Synthesis and biological evaluation of new 4β-anilino-4′-O- demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 285-296

  Wang, Li ^a   Yang, Fenyan ^a   Yang, Xiaochun ^a   Guan, Xianghong ^a   Hu, Chunqi ^a   Liu, Tao ^a   He, Qiaojun ^a   Yang, Bo ^a   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

4 Anilino 4 O demethyl 4 desoxypodophyllotoxin derivative; Cytotoxicity; Drug resistance; Tumor growth inhibition

Indexed keywords

2'' DEOXY 2'' (DIMETHYLAMINO)ETOPOSIDE; 4BETA [N (4''' ACETYLOXYLPHENYL 1''' CARBONYL) 4'' AMINOANILINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N (PHENYL 1''' ETHYLCARBONYL) 4'' AMINOANILINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [3 (2 (DIETHYLAMINO)ETHYL]PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [3 (2 MORPHOLIN 4 YLETHYL]PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [3 (2 PIPERIDIN 1 YLETHYL)PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [3 (2 PYRROLIDIN 1 YLETHYL]PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 (2 HYDROXYETHOXY)PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 (2 MORPHOLIN 4 YLETHYL)PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 (2 OXO 2 (DIETHYLAMINO)ETHYL)PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 (2 OXO 2 PIPERIDIN 1 YLETHYL)PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 (2 OXO 2 PYRROLIDIN 1 YLETHYL)PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 (2 PIPERIDIN 1 YLETHYL)PHENYL]AMINO) 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 (2 PYRROLIDIN 1 YLETHYL)PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 [(2 HYDROXYETHOXY)METHYL]PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 [(3 HYDROXYPROPOXY)METHYL]PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 [(4 HYDROXYBUTOXY)METHYL]PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 [2 (DIETHYLAMINO)ETHYL]PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 [2 (DIETHYLAMINO)YLETHYL]PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 [2 (DIISOPROPYLAMINO)ETHYL]PHENYL]AMINO] 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA [N [4 [TERT BUTYL (4 AMINOPHENYL)CARBAMATE]]]4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN; 4BETA ANILINO 4' O DEMETHYL 4 DESOXYPODOPHYLLOTOXIN DERIVATIVE; ANTINEOPLASTIC AGENT; DEOXYPODOPHYLLOTOXIN; ETOPOSIDE; GL 331; PODOPHYLLOTOXIN; TAFLUPOSIDE; TENIPOSIDE; TOP 53; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; METASTASIS; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; MICE; PHYSICOCHEMICAL PROCESSES; PODOPHYLLOTOXIN; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78650511666     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.016     Document Type: Article

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