Organogenetic tolerance

Organogenesis

Volumn 6, Issue 4, 2010, Pages 270-275

  Hammerman, Marc R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Beta cell; Diabetes mellitus; Non human primates; Transplantation; Xenotransplantation

Indexed keywords

GLUCOSE; IMMUNOSUPPRESSIVE AGENT; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL STRUCTURE; CELL TRANSPLANTATION; CONTROLLED STUDY; DIABETES MELLITUS; ENGRAFTMENT; GLUCOSE TOLERANCE; HOST; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IMPLANTATION; NONHUMAN; ORGAN DONOR; OUTCOME ASSESSMENT; PANCREAS ISLET; RAT; REVIEW; XENOTRANSPLANTATION;

ANIMALS; HUMANS; IMMUNE TOLERANCE; ORGANOGENESIS; RATS; SWINE; TRANSPLANTATION, HETEROLOGOUS;

MACACA MULATTA; PRIMATES; RATTUS; SUIDAE; SUS;

EID: 78650507815     PISSN: 15476278     EISSN: 15558592     Source Type: Journal    
DOI: 10.4161/org.6.4.13283     Document Type: Review

References (35)

1. Hammerman MR. Pancreas and kidney transplantation using embryonic donor organs. Organogenesis 2004;1:3-13.
2. Hammerman MR. Transplantation of kidney and endocrine pancreas: The window opens. Organogenesis 2007;3:59-66.
3. Rogers SA, Chen F, Talcott MR, Faulkner C, Thomas JM, Thevis M, et al. Long-term engraftment following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic rhesus macaques. Xenotransplantation 2007;14:591-602.
4. Ibrahim Z, Busch J, Awwad M, Wagner R, Wells K, Cooper D K C. Selected physiologic compatibilities and incompatibilities between human and porcine organ systems. Xenotransplantation 2006;13:488-99.
5. Hering BJ, Walawalkar N. Pig-to-nonhuman primate islet xenotransplantation. Transplant Immunol 2009;21:81-6.
6. Groth CG, Korsgren O, Tibell A, Tollemar J, Moller E, Bolinder J, et al. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 1994;344:1402-4.
7. Hering B, Wijkstrom M, Graham M, Hardstedt M, Aasheim TC, Jie T, et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006;12:301-3.
8. Cardona K, Korbutt GS, Milas Z, Lyon J, Cano J, Jiang W, et al. Long-term survival of neonatal porcine islets in non-human primates by targeting costimulation pathways. Nat Med 2006;12:304-6.
9. van der Windt DJ, Bottino R, Casu A, Campanile N, Smetanka C, He J, et al. Long term controlled normoglycemia in diabetic non-human primates after transplantation with hCD46 transgenic porcine islets. Am J Transpl 2009;9:2716-26.
10. Rogers SA, Chen F, Talcott M, Hammerman MR. Islet cell engraftment and control of diabetes in rats following transplantation of pig pancreatic anlagen. Am J Physiol 2004;286:502-9.
11. Rogers SA, Liapis H, Hammerman MR. Normalization of glucose post-transplantation of pig pancreatic anlagen into non-immunosuppressed diabetic rats depends on obtaining anlagen prior to embryonic day 35. Transplant Immunol 2005;14:67-75.
12. Rogers SA, Mohanakumar T, Liapis H, Hammerman MR. Engraftment of cells from porcine islets of Langerhans and normalization of glucose tolerance following transplantation of pig pancreatic primordia in non-immune suppressed diabetic rats. Am J Pathol 2010;177:854-64.
13. Rogers SA, Chen F, Talcott M, Liapis H, Hammerman MR. Glucose tolerance normalization following transplantation of pig pancreatic primordia into non-immunosuppressed diabetic ZDF rats. Transplant Immunol 2006;16:176-84.
14. Wu GS, Korsgren O, Zhang JG, Song ZS, Van Rooijen N, Tibell A. Pig islet xenograft rejection is markedly delayed in macrophage-depleted mice: a study in streptozotocin diabetic animals. Xenotransplantation 2000;7:214-20.
