Circulating endothelial cells, microparticles and progenitors: Towards the definition of vascular competence;Cellules endothéliales circulantes, microparticules et progéniteurs: vers la définition de la « vasculocompétence »

Revue de Medecine Interne

Volumn 32, Issue 1, 2011, Pages 54-63

  Sabatier, F ^a,b   Lacroix, R ^a,b   Camoin Jau, L ^a,b   Anfosso, F ^a   Sampol, J ^a   Dignat George, F ^a,b  

^a INSERM   (France)

^b HÔPITAL DE LA CONCEPTION   (France)

Author keywords

Biomarkers; Circulating endothelial cells; Circulating endothelial progenitor cells; Endothelial derived microparticles

Indexed keywords

BIOLOGICAL MARKER;

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL MICROPARTICLE; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; NON INVASIVE PROCEDURE; PROGNOSIS; RISK ASSESSMENT; SHORT SURVEY; TISSUE REGENERATION; VASCULAR ENDOTHELIUM;

APOPTOSIS; BLOOD VESSELS; CARDIOVASCULAR DISEASES; CELL-DERIVED MICROPARTICLES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; REGENERATION; STEM CELLS; WOUND HEALING;

EID: 78650535016     PISSN: 02488663     EISSN: 17683122     Source Type: Journal    
DOI: 10.1016/j.revmed.2010.03.341     Document Type: Short Survey

References (128)

