Tusi, B.K.4
Burgold, T.5
Austenaa, L.6
Bucci, G.7
Caganova, M.8
Notarbartolo, S.9
Casola, S.10
Testa, G.11
Sungwkwei, C.L.12
Natoli, G.13
-
12
-
-
77950652940
-
Integrating multiple evidence sources to predict transcription factor binding in the human genome
-
Ernst J, Plasterer HL, Simon I, Bar-Joseph Z (2010) Integrating multiple evidence sources to predict transcription factor binding in the human genome. Genome Res 20: 526-536
-
(2010)
Genome Res
, vol.20
, pp. 526-536
-
-
Ernst, J.1
Plasterer, H.L.2
Simon, I.3
Bar-Joseph, Z.4
-
13
-
-
68949213578
-
Insights from genomic profiling of transcription factors
-
Farnham PJ (2009) Insights from genomic profiling of transcription factors. Nat Rev Genet 10: 605-616
-
(2009)
Nat Rev Genet
, vol.10
, pp. 605-616
-
-
Farnham, P.J.1
-
14
-
-
33748191291
-
Statistical mechanical modeling of genome-wide transcription factor occupancy data by Matrix REDUCE
-
Foat BC, Morozov AV, Bussemaker HJ (2006) Statistical mechanical modeling of genome-wide transcription factor occupancy data by Matrix REDUCE. Bioinformatics 22: e141-e149
-
(2006)
Bioinformatics
, vol.22
-
-
Foat, B.C.1
Morozov, A.V.2
Bussemaker, H.J.3
-
15
-
-
70449103609
-
An oestrogen-receptor-a-bound human chromatin interactome
-
Fullwood MJ, Liu MH, Pan YF, Liu J, Xu H, Mohamed YB, Orlov YL, Velkov S, Ho A, Mei PH, ChewEGY, Huang PYH,Welboren WJ, Han Y, Ooi HS, Ariyaratne PN, Vega VB, Luo Y, Tan PY, Choy PY et al (2009) An oestrogen-receptor-a-bound human chromatin interactome. Nature 462: 58-64
-
(2009)
Nature
, vol.462
, pp. 58-64
-
-
Fullwood, M.J.1
Liu, M.H.2
Pan, Y.F.3
Liu, J.4
Xu, H.5
Mohamed, Y.B.6
Orlov, Y.L.7
Velkov, S.8
Ho, A.9
Mei, P.H.10
Chew, E.G.Y.11
Huang, P.Y.H.12
Welboren, W.J.13
Han, Y.14
Ooi, H.S.15
Ariyaratne, P.N.16
Vega, V.B.17
Luo, Y.18
Tan, P.Y.19
Choy, P.Y.20
more..
-
16
-
-
34250369627
-
FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin
-
Giresi PG, Kim J, McDaniell RM, Iyer VR, Lieb JD (2007) FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Res 17: 877-885
-
(2007)
Genome Res
, vol.17
, pp. 877-885
-
-
Giresi, P.G.1
Kim, J.2
McDaniell, R.M.3
Iyer, V.R.4
Lieb, J.D.5
-
17
-
-
0032518443
-
Chromatin and transcription-how transcription factors battle with a repressive chromatin environment
-
Gregory PD, Horz W (1998) Chromatin and transcription-how transcription factors battle with a repressive chromatin environment. Eur J Biochem 251: 9-18
-
(1998)
Eur J Biochem
, vol.251
, pp. 9-18
-
-
Gregory, P.D.1
Horz, W.2
-
18
-
-
33847334699
-
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
-
Heintzman ND, Stuart RK, Hon G, Fu Y, Ching CW, Hawkins RD, Barrera LO, Van Calcar S, Qu C, Ching KA,WangW,Weng Z, Green RD, Crawford GE, Ren B (2007) Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat Genet 39: 311-318
