Synthesis of deuterium-labelled drugs by hydrogen-deuterium (H-D) exchange using heterogeneous catalysis

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 53, Issue 11-12, 2010, Pages 686-692

  Modutlwa, Nkaelang ^a   Maegawa, Tomohiro ^a,b   Monguchi, Yasunari ^a   Sajiki, Hironao ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

deuterium oxide; heavy hydrogen drug; hydrogen deuterium exchange; multiple deuteration; palladium on carbon; platinum on carbon; rhodium on carbon

Indexed keywords

CATALYSIS; DEUTERIUM; HYDROGEN; OXIDES; PALLADIUM; PLATINUM;

DEUTERATIONS; DEUTERIUM INCORPORATIONS; HEAVY-HYDROGEN DRUG; HYDROGEN/DEUTERIUM EXCHANGE; MULTIPLE DEUTERATION; PALLADIUM ON CARBONS; PHENYTOIN; PLATINUM ON CARBON; RHODIUM ON CARBON; TRIMETHOPRIM;

CARBON;

CAFFEINE; DEUTERIUM OXIDE; PHENYTOIN; THEOPHYLLINE; TRIMETHOPRIM; VALPROMIDE;

ARTICLE; CATALYSIS; DEUTERIUM HYDROGEN EXCHANGE; DEUTERON NUCLEAR MAGNETIC RESONANCE; DRUG SYNTHESIS; HUMAN; ISOTOPE LABELING; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 78650470078     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1848     Document Type: Article

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