1. Landmesser U., Drexler H. Endothelial function and hypertension. Curr Opin Cardiol 2007, 22:316-320.
2. Goligorsky M.S. Clinical assessment of endothelial dysfunction: combine and rule. Curr Opin Nephrol Hypertens 2006, 15:617-624.
3. Sabatier F., Camoin-Jau L., Anfosso F., Sampol J., Dignat-George F. Circulating endothelial cells, microparticles and progenitors: key players towards the definition of vascular competence. J Cell Mol Med 2009, 13:454-471.
4. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993, 362:801-809.
5. Combes V., Simon A.C., Grau G.E., Arnoux D., Camoin L., Sabatier F., et al. In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant. J Clin Invest 1999, 104:93-102.
6. George F., Brisson C., Poncelet P., Laurent J.C., Massot O., Arnoux D., et al. Rapid isolation of human endothelial cells from whole blood using S-Endo1 monoclonal antibody coupled to immuno-magnetic beads: demonstration of endothelial injury after angioplasty. Thromb Haemost 1992, 67:147-153.
7. Asahara T., Masuda H., Takahashi T., Kalka C., Pastore C., Silver M., et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999, 85:221-228.
8. Murphy C., Kanaganayagam G.S., Jiang B., Chowienczyk P.J., Zbinden R., Saha M., et al. Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men. Arterioscler Thromb Vasc Biol 2007, 27:936-942.
9. George F., Poncelet P., Laurent J.C., Massot O., Arnoux D., Lequeux N., et al. Cytofluorometric detection of human endothelial cells in whole blood using S-Endo 1 monoclonal antibody. J Immunol Methods 1991, 139:65-75.
10. Woywodt A., Blann A.D., Kirsch T., Erdbruegger U., Banzet N., Haubitz M., et al. Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol. J Thromb Haemost 2006, 4:671-677.
11. Blann A.D., Woywodt A., Bertolini F., Bull T.M., Buyon J.P., Clancy R.M., et al. Circulating endothelial cells. Biomarker of vascular disease. Thromb Haemost 2005, 93:228-235.
12. Rowand J.L., Martin G., Doyle G.V., Miller M.C., Pierce M.S., Connelly M.C., et al. Endothelial cells in peripheral blood of healthy subjects and patients with metastatic carcinomas. Cytometry A 2007, 71:105-113.
13. Widemann A., Sabatier F., Arnaud L., Bonello L., Al-Massarani G., Paganelli F., et al. CD146-based immunomagnetic enrichment followed by multiparameter flow cytometry: a new approach to counting circulating endothelial cells. J Thromb Haemost 2008, 6:869-876. [see comment].
14. Vroling L., Yuana Y., Schuurhuis G.J., van Hinsbergh V.W., Gundy C., de Haas R., et al. VEGFR2 expressing circulating (progenitor) cell populations in volunteers and cancer patients. Thromb Haemost 2007, 98:440-450.
15. Goon P.K., Boos C.J., Stonelake P.S., Blann A.D., Lip G.Y. Detection and quantification of mature circulating endothelial cells using flow cytometry and immunomagnetic beads: a methodological comparison. Thromb Haemost 2006, 96:45-52.
16. Jacques N., Vimond N., Conforti R., Griscelli F., Lecluse Y., Laplanche A., et al. Quantification of circulating mature endothelial cells using a whole blood four-color flow cytometric assay. J Immunol Methods 2008, 337:132-143.
17. Makin A.J., Blann A.D., Chung N.A., Silverman S.H., Lip G.Y. Assessment of endothelial damage in atherosclerotic vascular disease by quantification of circulating endothelial cells. Relationship with von Willebrand factor and tissue factor. Eur Heart J 2004, 25:371-376.
18. Nadar S.K., Lip G.Y., Lee K.W., Blann A.D. Circulating endothelial cells in acute ischaemic stroke. Thromb Haemost 2005, 94:707-712.
19. Rajagopalan S., Somers E.C., Brook R.D., Kehrer C., Pfenninger D., Lewis E., et al. Endothelial cell apoptosis in systemic lupus erythematosus: a common pathway for abnormal vascular function and thrombosis propensity. Blood 2004, 103:3677-3683.
20. Bull T.M., Golpon H., Hebbel R.P., Solovey A., Cool C.D., Tuder R.M., et al. Circulating endothelial cells in pulmonary hypertension. Thromb Haemost 2003, 90:698-703.
21. Woywodt A., Streiber F., de Groot K., Regelsberger H., Haller H., Haubitz M. Circulating endothelial cells as markers for ANCA-associated small-vessel vasculitis. Lancet 2003, 361:206-210. [see comment].
22. Smadja D.M., Gaussem P., Mauge L., Israel-Biet D., Dignat-George F., Peyrard S., et al. Circulating endothelial cells: a new candidate biomarker of irreversible pulmonary hypertension secondary to congenital heart disease. Circulation 2009, 119:374-381.