15. Wennberg L, Song Z, Benet W, Zhang J, Nava S, Sundberg B, et al. Diabetic rats transplanted with adult porcine islets and immunosuppressed with cyclosporine A mycophenolate mofetil and leflunomide remain normoglycemic for up to 100 days. Transplantation 2001;71:1024-33.
16. Korsgren O, Wallgran AC, Satake M, Karlsson-Parra A. Xenograft rejection of fetal porcine islet-like cell clusters in the rat: effect of active and passive immunization. Xenotransplantation 1999;6:271-80.
17. Schroeder RA, Marroquin CE, Kuo PC. Tolerance and the "Holy Grail" of transplantation. J Surg Res 2003;111:109-19.
18. Tchorsh-Yutsis D, Hecht G, Aronovich A, Shezen E, Klionsky Y, Rosen C, et al. Pig embryonic pancreatic tissue as a source for transplantation in diabetes: transient treatment with anti-LFA1, anti-CD48 and FTY720 enables long term graft maintenance in mice with only mild ongoing immune suppression Diabetes 2009;58:1585-94.
19. Hecht G, Eventov-Friedman S, Rosen C, Shezen E, Tchorsh D, Aronovich A, et al. Embryonic pig pancreatic tissue for the treatment of diabetes in a nonhuman primate model. Proc Natl Acad Sci USA 2009;106:8659-64.
20. Eloy R, Haffen K, Kedinger M, Griener JF. Chick embryo pancreatic transplants reverse experimental diabetes of rats. J Clin Invest 1979;64:361-73.
21. Abraham EJ, Kodama S, Lin JC, Ubeda M, Faustman DL, Habener JF. Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice. Am J Pathol 2004;164:817-30.
22. Rossini AA, Greiner DL, Mordes JP. Induction of immunologic tolerance for transplantation. Physiol Rev 1999;79:99-141.
23. Korsgren O. Acute cellular xenograft rejection. Xenotransplantation 1997;4:11-9.
24. Porta C, Rimoldi M, Raes G, Brys L, Ghezzi P, Di Liberto D, et al. Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci USA 2009;106:14978-83.
25. Hammerman MR. Xenotransplantation of pancreatic and kidney primordia: Where do we stand? Transplant Immunol 2009;21:93-100.
26. MacPherson AJ, Smith K. Mesenteric lymph nodes at the center of immune anatomy. J Exp Med 2006;203:497-500.
27. Crispe IN. Hepatic cells and liver tolerance Nat Rev Immunol 2003;3:51-62.
28. Worbs T, Bode U, Yan S, Hoffmann MW, Hintzen G, Bernhardt G, et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 2006;203:519-27.
29. Matsunaga T, Rahman A. In search of the origin of the thymus: the thymus and GALT may be evolutionarily related. Scand J Immunol 2001;53:1-6.
30. Youson JH, Al-Mahrouki AA. Ontogenetic and phylogenetic development of the endocrine pancreas (islet organ) in fishes. Gen Comp Endocrinol 1999;116:303-35.
31. Jansen A, Vorbi H A M, Jeucken P H M, Bruning GJ, Hooljkass H, Drexhage HA. An immunohistochemical study on organized lymphoid cell infiltrates in fetal and neonatal pancreases: a comparison with similar infiltrates found in the pancreas of a diabetic infant Autoimmunity 1993;15:31-8.
32. Turley SJ, Lee JW, Dutton-Swain N, Mathis D, Benoist C. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci USA 2005;102:17729-33.
33. Chen Y, Inobe J, Marks R, Gonnela P, Kuchroo VK, Weiner HJ. Peripheral deletion of antigen reactive T cells in oral tolerance. Nature 1995;376:177-80.
34. Spahn TW, Weiner HL, Rennert PD, Lugering N, Fontana A, Domschke W, et al. Mesenteric lymph nodes are critical for the induction of high dose oral tolerance in the absence of Peyer's Patches. Eur J Immunol 2002;32:1109-13.
35. Mandel TE. Fetal islet xenotransplantation in rodents and primates. J Mol Med 1999;77:155-60.