-
(2007)
Nat Genet
, vol.39
, pp. 311-318
-
-
Heintzman, N.D.1
Stuart, R.K.2
Hon, G.3
Fu, Y.4
Ching, C.W.5
Hawkins, R.D.6
Barrera, L.O.7
Van Calcar, S.8
Qu, C.9
Ching Kawangwweng, Z.10
Green, R.D.11
Crawford, G.E.12
Ren, B.13
-
19
-
-
57349113761
-
Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen
-
Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS (2008) Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen. Nature 456: 663-666
-
(2008)
Nature
, vol.456
, pp. 663-666
-
-
Hurtado, A.1
Holmes, K.A.2
Geistlinger, T.R.3
Hutcheson, I.R.4
Nicholson, R.I.5
Brown, M.6
Jiang, J.7
Howat, W.J.8
Ali, S.9
Carroll, J.S.10
-
20
-
-
0028287546
-
Estrogen receptor-Spl complexes mediate estrogen-induced Cathepsin D gene expression in MCF-7 human breast cancer cells
-
Krishnan V, Wang X, Safe S (1994) Estrogen receptor-Spl complexes mediate estrogen-induced Cathepsin D gene expression in MCF-7 human breast cancer cells. J Biol Chem 269: 15912-15917
-
(1994)
J Biol Chem
, vol.269
, pp. 15912-15917
-
-
Krishnan, V.1
Wang, X.2
Safe, S.3
-
21
-
-
33646865180
-
Control of developmental regulators by Polycomb in human embryonic stem cells
-
Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, Yuan B, Bell GW, Herbolsheimer E, Hannett NM, Sun K et al (2006) Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 125: 301-313
-
(2006)
Cell
, vol.125
, pp. 301-313
-
-
Lee, T.I.1
Jenner, R.G.2
Boyer, L.A.3
Guenther, M.G.4
Levine, S.S.5
Kumar, R.M.6
Chevalier, B.7
Johnstone, S.E.8
Cole, M.F.9
Isono, K.10
Koseki, H.11
Fuchikami, T.12
Abe, K.13
Murray, H.L.14
Zucker, J.P.15
Yuan, B.16
Bell, G.W.17
Herbolsheimer, E.18
Hannett, N.M.19
Sun, K.20
more..
-
22
-
-
34748826166
-
A high-resolution atlas of nucleosome occupancy in yeast
-
Lee W, Tillo D, Bray N, Morse RH, Davis RW, Hughes TR, Nislow C (2007) A high-resolution atlas of nucleosome occupancy in yeast. Nat Genet 39: 1235-1244
-
(2007)
Nat Genet
, vol.39
, pp. 1235-1244
-
-
Lee, W.1
Tillo, D.2
Bray, N.3
Morse, R.H.4
Davis, R.W.5
Hughes, T.R.6
Nislow, C.7
-
23
-
-
34347345081
-
Whole genome cartography of estrogen receptor a binding sites
-
Lin CY, Vega VB, Thomsen JS, Zhang T, Kong SL, Xie M, Chiu KP, Lipovich L, Barnett DH, Stossi F, Yeo A, George J, Kuznetsov VA, Lee YK, Charn TH, Palanisamy N, Miller LD, Cheung E, Katzenellenbogen BS, Ruan Y et al (2007) Whole genome cartography of estrogen receptor a binding sites. PLOS Genet 3: e87
-
(2007)
PLOS Genet
, vol.3
-
-
Lin, C.Y.1
Vega, V.B.2
Thomsen, J.S.3
Zhang, T.4
Kong, S.L.5
Xie, M.6
Chiu, K.P.7
Lipovich, L.8
Barnett, D.H.9
Stossi, F.10
Yeo, A.11
George, J.12
Kuznetsov, V.A.13
Lee, Y.K.14
Charn, T.H.15
Palanisamy, N.16
Miller, L.D.17
Cheung, E.18
Katzenellenbogen, B.S.19
Ruan, Y.20
more..
