Effects of the protein kinase inhibitor PKC412 on gene expression and link to physiological effects in zebrafish Danio rerio eleuthero-embryos

Toxicological Sciences

Volumn 119, Issue 1, 2011, Pages 104-115

  Oggier, Daniela M ^a,b   Lenard, Anna ^c   Küry, Michael ^a   Hoeger, Birgit ^d   Affolter, Markus ^c   Fent, Karl ^a,e  

^a UNIVERSITY OF APPLIED SCIENCES AND ARTS NORTHWESTERN SWITZERLAND   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d NOVARTIS PHARMA AG   (Switzerland)

^e ETH ZURICH   (Switzerland)

Author keywords

Angiogenesis; Apoptosis; Danio rerio; Microarray; PKC412; Transgenic zebrafish

Indexed keywords

MIDOSTAURIN; REACTIVE OXYGEN METABOLITE;

ANGIOGENESIS; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BLASTULA; CIRCADIAN RHYTHM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DAMAGE; EMBRYO; ENVIRONMENTAL FACTOR; FERTILIZATION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PERINATAL DRUG EXPOSURE; SWIMMING; ZEBRA FISH;

DANIO RERIO;

EID: 78650535745     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq330     Document Type: Article

References (45)

1. Campochiaro, P. A. (2004). Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412. Invest. Ophthalmol. Vis. Sci. 45, 922-931.
2. Carmeliet, P., and Jain, R. K. (2000). Angiogenesis in cancer and other diseases. Nature 407, 249-257.
3. Chabner, B. A., Ryan, D. P., Paz-Ares, L., Garcia-Carbonero, R., and Calabresi, P. (2006). Antineoplastic agents. In Goodman and Gilman's-The Pharmalogical Basis of Therapeutics (Hardman, J. G. and Limbird, L. E., Eds.), pp. 1396-1397. McGraw-Hill, New York.
4. Chan, J., Bayliss, P. E., Wood, J. M., and Roberts, T. M. (2002). Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell 1, 257-267.
5. Christen, V., Hickmann, S., Rechenberg, B., and Fent, K. (2010). Highly active human pharmaceuticals in aquatic systems: A concept for their identification based on their mode of action. Aquat. Toxicol. 96, 167-181.
6. Clark, J. I. (2004). Order and disorder in the transparent media of the eye. Exp. Eye Res. 78, 427-432.
7. Comolli, J. C., and Hastings, J. W. (1999). Novel effects on the Gonyaulax circadian system produced by the protein kinase inhibitor staurosporine. J. Biol. Rhythms 14, 11-19.
8. Deng, J., Yu, L., Liu, C., Yu, K., Shi, X., Yeung, L. W., Lam, P. K., Wu, R. S., and Zhou, B. (2009). Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquat. Toxicol. 93, 29-36.
9. Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A., and Breitman, M. L. (1994). Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo. Genes Dev. 8, 1897-1909.
10. Duong, F. H., Christen, V., Lin, S., and Heim, M. H. (2010). Hepatitis C virus-induced up-regulation of protein phosphatase 2A inhibits histone modification and DNA damage repair. Hepatology 51, 741-751.
11. European Medicines Agency (EMEA). (2006). Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use. EMEA, London.
12. Fabbro, D., Ruetz, S., Bodis, S., Pruschy, M., Csermak, K., Man, A., Campochiaro, P., Wood, J., O'Reilly, T., and Meyer, T. (2000). PKC412-a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 15, 17-28.
13. Fent, K., Weston, A. A., and Caminada, D. (2006). Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 76, 122-159.
14. Gerhardt, A., Clostermann, M., Fridlund, B., and Svensson, E. (1994). Monitoring of behavioral patterns of aquatic organisms with an impedance conversion technique. Environ. Int. 20, 209-219.
15. Gunnarsson, L., Jauhiainen, A., Kristiansson, E., Nerman, O., and Larsson, D. G. (2008). Evolutionary conservation of human drug targets in organisms used for environmental risk assessments. Environ. Sci. Technol. 42, 5807-5813.
16. Hastings, M. H. (1997). Central clocking. Trends Neurosci. 20, 459-464.
17. Hill, M. M., Andjelkovic, M., Brazil, D. P., Ferrari, S., Fabbro, D., and Hemmings, B. A. (2001). Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase. J. Biol. Chem. 276, 25643-25646.
18. Jakubcakova, V., Oster, H., Tamanini, F., Cadenas, C., Leitges, M., van der Horst, G. T., and Eichele, G. (2007). Light entrainment of the mammalian circadian clock by a PRKCA-dependent posttranslational mechanism. Neuron 54, 831-843.
19. Jones, O. A., Voulvoulis, N., and Lester, J. N. (2007). Ecotoxicity of pharmaceuticals. In Analysis, Fate and Removal of Pharmaceuticals in the Water Cycle (Petrovic, M., and Barcelo, D., Eds.), pp. 387-424. Oxford, Elsevier.
20. Karaman, M. W., Herrgard, S., Treiber, D. K., Gallant, P., Atteridge, C. E., Campbell, B. T., Chan, K. W., Ciceri, P., Davis, M. I., Edeen, P. T., et al. (2008). A quantitative analysis of kinase inhibitor selectivity. Nat. Biotechnol. 26, 127-132.
21. Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B., and Schilling, T. F. (1995). Stages of embryonic development of the zebrafish. Dev. Dyn. 203, 253-310.
22. Kling, P. G., and Olsson, P.-E. (2000). Involvement of differential metallothionein expression in free radical sensitivity of RTG-2 and CHSE-214 cells. Free Radic. Biol. Med. 28, 1628-1637.
23. Kubota, Y., Oike, Y., Satoh, S., Tabata, Y., Niikura, Y., Morisada, T., Akao, M., Urano, T., Ito, Y., Miyamoto, T., et al. (2005). Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development. Proc. Natl. Acad. Sci. U.S.A. 102, 13502-13507.
24. Lawson, N. D., and Weinstein, B. M. (2002). In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev. Biol. 248, 307-318.
25. Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997). Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277, 55-60.
26. Mimeault, C., Trudeau, V. L., and Moon, T. W. (2006). Waterborne gemfibrozil challenges the hepatic antioxidant defense system and down-regulates peroxisome proliferator-activated receptor beta (PPARb) mRNA levels in male goldfish (Carassius auratus). Toxicology 228, 140-150.
27. Monteiro, S. C., and Boxall, A. B. (2010). Occurrence and fate of human pharmaceuticals in the environment. Rev. Environ. Contam. Toxicol. 202, 53-154.
28. Oggier, D. M., Weisbrod, C., Stoller, A., Zenker, A., and Fent, K. (2010). Effects of diazepam on gene expression and link to physiological effects in different life stages in zebrafish. Danio rerio. Environ. Sci. Technol. 44, 7685-7691.
29. Patten, S. A., Sihra, R. K., Dhami, K. S., Coutts, C. A., and Ali, D. W. (2007). Differential expression of PKC isoforms in developing zebrafish. Int. J. Dev. Neurosci. 25, 155-164.
30. Pham, V. N., Roman, B. L., and Weinstein, B. M. (2001). Isolation and expression analysis of three zebrafish angiopoietin genes. Dev. Dyn. 221, 470-474.
31. Robbens, J., van der Ven, K., Maras, M., Blust, R., and De Coen, W. (2007). Ecotoxicological risk assessment using DNA chips and cellular reporters. Trends Biotechnol. 25, 460-466.
32. Runnalls, T. J., Hala, D. N., and Sumpter, J. P. (2007). Preliminary studies into the effects of the human pharmaceutical clofibric acid on sperm parameters in adult fathead minnow. Aquat. Toxicol. 84, 111-118.
33. Saishin, Y., Takahashi, K., Seo, M. S., Melia, M., and Campochiaro, P. A. (2003). The kinase inhibitor PKC412 suppresses epiretinal membrane formation and retinal detachment in mice with proliferative retinopathies. Invest. Ophthalmol. Vis. Sci. 44, 3656-3662.
34. Schak, K. M., and Harrington, M. E. (1999). Protein kinase C inhibition and activation phase advances the hamster circadian clock. Brain Res. 840, 158-161.
35. Seedhouse, C. H., Hunter, H. M., Lloyd-Lewis, B., Massip, A. M., Pallis, M., Carter, G. I., Grundy, M., Shang, S., and Russell, N. H. (2006). DNA repair contributes to the drug-resistant phenotype of primary acute myeloid leukaemia cells with FLT3 internal tandem duplications and is reversed by the FLT3 inhibitor PKC412. Leukemia 20, 2130-2136.
36. Si, M. S., Reitz, B. A., and Borie, D. C. (2005). Effects of the kinase inhibitor CGP41251 (PKC 412) on lymphocyte activation and TNF-alpha production. Int. Immunopharmacol. 5, 1141-1149.
37. Slatter, C. A. B., Kanji, H., Coutts, C. A., and Ali, D. W. (2005). Expression of PKC in the developing zebrafish, Danio rerio. J. Neurobiol. 62, 425-438.
38. Stolzel, F., Steudel, C., Oelschlagel, U., Mohr, B., Koch, S., Ehninger, G., and Thiede, C. (2010). Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells. Ann. Hematol. 89, 653-662.
39. Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S., Sato, T. N., and Yancopoulos, G. D. (1996). Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87, 1171-1180.
40. Takahashi, I., Saitoh, Y., Yoshida, M., Sano, H., Nakano, H., Morimoto, M., and Tamaoki, T. (1989). UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities. J. Antibiot. (Tokyo) 42, 571-576.
41. Takechi, M., and Kawamura, S. (2005). Temporal and spatial changes in the expression pattern of multiple red and green subtype opsin genes during zebrafish development. J. Exp. Biol. 208, 1337-1345.
42. Tenzer, A., Zingg, D., Rocha, S., Hemmings, B., Fabbro, D., Glanzmann, C., Schubiger, P. A., Bodis, S., and Pruschy, M. (2001). The phosphatidylinosi-tide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res. 61, 8203-8210.
43. Ternes, T. A. (1998). Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32, 3245-3260.
44. Traver, D., Paw, B. H., Poss, K. D., Penberthy, W. T., Lin, S., and Zon, L. I. (2003). Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat. Immunol. 4, 1238-1246.
45. Van der Zee, E. A., and Bult, A. (1995). Distribution of AVP and Ca2+-dependent PKC-isozymes in the suprachiasmatic nucleus of the mouse and rabbit. Brain Res. 701, 99-107.