Solvent-free organocatalytic Michael addition of diethyl malonate to nitroalkenes: The practical synthesis of Pregabalin and γ-nitrobutyric acid derivatives

Tetrahedron

Volumn 67, Issue 3, 2011, Pages 636-640

  Liu, Jin Ming ^a   Wang, Xin ^a   Ge, Ze Mei ^a   Sun, Qi ^a   Cheng, Tie Ming ^a   Li, Run Tao ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Nitrobutyric acid derivatives; Michael addition; Organocatalysis; Pregabalin; Solvent free

Indexed keywords

GAMMA NITROBUTYRIC ACID DERIVATIVE; MALONIC ACID DIETHYL ESTER; NITROALKENE; PREGABALIN; SOLVENT; THIOUREA; UNCLASSIFIED DRUG;

ARTICLE; ASYMMETRIC SYNTHESIS; CATALYSIS; CATALYST; DRUG SYNTHESIS; ENANTIOSELECTIVITY; MICHAEL ADDITION; PRIORITY JOURNAL;

EID: 78650515838     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2010.11.053     Document Type: Article

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