23. Morel O., Toti F., Hugel B., Bakouboula B., Camoin-Jau L., Dignat-George F., et al. Procoagulant microparticles: disrupting the vascular homeostasis equation?. Arterioscler Thromb Vasc Biol 2006, 26:2594-2604.
24. Aras O., Shet A., Bach R.R., Hysjulien J.L., Slungaard A., Hebbel R.P., et al. Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia. Blood 2004, 103:4545-4553.
25. Shet A.S., Aras O., Gupta K., Hass M.J., Rausch D.J., Saba N., et al. Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. Blood 2003, 102:2678-2683.
26. Mallat Z., Hugel B., Ohan J., Leseche G., Freyssinet J.M., Tedgui A. Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity. Circulation 1999, 99:348-353.
27. Mallat Z., Benamer H., Hugel B., Benessiano J., Steg P.G., Freyssinet J.M., et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 2000, 101:841-843.
28. Perez-Casal M., Downey C., Fukudome K., Marx G., Toh C.H. Activated protein C induces the release of microparticle-associated endothelial protein C receptor. Blood 2005, 105:1515-1522.
29. Lacroix R., Sabatier F., Mialhe A., Basire A., Pannell R., Borghi H., et al. Activation of plasminogen into plasmin at the surface of endothelial microparticles: a mechanism that modulates angiogenic properties of endothelial progenitor cells in vitro. Blood 2007, 110:2432-2439.
30. Freyssinet J.M., Dignat-George F. More on: measuring circulating cell-derived microparticles. J Thromb Haemost 2005, 3:613-614. [comment].
31. Jy W., Horstman L.L., Jimenez J.J., Ahn Y.S., Biro E., Nieuwland R., et al. Measuring circulating cell-derived microparticles. J Thromb Haemost 2004, 2:1842-1851. [comment].
32. Koga H., Sugiyama S., Kugiyama K., Watanabe K., Fukushima H., Tanaka T., et al. Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol 2005, 45:1622-1630.
33. Simak J., Gelderman M.P., Yu H., Wright V., Baird A.E. Circulating endothelial microparticles in acute ischemic stroke: a link to severity, lesion volume and outcome. J Thromb Haemost 2006, 4:1296-1302.
34. Brodsky S.V., Zhang F., Nasjletti A., Goligorsky M.S. Endothelium-derived microparticles impair endothelial function in vitro. Am J Physiol Heart Circ Physiol 2004, 286:H1910-H1915.
35. Asahara T., Murohara T., Sullivan A., Silver M., van der Zee R., Li T., et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275:964-967.
36. Asahara T., Kawamoto A. Endothelial progenitor cells for postnatal vasculogenesis. Am J Physiol Cell Physiol 2004, 287:C572-C579.
37. Case J., Mead L.E., Bessler W.K., Prater D., White H.A., Saadatzadeh M.R., et al. Human CD34+AC133+VEGFR-2+ cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol 2007, 35:1109-1118. [see comment].
38. Yoder M.C., Mead L.E., Prater D., Krier T.R., Mroueh K.N., Li F., et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 2007, 109:1801-1809. [see comment].
39. Fadini G.P., Baesso I., Albiero M., Sartore S., Agostini C., Avogaro A. Technical notes on endothelial progenitor cells: ways to escape from the knowledge plateau. Atherosclerosis 2008, 197:496-503.
40. George J., Shmilovich H., Deutsch V., Miller H., Keren G., Roth A. Comparative analysis of methods for assessment of circulating endothelial progenitor cells. Tissue Eng 2006, 12:331-335.
41. Prater D.N., Case J., Ingram D.A., Yoder M.C. Working hypothesis to redefine endothelial progenitor cells. Leukemia 2007, 21:1141-1149.
42. Xiao Q., Kiechl S., Patel S., Oberhollenzer F., Weger S., Mayr A., et al. Endothelial progenitor cells, cardiovascular risk factors, cytokine levels and atherosclerosis: results from a large population-based study. PLoS ONE 2007, 2:e975.
43. Geft D., Schwartzenberg S., George J. Circulating endothelial progenitor cells in cardiovascular disorders. Expert Rev Cardiovasc Ther 2008, 6:1115-1121.
44. Hill J.M., Zalos G., Halcox J.P., Schenke W.H., Waclawiw M.A., Quyyumi A.A., et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003, 348:593-600. [see comment. Reprint in Can J Cardiol 2004;20(Suppl. B):44B-48B; PMID: 15309205].
45. Werner N., Wassmann S., Ahlers P., Schiegl T., Kosiol S., Link A., et al. Endothelial progenitor cells correlate with endothelial function in patients with coronary artery disease. Basic Res Cardiol 2007, 102:565-571.
46. Werner N., Kosiol S., Schiegl T., Ahlers P., Walenta K., Link A., et al. Circulating endothelial progenitor cells and cardiovascular outcomes [see comment]. N Engl J Med 2005, 353:999-1007. [see comment].
