Preliminary studies into the effects of the human pharmaceutical Clofibric acid on sperm parameters in adult Fathead minnow

Aquatic Toxicology

Volumn 84, Issue 1, 2007, Pages 111-118

  Runnalls, Tamsin J ^a   Hala, David N ^a   Sumpter, John P ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

Aquatic environment; CASA; Clofibric acid; Fathead minnow; Pharmaceuticals; Sperm parameters

Indexed keywords

ANDROGEN; ANTILIPEMIC AGENT; CLOFIBRATE; CLOFIBRIC ACID;

ACID; ANDROGEN; CARDIOVASCULAR DISEASE; CYPRINID; DRUG; EXPERIMENTAL STUDY; METABOLITE; REPRODUCTIVE DISORDER; SPERM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR PARAMETERS; CONTROLLED STUDY; FEMALE; FISH; MALE; MARINE ENVIRONMENT; NONHUMAN; PIMEPHALES PROMELAS; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SEMEN ANALYSIS; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY;

ANIMALS; CHOLESTEROL; CLOFIBRIC ACID; CYPRINIDAE; FEMALE; HYPOLIPIDEMIC AGENTS; MALE; SPERM COUNT; SPERM MOTILITY; SPERMATOGENESIS; SPERMATOZOA; TESTOSTERONE; TRIGLYCERIDES; WATER POLLUTANTS, CHEMICAL;

MAMMALIA; PIMEPHALES PROMELAS; VERTEBRATA;

EID: 34447621202     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2007.06.005     Document Type: Article

References (30)