-
24
-
-
0036324753
-
An algorithm for finding protein-DNA binding sites with applications to chromatin-immunoprecipitation microarray experiments
-
Liu XS, Brutlag DL, Liu JS (2002) An algorithm for finding protein-DNA binding sites with applications to chromatin-immunoprecipitation microarray experiments. Nat Biotechnol 20: 835-839
-
(2002)
Nat Biotechnol
, vol.20
, pp. 835-839
-
-
Liu, X.S.1
Brutlag, D.L.2
Liu, J.S.3
-
25
-
-
40849085514
-
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription
-
Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, BrownM(2008) FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Cell 132: 958-970
-
(2008)
Cell
, vol.132
, pp. 958-970
-
-
Lupien, M.1
Eeckhoute, J.2
Meyer, C.A.3
Wang, Q.4
Zhang, Y.5
Li, W.6
Carroll, J.S.7
Liu Xs Brown, M.8
-
26
-
-
0037154974
-
Combinatorial control of gene expression by nuclear receptors and coregulators
-
McKenna NJ, OMalley BW (2002) Combinatorial control of gene expression by nuclear receptors and coregulators. Cell 108: 465-474
-
(2002)
Cell
, vol.108
, pp. 465-474
-
-
McKenna, N.J.1
Omalley, B.W.2
-
27
-
-
0042733700
-
Getting into chromatin: How do transcription factors get past the histones?
-
Morse RH (2003) Getting into chromatin: how do transcription factors get past the histones? Biochem Cell Biol 81: 101-112
-
(2003)
Biochem Cell Biol
, vol.81
, pp. 101-112
-
-
Morse, R.H.1
-
28
-
-
57749083496
-
Regulation of estrogen receptormediated long range transcription via evolutionarily conserved distal response elements
-
Pan YF,Wansa KD, Liu MH, Zhao B, Hong SZ, Tan PY, Lim KS, Bourque G, Liu ET, Cheung E (2008) Regulation of estrogen receptormediated long range transcription via evolutionarily conserved distal response elements. J Biol Chem 283: 32977-32988
-
(2008)
J Biol Chem
, vol.283
, pp. 32977-32988
-
-
Pan Yfwansa, K.D.1
Liu, M.H.2
Zhao, B.3
Hong, S.Z.4
Tan, P.Y.5
Lim, K.S.6
Bourque, G.7
Liu, E.T.8
Cheung, E.9
-
29
-
-
46149108345
-
Rapid, transcription-independent loss of nucleosomes over a large chromatin domain at Hsp70 loci
-
Petesch SJ, Lis JT (2008) Rapid, transcription-independent loss of nucleosomes over a large chromatin domain at Hsp70 loci. Cell 134: 74-84
-
(2008)
Cell
, vol.134
, pp. 74-84
-
-
Petesch, S.J.1
Lis, J.T.2
-
30
-
-
34250168295
-
Rules and regulation in the primary structure of chromatin
-
Rando OJ, Ahmad K (2007) Rules and regulation in the primary structure of chromatin. Curr Opin Cell Biol 19: 250-256
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 250-256
-
-
Rando, O.J.1
Ahmad, K.2
-
31
-
-
57149096220
-
Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding
-
Robertson AG, Bilenky M, Tam A, Zhao Y, Zeng T, Thiessen N, Cezard T, Fejes AP, Wederell ED, Cullum R, Euskirchen G, Krzywinski M, Birol I, Snyder M, Hoodless PA, Hirst M, Marra MA, Jones SJ (2008) Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding. Genome Res 18: 1906-1917
-
(2008)
Genome Res
, vol.18
, pp. 1906-1917
-
-
Robertson, A.G.1
Bilenky, M.2
Tam, A.3
Zhao, Y.4
Zeng, T.5
Thiessen, N.6
Cezard, T.7
Fejes, A.P.8