47. Fadini G.P., Albiero M., Boscaro E., Agostini C., Avogaro A. Endothelial progenitor cells as resident accessory cells for post-ischemic angiogenesis. Atherosclerosis 2009, 204:20-22.
48. Woywodt A., Bahlmann F.H., De Groot K., Haller H., Haubitz M. Circulating endothelial cells: life, death, detachment and repair of the endothelial cell layer. Nephrol Dial Transplant 2002, 17:1728-1730.
49. Abid Hussein M.N., Boing A.N., Biro E., Hoek F.J., Vogel G.M., Meuleman D.G., et al. Phospholipid composition of in vitro endothelial microparticles and their in vivo thrombogenic properties. Thromb Res 2008, 121:865-871.
50. Jimenez J.J., Jy W., Mauro L.M., Soderland C., Horstman L.L., Ahn Y.S. Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb Res 2003, 109:175-180.
51. Solovey A.A., Solovey A.N., Harkness J., Hebbel R.P. Modulation of endothelial cell activation in sickle cell disease: a pilot study. Blood 2001, 97:1937-1941.
52. Bonello L., Basire A., Sabatier F., Paganelli F., Dignat-George F. Endothelial injury induced by coronary angioplasty triggers mobilization of endothelial progenitor cells in patients with stable coronary artery disease. J Thromb Haemost 2006, 4:979-981. [see comments].
53. Bulut D., Maier K., Bulut-Streich N., Borgel J., Hanefeld C., Mugge A. Circulating endothelial microparticles correlate inversely with endothelial function in patients with ischemic left ventricular dysfunction. J Card Fail 2008, 14:336-340.
54. Pirro M., Schillaci G., Paltriccia R., Bagaglia F., Menecali C., Mannarino M.R., et al. Increased ratio of CD31+/CD42- microparticles to endothelial progenitors as a novel marker of atherosclerosis in hypercholesterolemia. Arterioscler Thromb Vasc Biol 2006, 26:2530-2535.
55. Leroyer A.S., Ebrahimian T.G., Cochain C., Recalde A., Blanc-Brude O., Mees B., et al. Microparticles from ischemic muscle promotes postnatal vasculogenesis. Circulation 2009, 119:2808-2817.
56. Mutin M., Canavy I., Blann A., Bory M., Sampol J., Dignat-George F. Direct evidence of endothelial injury in acute myocardial infarction and unstable angina by demonstration of circulating endothelial cells. Blood. 1999, 93:2951-2958. [see comments].
57. Quilici J., Banzet N., Paule P., Meynard J.B., Mutin M., Bonnet J.L., et al. Circulating endothelial cell count as a diagnostic marker for non-ST-elevation acute coronary syndromes. Circulation 2004, 110:1586-1591.
58. Lee K.W., Blann A.D., Lip G.Y. Plasma markers of endothelial damage/dysfunction, inflammation and thrombogenesis in relation to TIMI risk stratification in acute coronary syndromes. Thromb Haemost 2005, 94:1077-1083.
59. Chong A.Y., Blann A.D., Patel J., Freestone B., Hughes E., Lip G.Y. Endothelial dysfunction and damage in congestive heart failure: relation of flow-mediated dilation to circulating endothelial cells, plasma indexes of endothelial damage, and brain natriuretic peptide. Circulation 2004, 110:1794-1798.
60. McClung J.A., Naseer N., Saleem M., Rossi G.P., Weiss M.B., Abraham N.G., et al. Circulating endothelial cells are elevated in patients with type 2 diabetes mellitus independently of HbA(1)c. Diabetologia 2005, 48:345-350. [see comments].
61. Koc M., Richards H.B., Bihorac A., Ross E.A., Schold J.D., Segal M.S. Circulating endothelial cells are associated with future vascular events in hemodialysis patients. Kidney Int 2005, 67:1078-1083.
62. Erdbruegger U., Haubitz M., Woywodt A. Circulating endothelial cells: a novel marker of endothelial damage. Clin Chim Acta 2006, 373:17-26.
63. Solovey A., Lin Y., Browne P., Choong S., Wayner E., Hebbel R.P. Circulating activated endothelial cells in sickle cell anemia. N Engl J Med 1997, 337:1584-1590. [see comments].
64. Woywodt A., Schroeder M., Gwinner W., Mengel M., Jaeger M., Schwarz A., et al. Elevated numbers of circulating endothelial cells in renal transplant recipients. Transplantation 2003, 76:1-4.
65. Al-Massarani G., Vacher-Coponat H., Paul P., Widemann A., Arnaud L., Loundou A., et al. Impact of immunosuppressive treatment on endothelial biomarkers after kidney transplantation. Am J Transplant 2008, 8:2360-2367.
66. Woywodt A., Scheer J., Hambach L., Buchholz S., Ganser A., Haller H., et al. Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation. Blood 2004, 103:3603-3605.
