Fetal islet xenotransplantation in rodents and primates

Journal of Molecular Medicine

Volumn 77, Issue 1, 1999, Pages 155-160

  Mandel, T E ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Eosinophils; Fetal pancreas; Immunosuppression; Xenotransplantation Rejection

Indexed keywords

CELL DESTRUCTION; CONFERENCE PAPER; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORGAN DONOR; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIMATE; T LYMPHOCYTE; VASCULARIZATION; XENOGRAFT; XENOTRANSPLANTATION;

EID: 0033010318     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001090050326     Document Type: Conference Paper

References (43)

1. 1. Luzi L, Battezzati A, Perseghin G, Bianchi E, Terruzzi I, Spotti D, Vergani S, Secchi A, Larocca E, Ferrari G, Staudacher C, Castoldi R, Dicarlo V, Pozza G (1994) Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic uremic patients. J Clin Invest 93: 1948-1958
2. 2. Houwing H, Benthem L, Vansuylichem PTR, Vanderleest J, Strubbe JH, Steffens AB (1995) Islet transplantation in diabetic rats normalizes basal and exercise-induced energy metabolism. Diabetologia 38:919-926
3. 3. Hoffman L, Mandel TE, Carter WM, Koulmanda M, Martin FIR, Campbell DG, McMillan N (1983) Islet transplantation is more effective than parental insulin in the metabolic control and prevention of renal complications in diabetic mice. Metabolism 32: 451-456
4. 4. Nicholls K, Mandel TE (1989). Advanced glycosylation end-products in experimental murine diabetic nephropathy: effect of islet isografting and of amino guanidine. Lab Invest 60: 486-490
5. 5. Cuthbertson RA, Mandel TE (1989) Pancreatic islet transplantation ameliorates the effect of diabetes on retinal capillary endothelial cell kinetics. Current Eye Research 8: 681-686
6. 6. Gillies MC, Mandel TE (1990) The prevention of diabetic retinal and renal basement membrane thickening in mice by islet cell allografts. Aust NZ J Ophtholmol 18: 27-32
7. 7. Bilous RW, Mauer SM, Sutherland DER, Najarian JS, Goetz FC, Steffes MW (1989) The effects of pancreas transplantation on the glomerular structure of renal allografts in patients with insulin-dependent diabetes. N Engl J Med 321: 80-85
8. 8. Nyberg G, Holdaas H, Brekke IB, Hartmann A, Norden G, Olausson M, Osterby R (1996) Glomerular ultrastructure in kidneys transplanted simultaneously with a segmental pancreas to patients with type I diabetes. Nephrol Dialysis Transplant 11: 1029-1033
9. 9. The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329: 977-986
10. 10. Alejandro R (1995) Transplantation of islets of Langerhans in patients with insulin-dependent diabetes mellitus. Scand J Gastroenterol 30[Suppl 208]: 125-128
11. 11. Sutherland DER, Gores PF, Hering BJ, Wahoff D, McKeehen DA, Gruessner RWG (1996) Islet transplantation - an update. Diab Metab Rev 12: 137-150
12. 12. Pyzdrowski KL, Kendall DM, Halter JB, Nakhleh RE, Sutherland DER, Robertson RP (1992) Preserved insulin secretion and insulin independence in recipients of islet autografts. N Engl J Med 327: 220-226
13. 13. Ricordi C, Tzakis AG, Carroll PB, Zeng YJ, Rilo HL, Alejandro R, Shapiro A, Fung JJ, Demetris AJ, Mintz DH et al (1992) Human islet isolation and allotransplantation in 22 consecutive cases. Transplantation 53: 407-414
14. 14. Weir GC, Bonner-Weir S, Leahy JL (1990) Islet mass and function in diabetes and transplantation. Diabetes 39: 401-405
15. 15. Mandel TE (1990) The fetal pancreas: a valuable source of tissue for islet transplantation? Clin Transplant 4: 87-92
16. 16. Hoffman L, Mandel TE, Carter WM, Koulmanda M, Martin FIR (1982) Insulin Secretion by Foetal Human Pancreas in Organ Culture. Diabetologia 23: 426-430
17. 17. Simpson AM, Tuch BE, Vincent PC (1990) Pig fetal pancreatic monolayers. A model of potential use in transplantation. Transplantation. 49: 1133-1137