Wederell, E.D.9
Cullum, R.10
Euskirchen, G.11
Krzywinski, M.12
Birol, I.13
Snyder, M.14
Hoodless, P.A.15
Hirst, M.16
Marra, M.A.17
Jones, S.J.18
-
32
-
-
33750488431
-
The genomic landscape of histone modifications in human Tcells
-
Roh TY, Cuddapah S, Cui K, Zhao K (2006) The genomic landscape of histone modifications in human Tcells. Proc Natl Acad Sci USA 103: 15782-15787
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 15782-15787
-
-
Roh, T.Y.1
Cuddapah, S.2
Cui, K.3
Zhao, K.4
-
33
-
-
57749178899
-
Non-classical genomic estrogen receptor (ER)/ specificity protein and ER/activating protein-1 signaling pathways
-
Safe S, Kim K (2008) Non-classical genomic estrogen receptor (ER)/ specificity protein and ER/activating protein-1 signaling pathways. J Mol Endocrinol 41: 263-275
-
(2008)
J Mol Endocrinol
, vol.41
, pp. 263-275
-
-
Safe, S.1
Kim, K.2
-
34
-
-
39749145198
-
Dynamic regulation of nucleosome positioning in the human genome
-
Schones DE, Cui K, Cuddapah S, Roh TY, Barski A, Wang Z, Wei G, Zhao K (2008) Dynamic regulation of nucleosome positioning in the human genome. Cell 132: 887-898
-
(2008)
Cell
, vol.132
, pp. 887-898
-
-
Schones, D.E.1
Cui, K.2
Cuddapah, S.3
Roh, T.Y.4
Barski, A.5
Wang, Z.6
Wei, G.7
Zhao, K.8
-
35
-
-
33644932610
-
Comprehensive copy number profiles of breast cancer cell model genomes
-
Shadeo A, Lam WL (2006) Comprehensive copy number profiles of breast cancer cell model genomes. Breast Cancer Res 8: R9
-
(2006)
Breast Cancer Res
, vol.8
-
-
Shadeo, A.1
Lam, W.L.2
-
37
-
-
0034610814
-
The language of covalent histone modifications
-
Strahl BD, Allis CD (2000) The language of covalent histone modifications. Nature 403: 41-45
-
(2000)
Nature
, vol.403
, pp. 41-45
-
-
Strahl, B.D.1
Allis, C.D.2
-
38
-
-
33750336243
-
Multiplatform genomewide identification and modeling of functional human estrogen receptor binding sites
-
Vega VB, Lin CY, Lai KS, Kong SL, Xie M, Su X, Teh HF, Thomsen JS, Yeo AL, Sung WK, Bourque G, Liu ET (2006) Multiplatform genomewide identification and modeling of functional human estrogen receptor binding sites. Genome Biol 7: R82
-
(2006)
Genome Biol
, vol.7
-
-
Vega, V.B.1
Lin, C.Y.2
Lai, K.S.3
Kong, S.L.4
Xie, M.5
Su, X.6
Teh, H.F.7
Thomsen, J.S.8
Yeo, A.L.9
Sung, W.K.10
Bourque, G.11
Liu, E.T.12
-
39
-
-
66549085342
-
ChIP-Seq of ERa and RNA polymerase II defines genes differentially responding to ligands
-
Welboren WJ, van Driel MA, Janssen-Megens EM, van Heeringen SJ, Sweep FC, Span PN, Stunnenberg HG (2009) ChIP-Seq of ERa and RNA polymerase II defines genes differentially responding to ligands. The EMBO J 28: 1418-1428
-
(2009)
The EMBO J
, vol.28
, pp. 1418-1428
-
-
Welboren, W.J.1
Van Driel, M.A.2
Janssen-Megens, E.M.3
Van Heeringen, S.J.4
Sweep, F.C.5
Span, P.N.6
Stunnenberg, H.G.7
-
40
-
-
74549209548
-
Inferring binding energies from selected binding sites
-
Zhao Y, Granas D, Stormo GD (2009) Inferring binding energies from selected binding sites. PLOS Comput Biol 5: e1000590
-
(2009)
PLOS Comput Biol
, vol.5
-
-
Zhao, Y.1
Granas, D.2
Stormo, G.D.3
|