67. Del Papa N., Colombo G., Fracchiolla N., Moronetti L.M., Ingegnoli F., Maglione W., et al. Circulating endothelial cells as a marker of ongoing vascular disease in systemic sclerosis. Arthritis Rheum 2004, 50:1296-1304.
68. Grefte A., van der Giessen M., van Son W., The T.H. Circulating cytomegalovirus (CMV)-infected endothelial cells in patients with an active CMV infection. J Infect Dis 1993, 167:270-277.
69. George F., Brouqui P., Boffa M.C., Mutin M., Drancourt M., Brisson C., et al. Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. Blood 1993, 82:2109-2116. [see comments].
70. Willett C.G., Boucher Y., di Tomaso E., Duda D.G., Munn L.L., Tong R.T., et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 2004, 10:145-147. [see comment. Erratum appears in Nat Med 2004;10(6):649].
71. Bernal-Mizrachi L., Jy W., Jimenez J.J., Pastor J., Mauro L.M., Horstman L.L., et al. High levels of circulating endothelial microparticles in patients with acute coronary syndromes. Am Heart J 2003, 145:962-970.
72. Preston R.A., Jy W., Jimenez J.J., Mauro L.M., Horstman L.L., Valle M., et al. Effects of severe hypertension on endothelial and platelet microparticles. Hypertension 2003, 41:211-217. [see comment].
73. Amabile N., Heiss C., Real W.M., Minasi P., McGlothlin D., Rame E.J., et al. Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension. Am J Respir Crit Care Med 2008, 177:1268-1275. [see comment].
74. Sabatier F., Darmon P., Hugel B., Combes V., Sanmarco M., Velut J.G., et al. Type 1 and type 2 diabetic patients display different patterns of cellular microparticles. Diabetes 2002, 51:2840-2845.
75. Amabile N., Guerin A.P., Leroyer A., Mallat Z., Nguyen C., Boddaert J., et al. Circulating endothelial microparticles are associated with vascular dysfunction in patients with end-stage renal failure. J Am Soc Nephrol 2005, 16:3381-3388.
76. Ferreira A.C., Peter A.A., Mendez A.J., Jimenez J.J., Mauro L.M., Chirinos J.A., et al. Postprandial hypertriglyceridemia increases circulating levels of endothelial cell microparticles. Circulation 2004, 110:3599-3603. [see comment].
77. Esposito K., Ciotola M., Schisano B., Gualdiero R., Sardelli L., Misso L., et al. Endothelial microparticles correlate with endothelial dysfunction in obese women. J Clin Endocrinol Metabol 2006, 91:3676-3679.
78. Simak J., Holada K., Risitano A.M., Zivny J.H., Young N.S., Vostal J.G. Elevated circulating endothelial membrane microparticles in paroxysmal nocturnal haemoglobinuria. Br J Haematol 2004, 125:804-813.
79. Dignat-George F., Camoin-Jau L., Sabatier F., Arnoux D., Anfosso F., Bardin N., et al. Endothelial microparticles: a potential contribution to the thrombotic complications of the antiphospholipid syndrome. Thromb Haemost 2004, 91:667-673. [see comment].
80. Brogan P.A., Shah V., Brachet C., Harnden A., Mant D., Klein N., et al. Endothelial and platelet microparticles in vasculitis of the young. Arthritis Rheum 2004, 50:927-936.
81. Massa M., Rosti V., Ferrario M., Campanelli R., Ramajoli I., Rosso R., et al. Increased circulating hematopoietic and endothelial progenitor cells in the early phase of acute myocardial infarction. Blood 2005, 105:199-206.
82. Lev E.I., Kleiman N.S., Birnbaum Y., Harris D., Korbling M., Estrov Z. Circulating endothelial progenitor cells and coronary collaterals in patients with non-ST segment elevation myocardial infarction. J Vasc Res 2005, 42:408-414.
83. Numaguchi Y., Sone T., Okumura K., Ishii M., Morita Y., Kubota R., et al. The impact of the capability of circulating progenitor cell to differentiate on myocardial salvage in patients with primary acute myocardial infarction. Circulation 2006, 114:I114-I119.
84. Leone A.M., Rutella S., Bonanno G., Abbate A., Rebuzzi A.G., Giovannini S., et al. Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function. Eur Heart J 2005, 26:1196-1204. [see comment].
85. George J., Goldstein E., Abashidze S., Deutsch V., Shmilovich H., Finkelstein A., et al. Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation. Eur Heart J 2004, 25:1003-1008. [see comment].
86. Sobrino T., Hurtado O., Moro M.A., Rodriguez-Yanez M., Castellanos M., Brea D., et al. The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome. Stroke 2007, 38:2759-2764.
87. Lemoli R.M., Catani L., Talarico S., Loggi E., Gramenzi A., Baccarani U., et al. Mobilization of bone marrow-derived hematopoietic and endothelial stem cells after orthotopic liver transplantation and liver resection. Stem Cells 2006, 24:2817-2825.