18. 18. Hoffman L, Carter W, Mandel TE, Martin FIR, Campbell DG (1981) The effect of short-term insulin treatment on the reversal of diabetes after transplantation of syngeneic cultured or uncultured fetal mouse pancreas. Transplantation 32: 342-344
19. 19. Collier SA, Mandel TE, Carter WM (1982) Detrimental effect of high medium glucose concentration on subsequent endocrine function of transplanted organ cultured foetal mouse pancreatic islets. Aust J Exp Biol Med Sci 60: 437-445
20. 20. Groth CG, Korsgren O, Tibell A, Tollemar J, Moller E, Bolinder J, Ostman J, Reinholt FP, Hellerstrom C, Andersson A (1994) Transplantation of porcine fetal pancreas to diabetic patients Lancet 344: 1402-1404
21. 21. Mandel TE, Koulmanda M (1995) Xenotransplantation of fetal pig pancreas in reversal of diabetes in spontaneously diabetic NOD mice. Transplant Proc 27: 2179-2180
22. 22. Mandel TE, Kovarik J, Koulmanda M (1995) A comparison of organ cultured fetal pancreas allo-, iso-and xenografts (pig) in non-immunosuppressed non-obese diabetic (NOD) mice. Am J Pathol 147: 834-844
23. 23. Mandel TE, Koulmanda M, Cozzi E, Waterworth P, Tolan M, Langford G, White DJG (1997) Transplantation of normal and DAF-transgenic fetal pig pancreas into cynomolgus monkeys, Transplant Proc 29:940
24. 24. Lawson JH, Platt JL (1996) Molecular barriers to xenotransplantation. Transplantation 62: 303-310
25. + T cells. J Exp Med 170: 991-996
26. 26. Mandel TE, Koulmanda M, Bacelj A (1990) Fetal pancreas transplantation in non-obese diabetic (NOD) mice: a comparison of iso, allo-, and xenografts. Horm Metab Res [Suppl] 25: 166-173
27. 27. Mandel TE, Koulmanda M, Loudovaris T, Bacelj A (1990) Xenografts of fetal pig islets in NOD mice: recurrence of disease and rejection of allografts precedes xenograft rejection in anti-CD-4 treated mice. "Lessons from Animal Diabetes, III", (ed E Shafrir). pp 120-125
28. + T cell-depleted mice. Transplantation 49: 849-856
29. 29. Silberstein DS, David JR (1987) The regulation of human eosinophil function by cytokines. Immunol Today 8: 380-385
30. + T cells, IL5, and mast cells. Clin Immunol Immunopathol 73: 305-311
31. + T cells and B cells. Transplantation 61: 1678-1684
32. 32. Weir MR, Hall-Craggs M, Shen SY, Posner JN, Alongi SV, Dagher FJ, Sadler JH (1986) The prognostic value of the eosinophil in acute renal allograft rejection. Transplantation 41: 709-712
33. 33. Kormendi F, Amend WJC (1988) The importance of eosinophil cells in kidney allograft rejection. Transplantation 45: 537-539
34. 34. Foster PF, Sankary HN, Hart M, Ashmann M, Williams JW (1989) Blood and graft eosinophilia as predictors of rejection in human liver transplantation. Transplantation 47: 72-74
35. 35. Hallgren R, Bohman SO, Fredens K (1991). Activated eosinophil infiltration and deposits of eosinophil cationic protein in renal allograft rejection. Nephron 59: 266-270
36. 36. Wang H, Nandra RS, Stein A, Avis L, Price A, Hibberd AD (1994) Eosinophils in acute renal allograft rejection. Transplant Immunol 2: 41-46
37. + macrophage and not a T lymphocyte. Transplantation 60: 594-601
38. 38. Tepper RI, Coffman RL, Leder P (1992) An eosinophil-dependent mechanism for the antitumor effect of interleukin-4. Sci-ence 257: 548-551
39. 39. Tepper RI, Pattengale PK, Leder P (1989) Murine interleukin-4 displays anti-tumor activity in vivo. Cell 57: 503-512
40. 40. Wardlaw AJ (1994) Eosinophils in the 1990s: new perspectives on their role in health and disease. Postgrad Med J 70: 536-552
41. 41. Faustman D, Coe C (1991) Prevention of xenograft rejection by masking donor HLA class I antigens. Science 252: 1700-1702
42. 42. Lenschow DJ, Zeng Y, Thistlethwaite JR, Montag A, Brady W, Gibson MG, Linsley PS, Bluestone JA (1992) Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA41g. Science 257: 789-792
43. 43. Ricordi C, Lacy PE, Sterbenz K, Davie JM (1987) Low-temperature culture of human islets or in vivo treatment with L3T4 anti-body produces a marked prolongation of islet human-to-mouse xenograft survival. Proc Natl Acad Sci USA 84: 8080-8084