1. Aravindakshan J., Paquet V., Gregory M., Dufresne J., Fournier M., Marcogliese D.J., and Cyr D.G. Consequences of Xenoestrogens exposure on male reproductive function in spottail shiner (Notropis hudsonius). Toxicol. Sci. 78 (2004) 156-165
2. Brian J.V., Harris C., Scholze M., Backhaus T., Booy P., Lamoree M., Pojana G., Jonkers N., Runnalls T., Bonfa A., Marcomini A., and Sumpter J.P. Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals. Environ. Health Perspect. 113 (2005) 721-728
3. Buser H.R., and Muller M.D. Occurrence of the pharmaceutical drug clofibric acid and the herbicide mecoprop in various Swiss lakes and in the North Sea. Environ. Sci. Technol. 32 (1998) 188-192
4. Cook J.C., Klinefelter G.R., Hardisty J.F., Sharpe R.M., and Foster P.M.D. Rodent Leydig cells tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans. CRC Crit. Rev. Toxicol. 29 (1999) 169-261
5. Fent K., Weston A., and Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 76 (2006) 122-159
6. Gage M., Macfarlane C.P., Yeates S., Ward R., Searle J.B., and Parker G.A. Spermatozoal traits and sperm competition in atlantic salmon: relative sperm velocity is the primary determinant of fertilization success. Curr. Biol. 14 (2004) 44-47
7. Green R.E., Newton I., Shultz S., Cunningham A.A., Gilbert M., Pain D.J., and Prakash V. Diclofenac poisoning as a cause of vulture population declines across the Indian subcontinent. J. Appl. Ecol. 41 (2004) 793-800
8. Harries J.E., Runnalls T., Hill E., Harris C.A., Maddix S., Sumpter J.P., and Tyler C.R. Development of a reproductive performance test for endocrine disrupting chemicals using pair-breeding fathead minnows (Pimephales promelas). Environ. Sci. Technol. 34 (2000) 3003-3011
9. Heberer T.H. Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data. Toxicol. Lett. 131 (2002) 5-17
10. Heberer T.H., and Stan H.J. Determination of Clofibric acid and N-(phenylsulfonyl)-sarcosine in sewage, river and drinking water. Int. J. Environ. Anal. Chem. 67 (1997) 113-124
11. Hignite C., and Azarnoff D. Drugs and drug metabolites as environmental contaminants: chlorophenoxyisobutyrate and salicyic acid in sewage water effluent. Life Sci. 20 (1977) 337-341
12. Huggett D.B., Khan I., Foran C.M., and Schlenk D. Determination of beta-adrenergic receptor blocking pharmaceuticals in United States wastewater effluent. Environ. Pollut. 121 (2003) 199-205
13. Jensen B.H., and Taylor M.H. Lipid transport in female Fundulus heteroclitus during the reproductive season. Fish Physiol. Biochem. 25 (2002) 141-151
14. Jobling S., Nolan M., Tyler C.R., Brighty G., and Sumpter J.P. Widespread sexual disruption in wild fish. Environ. Sci. Technol. 32 (1998) 2498-2506
15. Jobling S., Beresford N., Nolan M., Rogers-Gray T., Brighty G., Sumpter J.P., and Tyler C.R. Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biol. Reprod. 66 (2002) 272-281
16. Kazeto Y., Place A.R., and Trant J.M. Effects of endocrine disrupting chemicals on the expression of CYP19 genes in zebrafish (Danio rerio) juveniles. Aquat. Toxicol. 69 1 (2004) 25-34
17. Kime D., Van Look K., McAllister B.G., Huyskens G., Rurangwa E., and Ollevier F. Computer assisted sperm analysis (CASA) as a tool for monitoring sperm quality in fish. Comp. Biochem. Physiol. C. Pharmacol. Toxicol. Endocrinol. 130 (2001) 425-433
18. Lange R., Hutchinson T., Croudace C.P., Siegmund F., Schweinfurth H., Hampe P., Panter G., and Sumpter J.P. Effects of the synthetic estrogen 17α-ethinylestradiol on the life cycle of the fathead minnow (Pimephales Promales). Environ. Toxicol. Chem. 20 (2001) 1216-1227
19. Mimeault C., Woodhouse A., Miao X.-S., Metcalf C.D., Moon T.W., and Trudeau V.L. The human lipid regulator, gemfibrozil, bioconcentrates and reduces testosterone in the goldfish Carassius auratus. Aquat. Toxicol. 73 (2005) 44-54
20. Oaks J.L., Gilbert M., Virani M., Watson R., Meteyer C.U., Shivaprasad H.L., Ahmed S., Chaudhry M.J.I., Arshad S., Mahmood S., Ali A., and Khan A.A. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 427 (2004) 630-633
21. Ohta H., Shimma H., and Hirose K. Relationship between fertility and motility of cyropreserved spermatozoa of amago salmon Oncorhynchus masou ishikawae. Fish Sci. 61 (1995) 886-887
22. Richardson M.L., and Bowron J. The fate of pharmaceuticals in the aquatic environment. J. Pharm. Pharmacol. 37 (1985) 1-12
23. RxList, 2006. The Internet Drug Index. Web MD. Available: http://www.Rxlist.com [accessed March 2006].
24. Schulman L.J., Sargent E.V., Naumann B.D., Faria E.C., Dolan D.G., and Wargo J.P. A Human health risk assessment of pharmaceuticals in the aquatic environment. Human Ecol. Risk Assess. 8 (2002) 657-680
25. Schulz R.W., Vischer H., Cavaco J.E.B., Santos E.M., Tyler C.R., Goos H.J.Th., and Bogerd J. Gonadotrophins, their receptors, and the regulation of testicular functions in fish. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 129 (2001) 407-417
26. Slama R., Eustache F., Ducot B., Jensen T.K., Jorgensen N., Horte A., Irvine S., Suominen J., Andersen A.G., Auger J., Vierula M., Toppari J., Andersen A.N., Keiding N., Skakkebæk N.E., Spira A., and Jouannet P. Time to pregnancy and semen parameters: a cross-sectional study among fertile couples from four European cities. Hum. Reprod. 17 (2002) 503-515
27. Tauxe-Wuersch A., De Alen Castro L.F., Grandjean D., and Tarradellas J. Occurrence of several acidic drugs in sewage treatment plants in Switzerland and risk assessment. Water Res. 39 (2005) 1761-1772
28. Williams R.T. In: Williams R.T. (Ed). Human health pharmaceuticals in the environment: an introductory perspective. Science for assessing the impacts of human pharmaceuticals on aquatic ecosystems (2005), SETAC Press, Pensacola, FL 1-46
29. WHO. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. third ed. (1992), Cambridge University Press, Cambridge, UK
30. Zimetbaum P., Frishman W.H., and Kahn S. Effects of gemfibrozil and other fibric acid derivatives on blood lipids and lipoproteins. J. Clin. Pharmacol. 31 (1991) 25-37