88. Inoue T., Sata M., Hikichi Y., Sohma R., Fukuda D., Uchida T., et al. Mobilization of CD34-positive bone marrow-derived cells after coronary stent implantation: impact on restenosis. Circulation 2007, 115:553-561. [see comment].
89. Spiel A.O., Mayr F.B., Leitner J.M., Firbas C., Sieghart W., Jilma B. Simvastatin and rosuvastatin mobilize Endothelial Progenitor Cells but do not prevent their acute decrease during systemic inflammation. Thromb Res 2008, 123:108-113. [see comment].
90. Park K.W., Hwang K.K., Cho H.J., Hur J., Yang H.M., Yoon C.H., et al. Simvastatin enhances endothelial differentiation of peripheral blood mononuclear cells in hypercholesterolemic patients and induces pro-angiogenic cytokine IL-8 secretion from monocytes. Clin Chim Acta 2008, 388:156-166.
91. Landmesser U., Bahlmann F., Mueller M., Spiekermann S., Kirchhoff N., Schulz S., et al. Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans. Circulation 2005, 111:2356-2363. [see comment].
92. Deschaseaux F., Selmani Z., Falcoz P.E., Mersin N., Meneveau N., Penfornis A., et al. Two types of circulating endothelial progenitor cells in patients receiving long-term therapy by HMG-CoA reductase inhibitors. Eur J Pharmacol 2007, 562:111-118.
93. Bahlmann F.H., DeGroot K., Duckert T., Niemczyk E., Bahlmann E., Boehm S.M., et al. Endothelial progenitor cell proliferation and differentiation is regulated by erythropoietin. Kidney Int 2003, 64:1648-1652.
94. Lipsic E., van der Meer P., Voors A.A., Westenbrink B.D., van den Heuvel A.F., de Boer H.C., et al. A single bolus of a long-acting erythropoietin analogue darbepoetin alfa in patients with acute myocardial infarction: a randomized feasibility and safety study. Cardiovasc Drugs Ther 2006, 20:135-141.
95. Steiner S., Niessner A., Ziegler S., Richter B., Seidinger D., Pleiner J., et al. Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. Atherosclerosis 2005, 181:305-310.
96. Walther C., Adams V., Bothur I., Drechsler K., Fikenzer S., Sonnabend M., et al. Increasing physical education in high school students: effects on concentration of circulating endothelial progenitor cells. Eur J Cardiovasc Prev Rehabil 2008, 15:416-422.
97. Laufs U., Werner N., Link A., Endres M., Wassmann S., Jurgens K., et al. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 2004, 109:220-226.
98. Naik R.P., Jin D., Chuang E., Gold E.G., Tousimis E.A., Moore A.L., et al. Circulating endothelial progenitor cells correlate to stage in patients with invasive breast cancer. Breast Cancer Res Treat 2008, 107:133-138.
99. Igreja C., Courinha M., Cachaco A.S., Pereira T., Cabecadas J., da Silva M.G., et al. Characterization and clinical relevance of circulating and biopsy-derived endothelial progenitor cells in lymphoma patients. Haematologica 2007, 92:469-477. [see comment].
100. Shaked Y., Ciarrocchi A., Franco M., Lee C.R., Man S., Cheung A.M., et al. Therapy-induced acute recruitment of circulating endothelial progenitor cells to tumors. Science 2006, 313:1785-1787.
101. Vasa M., Fichtlscherer S., Aicher A., Adler K., Urbich C., Martin H., et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001, 89:E1-7.
102. Schmidt-Lucke C., Rossig L., Fichtlscherer S., Vasa M., Britten M., Kamper U., et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005, 111:2981-2987.
103. Wang H.Y., Gao P.J., Ji K.D., Shen W.F., Fan C.L., Lu L., et al. Circulating endothelial progenitor cells C-reactive protein and severity of coronary stenosis in Chinese patients with coronary artery disease. Hypertens Res Clin Exp 2007, 30:133-141.
104. Taguchi A., Matsuyama T., Moriwaki H., Hayashi T., Hayashida K., Nagatsuka K., et al. Circulating CD34-positive cells provide an index of cerebrovascular function. Circulation 2004, 109:2972-2975.
105. Junhui Z., Xingxiang W., Guosheng F., Yunpeng S., Furong Z., Junzhu C. Reduced number and activity of circulating endothelial progenitor cells in patients with idiopathic pulmonary arterial hypertension. Respir Med 2008, 102:1073-1079.
106. Diller G.P., van Eijl S., Okonko D.O., Howard L.S., Ali O., Thum T., et al. Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. Circulation 2008, 117:3020-3030.
107. Nonaka-Sarukawa M., Yamamoto K., Aoki H., Nishimura Y., Tomizawa H., Ichida M., et al. Circulating endothelial progenitor cells in congestive heart failure. Int J Cardiol 2007, 119:344-348.
108. Kissel C.K., Lehmann R., Assmus B., Aicher A., Honold J., Fischer-Rasokat U., et al. Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J Am Coll Cardiol 2007, 49:2341-2349. [see comment].
109. Valgimigli M., Rigolin G.M., Fucili A., Porta M.D., Soukhomovskaia O., Malagutti P., et al. CD34+ and endothelial progenitor cells in patients with various degrees of congestive heart failure. Circulation 2004, 110:1209-1212.
110. George J., Herz I., Goldstein E., Abashidze S., Deutch V., Finkelstein A., et al. Number and adhesive properties of circulating endothelial progenitor cells in patients with in-stent restenosis. Arterioscler Thromb Vasc Biol 2003, 23:e57-60.
111. Matsuo Y., Imanishi T., Hayashi Y., Tomobuchi Y., Kubo T., Hano T., et al. The effect of senescence of endothelial progenitor cells on in-stent restenosis in patients undergoing coronary stenting. Intern Med 2006, 45:581-587.
112. Egan C.G., Lavery R., Caporali F., Fondelli C., Laghi-Pasini F., Dotta F., et al. Generalised reduction of putative endothelial progenitors and CXCR4-positive peripheral blood cells in type 2 diabetes. Diabetologia 2008, 51:1296-1305.
113. Thum T., Fraccarollo D., Schultheiss M., Froese S., Galuppo P., Widder J.D., et al. Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes 2007, 56:666-674.
114. Kusuyama T., Omura T., Nishiya D., Enomoto S., Matsumoto R., Takeuchi K., et al. Effects of treatment for diabetes mellitus on circulating vascular progenitor cells. J Pharmacol Sci 2006, 102:96-102.
115. Fadini G.P., Miorin M., Facco M., Bonamico S., Baesso I., Grego F., et al. Circulating endothelial progenitor cells are reduced in peripheral vascular complications of type 2 diabetes mellitus. J Am Coll Cardiol 2005, 45:1449-1457. [see comment].
116. Loomans C.J., de Koning E.J., Staal F.J., Rookmaaker M.B., Verseyden C., de Boer H.C., et al. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 2004, 53:195-199.
117. Pirro M., Schillaci G., Menecali C., Bagaglia F., Paltriccia R., Vaudo G., et al. Reduced number of circulating endothelial progenitors and HOXA9 expression in CD34+ cells of hypertensive patients. J Hypertens 2007, 25:2093-2099.
118. Oliveras A., Soler M.J., Martinez-Estrada O.M., Vazquez S., Marco-Feliu D., Vila J.S., et al. Endothelial progenitor cells are reduced in refractory hypertension. J Human Hypertens 2008, 22:183-190.
119. Schlieper G., Hristov M., Brandenburg V., Kruger T., Westenfeld R., Mahnken A.H., et al. Predictors of low circulating endothelial progenitor cell numbers in haemodialysis patients. Nephrol Dial Transplant 2008, 23:2611-2618.
120. Chan C.T., Li S.H., Verma S. Nocturnal hemodialysis is associated with restoration of impaired endothelial progenitor cell biology in end-stage renal disease. Am J Physiol Renal Physiol 2005, 289:F679-F684.
121. de Groot K., Bahlmann F.H., Bahlmann E., Menne J., Haller H., Fliser D. Kidney graft function determines endothelial progenitor cell number in renal transplant recipients. Transplantation 2005, 79:941-945.
122. Choi J.H., Kim K.L., Huh W., Kim B., Byun J., Suh W., et al. Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure. Arterioscler Thromb Vasc Biol 2004, 24:1246-1252.
123. Chen J.Z., Zhang F.R., Tao Q.M., Wang X.X., Zhu J.H. Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia. Clin Sci 2004, 107:273-280.
124. Michaud S.E., Dussault S., Haddad P., Groleau J., Rivard A. Circulating endothelial progenitor cells from healthy smokers exhibit impaired functional activities. Atherosclerosis 2006, 187:423-432.
125. Kondo T., Hayashi M., Takeshita K., Numaguchi Y., Kobayashi K., Iino S., et al. Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers. Arterioscler Thromb Vasc Biol 2004, 24:1442-1447.
126. Tao J., Wang Y., Yang Z., Tu C., Xu M.G., Wang J.M. Circulating endothelial progenitor cell deficiency contributes to impaired arterial elasticity in persons of advancing age. J Human Hypertens 2006, 20:490-495. [see comment].
127. Hoetzer G.L., Van Guilder G.P., Irmiger H.M., Keith R.S., Stauffer B.L., DeSouza C.A. Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men. J Appl Physiol 2007, 102:847-852. [see comment].
128. Zhu J, Wang X., Chen J., Sun J., Zhang F. Reduced number and activity of circulating endothelial progenitor cells from patients with hyperhomocysteinemia. Arch Med Res 2006, 37:484-489.